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Autophagic Punctum

Article Commentary
Individual Atg8 paralogs exhibit unique properties in streptococcus pneumoniae-induced hierarchical autophagy
Sayaka Shizukuishi, Michinaga Ogawa & Yukihiro Akeda
Published online: 11 Jul 2024
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Editor’s corner

Editorial
Pho81 is a novel regulator of pexophagy induced by phosphate starvation
Yuxiang Huang & Daniel J. Klionsky
Published online: 11 Jul 2024
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Free Access

Research paper

Article
Comprehensive knockout analysis of the RAB family small GTPases reveals an overlapping role of RAB2 and RAB14 in autophagosome maturation
Kentaro Haga & Mitsunori Fukuda
Published online: 10 Jul 2024
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Autophagic Punctum

Article Commentary
Enhancing neuronal reticulophagy: a strategy for combating aging and APP toxicity
Wenqing Mou & Yixian Cui
Published online: 10 Jul 2024
  • 121 Views
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Open Access

Research paper

Article
Metabolic stress induces a double-positive feedback loop between AMPK and SQSTM1/p62 conferring dual activation of AMPK and NFE2L2/NRF2 to synergize antioxidant defense
Eun-Ji Choi, Hyun-Taek Oh, Seon-Hyeong Lee, Chen-Song Zhang, Mengqi Li, Soo-Youl Kim, Sunghyouk Park, Tong-Shin Chang, Byung-Hoon Lee, Sheng-Cai Lin & Sang-Min Jeon
Published online: 10 Jul 2024
  • 153 Views
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Autophagic Punctum

Article Commentary
SKArred 2 death: neuroinflammatory breakdown of the hippocampus
Thomas Bajaj, Tim Ebert, Larissa J. Dillmann, Clara Sokn, Nils C. Gassen & Jakob Hartmann
Published online: 10 Jul 2024
  • 73 Views
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Open Access

Commentary and View

Article Commentary
Let’s talk about flux: the rising potential of autophagy rate measurements in disease
Nitin Sai Beesabathuni, Matthew W. Kenaston, Ritika Gangaraju, Neil Alvin B. Adia, Vardhan Peddamallu & Priya S. Shah
Published online: 10 Jul 2024
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Review

Review Article
Last but not least: emerging roles of the autophagy-related protein ATG4D
Emily McMann & Sharon M. Gorski
Published online: 08 Jul 2024
  • 180 Views
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Open Access

Autophagic Punctum

Article Commentary
Electrostatic maturation of the autophagosome
Saori Shinoda & Noboru Mizushima
Published online: 06 Jul 2024
  • 70 Views
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Research Paper

Article
Extracellular NCOA4 is a mediator of septic death by activating the AGER-NFKB pathway
Jiao Liu, Yichun Wang, Ling Zeng, Chunhua Yu, Rui Kang, Daniel J. Klionsky, Jianxin Jiang & Daolin Tang
Published online: 04 Jul 2024
  • 164 Views
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Research paper

Article
Prohibitins, Phb1 and Phb2, function as Atg8 receptors to support yeast mitophagy and also play a negative regulatory role in Atg32 processing
Diana García-Chávez, Eunice Domínguez-Martín, Laura Kawasaki, Laura Ongay-Larios, Hilario Ruelas-Ramírez, Ariann E. Mendoza-Martinez, Juan P. Pardo, Soledad Funes & Roberto Coria
Published online: 04 Jul 2024
  • 72 Views
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Research paper

Article
TBC1D4 antagonizes RAB2A-mediated autophagic and endocytic pathways
Rui Tian, Pengwei Zhao, Xianming Ding, Xinyi Wang, Xiao Jiang, Shuai Chen, Zhijian Cai, Lin Li, She Chen, Wei Liu & Qiming Sun
Published online: 04 Jul 2024
  • 91 Views
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Research Paper

Article
HLH-30/TFEB mediates sexual dimorphism in immunity in caenorhabditis elegans
Jooyeon Sohn, Sujeong Kwon, Gee-Yoon Lee, Sieun S. Kim, Yujin Lee, Jongsun Lee, Yoonji Jung, Seokjin Ham, Hae-Eun H. Park, Sangsoon Park, Seokjun G. Ha, Daehan Lee & Seung-Jae V. Lee
Accepted author version posted online: 04 Jul 2024
  • 92 Views
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Research Paper

Article
FOXO-regulated DEAF1 controls muscle regeneration through autophagy
Kah Yong Goh, Wen Xing Lee, Sze Mun Choy, Gopal Krishnan Priyadarshini, Kenon Chua, Qian Hui Tan, Shin Yi Low, Hui San Chin, Chee Seng Wong, Shu-Yi Huang, Nai Yang Fu, Jun Nishiyama, Nathan Harmston & Hong-Wen Tang
Accepted author version posted online: 04 Jul 2024
  • 212 Views
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Open Access

