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Platelets Volume 20, 2009 - Issue 2
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Original Article

Anti-glycoprotein VI monoclonal antibodies directly aggregate platelets independently of FcγRIIa and induce GPVI ectodomain shedding

Mohammad Al-Tamimi Department of Immunology, Melbourne, Australia; Alfred Medical Research & Education Precinct, Australian Centre for Blood Diseases, Monash University, Melbourne, Australia
,
Fi-Tjen Mu Department of Immunology, Melbourne, Australia; Alfred Medical Research & Education Precinct, Australian Centre for Blood Diseases, Monash University, Melbourne, Australia
,
Jane F. Arthur Department of Immunology, Melbourne, Australia; Alfred Medical Research & Education Precinct, Australian Centre for Blood Diseases, Monash University, Melbourne, Australia
,
Yang Shen Department of Immunology, Melbourne, Australia; Alfred Medical Research & Education Precinct, Australian Centre for Blood Diseases, Monash University, Melbourne, Australia
,
Masaaki Moroi Department of Protein Biochemistry, Institute of Life Science, Kurume University, Kurume, Fukuoka, Japan
,
Michael C. Berndt Alfred Medical Research & Education Precinct, Australian Centre for Blood Diseases, Monash University, Melbourne, Australia; College of Medicine and Health, University College Cork, Western Road Cork, Ireland
,
Robert K. Andrews Department of Immunology, Melbourne, Australia; Alfred Medical Research & Education Precinct, Australian Centre for Blood Diseases, Monash University, Melbourne, Australia
&
Elizabeth E. Gardiner Department of Immunology, Melbourne, Australia; Alfred Medical Research & Education Precinct, Australian Centre for Blood Diseases, Monash University, Melbourne, AustraliaCorrespondence[email protected]
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Pages 75-82 | Received 28 Aug 2008, Accepted 24 Nov 2008, Published online: 07 Jul 2009

Citations (34)

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Read on this site (8)

Marie-Astrid van Dievoet, Davide Brusa, Marie Octave, Sandrine Horman & Xavier Stephenne. (2022) Anti-GPVI (HY101) activates platelets in a multicolor flow cytometry panel. Platelets 33:7, pages 1096-1099.
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Joanne C. Clark, Foteini-Nafsika Damaskinaki, Yam Fung Hilaire Cheung, Alexandre Slater & Steve P. Watson. (2021) Structure-function relationship of the platelet glycoprotein VI (GPVI) receptor: does it matter if it is a dimer or monomer?. Platelets 32:6, pages 724-732.
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Chiara Pallini, Jeremy A. Pike, Christopher O’Shea, Robert K. Andrews, Elizabeth E. Gardiner, Steve P. Watson & Natalie S. Poulter. (2021) Immobilized collagen prevents shedding and induces sustained GPVI clustering and signaling in platelets. Platelets 32:1, pages 59-73.
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Madhumita Chatterjee & Meinrad Gawaz. (2017) Clinical significance of receptor shedding-platelet GPVI as an emerging diagnostic and therapeutic tool. Platelets 28:4, pages 362-371.
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Amanda E. Au & Emma C. Josefsson. (2017) Regulation of platelet membrane protein shedding in health and disease. Platelets 28:4, pages 342-353.
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Walter J. Janse van Rensburg, Philip N. Badenhorst & Jan P. Roodt. (2015) The Cape Chacma baboon is not suitable for evaluating human targeted anti-GPVI agents. Platelets 26:6, pages 552-557.
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G. J. Pennings, A. S. C. Yong, C. Wong, M. Al-Tamimi, E. E. Gardiner, R. K. Andrews & L. Kritharides. (2014) Circulating levels of soluble EMMPRIN (CD147) correlate with levels of soluble glycoprotein VI in human plasma. Platelets 25:8, pages 639-642.
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Mohammad Al-Tamimi, Fi-Tjen Mu, Masaaki Moroi, Elizabeth E. Gardiner, Michael C. Berndt & Robert K. Andrews. (2009) Measuring soluble platelet glycoprotein VI in human plasma by ELISA. Platelets 20:3, pages 143-149.
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Articles from other publishers (26)

