Advanced search
Publication Cover
Xenobiotica
the fate of foreign compounds in biological systems
Volume 38, 2008 - Issue 3
Submit an article Journal homepage
392
Views
38
CrossRef citations to date
0
Altmetric
Research Article

Metabolism and related human risk factors for hepatic damage by usnic acid containing nutritional supplements

R. S. Foti Biochemistry and Biophysics Group, Pharmacokinetics and Drug Metabolism, Amgen, Inc., Seattle, WA, USA
,
L. J. Dickmann Biochemistry and Biophysics Group, Pharmacokinetics and Drug Metabolism, Amgen, Inc., Seattle, WA, USA
,
J. A. Davis Biochemistry and Biophysics Group, Pharmacokinetics and Drug Metabolism, Amgen, Inc., Seattle, WA, USA
,
R. J. Greene Biochemistry and Biophysics Group, Pharmacokinetics and Drug Metabolism, Amgen, Inc., Seattle, WA, USA
,
J. J. Hill Biochemistry and Biophysics Group, Pharmacokinetics and Drug Metabolism, Amgen, Inc., Seattle, WA, USA
,
M. L. Howard Biochemistry and Biophysics Group, Pharmacokinetics and Drug Metabolism, Amgen, Inc., Seattle, WA, USA
,
J. T. Pearson Biochemistry and Biophysics Group, Pharmacokinetics and Drug Metabolism, Amgen, Inc., Seattle, WA, USA
,
D. A. Rock Biochemistry and Biophysics Group, Pharmacokinetics and Drug Metabolism, Amgen, Inc., Seattle, WA, USA
,
J. C. Tay Biochemistry and Biophysics Group, Pharmacokinetics and Drug Metabolism, Amgen, Inc., Seattle, WA, USA
,
J. L. Wahlstrom Biochemistry and Biophysics Group, Pharmacokinetics and Drug Metabolism, Amgen, Inc., Seattle, WA, USA
&
J. G. Slatter Biochemistry and Biophysics Group, Pharmacokinetics and Drug Metabolism, Amgen, Inc., Seattle, WA, USA
 show all
Pages 264-280 | Received 02 Oct 2007, Accepted 12 Nov 2007, Published online: 22 Sep 2008

Citations (38)

Keep up to date with the latest research on this topic with citation updates for this article.

Subscribe to citation updates

Read on this site (6)

Robert A. Roth, Omar Kana, David Filipovic & Patricia E. Ganey. (2022) Pharmacokinetic and toxicodynamic concepts in idiosyncratic, drug-induced liver injury. Expert Opinion on Drug Metabolism & Toxicology 18:7-8, pages 469-481.
Read now
Pan Zhao, Bin Liu & Chunya Wang. (2017) Hepatotoxicity evaluation of traditional Chinese medicines using a computational molecular model. Clinical Toxicology 55:9, pages 996-1000.
Read now
A. A. S. Araújo, M. G. D. de Melo, T. K. Rabelo, P. S. Nunes, S. L. Santos, M. R. Serafini, M. R. V. Santos, L. J. Quintans-Júnior & D. P. Gelain. (2015) Review of the biological properties and toxicity of usnic acid. Natural Product Research 29:23, pages 2167-2180.
Read now
Gordon Liss & James H Lewis. (2009) Drug-induced liver injury: what was new in 2008?. Expert Opinion on Drug Metabolism & Toxicology 5:8, pages 843-860.
Read now
Masoud Jamei, Steve Marciniak, Kairui Feng, Adrian Barnett, Geoffrey Tucker & Amin Rostami-Hodjegan. (2009) The Simcyp® Population-based ADME Simulator. Expert Opinion on Drug Metabolism & Toxicology 5:2, pages 211-223.
Read now
LEI GUO, QIANG SHI, JIA-LONG FANG, NAN MEI, A. AFSHAN ALI, SHERRYM. LEWIS, JULIANE.A. LEAKEY & VASILIOSH. FRANKOS. (2008) Review of Usnic Acid and Usnea Barbata Toxicity. Journal of Environmental Science and Health, Part C 26:4, pages 317-338.
Read now

Articles from other publishers (32)

