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Research Article

Serum cystatin C is a better marker for preeclampsia than serum creatinine or serum urate

Pages 575-580 | Published online: 08 Jul 2009

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Anna Åkesson, Veronica Lindström, Ulf Nyman, Magnus Jonsson, Magnus Abrahamson, Anders Christensson, Jonas Björk & Anders Grubb. (2020) Shrunken pore syndrome and mortality: a cohort study of patients with measured GFR and known comorbidities. Scandinavian Journal of Clinical and Laboratory Investigation 80:5, pages 412-422.
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Hellen Cássia Dos Santos Gomes, Antônio Carlos Vieira Cabral, Silvia Passos Andrade, Henrique Vítor Leite, Patrícia Gonçalves Teixeira, Paula Peixoto Campos & Jaqueline Amorim Arantes Gomes. (2020) Cystatin C as an indicator of renal damage in pre-eclampsia. Hypertension in Pregnancy 39:3, pages 308-313.
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Erik Herou, Alain Dardashti, Shahab Nozohoor, Igor Zindovic, Per Ederoth, Anders Grubb & Henrik Bjursten. (2019) The mortality increase in cardiac surgery patients associated with shrunken pore syndrome correlates with the eGFRcystatin C/eGFRcreatinine-ratio. Scandinavian Journal of Clinical and Laboratory Investigation 79:3, pages 167-173.
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Araceli Jarquin Campos, Lorenz Risch, Marc Baumann, Mette-Triin Purde, Sebastian Neuber, Harald Renz, Beatrice Mosimann, Luigi Raio, Markus Mohaupt, Daniel Surbek & Martin Risch. (2019) Shrunken pore syndrome, preeclampsia, and markers of NO metabolism in pregnant women during the first trimester. Scandinavian Journal of Clinical and Laboratory Investigation 79:1-2, pages 91-98.
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Martin Risch, Mette-Triin Purde, Marc Baumann, Markus Mohaupt, Beatrice Mosimann, Harald Renz, Luigi Raio, Daniel Surbek & Lorenz Risch. (2017) High first-trimester maternal blood cystatin C levels despite normal serum creatinine predict pre-eclampsia in singleton pregnancies. Scandinavian Journal of Clinical and Laboratory Investigation 77:8, pages 634-643.
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Martin Risch, Lorenz Risch, Mette-Triin Purde, Harald Renz, Patrice Ambühl, Thomas Szucs & Yuki Tomonaga. (2016) Association of the cystatin C/creatinine ratio with the renally cleared hormones parathyroid hormone (PTH) and brain natriuretic peptide (BNP) in primary care patients: a cross-sectional study. Scandinavian Journal of Clinical and Laboratory Investigation 76:5, pages 379-385.
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Alain Dardashti, Shahab Nozohoor, Anders Grubb & Henrik Bjursten. (2016) Shrunken Pore Syndrome is associated with a sharp rise in mortality in patients undergoing elective coronary artery bypass grafting. Scandinavian Journal of Clinical and Laboratory Investigation 76:1, pages 74-81.
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Anders Grubb, Veronica Lindström, Magnus Jonsson, Sten-Erik Bäck, Tomas Åhlund, Bengt Rippe & Anders Christensson. (2015) Reduction in glomerular pore size is not restricted to pregnant women. Evidence for a new syndrome: ‘Shrunken pore syndrome’. Scandinavian Journal of Clinical and Laboratory Investigation 75:4, pages 333-340.
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Aleksandra Novakov Mikic, Velibor Cabarkapa, Aleksandra Nikolic, Daniela Maric, Snezana Brkic, Gorana Mitic, Marina Ristic & Zoran Stosic. (2012) Cystatin C in pre-eclampsia. The Journal of Maternal-Fetal & Neonatal Medicine 25:7, pages 961-965.
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Anders Larsson, Maria Palm, Lars-Olof Hansson & Ove Axelsson. (2010) Cystatin C and modification of diet in renal disease (MDRD) estimated glomerular filtration rate differ during normal pregnancy. Acta Obstetricia et Gynecologica Scandinavica 89:7, pages 939-944.
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Sherif Saleh, Antonios V. Antoniou, Kevin Harrington & Joseph Aquilina. (2010) Second Trimester Maternal Serum Cystatin C Levels in Preeclamptic and Normotensive Pregnancies: A Small Case-Control Study. Hypertension in Pregnancy 29:1, pages 112-119.
