Cancer Biology & Therapy, Volume 4, Issue 4 (2005)

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Cancer Biology & Therapy, Volume 4, Issue 4 (2005)

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Editor's Corner

Editorial
Cover Image
Page: i
Published online: 28 Apr 2005
AbstractforCover Image | PDF (984.3 KB)
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Correspondence

Letter
EpCAM is not a LAIR-1 ligand!
Andreas Nechansky & Ralf Kircheis
Page: 357
Published online: 09 Mar 2005
AbstractforEpCAM is not a LAIR-1 ligand! | PDF (152.3 KB)
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Letter
EpCAM is an Important Suppressor of Anti-Tumor Immunity
Stephen L. Eck & Andrew Armstrong
Page: 358
Published online: 09 Mar 2005
AbstractforEpCAM is an Important Suppressor of Anti-Tumor Immunity | PDF (177.5 KB)
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News

News
BDNF as a Target to Modulate Angiogenesis
Pages: 359-364
Published online: 08 Mar 2005
AbstractforBDNF as a Target to Modulate Angiogenesis | PDF (691.3 KB)
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News
Educated T-Cells Mount Stronger Anti-Tumor Response in Myeloma
Pages: 359-364
Published online: 08 Mar 2005
AbstractforEducated T-Cells Mount Stronger Anti-Tumor Response in Myeloma | PDF (691.3 KB)
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News
Small Molecule Targeting Stat3 Activity in Breast Cancer
Pages: 359-364
Published online: 16 Mar 2005
AbstractforSmall Molecule Targeting Stat3 Activity in Breast Cancer | PDF (691.3 KB)
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News
Timing of Vaccine Therapy May be Important in Prostate Cancer
Pages: 359-364
Published online: 16 Mar 2005
AbstractforTiming of Vaccine Therapy May be Important in Prostate Cancer | PDF (691.3 KB)
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News
Retro-Transposons Provide Clues to Genomic Instability in a Yeast Model
Pages: 359-364
Published online: 16 Mar 2005
AbstractforRetro-Transposons Provide Clues to Genomic Instability in a Yeast Model | PDF (691.3 KB)
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News
EBV Nuclear Protein EBNA3C Jump Starts the Cell Cycle Leading to Uncontrolled Growth
Pages: 359-364
Published online: 16 Mar 2005
AbstractforEBV Nuclear Protein EBNA3C Jump Starts the Cell Cycle Leading to Uncontrolled Growth | PDF (691.3 KB)
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News
Tel2 Cooperates with Myc in B-Cell Lymphomagenesis by Inactivating p53
Pages: 359-364
Published online: 24 Mar 2005
AbstractforTel2 Cooperates with Myc in B-Cell Lymphomagenesis by Inactivating p53 | PDF (691.3 KB)
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News
Stanley J. Korsmeyer, 1950-2005
Pages: 359-364
Published online: 05 Apr 2005
AbstractforStanley J. Korsmeyer, 1950-2005 | PDF (691.3 KB)
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Review

Review Article
Achieving hypoxia-inducible gene expression in tumours
L. Marignol, M. Lawler, M. Coffey & D. Hollywood
Pages: 365-370
Published online: 21 Feb 2005
AbstractforAchieving hypoxia-inducible gene expression in tumours | PDF (433 KB)
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Review Article
The epithelial-mesenchymal tansition (EMT) and colorectal cancer progression
Richard C. Bates & Arthur Mercurio
Pages: 371-376
Published online: 21 Feb 2005
AbstractforThe epithelial-mesenchymal tansition (EMT) and colorectal cancer progression | PDF (332.4 KB)
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Bedside to Bench Report

Article
Prostate specific antigen as a clinical biomarker for prostate cancer: What’s the take home message?
Frederick S. Leach, Moon S. Koh, Yung W. Chan, Samantha Bark, Robert Ray, Ronald A. Morton & Alan T. Remaley
Pages: 377-381
Published online: 21 Feb 2005
AbstractforProstate specific antigen as a clinical biomarker for prostate cancer: What’s the take home message? | PDF (412.6 KB)
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Journal Club

A novel WISp39 protein links Hsp90 and p21 stability to the G2/M checkpoint
Sharon Benzeno & J. Alan Diehl
Pages: 382-384
Published online: 21 Feb 2005
AbstractforA novel WISp39 protein links Hsp90 and p21 stability to the G2/M checkpoint | PDF (263.5 KB)
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Brief Communication

