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A Multilaboratory Toxicological Assessment of a Panel of 10 Engineered Nanomaterials to Human Health—ENPRA Project—The Highlights, Limitations, and Current and Future Challenges

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Regildo Márcio Gonçalves da Silva, Isabelly Do Nascimento Pereira, Laura Camargo Zibordi, Pedro Augusto Pereira Rosatto, Filipe Oliveira Granero, Célia Cristina Malaguti Figueiredo, Carlos José Leopoldo Constantino, Cibely da Silva Martin, Aldo Eloizo Job, Nilson Nicolau-Junior & Luciana Pereira Silva. (2024) Cytotoxic, antioxidant, and antiglycation activities, and tyrosinase inhibition using silver nanoparticles synthesized by leaf extract of Solanum aculeatissimum Jacq. Journal of Toxicology and Environmental Health, Part A 87:2, pages 57-76.
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Camila dos Reis Oliveira, Joedna Cavalcante Pereira, Andressa Barros Ibiapina, Italo Rossi Roseno Martins, João Marcelo de Castro e Sousa, Paulo Michel Pinheiro Ferreira & Felipe Cavalcanti Carneiro da Silva. (2023) Buthionine sulfoximine and chemoresistance in cancer treatments: a systematic review with meta-analysis of preclinical studies. Journal of Toxicology and Environmental Health, Part B 26:8, pages 417-441.
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Martha P. Cruces, Emilio Pimentel, Luz M. Vidal, Elizabeth Jiménez, Hugo Suárez, Enrique Camps & Enrique Campos-González. (2023) Genotoxic action of bifenthrin nanoparticles and its effect on the development, productivity, and behavior of Drosophila melanogaster. Journal of Toxicology and Environmental Health, Part A 86:18, pages 661-677.
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Maria João Bessa, Fátima Brandão, Fernanda Rosário, Luciana Moreira, Ana Teresa Reis, Vanessa Valdiglesias, Blanca Laffon, Sónia Fraga & João Paulo Teixeira. (2023) Assessing the in vitro toxicity of airborne (nano)particles to the human respiratory system: from basic to advanced models. Journal of Toxicology and Environmental Health, Part B 26:2, pages 67-96.
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Fatma Turna Demir. (2022) Protective effects of resveratrol against genotoxicity induced by nano and bulk hydroxyapatite in Drosophila melanogaster. Journal of Toxicology and Environmental Health, Part A 85:20, pages 850-865.
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Karina Alves Feitosa, Ricardo de Oliveira Correia, Ana Carolina Maragno Fattori, Yulli Roxenne Albuquerque, Patricia Brassolatti, Genoveva Flores Luna, Joice Margareth de Almeida Rodolpho, Camila T. Nogueira, Juliana Cancino Bernardi, Carlos Speglich & Fernanda de Freitas Anibal. (2022) Toxicological effects of the mixed iron oxide nanoparticle (Fe3O4 NP) on murine fibroblasts LA-9. Journal of Toxicology and Environmental Health, Part A 85:16, pages 649-670.
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Marlon Luiz Neves da Silva, Diego José Nogueira, Denice Schulz Vicentini, Rodrigo Costa Puerari, Paulo Roger Lopes Alves, Cristiane Funghetto Fuzinatto & William Gerson Matias. (2022) Rapid Communication: oxidative stress induced by mixed exposure to glyphosate and silver nanoparticles. Journal of Toxicology and Environmental Health, Part A 85:14, pages 586-590.
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Daniel Krewski, Patrick Saunders-Hastings, Patricia Larkin, Margit Westphal, Michael G. Tyshenko, William Leiss, Maurice Dusseault, Michael Jerrett & Doug Coyle. (2022) Principles of risk decision-making. Journal of Toxicology and Environmental Health, Part B 25:5, pages 250-278.
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Ricardo Andrade Furtado, Saulo Duarte Ozelin, Natália Helen Ferreira, Bárbara Ayumi Miura, Silvio Almeida Junior, Geórgia Modé Magalhães, Eduardo José Nassar, Mariza Abreu Miranda, Jairo Kenupp Bastos & Denise Crispim Tavares. (2022) Antitumor activity of solamargine in mouse melanoma model: relevance to clinical safety. Journal of Toxicology and Environmental Health, Part A 85:4, pages 131-142.
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Ali Kermanizadeh, Leagh G Powell & Vicki Stone. (2020) A review of hepatic nanotoxicology – summation of recent findings and considerations for the next generation of study designs. Journal of Toxicology and Environmental Health, Part B 23:4, pages 137-176.
