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Research Article

A Tiered Approach to Life Stages Testing for Agricultural Chemical Safety Assessment

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Pages 69-98 | Published online: 10 Oct 2008

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Crossref
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Crossref
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Shakil Ahmed Saghir. (2015) Rethinking guideline toxicity testing. Regulatory Toxicology and Pharmacology 72:2, pages 423-428.
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Crossref
Paul M. D. Foster. (2014) Regulatory Forum Opinion Piece. Toxicologic Pathology 42:8, pages 1165-1167.
Crossref
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Crossref
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Crossref
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Crossref
P.S. Coder, C.J. Bowman, E.D. Sloter & D.G. Stump. 2014. Reference Module in Biomedical Sciences. Reference Module in Biomedical Sciences.
Adejuwon Adewale Adeneye. 2014. Toxicological Survey of African Medicinal Plants. Toxicological Survey of African Medicinal Plants 99 133 .
Mary Sue Marty, Barbara H. Neal, Carol L. Zablotny, Barry L. Yano, Amanda K. Andrus, Michael R. Woolhiser, Darrell R. Boverhof, Shakil A. Saghir, Adam W. Perala, Julie K. Passage, Marie A. Lawson, James S. Bus, James C. LambIVIV & Larry Hammond. (2013) An F1-Extended One-Generation Reproductive Toxicity Study in Crl:CD(SD) Rats With 2,4-Dichlorophenoxyacetic Acid. Toxicological Sciences 136:2, pages 527-547.
Crossref
Shakil A. Saghir, Mary S. Marty, Carol L. Zablotny, Julie K. Passage, Adam W. Perala, Barbara H. Neal, Larry Hammond & James S. Bus. (2013) Life-Stage-, Sex-, and Dose-Dependent Dietary Toxicokinetics and Relationship to Toxicity of 2,4-Dichlorophenoxyacetic Acid (2,4-D) in Rats: Implications for Toxicity Test Dose Selection, Design, and Interpretation. Toxicological Sciences 136:2, pages 294-307.
Crossref
Kathryn L. Chapman, Henry Holzgrefe, Lauren E. Black, Marilyn Brown, Gary Chellman, Christine Copeman, Jessica Couch, Stuart Creton, Sean Gehen, Alan Hoberman, Lewis B. Kinter, Stephen Madden, Charles Mattis, Hugh A. Stemple & Stephen Wilson. (2013) Pharmaceutical toxicology: Designing studies to reduce animal use, while maximizing human translation. Regulatory Toxicology and Pharmacology 66:1, pages 88-103.
Crossref
Frank A Barile. 2013. Principles of Toxicology Testing. Principles of Toxicology Testing 13 19 .
M. Sue Marty. 2013. Endocrine Disrupters. Endocrine Disrupters 304 340 .
Keith A. Houck, Ann M. Richard, Richard S. Judson, Matthew T. Martin, David M. Reif & Imran Shah. 2013. High-Throughput Screening Methods in Toxicity Testing. High-Throughput Screening Methods in Toxicity Testing 1 31 .
Wiebke Prutner. 2013. Teratogenicity Testing. Teratogenicity Testing 517 543 .
Aldert H. Piersma. 2013. Teratogenicity Testing. Teratogenicity Testing 327 341 .
I. Fegert, R. Billington, P. Botham, E. Carney, R.E. FitzGerald, T. Hanley, R. Lewis, M.S. Marty, S. Schneider, L.P. Sheets, B. Stahl & B. van Ravenzwaay. (2012) Feasibility of the extended one-generation reproductive toxicity study (OECD 443). Reproductive Toxicology 34:3, pages 331-339.
Crossref
Aldert H. Piersma, Elisa C.M. Tonk, Susan L. Makris, Kevin M. Crofton, Rodney R. Dietert & Henk van Loveren. (2012) Juvenile toxicity testing protocols for chemicals. Reproductive Toxicology 34:3, pages 482-486.
Crossref
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Crossref
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Crossref
Michael P. Holsapple & Raegan O’Lone. (2012) Juvenile Immunotoxicology. Toxicologic Pathology 40:2, pages 248-254.