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Nora Franceschini, Chunfang Qiu, David A. Barrow & Michelle A. Williams. (2008) Cystatin C and Preeclampsia: A Case Control Study. Renal Failure 30:1, pages 89-95.
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K. Kristensen, V. Lindström, C. Schmidt, S. Blirup‐Jensen, A. Grubb, D. Wide‐Swensson & H. Strevens. (2007) Temporal changes of the plasma levels of cystatin C, β‐trace protein, β2‐microglobulin, urate and creatinine during pregnancy indicate continuous alterations in the renal filtration process. Scandinavian Journal of Clinical and Laboratory Investigation 67:6, pages 612-618.
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K. Kristensen, D. Wide-Swensson, C. Schmidt, S. Blirup-Jensen, V. Lindström, H. Strevens & A. Grubb. (2007) Cystatin C, β-2-microglobulin and β-trace protein in pre-eclampsia. Acta Obstetricia et Gynecologica Scandinavica 86:8, pages 921-926.
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Michele Mussap & Mario Plebani. (2004) Biochemistry and Clinical Role of Human Cystatin C. Critical Reviews in Clinical Laboratory Sciences 41:5-6, pages 467-550.
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Renata Araujo Avendanha, Guilherme Figueiredo Coelho Campos, Beatriz Castello Branco, Nicolle Coimbra Ishii, Luiz Henrique Nacife Gomes, Ailton José de Castro, Caio Ribeiro Vieira Leal & Ana Cristina Simões e Silva. (2024) Potential urinary biomarkers in preeclampsia: a narrative review. Molecular Biology Reports 51:1.
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Fatima Alshannag, Radwa M. M. Zaki, Eman Hemida, Mustafa M. M. ElBakry & Amani F. H. Noureldeen. (2023) Endostatin and Cystatin C as Potential Biomarkers for Early Prediction of Preeclampsia. ACS Omega 8:45, pages 42776-42786.
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Jieun Kang, Sangwon Hwang, Taesic Lee, Kwangjin Ahn, Dong Min Seo, Seong Jin Choi & Young Uh. (2023) Prediction Model for Pre-Eclampsia Using Gestational-Age-Specific Serum Creatinine Distribution. Biology 12:6, pages 816.
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Linnea Malmgren, Carl Öberg, Emil den Bakker, Felicia Leion, Joanna Siódmiak, Anna Åkesson, Veronica Lindström, Erik Herou, Alain Dardashti, Liana Xhakollari, Gabriel Grubb, Helena Strevens, Magnus Abrahamson, Johanna Helmersson‐Karlqvist, Martin Magnusson, Jonas Björk, Ulf Nyman, Johan Ärnlöv, Peter Ridefelt, Torbjörn Åkerfeldt, Magnus Hansson, Anna Sjöström, Johan Mårtensson, Yoshihisa Itoh, David Grubb, Olav Tenstad, Lars‐Olov Hansson, Isleifur Olafsson, Araceli Jarquin Campos, Martin Risch, Lorenz Risch, Anders Larsson, Gunnar Nordin, Hans Pottel, Anders Christensson, Henrik Bjursten, Arend Bökenkamp & Anders Grubb. (2022) The complexity of kidney disease and diagnosing it – cystatin C, selective glomerular hypofiltration syndromes and proteome regulation. Journal of Internal Medicine 293:3, pages 293-308.
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Na Yu, Xiaoyue Chen, Mengyang Du, Hui Li, Yanqiu Wang, Feizhou Jiang, Shihua Bao & Yinyan He. (2022) Long Non-Coding RNA ZEB2-AS1 Augments Activity of Trophoblast Cells and Prevents the Development of Recurrent Spontaneous Abortion in Mice Through EZH2-Mediated CST3 Inhibition. Reproductive Sciences 29:3, pages 963-974.
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Aysun Tekeli Taşkömür & Özlem Erten. (2021) The role of cystatin C, neutrophil-lymphocyte ratio and platelet-lymphocyte ratio in the evaluation of kidney function in women with preeclampsia. Taiwanese Journal of Obstetrics and Gynecology 60:4, pages 615-620.
