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Original

Nuclear receptors CAR and PXR in the regulation of hepatic metabolism

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Pages 1152-1163 | Received 03 Feb 2006, Accepted 27 Feb 2006, Published online: 11 Aug 2009

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Sue Marty, Manon Beekhuijzen, Alex Charlton, Nina Hallmark, Bethany R. Hannas, Sylvia Jacobi, Stephanie Melching-Kollmuss, Ursula G. Sauer, Larry P. Sheets, Volker Strauss, Daniel Urbisch, Philip A. Botham & Bennard van Ravenzwaay. (2021) Towards a science-based testing strategy to identify maternal thyroid hormone imbalance and neurodevelopmental effects in the progeny – part II: how can key events of relevant adverse outcome pathways be addressed in toxicological assessments?. Critical Reviews in Toxicology 51:4, pages 328-358.
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Clifford R. Elcombe, Richard C. Peffer, Douglas C. Wolf, Jason Bailey, Remi Bars, David Bell, Russell C. Cattley, Stephen S. Ferguson, David Geter, Amber Goetz, Jay I. Goodman, Susan Hester, Abigail Jacobs, Curtis J. Omiecinski, Rita Schoeny, Wen Xie & Brian G. Lake. (2014) Mode of action and human relevance analysis for nuclear receptor-mediated liver toxicity: A case study with phenobarbital as a model constitutive androstane receptor (CAR) activator. Critical Reviews in Toxicology 44:1, pages 64-82.
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M. A. Gray, J. N. Peacock & E. J. Squires. (2009) Characterization of the porcine constitutive androstane receptor (CAR) and its splice variants. Xenobiotica 39:12, pages 915-930.
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Jaime Kapitulnik, Olavi Pelkonen, Ursula Gundert-Remy, Svein G Dahl & Alan R Boobis. (2009) Effects of pharmaceuticals and other active chemicals at biological targets: mechanisms, interactions, and integration into PB-PK/PD models. Expert Opinion on Therapeutic Targets 13:7, pages 867-887.
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Thomas G. Osimitz & Brian G. Lake. (2009) Mode-of-action analysis for induction of rat liver tumors by pyrethrins: relevance to human cancer risk. Critical Reviews in Toxicology 39:6, pages 501-511.
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