Brief Report
Signal therapy of NF1-deficient tumor xenograft in mice by the anti-PAK1 drug FK228
Yumiko Hirokawa, C. Oliver Hanemann, Andreas Kurtz, Silke Frahm, Victor Mautner & Hiroshi Maruta
Pages: 385-387
Published online: 21 Feb 2005
AbstractforSignal therapy of NF1-deficient tumor xenograft in mice by the anti-PAK1 drug FK228 | PDF (255.1 KB)
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Research Paper

Article
Trichostatin a (TSA) sensitizes the human prostatic cancer cell line DU145 to death receptor ligands treatment
Agshin F. Taghiyev, Natalya V. Guseva, Mary T. Sturm, Oskar Rokhlin & Michael B. Cohen
Pages: 388-396
Published online: 21 Feb 2005
AbstractforTrichostatin a (TSA) sensitizes the human prostatic cancer cell line DU145 to death receptor ligands treatment | PDF (780.3 KB)
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Commentary

Article Commentary
Exploiting the TSA connections to overcome apoptosis-resistance
Padhma Ranganathan & Vivek M. Rangnekar
Pages: 397-398
Published online: 21 Feb 2005
AbstractforExploiting the TSA connections to overcome apoptosis-resistance | PDF (155 KB)
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Research Paper

Article
Enhancing TRAIL-induced apoptosis by Bcl-XL siRNA
Hongbo Zhu, Wei Gup, Lidong Zhang, John J. Davis, Shuhong Wu, Fuminori Teraishi, Xiaobo Cao, W. Roy Smythe & Bingliang Fang
Pages: 399-403
Published online: 21 Feb 2005
AbstractforEnhancing TRAIL-induced apoptosis by Bcl-XL siRNA | PDF (673.5 KB)
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Commentary

Silencing Bcl-XL in cancer therapy
Kunhong Kim
Pages: 404-405
Published online: 21 Feb 2005
AbstractforSilencing Bcl-XL in cancer therapy | PDF (164.6 KB)
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Research Paper

Article
Maspin regulates hypoxia-mediated stimulation of uPA/uPAR complex in invasive breast cancer cells
Sumaira Amir, Naira V. Margaryan, Valerie A. Odero-Marah, Zhila Khalkhali-Ellis & Mary J.C. Hendrix
Pages: 406-412
Published online: 21 Feb 2005
AbstractforMaspin regulates hypoxia-mediated stimulation of uPA/uPAR complex in invasive breast cancer cells | PDF (595.7 KB)
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Article
Enhanced growth inhibition and apoptosis induction in NSCLC cell lines by combination of celecoxib and 4HPR at clinically relevant concentrations
Shi-Yong Sun, Claudia P. Schroeder, Ping Yue, Dafna Lotan, Waun K. Hong & Reuben Lotan
Pages: 413-419
Published online: 21 Feb 2005
AbstractforEnhanced growth inhibition and apoptosis induction in NSCLC cell lines by combination of celecoxib and 4HPR at clinically relevant concentrations | PDF (661 KB)
  • 355 Views
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Article
The tumor suppressor protein p53 functions similarly to p63 and p73 in activating transcription in vitro
Neelima Mondal & Jeffrey D. Parvin
Pages: 420-424
Published online: 21 Feb 2005
AbstractforThe tumor suppressor protein p53 functions similarly to p63 and p73 in activating transcription in vitro | PDF (544.8 KB)
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Commentary

p53 family members: Similar biochemistry, Different biology
Christopher E. Barbieri & Jennifer A. Pietenpol
Pages: 425-426
Published online: 21 Feb 2005
Abstractforp53 family members: Similar biochemistry, Different biology | PDF (165.3 KB)
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Research Paper

Article
Augmentation of antitumor effects of p53 Gene therapy by combination with HDAC inhibitor
Rishu Takimoto, Junji Kato, Takeshi Terui, Koichi Takada, Ganji Kuroiwa, Jing Wu, HIroyuki Ohnuma, Daisuke Takahari, Masayoshi Kobune, Yasushi Sato, Tetsuji Takayama, Takuya Matsunaga & Yoshiro Niistu
Pages: 427-434
Published online: 21 Feb 2005
AbstractforAugmentation of antitumor effects of p53 Gene therapy by combination with HDAC inhibitor | PDF (1.2 MB)
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Article
RIα influences cellular proliferation in cancer cells by transporting RFC40 into the nucleus
Rakhee S. Gupte, Pozarowski Piotr, Jerzy Grabarek, Frank Traganos, Zbigniew Darzynkiewicz & Marietta Y.W.T. Lee
Pages: 435-443
Published online: 21 Feb 2005
AbstractforRIα influences cellular proliferation in cancer cells by transporting RFC40 into the nucleus | PDF (1 MB)
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Commentary

