Cancer Biology & Therapy, Volume 7, Issue 3 (2008)

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Cancer Biology & Therapy, Volume 7, Issue 3 (2008)

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Editor's Corner

Editorial
Cover Image
Page: i
Published online: 01 Mar 2008
AbstractforCover Image | PDF (195.6 KB)
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Review

Review Article
Tumor-initiating stem cells in liver cancer
Shan Yong Yi & Ke Jun Nan
Pages: 325-330
Published online: 01 Mar 2008
AbstractforTumor-initiating stem cells in liver cancer | PDF (393.7 KB)
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Journal Club

Genetic stability of tumor microenvironment
Matthew Danish, Tristan Sissung, Douglas K. Price & William D. Figg
Pages: 331-332
Published online: 01 Mar 2008
AbstractforGenetic stability of tumor microenvironment | PDF (67.3 KB)
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Clinical Study

Article
Phase I single-dose study of intracavitary-administered Nimotuzumab labeled with 188-Re in adult recurrent high-grade glioma
Angel Casaco, Gerardo López, Iván García, José Arsenio Rodríguez, Ramsés Fernández, Javier Figueredo, Leonel Torres, Alejandro Perera Pintado, Juan Batista, René Leyva, Yamilé Peña, Zaida Amador, Addys González, Barbara Estupiñan, Marcos Coca, Abel Hernández, Miguel Puig, Marbelia Iglesias, Astrid Hernández, Mayra Ramos, Leyanis Rodriquez & Niurelkis Suarez
Pages: 333-339
Published online: 01 Mar 2008
AbstractforPhase I single-dose study of intracavitary-administered Nimotuzumab labeled with 188-Re in adult recurrent high-grade glioma | PDF (667.5 KB)
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Article
BMI-1 autoantibody in serum as a new potential biomarker of nasopharyngeal carcinoma
Yong-Qing Tong, Bei Liu, Jian Huang, Yan Liu, Feng-Jie Guo, Guo-Hua Zhou, Ping-Li Xie, Yue-Hui Li, Jin-Yue Hu & Guan-Cheng Li
Pages: 340-344
Published online: 01 Mar 2008
AbstractforBMI-1 autoantibody in serum as a new potential biomarker of nasopharyngeal carcinoma | PDF (241.5 KB)
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Article
Co-expression patterns of tumor-associated antigen genes by non-small cell lung carcinomas: Implications for immunotherapy
Vaios Karanikas, Stefanos Tsochas, Konstantinos Boukas, Theodora Kerenidi, Marianna Nakou, Jubrail Dahabreh, Theodoros Poularakis, Konstantinos I. Gourgoulianis & Anastasios E. Germenis
Pages: 345-352
Published online: 01 Mar 2008
AbstractforCo-expression patterns of tumor-associated antigen genes by non-small cell lung carcinomas: Implications for immunotherapy | PDF (1 MB)
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Research Paper

Article
Sensitive and quantitative detection of KRAS2 gene mutations in pancreatic duct juice differentiates patients with pancreatic cancer from chronic pancreatitis, potential for early detection
Chanjuan Shi, Noriyoshi Fukushima, Tadayoshi Abe, Yansong Bian, Li Hua, Brian J. Wendelburg, Charles J. Yeo, Ralph H. Hruban, Michael G. Goggins & James R. Eshleman
Pages: 353-360
Published online: 01 Mar 2008
AbstractforSensitive and quantitative detection of KRAS2 gene mutations in pancreatic duct juice differentiates patients with pancreatic cancer from chronic pancreatitis, potential for early detection | PDF (671.4 KB)
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Commentary

Shining the spotlight on shed kras in pancreatic cancer
Lorenzo F. Sempere & Murray Korc
Pages: 361-363
Published online: 01 Mar 2008
AbstractforShining the spotlight on shed kras in pancreatic cancer | PDF (211.2 KB)
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Research Paper

Article
Differential response of human glioblastoma cell lines to combined camptothecin and ionizing radiation treatment
Cholpon S. Djuzenova, Teresa Güttler, Sabrina Berger, Astrid Katzer & Michael Flentje
Pages: 364-373
Published online: 01 Mar 2008
AbstractforDifferential response of human glioblastoma cell lines to combined camptothecin and ionizing radiation treatment | PDF (750.1 KB)
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Commentary

Broken beyond repair: Damaging DNA in glioblastoma cells with radiation and camptothecin
Zbigniew Darzynkiewicz
Pages: 374-375
Published online: 01 Mar 2008
AbstractforBroken beyond repair: Damaging DNA in glioblastoma cells with radiation and camptothecin | PDF (63.1 KB)
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Research Paper