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Liana Xhakollari, Amra Jujic, John Molvin, Peter Nilsson, Hannes Holm, Erasmus Bachus, Margret Leosdottir, Anders Grubb, Anders Christensson & Martin Magnusson. (2021) Proteins linked to atherosclerosis and cell proliferation are associated with the shrunken pore syndrome in heart failure patients. PROTEOMICS – Clinical Applications 15:4.
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Anders Grubb. (2020) Shrunken pore syndrome - a common kidney disorder with high mortality. Diagnosis, prevalence, pathophysiology and treatment options. Clinical Biochemistry 83, pages 12-20.
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Sheta M. Sheta, Magda A. Akl, Heba E. Saad & El-Sayed R. H. El-Gharkawy. (2020) A novel cerium( iii )–isatin Schiff base complex: spectrofluorometric and DFT studies and application as a kidney biomarker for ultrasensitive detection of human creatinine . RSC Advances 10:10, pages 5853-5863.
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Malamo E. CountourisJill R. DemirciArun JeyabalanJanet M. CatovEleanor B. Schwarz. (2019) Relationship of Postpartum Levels of Cystatin and High-Sensitivity C-Reactive Protein and Duration of Lactation in Mothers with Previous Gestational Hypertension or Preeclampsia. Breastfeeding Medicine 14:6, pages 408-415.
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Jianming Peng, Wen Wang, Lei Zheng, Yanfei Guan, Guicheng Ye, Huichun Tong, Ying Wang & Qian Wang. (2019) Serum Cystatin C Levels in Twin Pregnancy versus Singleton Pregnancy. Laboratory Medicine 50:2, pages 163-167.
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Ioannis Bellos, Georgia Fitrou, Georgios Daskalakis, Nikolaos Papantoniou & Vasilios Pergialiotis. (2019) Serum cystatin-c as predictive factor of preeclampsia: A meta-analysis of 27 observational studies. Pregnancy Hypertension 16, pages 97-104.
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Alisse Hauspurg, Malamo E. Countouris, Arun Jeyabalan, Carl A. Hubel, James M. Roberts, Eleanor B. Schwarz & Janet M. Catov. (2019) Risk of hypertension and abnormal biomarkers in the first year postpartum associated with hypertensive disorders of pregnancy among overweight and obese women. Pregnancy Hypertension 15, pages 1-6.
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Markus Sällman Almén, Jonas Björk, Ulf Nyman, Veronica Lindström, Magnus Jonsson, Magnus Abrahamson, AnnaLotta Schiller Vestergren, Örjan Lindhe, Gary Franklin, Anders Christensson & Anders Grubb. (2019) Shrunken Pore Syndrome Is Associated With Increased Levels of Atherosclerosis-Promoting Proteins. Kidney International Reports 4:1, pages 67-79.
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Krittanont Wattanavaekin, Maethaphan Kitporntheranunt & Chatchai Kreepala. (2018) Cystatin C as a novel predictor of preterm labor in severe preeclampsia. Kidney Research and Clinical Practice 37:4, pages 338-346.
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Dietrich Rothenbacher, Stefanie Braig, Chad A. Logan, Gertrud Feike, Miriam Müller, Wolfgang Koenig, Frank Reister & Jon Genuneit. (2018) Association of maternal uric acid and cystatin C serum concentrations with maternal and neonatal cardiovascular risk markers and neonatal body composition: The Ulm SPATZ Health Study. PLOS ONE 13:7, pages e0200470.
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Apeksha Niraula, Madhab Lamsal, Nirmal Baral, Shankar Majhi, Seraj Ahmed Khan, Pritha Basnet & Kashyap Dahal. (2017) Cystatin-C as a Marker for Renal Impairment in Preeclampsia. Journal of Biomarkers 2017, pages 1-7.
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A. Grubb. 2017. Biomarkers of Kidney Disease. Biomarkers of Kidney Disease 225 240 .
Ahmed Samy Elagwany, Tamer Mamdouh Abd Eldayem, Tarek Abdel Zaher Karkour, Akram Abd Elmoneem ELdeghedy & Heba Ragab Morsy. (2015) The application of serum cystatin C in estimating the renal function in women with severe preeclamptic toxemia. Progresos de Obstetricia y Ginecología.
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Guido Filler, Carola Kusserow, Laudelino Lopes & Marta Kobrzyński. (2014) Beta-trace protein as a marker of GFR — History, indications, and future research. Clinical Biochemistry 47:13-14, pages 1188-1194.