Research paper

Article
(-)-Epigallocatechin 3-gallate protects pancreatic β-cell against excessive autophagy-induced injury through promoting FTO degradation
Yixue Shao, Yuhan Zhang, Suyun Zou, Jianan Wang, Xirui Li, Miaozhen Qin, Liangjun Sun, Wenyue Yin, Xiaoai Chang, Shusen Wang, Xiao Han, Tijun Wu & Fang Chen
Published online: 03 Jul 2024
  • 199 Views
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Research paper

Article
The autophagy protein RUBCNL/PACER represses RIPK1 kinase-dependent apoptosis and necroptosis
Diego Rojas-Rivera, Sebastián Beltrán, Francisco Muñoz-Carvajal, Pablo Ahumada-Montalva, Lorena Abarzúa, Laura Gomez, Fernanda Hernandez, Cristian A. Bergmann, Luis Labrador, Melissa Calegaro-Nassif, Mathieu J.M. Bertrand, Patricio A. Manque & Ute Woehlbier
Published online: 03 Jul 2024
  • 200 Views
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Research paper

Article
An APEX2-based proximity-dependent biotinylation assay with temporal specificity to study protein interactions during autophagy in the yeast Saccharomyces cerevisiae
Yasmina Filali-Mouncef, Alexandre Leytens, Prado Vargas Duarte, Mattia Zampieri, Jörn Dengjel & Fulvio Reggiori
Published online: 03 Jul 2024
  • 373 Views
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Open Access

Translational Research Paper

Article
Adult-onset deactivation of autophagy leads to loss of synapse homeostasis and cognitive impairment, with implications for alzheimer disease
Hilary Grosso Jasutkar, Elizabeth M. Wasserlein, Azeez Ishola, Nicole Litt, Agnieszka Staniszewski, Ottavio Arancio & Ai Yamamoto
Published online: 01 Jul 2024
  • 482 Views
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Open Access

Research Paper

Article
EDIL3/Del-1 prevents aortic dissection through enhancing internalization and degradation of apoptotic vascular smooth muscle cells
Zheng Yin, Jishou Zhang, Mengmeng Zhao, Jianfang Liu, Yao Xu, Shanshan Peng, Wei Pan, Cheng Wei, Zihui Zheng, Siqi Liu, Juan-Juan Qin, Jun Wan & Menglong Wang
Published online: 01 Jul 2024
  • 244 Views
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Research Paper

Article
Bunyavirus SFTSV NSs utilizes autophagy to escape the antiviral innate immune response
Ze-Min Li, Shu-Hui Duan, Tian-Mei Yu, Bang Li, Wen-Kang Zhang, Chuan-Min Zhou & Xue-Jie Yu
Published online: 30 Jun 2024
  • 517 Views
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Autophagic Punctum

Article Commentary
Secretory autophagy – a new paradigm regulating synaptic plasticity
Yen-Ching Chang & Karen T. Chang
Published online: 30 Jun 2024
  • 128 Views
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Autophagic Punctum

Article Commentary
RCHY1 and OPTN: an E3-ligase and an autophagy receptor required for melanophagy, respectively
Ki Won Lee, Yong-Yeon Cho & Kwang Dong Kim
Published online: 27 Jun 2024
  • 114 Views
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Research paper

Article
PGAM5 interacts with and maintains BNIP3 to license cancer-associated muscle wasting
Qingyuan Zhang, Chunhui Chen, Ye Ma, Xinyi Yan, Nianhong Lai, Hao Wang, Baogui Gao, Anna Meilin Gu, Qinrui Han, Qingling Zhang, Lei La & Xuegang Sun
Published online: 26 Jun 2024
  • 235 Views
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Research paper

Article
The different roles of V-ATPase a subunits in phagocytosis/endocytosis and autophagy
Qi Chen, Hanjing Kou, Doris Lou Demy, Wei Liu, Jianchao Li, Zilong Wen, Philippe Herbomel, Zhibin Huang, Wenqing Zhang & Jin Xu
Published online: 25 Jun 2024
  • 489 Views
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Autophagic Punctum

Article Commentary
DDHD2 promotes lipid droplet catabolism by acting as a TAG lipase and a cargo receptor for lipophagy
Kun Gao, Fei Jia, Yao Li & Chenji Wang
Published online: 23 Jun 2024
  • 107 Views
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Research Paper

Article
An initial HOPS-mediated fusion event is critical for autophagosome transport initiation from the axon terminal
Serena R. Wisner, Madison Chlebowski, Amrita Mandal, Don Mai, Chris Stein, Ronald S. Petralia, Ya-Xian Wang & Catherine M. Drerup
Published online: 20 Jun 2024
  • 174 Views
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Research paper