Crossref
Susan L. Makris. 2012. Pediatric Nonclinical Drug Testing. Pediatric Nonclinical Drug Testing 93 113 .
Debra Kirchner & Susan Henwood. 2012. The Laboratory Rabbit, Guinea Pig, Hamster, and Other Rodents. The Laboratory Rabbit, Guinea Pig, Hamster, and Other Rodents 275 300 .
Ronald D. HoodSusan L. Makris. 2011. Developmental and Reproductive Toxicology: A Practical Approach. Developmental and Reproductive Toxicology: A Practical Approach 675 707 .
Ronald D. HoodLeigh Ann Burns-Naas. 2011. Developmental and Reproductive Toxicology: A Practical Approach. Developmental and Reproductive Toxicology: A Practical Approach 491 508 .
Ronald D. HoodDonald G. Stump, Mark D. Nemec, George A. Parker, Prägati Sawhney Coder, Eddie D. Sloter & Bennett J. Varsho. 2011. Developmental and Reproductive Toxicology: A Practical Approach. Developmental and Reproductive Toxicology: A Practical Approach 229 301 .
Ronald D. HoodRobert M. Parker. 2011. Developmental and Reproductive Toxicology: A Practical Approach. Developmental and Reproductive Toxicology: A Practical Approach 184 228 .
David J. Esdaile, Raluca Kubaszky, Peter Maslej, Judit Hargitai, Thomas Hanley, Daniel Minnema, Jayne Wright & Lewis Richard. (2011) Reproductive, neuro- and immuno-toxicity in an extended one generation toxicity test with lead acetate. Toxicology 290:2-3, pages 144.
Crossref
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Crossref
Susan L. Makris, James H. Kim, Amy Ellis, Willem Faber, Wafa Harrouk, Joseph M. Lewis, Merle G. Paule, Jennifer Seed, Melissa Tassinari & Rochelle Tyl. (2011) Current and future needs for developmental toxicity testing. Birth Defects Research Part B: Developmental and Reproductive Toxicology 92:5, pages 384-394.
Crossref
Kimberly C. Brannen, Suzanne E. Fenton, Deborah K. Hansen, Wafa Harrouk, James H. Kim & Dana Shuey. (2011) Developmental toxicology-new directions workshop: refining testing strategies and study designs. Birth Defects Research Part B: Developmental and Reproductive Toxicology 92:5, pages 404-412.
Crossref
Kristie Sullivan, Nancy Beck, Chad Sandusky & Catherine Willett. (2011) A discussion of the impact of us chemical regulation legislation on the field of toxicity testing. Toxicology in Vitro 25:6, pages 1231-1236.
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Elisa C.M. Tonk, Didima M.G. de Groot, André H. Penninks, Ine D.H. Waalkens-Berendsen, André P.M. Wolterbeek, Aldert H. Piersma & Henk van Loveren. (2011) Developmental immunotoxicity of di-n-octyltin dichloride (DOTC) in an extended one-generation reproductive toxicity study. Toxicology Letters 204:2-3, pages 156-163.
Crossref
A.H. Piersma, E. Rorije, M.E.W. Beekhuijzen, R. Cooper, D.J. Dix, B. Heinrich-Hirsch, M.T. Martin, E. Mendez, A. Muller, M. Paparella, D. Ramsingh, E. Reaves, P. Ridgway, E. Schenk, L. Stachiw, B. Ulbrich & B.C. Hakkert. (2011) Combined retrospective analysis of 498 rat multi-generation reproductive toxicity studies: On the impact of parameters related to F1 mating and F2 offspring. Reproductive Toxicology 31:4, pages 392-401.
