Cancer Biology & Therapy, Volume 7, Issue 7 (2008)

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Cancer Biology & Therapy, Volume 7, Issue 7 (2008)

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Editor's Corner

Editorial
Cover Caption
Page: i
Published online: 01 Jul 2008
AbstractforCover Caption | PDF (83.4 MB)
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Special Article

Article
Evaluating the drug-target relationship between thymidylate synthase expression and tumor response to 5-fluorouracil: Is it time to move forward?
Shayna L. Showalter, Timothy N. Showalter, Agnes Witkiewicz, Robert Havens, Eugene P. Kennedy, Tomas Hucl, Scott E. Kern, Charles J. Yeo & Jonathan R. Brody
Pages: 986-994
Published online: 01 Jul 2008
AbstractforEvaluating the drug-target relationship between thymidylate synthase expression and tumor response to 5-fluorouracil: Is it time to move forward? | PDF (1 MB)
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Commentary

Thymidylate synthase and 5-fluorouracil: a cautionary tale
Fred Bunz
Pages: 995-996
Published online: 01 Jul 2008
AbstractforThymidylate synthase and 5-fluorouracil: a cautionary tale | PDF (550 KB)
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Review

Review Article
Transcriptional control of the melanoma malignant phenotype
Vladislava O. Melnikova & Menashe Bar-Eli
Pages: 997-1003
Published online: 01 Jul 2008
AbstractforTranscriptional control of the melanoma malignant phenotype | PDF (671.3 KB)
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Journal Club

Secondary BRCA1 and BRCA2 alterations and acquired chemoresistance
Weixin Wang & William D. Figg
Pages: 1004-1005
Published online: 01 Jul 2008
AbstractforSecondary BRCA1 and BRCA2 alterations and acquired chemoresistance | PDF (485.2 KB)
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Research Paper

Article
Contrast enhanced MRI and intravital fluorescence microscopy indicate improved tumor microcirculation in highly vascularized melanomas upon short-term anti-VEGFR treatment
M.E. Eichhorn, S. Strieth, S. Luedemann, A. Kleespies, U. Noth, A. Passon, G. Brix, K.W. Jauch, C.J. Bruns & M. Dellian
Pages: 1006-1013
Published online: 01 Jul 2008
AbstractforContrast enhanced MRI and intravital fluorescence microscopy indicate improved tumor microcirculation in highly vascularized melanomas upon short-term anti-VEGFR treatment | PDF (1.3 MB)
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Commentary

Vessel normalization by VEGF inhibition: a complex story
An Claes & William Leenders
Pages: 1014-1016
Published online: 01 Jul 2008
AbstractforVessel normalization by VEGF inhibition: a complex story | PDF (753.3 KB)
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Research Paper

Article
Dihydroartemisinin induces apoptosis in HL-60 leukemia cells dependent of iron and p38 mitogen-activated protein kinase activation but independent of reactive oxygen species
Jin-Jian Lu, Ling-Hua Meng, Yu-Jun Cai, Qin Chen, Lin-Jiang Tong, Li-Ping Lin & Jian Ding
Pages: 1017-1023
Published online: 01 Jul 2008
AbstractforDihydroartemisinin induces apoptosis in HL-60 leukemia cells dependent of iron and p38 mitogen-activated protein kinase activation but independent of reactive oxygen species | PDF (1.2 MB)
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Article
Synergistic effects of the purine analog sulfinosine and curcumin on the multidrug resistant human non-small cell lung carcinoma cell line (NCI-H460/R)
Tijana Andjelkovic, Milica Pesic, Jasna Bankovic, Nikola Tanic, Ivanka D. Markovic & Sabera Ruzdijic
Pages: 1024-1032
Published online: 01 Jul 2008
AbstractforSynergistic effects of the purine analog sulfinosine and curcumin on the multidrug resistant human non-small cell lung carcinoma cell line (NCI-H460/R) | PDF (988.3 KB)
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Article
Downregulation of c-jun results in apoptosis-mediated anti-osteosarcoma activity in an orthotopic model
Crispin R. Dass, Anna M. Friedhuber, Levon M. Khachigian, Dave E. Dunstan & Peter F. M. Choong
Pages: 1033-1036
Published online: 01 Jul 2008
AbstractforDownregulation of c-jun results in apoptosis-mediated anti-osteosarcoma activity in an orthotopic model | PDF (903.5 KB)
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Article
A critical role of CCR7 in invasiveness and metastasis of SW620 colon cancer cell in vitro and in vivo
Yu Shuyi, Duan Juping, Zhou Zhiqun, Pang Qiong, Ji Wuyang, Liu Ting, He Xiaowen, Xinfa Liu & Chen Yuxiang
Pages: 1037-1043
Published online: 01 Jul 2008
AbstractforA critical role of CCR7 in invasiveness and metastasis of SW620 colon cancer cell in vitro and in vivo | PDF (1.1 MB)
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Article
Dexamethasone reduces tumor recurrence and metastasis after pancreatic tumor resection in SCID mice
Jan-Hendrik Egberts, Bodo Schniewind, Miriam Pätzold, Bastian Kettler, Jürgen Tepel, Holger Kalthoff & Anna Trauzold
Pages: 1044-1050
Published online: 01 Jul 2008
AbstractforDexamethasone reduces tumor recurrence and metastasis after pancreatic tumor resection in SCID mice | PDF (964.8 KB)
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Commentary