Eduardo Fuentes. (2022) Modulation of Glycoprotein VI and Its Downstream Signaling Pathways as an Antiplatelet Target. International Journal of Molecular Sciences 23:17, pages 9882.
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Raluca A. I. Neagoe, Elizabeth E. Gardiner, David Stegner, Bernhard Nieswandt, Steve P. Watson & Natalie S. Poulter. (2022) Rac Inhibition Causes Impaired GPVI Signalling in Human Platelets through GPVI Shedding and Reduction in PLCγ2 Phosphorylation. International Journal of Molecular Sciences 23:7, pages 3746.
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Holly FosterClare WilsonHelen PhilippouRichard Foster. (2020) Progress toward a Glycoprotein VI Modulator for the Treatment of Thrombosis. Journal of Medicinal Chemistry 63:21, pages 12213-12242.
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Samantha J. Montague, Sarah M. Hicks, Christine S‐M. Lee, Lucy A. Coupland, Christopher R. Parish, Woei M. Lee, Robert K. Andrews & Elizabeth E. Gardiner. (2020) Fibrin exposure triggers αIIbβ3‐independent platelet aggregate formation, ADAM10 activity and glycoprotein VI shedding in a charge‐dependent manner. Journal of Thrombosis and Haemostasis 18:6, pages 1447-1458.
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Yik C. Ho, Kiran D.K. Ahuja, Robert K. Andrews & Murray J. Adams. (2020) Shedding of soluble glycoprotein VI is neither affected by animal-derived antibeta-2-glycoprotein 1 antibodies nor IgG fractions from patients with systemic lupus erythematosus. Blood Coagulation & Fibrinolysis 31:4, pages 258-263.
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Masaaki Moroi, Richard W. Farndale & Stephanie M. Jung. (2020) Activation‐induced changes in platelet surface receptor expression and the contribution of the large‐platelet subpopulation to activation. Research and Practice in Thrombosis and Haemostasis 4:2, pages 285-297.
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Alan T. Nurden. (2019) Clinical significance of altered collagen-receptor functioning in platelets with emphasis on glycoprotein VI. Blood Reviews 38, pages 100592.
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Jianlin Qiao, Jane F. Arthur, Elizabeth E. Gardiner, Robert K. Andrews, Lingyu Zeng & Kailin Xu. (2018) Regulation of platelet activation and thrombus formation by reactive oxygen species. Redox Biology 14, pages 126-130.
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Elizabeth E. Gardiner. (2018) Proteolytic processing of platelet receptors. Research and Practice in Thrombosis and Haemostasis 2:2, pages 240-250.
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I. Induruwa, M. Moroi, A. Bonna, J.‐D. Malcor, J.‐M. Howes, E.A. Warburton, R.W. Farndale & S.M. Jung. (2018) Platelet collagen receptor Glycoprotein VI‐dimer recognizes fibrinogen and fibrin through their D‐domains, contributing to platelet adhesion and activation during thrombus formation. Journal of Thrombosis and Haemostasis 16:2, pages 389-404.
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Isuru Induruwa, Stephanie M Jung & Elizabeth A Warburton. (2016) Beyond antiplatelets: The role of glycoprotein VI in ischemic stroke. International Journal of Stroke 11:6, pages 618-625.
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Ulrike Flierl, Tracy L. Nero, Bock Lim, Jane F. Arthur, Yu Yao, Stephanie M. Jung, Eelo Gitz, Alice Y. Pollitt, Maria T.K. Zaldivia, Martine Jandrot-Perrus, Andreas Schäfer, Bernhard Nieswandt, Robert K. Andrews, Michael W. Parker, Elizabeth E. Gardiner & Karlheinz Peter. (2015) Phosphorothioate backbone modifications of nucleotide-based drugs are potent platelet activators. Journal of Experimental Medicine 212:2, pages 129-137.
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Isabel Sánchez Guiu, Irene Martínez-Martinez, Constantino Martínez, José Navarro-Fernandez, Faustino Garcia-Candel, Francisca Ferrer-Marín, Vicente Vicente, Steve Watson, Robert Andrews, Elizabeth Gardiner, María Lozano & José Rivera. (2017) An atypical IgM class platelet cold agglutinin induces GPVI-dependent aggregation of human platelets. Thrombosis and Haemostasis 114:08, pages 313-324.