Marzia Vasarri, Linda Ponti, Donatella Degl'Innocenti & Maria Camilla Bergonzi. (2024) Liposomal Formulation Improves the Bioactivity of Usnic Acid in RAW 264.7 Macrophage Cells Reducing its Toxicity. Current Drug Delivery 21:1, pages 91-103.
Crossref
Łukasz Furmanek & Mark R.D. Seaward. (2023) Anti-yeast potential of lichen-extracted substances – An analytical review. South African Journal of Botany 161, pages 720-779.
Crossref
Erick Poulsen-Silva, Felipe Gordillo-Fuenzalida, Cristian Atala, Adrián A. Moreno & María Carolina Otero. (2023) Bioactive Lichen Secondary Metabolites and Their Presence in Species from Chile. Metabolites 13:7, pages 805.
Crossref
Hanxue Wang, Min Xuan, Juanjuan Diao, Nan Xu, Manlin Li, Cheng Huang & Changhong Wang. (2023) Metabolism and toxicity of usnic acid and barbatic acid based on microsomes, S9 fraction, and 3T3 fibroblasts in vitro combined with a UPLC-Q-TOF-MS method. Frontiers in Pharmacology 14.
Crossref
Gregory A. Gunawan, Mariola Gimła, Michael G. Gardiner, Anna Herman-Antosiewicz & Tristan A. Reekie. (2023) Divergent reactivity of usnic acid and evaluation of its derivatives for antiproliferative activity against cancer cells. Bioorganic & Medicinal Chemistry 79, pages 117157.
Crossref
Shilpa Sannapaneni, Sarah Philip, Amit Desai, James Mitchell & Mark Feldman. (2023) Kombucha-Induced Massive Hepatic Necrosis: A Case Report and a Review of Literature. Gastro Hep Advances 2:2, pages 196-198.
Crossref
Hanxue Wang, Min Xuan, Cheng Huang & Changhong Wang. (2022) Advances in Research on Bioactivity, Toxicity, Metabolism, and Pharmacokinetics of Usnic Acid In Vitro and In Vivo. Molecules 27:21, pages 7469.
Crossref
Nicoletta Croce, Michele Pitaro, Valentina Gallo & Giovanni Antonini. (2022) Toxicity of Usnic Acid: A Narrative Review. Journal of Toxicology 2022, pages 1-12.
Crossref
D. C. S. Macedo, F. J. F. Almeida, M. S. O. Wanderley, M. S. Ferraz, N. P. S. Santos, A. M. Q. López, N. S. Santos-Magalhães & M. C. B. Lira-Nogueira. (2020) Usnic acid: from an ancient lichen derivative to promising biological and nanotechnology applications. Phytochemistry Reviews 20:3, pages 609-630.
Crossref
Qian Xu, Hao Deng, Xiaoting Li & Zhe-Shan Quan. (2021) Application of Amino Acids in the Structural Modification of Natural Products: A Review. Frontiers in Chemistry 9.
Crossref
Sukfan P. Kwong, Zhenlin Huang, Lili Ji & Changhong Wang. (2021) PORIMIN: The key to (+)-Usnic acid-induced liver toxicity and oncotic cell death in normal human L02 liver cells. Journal of Ethnopharmacology 270, pages 113873.
Crossref
Asghar Sepahvand, Elżbieta Studzińska-Sroka, Parvin Ramak & Vahid Karimian. (2021) Usnea sp.: Antimicrobial potential, bioactive compounds, ethnopharmacological uses and other pharmacological properties; a review article. Journal of Ethnopharmacology 268, pages 113656.
Crossref
Sukfan P. Kwong & Changhong Wang. (2020) Review: Usnic acid-induced hepatotoxicity and cell death. Environmental Toxicology and Pharmacology 80, pages 103493.
Crossref
Michał Hubert Węgrzyn, Paulina Wietrzyk-Pełka, Agnieszka Galanty, Beata Cykowska-Marzencka & Monica Alterskjær Sundset. (2019) Incomplete degradation of lichen usnic acid and atranorin in Svalbard reindeer (Rangifer tarandus platyrhynchus). Polar Research 38:0.
Crossref
Kamil Piska, Agnieszka Galanty, Paulina Koczurkiewicz, Paweł Żmudzki, Joanna Potaczek, Irma Podolak & Elżbieta Pękala. (2018) Usnic acid reactive metabolites formation in human, rat, and mice microsomes. Implication for hepatotoxicity. Food and Chemical Toxicology 120, pages 112-118.
Crossref
Elizabeth S. Childress, Stephanie J. Alexopoulos, Kyle L. Hoehn & Webster L. Santos. (2017) Small Molecule Mitochondrial Uncouplers and Their Therapeutic Potential. Journal of Medicinal Chemistry 61:11, pages 4641-4655.
Crossref