Crossref
Sarah Adler, David Basketter, Stuart Creton, Olavi Pelkonen, Jan van Benthem, Valérie Zuang, Klaus Ejner Andersen, Alexandre Angers-Loustau, Aynur Aptula, Anna Bal-Price, Emilio Benfenati, Ulrike Bernauer, Jos Bessems, Frederic Y. Bois, Alan Boobis, Esther Brandon, Susanne Bremer, Thomas Broschard, Silvia Casati, Sandra Coecke, Raffaella Corvi, Mark Cronin, George Daston, Wolfgang Dekant, Susan Felter, Elise Grignard, Ursula Gundert-Remy, Tuula Heinonen, Ian Kimber, Jos Kleinjans, Hannu Komulainen, Reinhard Kreiling, Joachim Kreysa, Sofia Batista Leite, George Loizou, Gavin Maxwell, Paolo Mazzatorta, Sharon Munn, Stefan Pfuhler, Pascal Phrakonkham, Aldert Piersma, Albrecht Poth, Pilar Prieto, Guillermo Repetto, Vera Rogiers, Greet Schoeters, Michael Schwarz, Rositsa Serafimova, Hanna Tähti, Emanuela Testai, Joost van Delft, Henk van Loveren, Mathieu Vinken, Andrew Worth & José-Manuel Zaldivar. (2011) Alternative (non-animal) methods for cosmetics testing: current status and future prospects—2010. Archives of Toxicology 85:5, pages 367-485.
Crossref
Steffen Schneider, Wolfgang Kaufmann, Volker Strauss & Bennard van Ravenzwaay. (2011) Vinclozolin: A feasibility and sensitivity study of the ILSI-HESI F1-extended one-generation rat reproduction protocol. Regulatory Toxicology and Pharmacology 59:1, pages 91-100.
Crossref
Susan L. Makris & Scott Glaberman. 2011. Reproductive and Developmental Toxicology. Reproductive and Developmental Toxicology 219 225 .
Carmen Estevan Martínez, David Pamies, Miguel Angel Sogorb & Eugenio Vilanova. 2011. Reproductive and Developmental Toxicology. Reproductive and Developmental Toxicology 123 133 .
Efstathios Nikolaidis. 2011. Reproductive and Developmental Toxicology. Reproductive and Developmental Toxicology 111 121 .
Laura M. Plunkett, A. Michael Kaplan & Richard A. Becker. (2010) An enhanced tiered toxicity testing framework with triggers for assessing hazards and risks of commodity chemicals. Regulatory Toxicology and Pharmacology 58:3, pages 382-394.
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Elisa C. M. Tonk, Didima M. G. de Groot, André H. Penninks, Ine D. H. Waalkens-Berendsen, André P. M. Wolterbeek, Wout Slob, Aldert H. Piersma & Henk van Loveren. (2010) Developmental Immunotoxicity of Methylmercury: The Relative Sensitivity of Developmental and Immune Parameters. Toxicological Sciences 117:2, pages 325-335.
Crossref
Kathleen C. Raffaele, Jess Rowland, Brenda May, Susan L. Makris, Kelly Schumacher & Louis J. Scarano. (2010) The use of developmental neurotoxicity data in pesticide risk assessments. Neurotoxicology and Teratology 32:5, pages 563-572.
Crossref
Rochelle W. Tyl. (2010) In honor of the Teratology Society's 50th anniversary: The role of Teratology Society members in the development and evolution of in vivo developmental toxicity test guidelines. Birth Defects Research Part C: Embryo Today: Reviews 90:2, pages 99-102.
Crossref
Richard Vogel, Troy Seidle & Horst Spielmann. (2010) A modular one-generation reproduction study as a flexible testing system for regulatory safety assessment. Reproductive Toxicology 29:2, pages 242-245.
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Wayland J. HayesJr.Jr., James Bruckner & John Doull. 2010. Hayes' Handbook of Pesticide Toxicology. Hayes' Handbook of Pesticide Toxicology 1255 1293 .
Tammy E. Stoker & Robert J. Kavlock. 2010. Hayes' Handbook of Pesticide Toxicology. Hayes' Handbook of Pesticide Toxicology 551 569 .
P.S. Coder, E.D. Sloter, D.G. Stump, M.D. Nemec & C.J. Bowman. 2010. Comprehensive Toxicology. Comprehensive Toxicology 61 86 .
E.C.M. Tonk, A.H. Piersma & H. Van Loveren. 2010. Comprehensive Toxicology. Comprehensive Toxicology 249 269 .
D.R. Germolec, R.W. Luebke & M.I. Luster. 2010. Comprehensive Toxicology. Comprehensive Toxicology 211 223 .