Article
Activation of BK channels prevents diabetes-induced osteopenia by regulating mitochondrial Ca2+ and SLC25A5/ANT2-PINK1-PRKN-mediated mitophagy
Lan Jiang, Haidong He, Yuyan Tang, Jiawei Li, Svetlana Reilly, Hong Xin, Zhiping Li, Hui Cai & Xuemei Zhang
Published online: 19 Jun 2024
  • 286 Views
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Research paper

Article
Signal-Sustained Imaging of Mitophagy with an Enzyme-Activatable Metabolic Lipid Labeling Probe
Xiaoxue Zou, Shixiong Wen, Lichun Xu, Lei Gao, Xunxiang Wang, Xiao Hu, Jiahuai Han & Shoufa Han
Published online: 19 Jun 2024
  • 208 Views
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Research paper

Article
PLK2-mediated phosphorylation of SQSTM1 S349 promotes aggregation of polyubiquitinated proteins upon proteasomal dysfunction
Yun-Da Chen, Xiu-Ping Lin, Zi-Lun Ruan, Mi Li, Xue-Mei Yi, Xu Zhang, Shu Li & Hong-Bing Shu
Published online: 19 Jun 2024
  • 121 Views
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Research paper

Review Article
Dysregulation of pancreatic β-cell autophagy and the risk of type 2 diabetes
Hayder M. Al-kuraishy, Majid S. Jabir, Ali I. Al-Gareeb, Daniel J. Klionsky & Ali K. Albuhadily
Published online: 18 Jun 2024
  • 95 Views
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Brief Report

Brief Report
CCDC50 mediates the clearance of protein aggregates to prevent cellular proteotoxicity
Yu Ye, Penghui Jia, Jiafan Miao, Yicheng Wang, Zibo Li, Yuxin Lin, Miao He, Shurui Liu, Bi-Rong Zheng, Junyu Wu, Ji’an Pan, Chun-Mei Li, Panpan Hou & Deyin Guo
Accepted author version posted online: 13 Jun 2024
  • 208 Views
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Research paper

Article
ATG10S promotes IFNL1 expression and autophagic degradation of multiple viral proteins mediated by IFNL1
Miao-Qing Zhang, Jian-Rui Li, Lu Yang, Zong-Gen Peng, Shuo Wu & Jing-Pu Zhang
Published online: 11 Jun 2024
  • 780 Views
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Open Access

Research Paper

Article
The mammalian actin elongation factor ENAH/MENA contributes to autophagosome formation via its actin regulatory function
Yueheng Li, Yafei Zhang, Menghui Wang, Junhui Su, Xinjue Dong, Yuqi Yang, Hongshan Wang & QingQuan Li
Published online: 11 Jun 2024
  • 406 Views
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Addendum

Article Commentary
The DNA damage response and autophagy during cancer development: an antagonistic pleiotropy entanglement
Vassilis G. Gorgoulis, Konstantinos Evangelou & Daniel J Klionsky
Published online: 10 Jun 2024
  • 138 Views
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Research Paper

Article
ATG16L1 in myeloid cells limits colorectal tumor growth in ApcMin/+ mice infected with colibactin-producing Escherichia coli via decreasing inflammasome activation
Laurène Salesse, Angéline Duval, Pierre Sauvanet, Alison Da Silva, Nicolas Barnich, Catherine Godfraind, Guillaume Dalmasso & Hang Thi Thu Nguyen
Published online: 10 Jun 2024
  • 556 Views
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Open Access

Autophagic Punctum

Article Commentary
ARHGAP26/GRAF1 orchestrates actin remodeling and membrane dynamics to drive mitochondrial clearance and promote fuel flexibility
Qiang Zhu & Joan M. Taylor
Published online: 10 Jun 2024
  • 141 Views
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Research Article

Article
TMX2 potentiates cell viability of hepatocellular carcinoma by promoting autophagy and mitophagy
Weiyu Zhang, Yao Tang, Pengfei Yang, Yutong Chen, Zhijie Xu, Chunhui Qi, Hongbin Huang, Ruiyang Liu, Haorui Qin, Haoying Ke, Caini Huang, Fuyuan Xu, Pengfei Pang, Zhiju Zhao, Hong Shan & Fei Xiao
Published online: 10 Jun 2024
  • 517 Views
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Research paper

Article
The novel lnc-HZ12 suppresses autophagy degradation of BBC3 by preventing its interactions with HSPA8 to induce trophoblast cell apoptosis
Jingsong Zhao, Zhongyan Xu, Jiayu Xie, Tingting Liang, Rong Wang, Weina Chen, Chenyang Mi, Peng Tian, Jiarong Guo & Huidong Zhang
Published online: 06 Jun 2024
  • 204 Views
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Brief report