Article
Synergy of pancratistatin and tamoxifen on breast cancer cells in inducing apoptosis by targeting mitochondria
Peter Siedlakowski, Amanda McLachlan-Burgess, Carly Griffin, Sridhar S. Tirumalai, James McNulty & Siyaram Pandey
Pages: 376-384
Published online: 01 Mar 2008
AbstractforSynergy of pancratistatin and tamoxifen on breast cancer cells in inducing apoptosis by targeting mitochondria | PDF (1.1 MB)
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Commentary

Synergy of pancratistatin and tamoxifen in inducing apoptosis in breast cancer cells
Sidhartha Ray
Pages: 385-386
Published online: 01 Mar 2008
AbstractforSynergy of pancratistatin and tamoxifen in inducing apoptosis in breast cancer cells | PDF (155.1 KB)
  • 151 Views
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Research Paper

Article
High-resolution analysis of genomic profiles of hepatocellular carcinoma cells with differential osteopontin expression
Bingsheng Sun, Jincai Wu, Ti Zhang & Changli Wang
Pages: 387-391
Published online: 01 Mar 2008
AbstractforHigh-resolution analysis of genomic profiles of hepatocellular carcinoma cells with differential osteopontin expression | PDF (273 KB)
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Article
Synergistic effect of mTOR inhibitor rapamycin and fluorouracil in inducing apoptosis and cell senescence in hepatocarcinoma cells
Xinxin Bu, Chen Le, Fengqi Jia, Xianling Guo, Li Zhang, Mengchao Wu & Lixin Wei
Pages: 392-396
Published online: 01 Mar 2008
AbstractforSynergistic effect of mTOR inhibitor rapamycin and fluorouracil in inducing apoptosis and cell senescence in hepatocarcinoma cells | PDF (362.5 KB)
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Commentary

A new trick for an old drug: mTOR inhibitor rapamycin augments the effect of fluorouracil on hepatocellular carcinoma by inducing cell senescence
Yufang Shi & David A. August
Pages: 397-398
Published online: 01 Mar 2008
AbstractforA new trick for an old drug: mTOR inhibitor rapamycin augments the effect of fluorouracil on hepatocellular carcinoma by inducing cell senescence | PDF (123 KB)
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Research Paper

Article
Antibacterial, antifungal, and anticancer activities of volatile oils and extracts from stems, leaves, and flowers of Eucalyptus sideroxylon and Eucalyptus torquata
Hossam M. Ashour
Pages: 399-403
Published online: 01 Mar 2008
AbstractforAntibacterial, antifungal, and anticancer activities of volatile oils and extracts from stems, leaves, and flowers of Eucalyptus sideroxylon and Eucalyptus torquata | PDF (1.2 MB)
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Article
Cellular differentiation in three-dimensional lung cell cultures
Roger A. Vertrees, Joseph B. Zwischenberger, Paul J. Boor, Vselovod Popov, Maureen McCarthy, Thomas Goodwin & Travis Solley
Pages: 404-411
Published online: 01 Mar 2008
AbstractforCellular differentiation in three-dimensional lung cell cultures | PDF (541.7 KB)
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Article
Lack of ABC transporter autoinduction in mice following long-term exposure to imatinib
Erin R. Gardner, Alex Sparreboom, Jaap Verweij & William D. Figg
Pages: 412-415
Published online: 01 Mar 2008
AbstractforLack of ABC transporter autoinduction in mice following long-term exposure to imatinib | PDF (152.8 KB)
  • 194 Views
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Commentary

Transporter pumps and imatinib: A cause of pharmacokinetic resistance?
Heinz-Josef Klumpen, Chris Liddle & Howard Gurney
Pages: 416-418
Published online: 01 Mar 2008
AbstractforTransporter pumps and imatinib: A cause of pharmacokinetic resistance? | PDF (114.6 KB)
  • 279 Views
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Research Paper

Article
Thymosin beta 4 is overexpressed in human pancreatic cancer cells and stimulates proinflammatory cytokine secretion and JNK activation
Yuqing Zhang, Louis W. Feurino, Qihui Zhai, Hao Wang, William E. Fisher, Changyi Chen, Qizhi Yao & Min Li
Pages: 419-423
Published online: 01 Mar 2008
AbstractforThymosin beta 4 is overexpressed in human pancreatic cancer cells and stimulates proinflammatory cytokine secretion and JNK activation | PDF (518.6 KB)
  • 388 Views
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Article
Increased expression of cytoplasmic HuR in familial adenomatous polyposis
Lodewijk A.A. Brosens, Josbert J. Keller, Leena Pohjola, Caj Haglund, Folkert H. Morsink, Christine Iacobuzio-Donahue, Michael Goggins, Francis M. Giardiello, Ari Ristimäki & Johan A. Offerhaus
Pages: 424-427
Published online: 01 Mar 2008
AbstractforIncreased expression of cytoplasmic HuR in familial adenomatous polyposis | PDF (226 KB)
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Commentary