Hanxue Wang, Tao Yang, Xuemei Cheng, Sukfan Kwong, Chenghai Liu, Rui An, Guowen Li, Xinhong Wang & Changhong Wang. (2018) Simultaneous determination of usnic, diffractaic, evernic and barbatic acids in rat plasma by ultra-high-performance liquid chromatography-quadrupole exactive Orbitrap mass spectrometry and its application to pharmacokinetic studies. Biomedical Chromatography 32:3, pages e4123.
Crossref
Rafi Ahmad, Paulina Borowiec, Anne Bergljot Falck-Ytter & Knut Olav Strætkvern. (2017) Extraction, Solubility and Antimicrobial Activity of (-) Usnic Acid in Ethanol, a Pharmaceutically Relevant Solvent. Natural Product Communications 12:7, pages 1934578X1701200.
Crossref
Nayane Moreira Machado, Alexandre Azenha Alves de Rezende, Júlio César Nepomuceno, Denise Crispim Tavares, Wilson Roberto Cunha & Mário Antônio Spanó. (2016) Evaluation of mutagenic, recombinogenic and carcinogenic potential of (+)-usnic acid in somatic cells of Drosophila melanogaster. Food and Chemical Toxicology 96, pages 226-233.
Crossref
O. A. Luzina & N. F. Salakhutdinov. (2016) Biological activity of usnic acid and its derivatives: Part 2. effects on higher organisms. Molecular and physicochemical aspects. Russian Journal of Bioorganic Chemistry 42:3, pages 249-268.
Crossref
M. Suwalsky, M. Jemiola-Rzeminska, C. Astudillo, M.J. Gallardo, J.P. Staforelli, F. Villena & K. Strzalka. (2015) An in vitro study on the antioxidant capacity of usnic acid on human erythrocytes and molecular models of its membrane. Biochimica et Biophysica Acta (BBA) - Biomembranes 1848:11, pages 2829-2838.
Crossref
Gabriela Mazzanti, Antonella Di Sotto & Annabella Vitalone. (2015) Hepatotoxicity of green tea: an update. Archives of Toxicology 89:8, pages 1175-1191.
Crossref
Verena Kulak & Genevieve Newton. (2014) A guide to using case-based learning in biochemistry education. Biochemistry and Molecular Biology Education 42:6, pages 457-473.
Crossref
Qiang Shi, James Greenhaw & William F. Salminen. (2014) Inhibition of cytochrome P450s enhances (+)-usnic acid cytotoxicity in primary cultured rat hepatocytes. Journal of Applied Toxicology 34:8, pages 835-840.
Crossref
Ina L. LauingerLivia VivasRemo Perozzo, Christopher Stairiker, Alice Tarun, Mire ZlohXujie Zhang, Hua Xu, Peter J. Tonge, Scott G. Franzblau, Duc-Hung Pham, Camila V. Esguerra, Alexander D. Crawford, Louis Maes & Deniz Tasdemir. (2013) Potential of Lichen Secondary Metabolites against Plasmodium Liver Stage Parasites with FAS-II as the Potential Target . Journal of Natural Products 76:6, pages 1064-1070.
Crossref
T. V. Burkova & I. A. Goncharova. (2013) GENETIC FACTORS INFLUENCING THE EFFECTIVENESS AND SAFETY OF LONG-TERM ANTICOAGULANT THERAPY. Cardiovascular Therapy and Prevention 12:3, pages 89-94.
Crossref
Gajendra Shrestha & Larry L. St. Clair. (2013) Lichens: a promising source of antibiotic and anticancer drugs. Phytochemistry Reviews 12:1, pages 229-244.
Crossref
Saura C. Sahu, Michael W. O'DonnellJrJr & Robert L. Sprando. (2012) Interactive toxicity of usnic acid and lipopolysaccharides in human liver HepG2 cells. Journal of Applied Toxicology 32:9, pages 739-749.
Crossref
Saura C. Sahu, Margaret Amankwa-Sakyi, Michael W. O'DonnellJrJr & Robert L. Sprando. (2012) Effects of usnic acid exposure on human hepatoblastoma HepG2 cells in culture. Journal of Applied Toxicology 32:9, pages 722-730.
Crossref
Jinghai J. Xu. 2010. Predictive Toxicology in Drug Safety. Predictive Toxicology in Drug Safety 54 75 .
James H. Lewis. 2010. Sleisenger and Fordtran's Gastrointestinal and Liver Disease. Sleisenger and Fordtran's Gastrointestinal and Liver Disease 1447 1459.e3 .
Masoud Jamei, Gemma L. Dickinson & Amin Rostami-Hodjegan. (2009) A Framework for Assessing Inter-individual Variability in Pharmacokinetics Using Virtual Human Populations and Integrating General Knowledge of Physical Chemistry, Biology, Anatomy, Physiology and Genetics: A Tale of ‘Bottom-Up’ vs ‘Top-Down’ Recognition of Covariates. Drug Metabolism and Pharmacokinetics 24:1, pages 53-75.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.