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Jéssica Schveitzer Köerich, Diego José Nogueira, Vitor Pereira Vaz, Carmen Simioni, Marlon Luiz Neves Da Silva, Luciane Cristina Ouriques, Denice Schulz Vicentini & William Gerson Matias. (2020) Toxicity of binary mixtures of Al2O3 and ZnO nanoparticles toward fibroblast and bronchial epithelium cells. Journal of Toxicology and Environmental Health, Part A 83:9, pages 363-377.
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Lisa Kobos, Saeed Alqahtani, Li Xia, Vincent Coltellino, Riley Kishman, Daniel McIlrath, Carlos Perez-Torres & Jonathan Shannahan. (2020) Comparison of silver nanoparticle-induced inflammatory responses between healthy and metabolic syndrome mouse models. Journal of Toxicology and Environmental Health, Part A 83:7, pages 249-268.
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Yuqiang Bi, Andrew K. Marcus, Hervé Robert, Rosa Krajmalnik-Brown, Bruce E. Rittmann, Paul Westerhoff, Marie-Hélène Ropers & Muriel Mercier-Bonin. (2020) The complex puzzle of dietary silver nanoparticles, mucus and microbiota in the gut. Journal of Toxicology and Environmental Health, Part B 23:2, pages 69-89.
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Xiaoqing Guo, Ji-Eun Seo, Xilin Li & Nan Mei. (2020) Genetic toxicity assessment using liver cell models: past, present, and future. Journal of Toxicology and Environmental Health, Part B 23:1, pages 27-50.
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Sam Lekamge, Ana F. Miranda, Ben Pham, Andrew S. Ball, Ravi Shukla & Dayanthi Nugegoda. (2019) The toxicity of non-aged and aged coated silver nanoparticles to the freshwater shrimp Paratya australiensis. Journal of Toxicology and Environmental Health, Part A 82:23-24, pages 1207-1222.
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Yang Liu, Jun Ji, Le Ji, Yuanyuan Li, Bowen Zhang, Tongwang Yang, Jing Yang, Liping Lv & Gang Wu. (2019) Translocation of intranasal (i.n.) instillation of different-sized cerium dioxide (CeO2) particles: potential adverse effects in mice. Journal of Toxicology and Environmental Health, Part A 82:20, pages 1069-1075.
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Shunbang Yu, Yongping Mu, Xudong Zhang, Jian Li, Charles Lee & He Wang. (2019) Molecular mechanisms underlying titanium dioxide nanoparticles (TiO2NP) induced autophagy in mesenchymal stem cells (MSC). Journal of Toxicology and Environmental Health, Part A 82:18, pages 997-1008.
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Mauro Petretta, Giovanna Desando, Brunella Grigolo & Livia Roseti. (2019) 3D printing of musculoskeletal tissues: impact on safety and health at work. Journal of Toxicology and Environmental Health, Part A 82:16, pages 891-912.
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K. Krajnak, S. Waugh, Ab Stefaniak, D Schwegler-Berry, Ka Roach, M Barger & Jr. Roberts. (2019) Exposure to graphene nanoparticles induces changes in measures of vascular/renal function in a load and form-dependent manner in mice. Journal of Toxicology and Environmental Health, Part A 82:12, pages 711-726.
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Lin Li, Lu Li, Xuejiao Zhou, Yang Yu, Zengqiang Li, Daiying Zuo & Yingliang Wu. (2019) Silver nanoparticles induce protective autophagy via Ca2+/CaMKKβ/AMPK/mTOR pathway in SH-SY5Y cells and rat brains. Nanotoxicology 13:3, pages 369-391.
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Bedanta Kumar Barik & Monalisa Mishra. (2019) Nanoparticles as a potential teratogen: a lesson learnt from fruit fly. Nanotoxicology 13:2, pages 258-284.
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Maolin Wang, Qianyu Yang, Jimin Long, Yanghuai Ding, Xiaoqing Zou, Guochao Liao & Yi Cao. (2018) A comparative study of toxicity of TiO2, ZnO, and Ag nanoparticles to human aortic smooth-muscle cells. International Journal of Nanomedicine 13, pages 8037-8049.
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Hongying Liang, Tong He, Jimin Long, Liangliang Liu, Guochao Liao, Yanhuai Ding & Yi Cao. (2018) Influence of bovine serum albumin pre-incubation on toxicity and ER stress-apoptosis gene expression in THP-1 macrophages exposed to ZnO nanoparticles. Toxicology Mechanisms and Methods 28:8, pages 587-598.
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Fernanda Rosário, Peter Hoet, António José Arsénia Nogueira, Conceição Santos & Helena Oliveira. (2018) Differential pulmonary in vitro toxicity of two small-sized polyvinylpyrrolidone-coated silver nanoparticles. Journal of Toxicology and Environmental Health, Part A 81:15, pages 675-690.
