Cancer Biology & Therapy, Volume 2, Issue 5 (2003)

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Cancer Biology & Therapy, Volume 2, Issue 5 (2003)

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Editor's Corner

Editorial
Cover Image
Kornelia Polyak
Page: i
Published online: 04 May 2003
AbstractforCover Image | PDF (26.5 MB)
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Review

Review Article
Targeting Adult and Pediatric Cancers via Cell-Based Vaccines and the Prospect of Activated B Lymphocytes as a Novel Modality
Christina M. Coughlin & Robert H. Vonderheide
Pages: 466-470
Published online: 04 May 2003
AbstractforTargeting Adult and Pediatric Cancers via Cell-Based Vaccines and the Prospect of Activated B Lymphocytes as a Novel Modality | PDF (103.6 KB)
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Review Article
Rhebbing up mTOR: New Insights on TSC1 and TSC2, and the Pathogenesis of Tuberous Sclerosis
David J. Kwiatkowski
Pages: 471-476
Published online: 04 May 2003
AbstractforRhebbing up mTOR: New Insights on TSC1 and TSC2, and the Pathogenesis of Tuberous Sclerosis | PDF (133.1 KB)
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Review Article
Apoptosis Genes and Resistance to Cancer Therapy: What Does the Experimental and Clinical Data Tell Us?
J. Martin Brown & George Wilson
Pages: 477-490
Published online: 04 May 2003
AbstractforApoptosis Genes and Resistance to Cancer Therapy: What Does the Experimental and Clinical Data Tell Us? | PDF (416 KB)
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Review Article
Histone Methyltransferases in Tumor Suppression
Keun-Cheol Kim & Shi Huang
Pages: 491-499
Published online: 04 May 2003
AbstractforHistone Methyltransferases in Tumor Suppression | PDF (143.6 KB)
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Bedside to Bench Report

Article
Clinicopathologic and Molecular Features of Hodgkin Lymphoma
Anas Younes & Antonino Carbone
Pages: 500-507
Published online: 04 May 2003
AbstractforClinicopathologic and Molecular Features of Hodgkin Lymphoma | PDF (489.1 KB)
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Letter to the Editor

Letter
BAG3 Protein Regulates Cell Survival in Childhood Acute Lymphoblastic Leukemia Cells
Maria Fiammetta Romano, Michelina Festa, Antonello Petrella, Maria Pascale, Rita Bisogni, Vincenzo Poggi, Elise C. Kohn, Salvatore Venuta, Maria Caterina Turco & Arturo Leone
Pages: 508-510
Published online: 04 May 2003
AbstractforBAG3 Protein Regulates Cell Survival in Childhood Acute Lymphoblastic Leukemia Cells | PDF (125.8 KB)
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Research Paper

Article
Enhanced Adenovirus Infection of Melanoma Cells by Fiber-Modification: Incorporation of RGD Peptide or Ad5/3 Chimerism
Andrea L. Volk, Angel A. Rivera, Anna Kanerva, Gerd Bauerschmitz, Igor Dmitriev, Dirk M. Nettelbeck & David T. Curiel
Pages: 511-515
Published online: 04 May 2003
AbstractforEnhanced Adenovirus Infection of Melanoma Cells by Fiber-Modification: Incorporation of RGD Peptide or Ad5/3 Chimerism | PDF (184 KB)
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Commentary

Ad5 and Ad3 Chimeric Fiber Travels Into the Cell Without the CAR
Kunjlata M. Amin
Pages: 516-517
Published online: 04 May 2003
AbstractforAd5 and Ad3 Chimeric Fiber Travels Into the Cell Without the CAR | PDF (44.2 KB)
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Research Paper

Article
Altered HOX Gene Expression in Human Skin and Breast Cancer Cells
Terje Svingen & Kathryn F. Tonissen
Pages: 518-523
Published online: 04 May 2003
AbstractforAltered HOX Gene Expression in Human Skin and Breast Cancer Cells | PDF (121.8 KB)
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Commentary

HOX Genes — Emerging Stars in Cancer
Hexin Chen & Saraswati Sukumar
Pages: 524-525
Published online: 04 May 2003
AbstractforHOX Genes — Emerging Stars in Cancer | PDF (46.1 KB)
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Research Paper

Article
Epidermal Growth Factor Receptor Mediates Silibinin-Induced Cytotoxicity in a Rat Glioma Cell Line
Lin Qi, Rana P. Singh, Yingnian Lu, Rajesh Agarwal, Gail S. Harrison, Alex Franzusoff & L. Michael Glode
Pages: 526-531
Published online: 04 May 2003
AbstractforEpidermal Growth Factor Receptor Mediates Silibinin-Induced Cytotoxicity in a Rat Glioma Cell Line | PDF (308 KB)
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Commentary

Silibinin: A Thorny Therapeutic for EGFR Expressing Tumors?
Jonathan Hannay & Dihua Yu
Pages: 532-533
Published online: 04 May 2003
AbstractforSilibinin: A Thorny Therapeutic for EGFR Expressing Tumors? | PDF (50.6 KB)
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Research Paper

Article
Activation and Suppression of the TRAIL Death-Receptor Pathway in Chemotherapy Sensitive and Resistant Follicular Lymphoma Cells
Klaus W. Wagner, Fred King, Ken Nomoto, Deborah A. Knee, Garret Hampton, Marc Nasoff & Quinn L. Deveraux
Pages: 534-540
Published online: 04 May 2003
AbstractforActivation and Suppression of the TRAIL Death-Receptor Pathway in Chemotherapy Sensitive and Resistant Follicular Lymphoma Cells | PDF (567 KB)
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Commentary