Brief Report
Atg44/Mdi1/mitofissin facilitates Dnm1-mediated mitochondrial fission
Kentaro Furukawa, Manabu Hayatsu, Kentaro Okuyama, Tomoyuki Fukuda, Shun-Ichi Yamashita, Keiichi Inoue, Shinsuke Shibata & Tomotake Kanki
Published online: 04 Jun 2024
  • 514 Views
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Open Access

Research Paper

Article
Unexpected roles for AMPK in the suppression of autophagy and the reactivation of MTORC1 signaling during prolonged amino acid deprivation
Dubek Kazyken, Sydney G. Dame, Claudia Wang, Maxwell Wadley & Diane C. Fingar
Published online: 04 Jun 2024
  • 893 Views
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Open Access

Autophagic Punctum

Article Commentary
Vesicle-vesicle fusion promoted by the Atg8-family autophagy protein LC3C: relevance of the N-terminal region
Uxue Ballesteros, Alicia Alonso, L. Ruth Montes & Asier Etxaniz
Published online: 31 May 2024
  • 139 Views
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Brief Report

Brief Report
RTN3L and CALCOCO1 function in parallel to maintain proteostasis in the endoplasmic reticulum
Kamal Kumar, Ravi Chidambaram, Smriti Parashar & Susan Ferro-Novick
Published online: 31 May 2024
  • 354 Views
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Research Paper

Article
Bacterial ubiquitin ligases hijack the host deubiquitinase OTUB1 to inhibit MTORC1 signaling and promote autophagy
Kelong Ma, Wei Xian, Hongtao Liu, Rundong Shu, Jinli Ge, Zhao-Qing Luo, Xiaoyun Liu & Jiazhang Qiu
Published online: 31 May 2024
  • 401 Views
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Commentary and Views

Article Commentary
When an underdog becomes a major player: the role of protein structural disorder in the Atg8 conjugation system
Hana Popelka & Daniel J. Klionsky
Published online: 29 May 2024
  • 486 Views
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Open Access

Research Paper

Article
Structural and functional characterization of the role of acetylation on the interactions of the human Atg8-family proteins with the autophagy receptor TP53INP2/DOR
Mohamed G. Ali, Haytham M. Wahba, Sebastian Igelmann, Normand Cyr, Gerardo Ferbeyre & James G. Omichinski
Published online: 27 May 2024
  • 248 Views
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Research Paper

Article
Development and characterization of phospho-ubiquitin antibodies to monitor PINK1-PRKN signaling in cells and tissue
Jens O. Watzlawik, Xu Hou, Tyrique Richardson, Szymon L. Lewicki, Joanna Siuda, Zbigniew K. Wszolek, Casey N. Cook, Leonard Petrucelli, Michael DeTure, Dennis W. Dickson, Odetta Antico, Miratul M. K. Muqit, Jordan B. Fishman, Karima Pirani, Ravindran Kumaran, Nicole K. Polinski, Fabienne C. Fiesel & Wolfdieter Springer
Published online: 27 May 2024
  • 1079 Views
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Open Access

Research Paper

Article
VCP/p97 UFMylation stabilizes BECN1 and facilitates the initiation of autophagy
Zhifeng Wang, Shuhui Xiong, Zhaoyi Wu, Xingde Wang, Yamin Gong, Wei-Guo Zhu & Xingzhi Xu
Published online: 26 May 2024
  • 731 Views
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Autophagic Punctum

Article
Autophagy in hematopoietic stem cell development of the embryo
Yumin Liu, Sifan Luo, Yuehang Chen & Zhuan Li
Published online: 22 May 2024
  • 116 Views
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Research Paper

Article
ROS-mediated lysosomal membrane permeabilization and autophagy inhibition regulate bleomycin-induced cellular senescence
Zhangyang Qi, Weiqi Yang, Baibing Xue, Tingjun Chen, Xianjie Lu, Rong Zhang, Zhichao Li, Xiaoqing Zhao, Yang Zhang, Fabin Han, Xiaohong Kong, Ruikang Liu, Xue Yao, Rui Jia & Shiqing Feng
Published online: 18 May 2024
  • 1104 Views
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Research Paper

Article
SCFFBXW5-mediated degradation of AQP3 suppresses autophagic cell death through the PDPK1-AKT-MTOR axis in hepatocellular carcinoma cells
Yupei Liang, Ping Chen, Shiwen Wang, Lili Cai, Feng Zhu, Yanyu Jiang, Lihui Li, Lihua Zhu, Yongqing Heng, Wenjuan Zhang, Yongfu Pan, Wenyi Wei & Lijun Jia
Published online: 18 May 2024
  • 300 Views
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