Nuclear localization of RFC40 by RIα: A link between cellular signaling and proliferation
Neerja Karnani & Anindya Dutta
Pages: 444-445
Published online: 21 Feb 2005
AbstractforNuclear localization of RFC40 by RIα: A link between cellular signaling and proliferation | PDF (177.5 KB)
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Research Paper

Article
A DNA repeat, NBL2, is hypermethylated in some cancers but hypomethylated in others
Rie Nishiyama, LIxin Qi, Koji Tsumagari, Karen Weissbecker, Louis Dubeau, Martin Champagne, Suresh Sikka, Hisaki Nagai & Melanie Ehrlich
Pages: 446-454
Published online: 21 Feb 2005
AbstractforA DNA repeat, NBL2, is hypermethylated in some cancers but hypomethylated in others | PDF (750.3 KB)
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Article
Aberrant laminin beta-3 isoforms downstream of EWS-ETS fusion genes in ewing family tumors
Hideto Irifune, HIroyuki Nishimori, Goichi Watanabe, Kouichi Yoshida, Tatsuru Ikeda, Chihiro Matsui, Masaaki Morohashi, Satoshi Kawaguchi, Satoshi Nagoya, Takuro Wada, Toshihiko Yamashita, Yusuke Nakamura & Takashi Tokino
Pages: 455-461
Published online: 21 Feb 2005
AbstractforAberrant laminin beta-3 isoforms downstream of EWS-ETS fusion genes in ewing family tumors | PDF (720.9 KB)
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Commentary

Looking downstream of sarcoma-associated chimeric transcription factors: When is a target really a target?
Gabriela E. Mercado & Frederic G. Barr
Pages: 462-464
Published online: 21 Feb 2005
AbstractforLooking downstream of sarcoma-associated chimeric transcription factors: When is a target really a target? | PDF (165.7 KB)
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Research Paper

Article
Bax and Bak are required for cytochrome c release during arsenic trioxide-induced apoptosis
Leta K. Nutt, Vladimir Gogvadze, Wanlaya Uthaisang, Banafsheh Mirnikjoo, David J. McConkey & Sten Orrenius
Pages: 465-473
Published online: 21 Feb 2005
AbstractforBax and Bak are required for cytochrome c release during arsenic trioxide-induced apoptosis | PDF (436.5 KB)
  • 383 Views
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Article
Reversal of multidrug resistance in KB cells with tea polyphenol antioxidant capacity
Yuying Mei, Dongzhi Wei & Jianwen Liu
Pages: 474-479
Published online: 21 Feb 2005
AbstractforReversal of multidrug resistance in KB cells with tea polyphenol antioxidant capacity | PDF (770.9 KB)
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Article
Natural retinoids inhibit proliferation and induce apoptosis in pancreatic cancer cells previously reported to be retinoid resistant
Tarek H. El-Metwally, Mahmoud R. Hussein, Parviz M. Pour, Charles A. Kuszynksi & Thomas E. Adrian
Pages: 480-489
Published online: 21 Feb 2005
AbstractforNatural retinoids inhibit proliferation and induce apoptosis in pancreatic cancer cells previously reported to be retinoid resistant | PDF (893.1 KB)
  • 391 Views
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Article
Kinase-addiction and bi-phasic sensitivity-resistance of Bcr-Abl- and Raf-1-expressing cells to imatinib and geldanamycin
Zoya N. Demidenko, Won An, John T. Lee, Larisa Y. Romanova, James A. McCubrey & Mikhail V. Blagosklonny
Pages: 490-496
Published online: 21 Feb 2005
AbstractforKinase-addiction and bi-phasic sensitivity-resistance of Bcr-Abl- and Raf-1-expressing cells to imatinib and geldanamycin | PDF (650.7 KB)
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Commentary

Velcade displays promising activity in primary effusion lymphoma cells
David J. McConkey, Steffan T. Nawrocki & Robert Andtbacka
Pages: 497-498
Published online: 21 Feb 2005
AbstractforVelcade displays promising activity in primary effusion lymphoma cells | PDF (163.6 KB)
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Research Philosophy

Editorial
Why cancer centers matter
Judith C. Gasson
Pages: 499-501
Published online: 21 Feb 2005
AbstractforWhy cancer centers matter | PDF (564.1 KB)
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