Anti-inflammatory therapy for pancreatic cancer: A sorely needed advance in therapeutics?
Anthony Rizzo & Keith A. Cengel
Pages: 1051-1052
Published online: 01 Jul 2008
AbstractforAnti-inflammatory therapy for pancreatic cancer: A sorely needed advance in therapeutics? | PDF (487.7 KB)
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Research Paper

Article
Survivin knockdown combined with apoptin overexpression inhibits cell growth significantly
Qin Liu, Hanjiang Fu, Ruiyun Xing, Yi Tie, Jie Zhu, Zhixian Sun & Xiaofei Zheng
Pages: 1053-1060
Published online: 01 Jul 2008
AbstractforSurvivin knockdown combined with apoptin overexpression inhibits cell growth significantly | PDF (1.1 MB)
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Commentary

The art of killing: double stroke with apoptin and survivin as a novel approach in cancer therapy
Soumya Panigrahi, Thomas Klonisch & Marek Los
Pages: 1061-1062
Published online: 01 Jul 2008
AbstractforThe art of killing: double stroke with apoptin and survivin as a novel approach in cancer therapy | PDF (627.9 KB)
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Research Paper

Article
Stereomicroscopic fluorescence imaging of head and neck cancer xenografts targeting CD147
J. Robert Newman, John P. Gleysteen, Christopher F. Barañano, Jennifer R. Bremser, Wenyue Zhang, Kurt R. Zinn & Eben L. Rosenthal
Pages: 1063-1070
Published online: 01 Jul 2008
AbstractforStereomicroscopic fluorescence imaging of head and neck cancer xenografts targeting CD147 | PDF (3.1 MB)
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Commentary

CD147: A potential regulator of oncogenesis non-invasive imaging of CD147 in living subjects
Pritha Ray & Shahriar S. Yaghoubi
Pages: 1071-1072
Published online: 01 Jul 2008
AbstractforCD147: A potential regulator of oncogenesis non-invasive imaging of CD147 in living subjects | PDF (623.5 KB)
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Research Paper

Article
Involvement of PI3K/AKT/GSK3ß pathway in tetrandrine-induced G1 arrest and apoptosis
Xuan Li Chen, Kai Huan Ren, Hong-Wei He & Rong-Guang Shao
Pages: 1073-1078
Published online: 01 Jul 2008
AbstractforInvolvement of PI3K/AKT/GSK3ß pathway in tetrandrine-induced G1 arrest and apoptosis | PDF (1.7 MB)
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Commentary

GSK-3β is a critical mediator of tetrandrine induced cell cycle arrest and cytotoxicity
James A McCubrey, Jörg Bäsecke, Melchiorre Cervello, Alberto M. Martelli & Richard A. Franklin
Page: 1079
Published online: 01 Jul 2008
AbstractforGSK-3β is a critical mediator of tetrandrine induced cell cycle arrest and cytotoxicity | PDF (480.9 KB)
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Research Paper

Article
Sustained ERK activation is involved in the kaempferol-induced apoptosis of breast cancer cells and is more evident under 3-D culture condition
Bong-Woo Kim, Eung-Ryoung Lee, Hye-Min Min, Hyo-Soon Jeong, Jae-Yeon Ahn, Jung-Hyun Kim, Hye-Yeon Choi, Hana Choi, Eun Young Kim, Se Pill Park & Ssang-Goo Cho
Pages: 1080-1089
Published online: 01 Jul 2008
AbstractforSustained ERK activation is involved in the kaempferol-induced apoptosis of breast cancer cells and is more evident under 3-D culture condition | PDF (2.3 MB)
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Article
Anti-ErbB4 targeting approaches for prostate cancer treatment
Akiva Vexler, Ghalib Lidawi, Vered Loew, Itay Barnea, Victoriya Karaush, Alexander Shtabsky & Rami Ben-Yosef
Pages: 1090-1094
Published online: 01 Jul 2008
AbstractforAnti-ErbB4 targeting approaches for prostate cancer treatment | PDF (857.3 KB)
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Commentary

