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Original Article

Suppression of Retinal Neovascularization by shRNA Targeting HIF-1α

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Pages 892-902 | Received 20 Sep 2007, Accepted 17 Aug 2008, Published online: 02 Jul 2009

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Olachi J. Mezu-Ndubuisi, Yuyuan Wang, Jamee Schoephoerster, Juliana Falero-Perez, Ismail S. Zaitoun, Nader Sheibani & Shaoqin Gong. (2019) Intravitreal Delivery of VEGF-A165-loaded PLGA Microparticles Reduces Retinal Vaso-Obliteration in an In Vivo Mouse Model of Retinopathy of Prematurity. Current Eye Research 44:3, pages 275-286.
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Qianying Gao, Wencong Wang, Yuqing Lan, Xiaoqing Chen, Wei Yang, Yongguang Yuan, Juan Tan, Yao Zong & Zhaoxin Jiang. (2013) The inhibitory effect of small interference RNA protein kinase C-alpha on the experimental proliferative vitreoretinopathy induced by dispase in mice. International Journal of Nanomedicine 8, pages 1563-1572.
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Ahmed M Abu El-Asrar, Hani S Al-Mezaine & Mohammad Shamsul Ola. (2009) Pathophysiology and management of diabetic retinopathy. Expert Review of Ophthalmology 4:6, pages 627-647.
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Articles from other publishers (12)

Yaowu Qin, Jing Zhang, Savalan Babapoor-FarrokhranBrooks ApplewhiteMonika DeshpandeHaley MegarityMiguel Flores-Bellver, Silvia Aparicio-DomingoTao Ma, Yuan Rui, Stephany Y. Tzeng, Jordan J. Green, M. Valeria Canto-Soler, Silvia MontanerAkrit Sodhi. (2022) PAI-1 is a vascular cell–specific HIF-2–dependent angiogenic factor that promotes retinal neovascularization in diabetic patients. Science Advances 8:9.
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Hui-Yao Li, Yue Yuan, Yu-Hong Fu, Ying Wang & Xin-Yuan Gao. (2020) Hypoxia-inducible factor-1α: A promising therapeutic target for vasculopathy in diabetic retinopathy. Pharmacological Research 159, pages 104924.
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Huan Ren, Jian-Quan Luo, Yong-Chao Gao, Man-Yun Chen, Xiao-Ping Chen, Hong-Hao Zhou, Ying Jiang & Wei Zhang. (2020) Genetic association of hypoxia inducible factor 1-alpha (HIF1A) Pro582Ser polymorphism with risk of diabetes and diabetic complications. Aging 12:13, pages 12783-12798.
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Zhiping Liu, Siyuan Yan, Jiaojiao Wang, Yiming Xu, Yong Wang, Shuya Zhang, Xizhen Xu, Qiuhua Yang, Xianqiu Zeng, Yaqi Zhou, Xuejiao Gu, Sarah Lu, Zhongjie Fu, David J. Fulton, Neal L. Weintraub, Ruth B. Caldwell, Wenbo Zhang, Chaodong Wu, Xiao-Ling Liu, Jiang-Fan Chen, Aftab Ahmad, Ismail Kaddour-Djebbar, Mohamed Al-Shabrawey, Qinkai Li, Xuejun Jiang, Ye Sun, Akrit Sodhi, Lois Smith, Mei Hong & Yuqing Huo. (2017) Endothelial adenosine A2a receptor-mediated glycolysis is essential for pathological retinal angiogenesis. Nature Communications 8:1.
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Gumeng Cheng, Kailin Tian, Lu Zhang, Ning Yang, Yiqiao Xing & Tao He. (2015) S100A4 gene silencing in oxygen-induced ischemic retinopathy inhibits retinal neovascularization via down-regulation of CREB expression. Graefe's Archive for Clinical and Experimental Ophthalmology 254:1, pages 97-108.
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Lijie Dong, Hong Nian, Yan Shao, Yan Zhang, Qiutang Li, Yue Yi, Fang Tian, Wenbo Li, Hong Zhang, Xiaomin Zhang, Fei Wang & Xiaorong Li. (2015) PTB-associated splicing factor inhibits IGF-1-induced VEGF upregulation in a mouse model of oxygen-induced retinopathy. Cell and Tissue Research 360:2, pages 233-243.
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LIXIN ZHANG, JIAN JIANG & XIAOBO XIA. (2014) Suppression of retinal neovascularization by small interfering RNA targeting PGC-1α. International Journal of Molecular Medicine 33:6, pages 1523-1530.
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Na Chen, Jiaqi Wang, Yijun Hu, Bei Cui, Wenjie Li, Guixia Xu, Lin Liu & Shanrong Liu. (2014) MicroRNA-410 Reduces the Expression of Vascular Endothelial Growth Factor and Inhibits Oxygen-Induced Retinal Neovascularization. PLoS ONE 9:4, pages e95665.
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Natacha Le Moan, Daniel M. Houslay, Frank Christian, Miles D. Houslay & Katerina Akassoglou. (2011) Oxygen-Dependent Cleavage of the p75 Neurotrophin Receptor Triggers Stabilization of HIF-1α. Molecular Cell 44:3, pages 476-490.
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Xiong-Ze Zhang, Xi Huang, Ji-Hong Qiao, Jun-Jun Zhang & Mei-Xia Zhang. (2011) Inhibition of hypoxia-induced retinal neovascularization in mice with short hairpin RNA targeting Rac1, possibly via blockading redox signaling. Experimental Eye Research 92:6, pages 473-481.
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Shaker A. Mousa & Shaymaa S. Mousa. (2010) Current Status of Vascular Endothelial Growth Factor Inhibition in Age-Related Macular Degeneration. BioDrugs 24:3, pages 183-194.
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C Zhang, Y-S Wang, H Wu, Z-X Zhang, Y Cai, H-Y Hou, W Zhao, X-M Yang & J-X Ma. (2009) Inhibitory efficacy of hypoxia-inducible factor 1α short hairpin RNA plasmid DNA-loaded poly (D, L-lactide-co-glycolide) nanoparticles on choroidal neovascularization in a laser-induced rat model. Gene Therapy 17:3, pages 338-351.
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