R.L. Cooper & N.G. Doerrer. 2010. Comprehensive Toxicology. Comprehensive Toxicology 159 172 .
Horst Spielmann. (2009) The Way Forward in Reproductive/Developmental Toxicity Testing. Alternatives to Laboratory Animals 37:6, pages 641-656.
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Susan L. Makris & Kathleen C. Raffaele. 2009. General, Applied and Systems Toxicology. General, Applied and Systems Toxicology.
Manon Beekhuijzen, Amy Zmarowski, Harry Emmen & Wilbert Frieling. (2009) To mate or not to mate: A retrospective analysis of two-generation studies for evaluation of criteria to trigger additional mating in the extended one-generation design. Reproductive Toxicology 28:2, pages 203-208.
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Ralph L. Cooper. (2009) Current developments in reproductive toxicity testing of pesticides. Reproductive Toxicology 28:2, pages 180-187.
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Zhi-Chao Dang, Emiel Rorije, Thijs Hogen Esch, André Muller, Betty C. Hakkert & Aldert H. Piersma. (2009) Retrospective analysis of relative parameter sensitivity in multi-generation reproductive toxicity studies. Reproductive Toxicology 28:2, pages 196-202.
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Philip Marx-StoeltingEls AdriaensHans-Jürgen AhrSusanne BremerBernward GarthoffHeinz-Peter GelbkeAldert PiersmaCristian PellizzerUlrike ReuterVera RogiersBarbara SchenkSilke SchwengbergAndrea SeilerHorst SpielmannMargino SteemansDonald B. StedmanPhilippe VanparysJoan Albert VericatMiriam VerweiFemke van de WaterMarc Weimer & Michael Schwarz. (2009) A Review of the Implementation of the Embryonic Stem Cell Test (EST). Alternatives to Laboratory Animals 37:3, pages 313-328.
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Matthew T. Martin, Elizabeth Mendez, Daniel G. Corum, Richard S. Judson, Robert J. Kavlock, Daniel M. Rotroff & David J. Dix. (2009) Profiling the Reproductive Toxicity of Chemicals from Multigeneration Studies in the Toxicity Reference Database. Toxicological Sciences 110:1, pages 181-190.
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. (2009) Existing approaches incorporating replacement, reduction and refinement of animal testing: applicability in food and feed risk assessment. EFSA Journal 7:6.
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Nigel Moore, Susanne Bremer, Neil Carmichael, George Daston, Matt Dent, Wassila Gaoua-Chapelle, Nina Hallmark, Thomas Hartung, Beate Holzum, Ulrich Hübel, Marie-Louise Meisters, Steffen Schneider, Bennard van Ravenzwaay & Christa Hennes. (2009) A Modular Approach to the Extended One-generation Reproduction Toxicity Study. Alternatives to Laboratory Animals 37:2, pages 219-225.
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Susan L. Makris, Kathleen Raffaele, Sandra Allen, Wayne J. Bowers, Ulla Hass, Enrico Alleva, Gemma Calamandrei, Larry Sheets, Patric Amcoff, Nathalie Delrue & Kevin M. Crofton. (2009) A Retrospective Performance Assessment of the Developmental Neurotoxicity Study in Support of OECD Test Guideline 426. Environmental Health Perspectives 117:1, pages 17-25.
Crossref
Yuri Bruinen de Bruin, Chantra Eskes, Ingrid Langezaal, Sandra Coecke, Agnieszka Kinsner-Ovaskainen & Pertti J. Hakkinen. 2009. Information Resources in Toxicology. Information Resources in Toxicology 497 513 .
Allan S. Felsot. 2009. Information Resources in Toxicology. Information Resources in Toxicology 151 165 .
Joseph ManuppelloCatherine Willett. (2008) Longer Rodent Bioassay Fails to Address 2-Year Bioassay’s Flaws. Environmental Health Perspectives 116:12.
Crossref
Werner Lilienblum. (2008) Alternativmethoden zum TierversuchAlternative methods to animal experiments. What can they afford in the safety testing of chemical substances under REACH?. Bundesgesundheitsblatt - Gesundheitsforschung - Gesundheitsschutz 51:12, pages 1434-1443.
