Association of FHL5 and LPA genetic polymorphisms with diabetes mellitus risk: a case-control study

Abstract

Background

China is one of the countries with the fastest growing prevalence of diabetes mellitus (DM) in the world. This study intended to investigate the association of single nucleotide polymorphisms (SNPs) of FHL5 and LPA with DM risk in the Chinese population.

Methods

This case-control study involved 1,420 Chinese individuals (710 DM patients and 710 controls). Four candidate loci (rs2252816/rs9373985 in FHL5 and rs3124784/rs7765781 in LPA) were successfully screened. The association of SNPs with DM risk was assessed by logistic regression analysis. Differences in clinical characteristics among subjects with different genotypes were analyzed by one-way analysis of variance.

Results

Overall analysis indicated that rs3124784 was associated with an increased risk of DM. Stratification analysis showed that rs3124784 significantly increased DM risk in different subgroups (male, non-smoking, non-drinking, and BMI > 24), while rs7765781 increased DM risk only in participants with BMI ≤ 24. Rs2252816 was associated with the course of DM. We also found that rs2252816 GG genotype and rs9373985 GG genotype were linked to the increased cystatin c in DM patients.

Conclusion

The genetic polymorphisms of LPA may be associated with DM risk in the Chinese population, which will provide useful information for the prevention and diagnosis of DM.

Keywords:

• Diabetes mellitus
• case-control study
• FHL5
• LPA
• single nucleotide polymorphisms

Acknowledge

We are very grateful to all volunteers, clinicians and hospital staff who participated in this study.

Ethical approval and consent to participation

This study fully followed the principles of the Declaration of Helsinki and was approved by the Ethics Committee of People’s Hospital of Wanning. Informed consent from all participants was obtained.

Author contributions

Xuezhong Xu wrote the paper; Xuezhong Xu, Fangyun Liang, Jinmei Chen analyzed and interpreted the data; Yipeng Ding conceived and designed the experiments; Feihong Chen, Lingyi Kong performed the experiments. All authors reviewed the manuscript.

Disclosure statement

No potential conflict of interest was reported by the author(s).

Additional information

Funding

This work was supported by the Hainan Province Medical and Health Scientific Research Project [grant number 21A200287].