ErbB4 targeting approaches for prostate cancer treatment
DL Wheeler, VM Rangnekar & SR Schwarze
Pages: 1095-1097
Published online: 01 Jul 2008
AbstractforErbB4 targeting approaches for prostate cancer treatment | PDF (722.5 KB)
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Research Paper

Article
EphA2 overexpression promotes ovarian cancer growth
Chunhua Lu, Mian M.K. Shahzad, Hua Wang, Charles N. Landen, Seung W. Kim, Julie Allen, Alpa M. Nick, Nicholas Jennings, Michael S. Kinch, Menashe Bar-Eli & Anil K. Sood
Pages: 1098-1103
Published online: 01 Jul 2008
AbstractforEphA2 overexpression promotes ovarian cancer growth | PDF (1.1 MB)
  • 359 Views
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Article
Remarkable enhancement of cytotoxicity of onconase and cepharanthine when used in combination on various tumor cell lines
Masamichi Ita, H. Dorota Halicka, Toshiki Tanaka, Akira Kurose, Barbara Ardelt, Kuslima Shogen & Zbigniew Darzynkiewicz
Pages: 1104-1108
Published online: 01 Jul 2008
AbstractforRemarkable enhancement of cytotoxicity of onconase and cepharanthine when used in combination on various tumor cell lines | PDF (752.1 KB)
  • 319 Views
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Article
IFN-α and IFN-λ differ in their antiproliferative effects and duration of JAK/STAT signaling activity
Stephen G. Maher, Faruk Sheikh, Anthony J. Scarzello, Ana L. Romero-Weaver, Darren P. Baker, Raymond P. Donnelly & Ana M. Gamero
Pages: 1109-1115
Published online: 01 Jul 2008
AbstractforIFN-α and IFN-λ differ in their antiproliferative effects and duration of JAK/STAT signaling activity | PDF (1.1 MB)
  • 908 Views
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Article
Pre-clinical evaluation and efficacy studies of a melanin-binding IgM antibody labeled with 188Re against experimental human metastatic melanoma in nude mice
E. Dadachova, E. Revskaya, M.A. Sesay, H. Damania, R. Boucher, R.S. Sellers, R.C. Howell, L. Burns, G.B. Thornton, A. Natarajan, G.R. Mirick, S.J. DeNardo, G.L. DeNardo & A. Casadevall
Pages: 1116-1127
Published online: 01 Jul 2008
AbstractforPre-clinical evaluation and efficacy studies of a melanin-binding IgM antibody labeled with 188Re against experimental human metastatic melanoma in nude mice | PDF (2 MB)
  • 688 Views
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Open Access
Article
Stable RNA interference of hexokinase II gene inhibits human colon cancer LoVo cell growth in vitro and in vivo
Qiuping Peng, Qi Zhou, Daping Zhong, Feng Pan, Houjie Liang & Jinming Zhou
Pages: 1128-1135
Published online: 01 Jul 2008
AbstractforStable RNA interference of hexokinase II gene inhibits human colon cancer LoVo cell growth in vitro and in vivo | PDF (2.7 MB)
  • 338 Views
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Commentary

Hacking hexokinase halts tumor growth
Yongjun Fan & Wei-Xing Zong
Pages: 1136-1138
Published online: 01 Jul 2008
AbstractforHacking hexokinase halts tumor growth | PDF (514.4 KB)
  • 284 Views
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Research Paper

Article
Serum levels of NF-κB and pro-inflammatory cytokines following administration of mucotoxic drugs
Richard M Logan, Andrea M Stringer, Joanne M Bowen, Rachel J Gibson, Stephen T Sonis & Dorothy M K Keefe
Pages: 1139-1145
Published online: 01 Jul 2008
AbstractforSerum levels of NF-κB and pro-inflammatory cytokines following administration of mucotoxic drugs | PDF (843.6 KB)
  • 1441 Views
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Article
Genome-wide profiling at methylated promoters in pancreatic adenocarcinoma
Noriyuki Omura, Chung-Pin Li, Ang Li, Seung-Mo Hong, Kimberly Walter, Antonio Jimeno, Manuel Hidalgo & Michael Goggins
Pages: 1146-1156
Published online: 01 Jul 2008
AbstractforGenome-wide profiling at methylated promoters in pancreatic adenocarcinoma | PDF (2.7 MB)
  • 740 Views
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Commentary

Genome-wide profiling of methylated promoters in pancreatic adenocarcinoma: defining the pancreatic cancer epigenome
Paul G. Corn
Pages: 1157-1159
Published online: 01 Jul 2008
AbstractforGenome-wide profiling of methylated promoters in pancreatic adenocarcinoma: defining the pancreatic cancer epigenome | PDF (71.8 KB)
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