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Critical Reviews in Food Science and Nutrition Volume 49, 2009 - Issue 8: Key Events Dose-Response Framework
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Original Articles

Application of Key Events Analysis to Chemical Carcinogens and Noncarcinogens

Alan R. Boobis Department of Experimental Medicine and Toxicology, Imperial College London, London, W12 0NN, UK
,
George P. Daston Miami Valley Laboratories, The Procter & Gamble Company, Cincinnati, OH, USA
,
R. Julian Preston National Health and Environmental Effects Research Laboratory, U.S. Environmental Protection Agency, Research Triangle Park, NC, USA
&
Stephen S. Olin ILSI Research Foundation, Washington, DC, USA
Pages 690-707 | Published online: 11 Sep 2009

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Harm Heusinkveld, Hedwig Braakhuis, Robin Gommans, Phil Botham, Marco Corvaro, Jan Willem van der Laan, Dick Lewis, Federica Madia, Irene Manou, Frédéric Schorsch, Gerrit Wolterink, Ruud Woutersen, Raffaella Corvi, Jyotigna Mehta & Mirjam Luijten. (2020) Towards a mechanism-based approach for the prediction of nongenotoxic carcinogenic potential of agrochemicals. Critical Reviews in Toxicology 50:9, pages 725-739.
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Susy Brescia. (2020) Thresholds of adversity and their applicability to endocrine disrupting chemicals. Critical Reviews in Toxicology 50:3, pages 213-218.
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Melvin E. Andersen, R. Julian Preston, Andrew Maier, Alison M. Willis & Jacqueline Patterson. (2014) Dose–response approaches for nuclear receptor-mediated modes of action for liver carcinogenicity: Results of a workshop. Critical Reviews in Toxicology 44:1, pages 50-63.
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J. Christopher Corton, Michael L. Cunningham, B. Timothy Hummer, Christopher Lau, Bette Meek, Jeffrey M. Peters, James A. Popp, Lorenz Rhomberg, Jennifer Seed & James E. Klaunig. (2014) Mode of action framework analysis for receptor-mediated toxicity: The peroxisome proliferator-activated receptor alpha (PPARα) as a case study. Critical Reviews in Toxicology 44:1, pages 1-49.
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Richard J. Albertini. (2013) Vinyl acetate monomer (VAM) genotoxicity profile: Relevance for carcinogenicity. Critical Reviews in Toxicology 43:8, pages 671-706.
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Susan P. Felter, Rory B. Conolly, Joel P. Bercu, P. Michael Bolger, Alan R. Boobis, Peter M. J. Bos, Philip Carthew, Nancy G. Doerrer, Jay I. Goodman, Wafa A. Harrouk, David J. Kirkland, Serrine S. Lau, G. Craig Llewellyn, R. Julian Preston, Rita Schoeny, A. Robert Schnatter, Angelika Tritscher, Frans van Velsen & Gary M. Williams. (2011) A proposed framework for assessing risk from less-than-lifetime exposures to carcinogens. Critical Reviews in Toxicology 41:6, pages 507-544.
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Elizabeth Julien , AlanR. Boobis, StephenS. Olin & The ILSI Research Foundation Threshold Working Group. (2009) The Key Events Dose-Response Framework: A Cross-Disciplinary Mode-of-Action Based Approach to Examining Dose-Response and Thresholds. Critical Reviews in Food Science and Nutrition 49:8, pages 682-689.
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