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Ragnar Rylander. (2014) Magnesium in pregnancy blood pressure and pre-eclampsia – A review. Pregnancy Hypertension: An International Journal of Women's Cardiovascular Health 4:2, pages 146-149.
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U.D. Anderson, M.G. Olsson, K.H. Kristensen, B. Åkerström & S.R. Hansson. (2012) Review: Biochemical markers to predict preeclampsia. Placenta 33, pages S42-S47.
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Patricia M. J. L. Koetje, Julia J. Spaan, Jeroen P. Kooman, Marc E. A. Spaanderman & Louis L. Peeters. (2011) Pregnancy Reduces the Accuracy of the Estimated Glomerular Filtration Rate Based on Cockroft-Gault and MDRD Formulas. Reproductive Sciences 18:5, pages 456-462.
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Anders Grubb. 2011. Biomarkers of Kidney Disease. Biomarkers of Kidney Disease 291 312 .
Rangeen Rafik Hamad, Anders Larsson, John Pernow, Katarina Bremme & Maria J Eriksson. (2009) Assessment of left ventricular structure and function in preeclampsia by echocardiography and cardiovascular biomarkers. Journal of Hypertension 27:11, pages 2257-2264.
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A Larsson. (2008) Author response to: Reference values for clinical chemistry tests during normal pregnancy. BJOG: An International Journal of Obstetrics & Gynaecology 115:13, pages 1716-1717.
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Stefan Herget-Rosenthal, Arend Bökenkamp & Walter Hofmann. (2007) How to estimate GFR-serum creatinine, serum cystatin C or equations?. Clinical Biochemistry 40:3-4, pages 153-161.
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Karl Kristensen, I. Larsson & S.R. Hansson. (2007) Increased cystatin C expression in the pre-eclamptic placenta. MHR: Basic science of reproductive medicine 13:3, pages 189-195*.
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Xiaofu Yang, Hanzhi Wang, Zhengping Wang & Minyue Dong. (2006) Alteration and significance of serum cardiac troponin I and cystatin C in preeclampsia. Clinica Chimica Acta 374:1-2, pages 168-169.
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Walter Hofmann. (2005) MDRD-Formel und Cystatin C. Verbesserungen zur Erfassung der glomerulären Filtrationsrate? MDRD formula and cystatin C. Improvements in the assessment of the glomerular filtration rate?. LaboratoriumsMedizin 29:3, pages 139-145.
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Ayub Akbari, Nathalie Lepage, Erin Keely, Heather D. Clark, James Jaffey, Martin MacKinnon & Guido Filler. (2005) Cystatin‐C and beta trace protein as markers of renal function in pregnancy. BJOG: An International Journal of Obstetrics & Gynaecology 112:5, pages 575-578.
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Guido Filler, Arend Bökenkamp, W. Hofmann, Thierry Le Bricon, Cecília Martínez-Brú & Anders Grubb. (2005) Cystatin C as a marker of GFR—history, indications, and future research. Clinical Biochemistry 38:1, pages 1-8.
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Helena Strevens, Dag Wide‐Swensson, Ingemar Ingemarsson & Anders Grubb. (2004) Author's Reply. BJOG: An International Journal of Obstetrics & Gynaecology 111:2, pages 193-195.
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Jan Mareš, David Stejskal, Jitka Vavroušková, Karel Urbánek, Roman Herzig & Petr Hluštík. (2003) USE OF CYSTATIN C DETERMINATION IN CLINICAL DIAGNOSTICS. Biomedical Papers 147:2, pages 177-180.
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Helena Strevens, Dag Wide‐Swensson, Anders Grubb, Alastair Hansen, Thomas Horn, Ingemar Ingemarsson, Svend Larsen, Jens R. Nyengaard, Ole Torffvit, Julian Willner & Steen Olsen. (2003) Serum cystatin C reflects glomerular endotheliosis in normal, hypertensive and pre‐eclamptic pregnancies. BJOG: An International Journal of Obstetrics & Gynaecology 110:9, pages 825-830.
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U. Pöge, B. Stoschus, B. Stoffel-Wagner, T. Gerhardt, H.U. Klehr, T. Sauerbruch & R.P. Woitas. (2003) Cystatin C as an Endogenous Marker of Glomerular Filtration Rate in Renal Transplant Patients. Kidney and Blood Pressure Research 26:1, pages 55-60.
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