HuRrying colon cancer progression
Natalia A. Ignatenko & Eugene W. Gerner
Pages: 428-429
Published online: 01 Mar 2008
AbstractforHuRrying colon cancer progression | PDF (251 KB)
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Research Paper

Article
19-nor-1α,25-Dihydroxyvitamin D2 (Paricalcitol) inhibits the proliferation of human pancreatic cancer cells in vitro and in vivo
Gary G. Schwartz, Dawn Eads, Christine Naczki, Scott Northrup, Tai Chen & Constantinos Koumenis
Pages: 430-436
Published online: 01 Mar 2008
Abstractfor19-nor-1α,25-Dihydroxyvitamin D2 (Paricalcitol) inhibits the proliferation of human pancreatic cancer cells in vitro and in vivo | PDF (530 KB)
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Commentary

Vitamin D for the treatment and prevention of pancreatic cancer.
Halcyon Skinner
Pages: 437-439
Published online: 01 Mar 2008
AbstractforVitamin D for the treatment and prevention of pancreatic cancer. | PDF (79.7 KB)
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Research Paper

Article
Tumor chemo-immunotherapy using gemcitabine and a synthetic dsRNA
Uyen M. Le, Nijaporn Yanasarn, Christian Lohr, Kay A. Fischer & Zhengrong Cui
Pages: 440-447
Published online: 01 Mar 2008
AbstractforTumor chemo-immunotherapy using gemcitabine and a synthetic dsRNA | PDF (407.5 KB)
  • 415 Views
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Article
Cancer gene therapy of adenovirus-mediated anti-4-1BB scFv in immunocompetent mice
Fang Liu, Qin Lu, Xun Ye, Chao Fang, Yi Zhao, Min Liang, Fang Hu, Andre Lieber & Hong-Zhuan Chen
Pages: 448-453
Published online: 01 Mar 2008
AbstractforCancer gene therapy of adenovirus-mediated anti-4-1BB scFv in immunocompetent mice | PDF (526 KB)
  • 475 Views
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Article
A direct protein-protein interaction is involved in the suppression of β-catenin transcription by retinoid X receptor α in colorectal cancer cells
Anjia Han, Chang Tong, Dong Hu, Xiuli Bi & Wancai Yang
Pages: 454-459
Published online: 01 Mar 2008
AbstractforA direct protein-protein interaction is involved in the suppression of β-catenin transcription by retinoid X receptor α in colorectal cancer cells | PDF (363.5 KB)
  • 192 Views
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Article
Jun activation domain-binding protein 1 negatively regulate p27kip1 in non-Hodgkin’s lymphomas
Yuchan Wang, Min Fei, Chun Cheng, Dongmei Zhang, Jianxin Lu, Song He, Yueming Zhao, You Wang & Aiguo Shen
Pages: 460-467
Published online: 01 Mar 2008
AbstractforJun activation domain-binding protein 1 negatively regulate p27kip1 in non-Hodgkin’s lymphomas | PDF (801.4 KB)
  • 222 Views
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Article
Emodin enhances cytotoxicity of chemotherapeutic drugs in prostate cancer cells: The mechanisms involve ROS-mediated suppression of multidrug resistance and hypoxia inducible factor-1
Xin-zhi Huang, Jie Wang, Chao Huang, Yu-ying Chen, Gui-ying Shi, Qing-shen Hu & Jing Yi
Pages: 468-475
Published online: 01 Mar 2008
AbstractforEmodin enhances cytotoxicity of chemotherapeutic drugs in prostate cancer cells: The mechanisms involve ROS-mediated suppression of multidrug resistance and hypoxia inducible factor-1 | PDF (349.3 KB)
  • 740 Views
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Commentary

Chemosensitization by emodin, a plant-derived anti-cancer agent: mechanism of action
Yi Sun
Pages: 476-478
Published online: 01 Mar 2008
AbstractforChemosensitization by emodin, a plant-derived anti-cancer agent: mechanism of action | PDF (724 KB)
  • 491 Views
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Erratum

Correction
Pre-clinical evaluation of 1-nitroacridine derived chemotherapeutic agent that has preferential cytotoxic activity towards prostate cancer
Kiranmayi Tadi, Badithe T. Ashok, Yuangen Chen, Debabrata Banerjee, Barbara Wysocka-Skrzela, Jerzy Konopa, Zbigniew Darzynkiewicz & Raj K. Tiwari
Page: 479
Published online: 01 Mar 2008
AbstractforPre-clinical evaluation of 1-nitroacridine derived chemotherapeutic agent that has preferential cytotoxic activity towards prostate cancer | PDF (100.7 KB)
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