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Eşref Demir & Ricard Marcos. (2018) Toxic and genotoxic effects of graphene and multi-walled carbon nanotubes. Journal of Toxicology and Environmental Health, Part A 81:14, pages 645-660.
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Birke J. Benedikter, Emiel F. M. Wouters, Paul H. M. Savelkoul, Gernot G. U. Rohde & Frank R. M. Stassen. (2018) Extracellular vesicles released in response to respiratory exposures: implications for chronic disease. Journal of Toxicology and Environmental Health, Part B 21:3, pages 142-160.
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Helinor J. Johnston, Rachel Verdon, Suzanne Gillies, David M. Brown, Teresa F. Fernandes, Theodore B. Henry, Adriano G. Rossi, Lang Tran, Carl Tucker, Charles R. Tyler & Vicki Stone. (2018) Adoption of in vitro systems and zebrafish embryos as alternative models for reducing rodent use in assessments of immunological and oxidative stress responses to nanomaterials. Critical Reviews in Toxicology 48:3, pages 252-271.
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Kelsey R. Babik, Matthew M. Dahm, Kevin H. Dunn, Kevin L. Dunn & Mary K. Schubauer-Berigan. (2018) Characterizing workforces exposed to current and emerging non-carbonaceous nanomaterials in the U.S.. Journal of Occupational and Environmental Hygiene 15:1, pages 44-56.
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Chitrada Kaweeteerawat, Preeyawis Na Ubol, Sanirat Sangmuang, Sasitorn Aueviriyavit & Rawiwan Maniratanachote. (2017) Mechanisms of antibiotic resistance in bacteria mediated by silver nanoparticles. Journal of Toxicology and Environmental Health, Part A 80:23-24, pages 1276-1289.
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Peter Møller & Nicklas Raun Jacobsen. (2017) Weight of evidence analysis for assessing the genotoxic potential of carbon nanotubes. Critical Reviews in Toxicology 47:10, pages 871-888.
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Airton da Cunha Martins$suffix/text()$suffix/text(), Lara Ferreira Azevedo, Cecília Cristina de Souza Rocha, Maria Fernanda Hornos Carneiro, Vinicius Paula Venancio, Mara Ribeiro de Almeida, Lusânia Maria Greggi Antunes, Rodrigo de Carvalho Hott, Jairo Lisboa Rodrigues, Abayomi T. Ogunjimi, Joseph A. Adeyemi & Fernando Barbosa$suffix/text()$suffix/text(). (2017) Evaluation of distribution, redox parameters, and genotoxicity in Wistar rats co-exposed to silver and titanium dioxide nanoparticles. Journal of Toxicology and Environmental Health, Part A 80:19-21, pages 1156-1165.
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Bárbara Mesquita, Isabel Lopes, Susana Silva, Maria João Bessa, Maksim Starykevich, Jorge Carneiro, Tiago L. P. Galvão, Mário G. S. Ferreira, João Tedim, João Paulo Teixeira & Sónia Fraga. (2017) Gold nanorods induce early embryonic developmental delay and lethality in zebrafish (Danio rerio). Journal of Toxicology and Environmental Health, Part A 80:13-15, pages 672-687.
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J. F. Gomes & R. M. Miranda. (2017) Determination of “safe” and “critical” nanoparticles exposure to welders in a workshop. Journal of Toxicology and Environmental Health, Part A 80:13-15, pages 767-775.
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Melisa Bunderson-Schelvan, Andrij Holian & Raymond F. Hamilton$suffix/text()$suffix/text(). (2017) Engineered nanomaterial-induced lysosomal membrane permeabilization and anti-cathepsin agents. Journal of Toxicology and Environmental Health, Part B 20:4, pages 230-248.
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Saud Alarifi, Daoud Ali & Saad Alkahtani. (2017) Involvement of mitochondrial dysfunction in nanosized lead oxide induced cellular damage in human lung alveolar epithelial cells. Toxicological & Environmental Chemistry 99:4, pages 680-690.
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Kyu-Bong Kim, Young Woo Kim, Seong Kwang Lim, Tae Hyun Roh, Du Yeon Bang, Seul Min Choi, Duck Soo Lim, Yeon Joo Kim, Seol-Hwa Baek, Min-Kook Kim, Hyo-Seon Seo, Min-Hwa Kim, Hyung Sik Kim, Joo Young Lee, Sam Kacew & Byung-Mu Lee. (2017) Risk assessment of zinc oxide, a cosmetic ingredient used as a UV filter of sunscreens. Journal of Toxicology and Environmental Health, Part B 20:3, pages 155-182.