Resistance of Follicular Lymphoma Cells to Chemotherapy Is More Than Just Bcl-2
Peter Hersey & Xu Dong Zhang
Pages: 541-543
Published online: 04 May 2003
AbstractforResistance of Follicular Lymphoma Cells to Chemotherapy Is More Than Just Bcl-2 | PDF (51.6 KB)
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Research Paper

Article
Induction of Apoptosis in BCR/ABL+ Cells By Histone Deacetylase Inhibitors Involves Reciprocal Effects on the RAF/MEK/ERK and JNK Pathways
Chunrong Yu, Mark Subler, Mohamed Rahmani, Erin Reese, Geoffrey Krystal, Daniel Conrad, Paul Dent & Steven Grant
Pages: 544-551
Published online: 04 May 2003
AbstractforInduction of Apoptosis in BCR/ABL+ Cells By Histone Deacetylase Inhibitors Involves Reciprocal Effects on the RAF/MEK/ERK and JNK Pathways | PDF (315.7 KB)
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Article
Specific Inhibition of DNMT1 by Antisense Oligonucleotides Induces Re-expression of Estrogen Receptor a (ER) in ER-negative Human Breast Cancer Cell Lines
Lan Yan, Sharyl J. Nass, Dawn Smith, William G. Nelson, James G. Herman & Nancy E. Davidson
Pages: 552-556
Published online: 04 May 2003
AbstractforSpecific Inhibition of DNMT1 by Antisense Oligonucleotides Induces Re-expression of Estrogen Receptor a (ER) in ER-negative Human Breast Cancer Cell Lines | PDF (243.2 KB)
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Commentary

Induction of the Estrogen Receptor by Ablation of DNMT1 in ER-Negative Breast Cancer Cells
Peter D. Adams & Paul Cairns
Pages: 557-558
Published online: 04 May 2003
AbstractforInduction of the Estrogen Receptor by Ablation of DNMT1 in ER-Negative Breast Cancer Cells | PDF (45.9 KB)
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Research Paper

Article
Lack of HIN-1 Methylation Defines Specific Breast Tumor Subtypes Including Medullary Carcinoma of the Breast and BRCA1-Linked Tumors
Pascaline Tisserand, Coralie Fouquet, Michel Barrois, Catherine Gallou, Rémi Dendale, Dominique Stoppa-Lyonnet, Xavier Sastre-Garau, Alain Fourquet & Thierry Soussi
Pages: 559-563
Published online: 04 May 2003
AbstractforLack of HIN-1 Methylation Defines Specific Breast Tumor Subtypes Including Medullary Carcinoma of the Breast and BRCA1-Linked Tumors | PDF (251.1 KB)
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Commentary

HIN-1 and the Nosology of Breast Cancer
Daniel Silver
Pages: 564-565
Published online: 04 May 2003
AbstractforHIN-1 and the Nosology of Breast Cancer | PDF (48.7 KB)
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Research Paper

Article
Differentially Expressed Apoptotic Genes in Early Stage Lung Adenocarcinoma Predicted by Expression Profiling
Sunil Singhal, Kunjlata M. Amin, Robert Kruklitis, M. Blair Marshall, John C. Kucharczuk, Peter DeLong, Leslie A. Litzky, Larry R. Kaiser & Steven M. Albelda
Pages: 566-571
Published online: 04 May 2003
AbstractforDifferentially Expressed Apoptotic Genes in Early Stage Lung Adenocarcinoma Predicted by Expression Profiling | PDF (193.7 KB)
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Article
Apoptotic Response to 5-Fluorouracil Treatment Is Mediated by Reduced Polyamines, Non-Autocrine Fas Ligand and Induced Tumor Necrosis Factor Receptor 2
Wei Zhang, Latha Ramdas, Weiping Shen, Sonya W. Song, Limei Hu & Stanley R. Hamilton
Pages: 572-578
Published online: 04 May 2003
AbstractforApoptotic Response to 5-Fluorouracil Treatment Is Mediated by Reduced Polyamines, Non-Autocrine Fas Ligand and Induced Tumor Necrosis Factor Receptor 2 | PDF (365 KB)
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Article
Tumor Expression of 4-1BB Ligand Sustains Tumor Lytic T Cells
Hua Zhang, Melinda S. Merchant, Kevin S. Chua, Chand Khanna, Lee J. Helman, Bill Telford, Yvona Ward, Jeffrey Summers, Jeffrey A. Toretsky, Elaine K. Thomas, Carl H. June & Crystal L. Mackall
Pages: 579-586
Published online: 04 May 2003
AbstractforTumor Expression of 4-1BB Ligand Sustains Tumor Lytic T Cells | PDF (378.5 KB)
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Commentary

Proper Costimulation of Tumor-Reactive T Lymphocytes May Provide a Key to Unlock Their Antitumor Activity
R. Todd Reilly
Pages: 587-588
Published online: 04 May 2003
AbstractforProper Costimulation of Tumor-Reactive T Lymphocytes May Provide a Key to Unlock Their Antitumor Activity | PDF (51.7 KB)
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Profiles in Science

Editorial
Surgeons as an Integral Part of the Cancer Research Team
Alfred M. Cohen
Pages: 589-591
Published online: 04 May 2003
AbstractforSurgeons as an Integral Part of the Cancer Research Team | PDF (59.7 KB)
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Meeting Reports

Meeting Report
The Hairy Powers of Oncogenes: From Biological Function to Cancer Therapy
Kornelia Polyak
Pages: 592-594
Published online: 04 May 2003
AbstractforThe Hairy Powers of Oncogenes: From Biological Function to Cancer Therapy | PDF (56.4 KB)
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Book Review

Book Review
Experiments with p53
Kumaravel Somasundaram
Pages: 595-596
Published online: 04 May 2003
AbstractforExperiments with p53 | PDF (40.2 KB)
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