Crossref
Elizabeth E. Gardiner & Robert K. Andrews. (2014) Plasma sGPVI: Changing levels in human disease. Thrombosis Research 133:3, pages 306-307.
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J. F. Arthur, Y. Shen, Y. Chen, J. Qiao, R. Ni, Y. Lu, R. K. Andrews, E. E. Gardiner & J. Cheng. (2013) Exacerbation of Glycoprotein VI-Dependent Platelet Responses in a Rhesus Monkey Model of Type 1 Diabetes. Journal of Diabetes Research 2013, pages 1-9.
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M. ZAHID, P. MANGIN, S. LOYAU, B. HECHLER, P. BILLIALD, C. GACHET & M. JANDROT‐PERRUS. (2012) The future of glycoprotein VI as an antithrombotic target. Journal of Thrombosis and Haemostasis 10:12, pages 2418-2427.
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Stephanie M. Jung, Masaaki Moroi, Kenji Soejima, Tomohiro Nakagaki, Yoshiki Miura, Michael C. Berndt, Elizabeth E. Gardiner, Joanna-Marie Howes, Nicholas Pugh, Dominique Bihan, Steve P. Watson & Richard W. Farndale. (2012) Constitutive Dimerization of Glycoprotein VI (GPVI) in Resting Platelets Is Essential for Binding to Collagen and Activation in Flowing Blood. Journal of Biological Chemistry 287:35, pages 30000-30013.
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J.F. ARTHUR, J. QIAO, Y. SHEN, A.K. DAVIS, E. DUNNE, M.C. BERNDT, E.E. GARDINER & R.K. ANDREWS. (2012) ITAM receptor‐mediated generation of reactive oxygen species in human platelets occurs via Syk‐dependent and Syk‐independent pathways. Journal of Thrombosis and Haemostasis 10:6, pages 1133-1141.
Crossref
Mohammad Al-TamimiChee Wee TanJianlin QiaoGabrielle J. PenningsAshkan JavadzadeganAndy S. C. YongJane F. ArthurAmanda K. DavisJing JingFi-Tjen MuJustin R. HamiltonShaun P. JacksonAndreas Ludwig, Michael C. Berndt, Christopher M. WardLeonard KritharidesRobert K. AndrewsElizabeth E. Gardiner. (2012) Pathologic shear triggers shedding of vascular receptors: a novel mechanism for down-regulation of platelet glycoprotein VI in stenosed coronary vessels. Blood 119:18, pages 4311-4320.
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Mohammad Al-Tamimi, Jane F. Arthur, Elizabeth E. Gardiner & Robert K. Andrews. (2017) Focusing on plasma glycoprotein VI. Thrombosis and Haemostasis 107:04, pages 648-655.
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Jianlin Qiao, Jane F. Arthur, Margaret Collecutt, Yang Shen, Fi-Tjen Mu, Michael C. Berndt, Amanda K. Davis, Robert K. Andrews & Elizabeth E. Gardiner. (2012) An Acquired Defect Associated with Abnormal Signaling of the Platelet Collagen Receptor Glycoprotein VI. Acta Haematologica 128:4, pages 233-241.
Crossref
Elizabeth E. Gardiner, Mohammad Al-Tamimi, Robert K. Andrews & Michael C. Berndt. 2012. Platelets and Megakaryocytes. Platelets and Megakaryocytes 321 339 .
Mohammad Al-TamimiGeorge GrigoriadisHuy TranEldho Paul, Patricia ServadeiMichael C. Berndt, Elizabeth E. GardinerRobert K. Andrews. (2011) Coagulation-induced shedding of platelet glycoprotein VI mediated by factor Xa. Blood 117:14, pages 3912-3920.
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J.F. ARTHUR, Y. SHEN, E.E. GARDINER, L. COLEMAN, D. KENNY, R.K. ANDREWS & M.C. BERNDT. (2011) TNF receptor‐associated factor 4 (TRAF4) is a novel binding partner of glycoprotein Ib and glycoprotein VI in human platelets. Journal of Thrombosis and Haemostasis 9:1, pages 163-172.
Crossref
Jian L. Qiao, Yang Shen, Elizabeth E. Gardiner & Robert K. Andrews. (2010) Proteolysis of platelet receptors in humans and other species. Biological Chemistry 391:8.
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P. NURDEN, N. TANDON, H. TAKIZAWA, L. COUZI, D. MOREL, M. FIORE, X. PILLOIS, S. LOYAU, M. JANDROT‐PERRUS & A.T. NURDEN. (2009) An acquired inhibitor to the GPVI platelet collagen receptor in a patient with lupus nephritis. Journal of Thrombosis and Haemostasis 7:9, pages 1541-1549.
Crossref

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