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Critical Reviews in Toxicology Volume 48, 2018 - Issue 3
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Review Articles

Adoption of in vitro systems and zebrafish embryos as alternative models for reducing rodent use in assessments of immunological and oxidative stress responses to nanomaterials

Helinor J. JohnstonNano Safety Research Group, Heriot-Watt University, Edinburgh, UK; Correspondence[email protected]
,
Rachel VerdonNano Safety Research Group, Heriot-Watt University, Edinburgh, UK;
,
Suzanne GilliesNano Safety Research Group, Heriot-Watt University, Edinburgh, UK;
,
David M. BrownNano Safety Research Group, Heriot-Watt University, Edinburgh, UK;
,
Teresa F. FernandesNano Safety Research Group, Heriot-Watt University, Edinburgh, UK;
,
Theodore B. HenryNano Safety Research Group, Heriot-Watt University, Edinburgh, UK; ORCID Iconhttp://orcid.org/0000-0002-9675-9454
ORCID Icon,
Adriano G. RossiMedical Research Council (MRC) Centre for Inflammation Research, The Queen's Medical Research Institute, University of Edinburgh, Edinburgh, UK;
,
Lang TranInstitute of Occupational Medicine, Edinburgh, UK;
,
Carl TuckerMedical Research Council (MRC) Centre for Inflammation Research, The Queen's Medical Research Institute, University of Edinburgh, Edinburgh, UK;
,
Charles R. TylerDepartment of Biosciences, College of Life and Environmental Sciences, University of Exeter, Exeter, UK
&
Vicki StoneNano Safety Research Group, Heriot-Watt University, Edinburgh, UK;
show all
Pages 252-271 | Received 15 Aug 2017, Accepted 10 Nov 2017, Published online: 14 Dec 2017

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Lidia Strużyńska, Beata Dąbrowska-Bouta & Grzegorz Sulkowski. (2022) Developmental neurotoxicity of silver nanoparticles: the current state of knowledge and future directions. Nanotoxicology 16:4, pages 500-525.
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L. G. Powell, S. Gillies, T. F. Fernandes, F. Murphy, E. Giubilato, V. Cazzagon, D. Hristozov, L. Pizzol, M. Blosi, A. L. Costa, A. Prina-Mello, H. Bouwmeester, H. Sarimveis, G. Janer & V. Stone. (2022) Developing Integrated Approaches for Testing and Assessment (IATAs) in order to support nanomaterial safety. Nanotoxicology 16:4, pages 484-499.
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Suzanne Gillies, Rachel Verdon, Vicki Stone, David M. Brown, Theodore Henry, Lang Tran, Carl Tucker, Adriano G. Rossi, Charles R. Tyler & Helinor J. Johnston. (2022) Transgenic zebrafish larvae as a non-rodent alternative model to assess pro-inflammatory (neutrophil) responses to nanomaterials. Nanotoxicology 16:3, pages 333-354.
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Sara Rastgar, Rashid Alijani Ardeshir, Helmut Segner, Charles R. Tyler, Willie J. G. M. Peijnenburg, Youji Wang, Amir Parviz Salati & Abdolali Movahedinia. (2022) Immunotoxic effects of metal-based nanoparticles in fish and bivalves. Nanotoxicology 16:1, pages 88-113.
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Rachel Verdon, Suzanne L. Gillies, David M. Brown, Theodore Henry, Lang Tran, Charles R. Tyler, Adriano G. Rossi, Vicki Stone & Helinor J. Johnston. (2021) Neutrophil activation by nanomaterials in vitro: comparing strengths and limitations of primary human cells with those of an immortalized (HL-60) cell line. Nanotoxicology 15:1, pages 1-20.
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