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Yuxiu Gu, Shanshan Cheng, Gui Chen, Yuexin Shen, Xiyue Li, Qin Jiang, Juan Li & Yi Cao. (2017) The effects of endoplasmic reticulum stress inducer thapsigargin on the toxicity of ZnO or TiO2 nanoparticles to human endothelial cells. Toxicology Mechanisms and Methods 27:3, pages 191-200.
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K. Krajnak, K. Sriram, C. Johnson, J. R. Roberts, R. Mercer, G. R. Miller, O. Wirth & J. M. Antonini. (2017) Effects of pulmonary exposure to chemically-distinct welding fumes on neuroendocrine markers of toxicity. Journal of Toxicology and Environmental Health, Part A 80:5, pages 301-314.
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Ali Kermanizadeh, Kim Jantzen, Michael B. Ward, Jon Ambæk Durhuus, Lene Juel Rasmussen, Steffen Loft & Peter Møller. (2017) Nanomaterial-induced cell death in pulmonary and hepatic cells following exposure to three different metallic materials: The role of autophagy and apoptosis. Nanotoxicology 11:2, pages 184-200.
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Saud Alarifi, Daoud Ali, Mohammed A Al Gurabi & Saad Alkahtani. (2017) Determination of nephrotoxicity and genotoxic potential of silver nanoparticles in Swiss albino mice. Toxicological & Environmental Chemistry 99:2, pages 294-301.
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Sreeparna Chakraborty, Vincent Castranova, Miriam K. Perez & Giovanni Piedimonte. (2017) Nanoparticles-induced apoptosis of human airway epithelium is mediated by proNGF/p75NTR signaling. Journal of Toxicology and Environmental Health, Part A 80:1, pages 53-68.
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Franziska Schramm, Martina Lange, Pia Hoppmann & Astrid Heutelbeck. (2016) Cytotoxicity of carbon nanohorns in different human cells of the respiratory system. Journal of Toxicology and Environmental Health, Part A 79:22-23, pages 1085-1093.
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Mariana T. Farcas, Elena R. Kisin, Autumn L. Menas, Dmitriy W. Gutkin, Alexander Star, Richard S. Reiner, Naveena Yanamala, Kai Savolainen & Anna A. Shvedova. (2016) Pulmonary exposure to cellulose nanocrystals caused deleterious effects to reproductive system in male mice. Journal of Toxicology and Environmental Health, Part A 79:21, pages 984-997.
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Sung-Hyun Hwang, Frank Thielbeer, Jiyoung Jeong, Youngju Han, Sunay V. Chankeshwara, Mark Bradley & Wan-Seob Cho. (2016) Dual contribution of surface charge and protein-binding affinity to the cytotoxicity of polystyrene nanoparticles in nonphagocytic A549 cells and phagocytic THP-1 cells. Journal of Toxicology and Environmental Health, Part A 79:20, pages 925-937.
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Yang Liu, Yuanyuan Li, Tongwang Yang, Jing Yang, He Wang & Gang Wu. (2016) Acute changes in murine hippocampus and olfactory bulb after nasal instillation of varying size cerium dioxide particles. Journal of Toxicology and Environmental Health, Part A 79:19, pages 869-877.
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Brandi N. Snyder-Talkington, Chunlin Dong, Dale W. Porter, Barbara Ducatman, Michael G. Wolfarth, Michael Andrew, Lori Battelli, Rebecca Raese, Vincent Castranova, Nancy L. Guo & Yong Qian. (2016) Multiwalled carbon nanotube-induced pulmonary inflammatory and fibrotic responses and genomic changes following aspiration exposure in mice: A 1-year postexposure study. Journal of Toxicology and Environmental Health, Part A 79:8, pages 352-366.
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Mohamed Alaraby, Balasubramanyam Annangi, Ricard Marcos & Alba Hernández. (2016) Drosophila melanogaster as a suitable in vivo model to determine potential side effects of nanomaterials: A review. Journal of Toxicology and Environmental Health, Part B 19:2, pages 65-104.
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Eman A. Mwafy & Ayman M. Mostafa. (2019) Multi walled carbon nanotube decorated cadmium oxide nanoparticles via pulsed laser ablation in liquid media. Optics & Laser Technology 111, pages 249-254.
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Georgios F. Kylafis, P. Andrew Sleigh, Alison S. Tomlin & Yaobo Ding. (2019) Evacuation characteristics of released airborne TiO2 nanomaterial particles under different ventilation rates in a confined environment. Journal of Environmental Management 233, pages 417-426.
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AT Saber, A Mortensen, J Szarek, NR Jacobsen, M Levin, IK Koponen, KA Jensen, U Vogel & H Wallin. (2018) Toxicity of pristine and paint-embedded TiO 2 nanomaterials . Human & Experimental Toxicology 38:1, pages 11-24.
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