Crossref
Christina Grindon, Robert Combes, Mark T.D. Cronin, David W. Roberts & John F. Garrod. (2008) Integrated Decision-tree Testing Strategies for Developmental and Reproductive Toxicity with Respect to the Requirements of the EU REACH Legislation. Alternatives to Laboratory Animals 36:1_suppl, pages 123-138.
Crossref
Tami S. McMullin, Ezra R. Lowe, Michael J. Bartels & Mary Sue Marty. (2008) Dynamic Changes in Lipids and Proteins of Maternal, Fetal, and Pup Blood and Milk during Perinatal Development in CD and Wistar Rats. Toxicological Sciences 105:2, pages 260-274.
Crossref
Andrew K. Hotchkiss, Cynthia V. Rider, Chad R. Blystone, Vickie S. Wilson, Phillip C. Hartig, Gerald T. Ankley, Paul M. Foster, Clark L. Gray & L. Earl Gray. (2008) Fifteen Years after “Wingspread”—Environmental Endocrine Disrupters and Human and Wildlife Health: Where We are Today and Where We Need to Go. Toxicological Sciences 105:2, pages 235-259.
Crossref
Marijana Radonjic, André Wolterbeek, Didima de Groot & Rob Stierum. (2008) Effects of methyl mercury on gene expression patterns in cerebellum and cerebrum of perinatally exposed Wistar rats. Toxicology Letters 180, pages S125.
Crossref
David P. Myers, Christopher R. Willoughby, Audrey M. Bottomley & Jochen Buschmann. (2008) An analysis of the results from Two-Generation Reproduction Toxicity Studies to assess the value of mating animals of the second (F1) generation for the detection of adverse treatment-related effects on reproductive performance. Reproductive Toxicology 26:1, pages 47-50.
Crossref
W. Lilienblum, W. Dekant, H. Foth, T. Gebel, J. G. Hengstler, R. Kahl, P.-J. Kramer, H. Schweinfurth & K.-M. Wollin. (2008) Alternative methods to safety studies in experimental animals: role in the risk assessment of chemicals under the new European Chemicals Legislation (REACH). Archives of Toxicology 82:4, pages 211-236.
Crossref
. (2008) Safety and Nutritional Assessment of GM Plants and derived food and feed: The role of animal feeding trials. EFSA Journal 6:3.
Crossref
Leigh Ann Burns-Naas, Kenneth L. Hastings, Gregory S. Ladics, Susan L. Makris, George A. Parker & Michael P. Holsapple. (2008) What’s So Special about the Developing Immune System?. International Journal of Toxicology 27:2, pages 223-254.
Crossref
. (2008) Safety and nutritional assessment of GM plants and derived food and feed: The role of animal feeding trials. Food and Chemical Toxicology 46, pages S2-S70.
Crossref
Christina Grindon, Robert Combes, Mark T.D. Cronin, David W. Roberts & John F. Garrod. (2008) Integrated Decision-tree Testing Strategies for Developmental and Reproductive Toxicity with Respect to the Requirements of the EU REACH Legislation. Alternatives to Laboratory Animals 36:1, pages 65-80.
Crossref
Frank Barile. 2007. Principles of Toxicology Testing. Principles of Toxicology Testing 89 99 .
Gemma Janer, Betty C. Hakkert, Wout Slob, Theo Vermeire & Aldert H. Piersma. (2007) A retrospective analysis of the two-generation study: What is the added value of the second generation?. Reproductive Toxicology 24:1, pages 97-102.
Crossref
. (2007) Opinion of the Scientific Panel PPR related to the revision of Annexes II and III to Council Directive 91/414/EEC concerning the placing of plant protection products on the market - Toxicological and metabolism studies. EFSA Journal 5:2, pages 449.
Crossref
Rodney R. Dietert & Michael P. Holsapple. (2007) Methodologies for developmental immunotoxicity (DIT) testing. Methods 41:1, pages 123-131.
Crossref
. (2006) Opinion of the Scientific Panel on Plant protection products and their residues (PPR) related to the choice of endpoints to assess the long term risk to mammals. EFSA Journal 4:4.
Crossref

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