Citations (47)
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Jiri Kassa, Jana Zdarova Karasova, Kamil Kuca & Kamil Musilek. (2010) A comparison of the reactivating and therapeutic efficacy of newly developed oximes (K347, K628) with commonly used oximes (obidoxime, HI-6) against tabun in rats and mice. Drug and Chemical Toxicology 33:3, pages 227-232.
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Lucie Musilova, Kamil Kuca, Young-Sik jung & Daniel Jun. (2009) In vitro oxime-assisted reactivation of paraoxon-inhibited human acetylcholinesterase and butyrylcholinesterase. Clinical Toxicology 47:6, pages 545-550.
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Kamil Kuca, Jiri Cabal, Daniel Jun & Vit Koleckar. (2008) In Vitro Comparison of Two Most Promising H-Oximes (HI-6 and HLö-7) and Currently Commercially Available Reactivators Pralidoxime and Obidoxime in Reactivation of Cyclosarin-Inhibited Human Cholinesterases. Toxicology Mechanisms and Methods 18:4, pages 329-333.
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Miroslav Pohanka, Daniel Jun & Kamil Kuca. (2008) Photometric microplate assay for estimation of the efficacy of paraoxon-inhibited acetylcholinesterase reactivation. Journal of Enzyme Inhibition and Medicinal Chemistry 23:6, pages 781-784.
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Danijela Z. Krstić, Mirjana Čolović, Mojca Bavcon kralj, Mladen Franko, Katarina Krinulović, Polonca Trebše & VESNA VASIĆ. (2008) Inhibition of AChE by malathion and some structurally similar compounds. Journal of Enzyme Inhibition and Medicinal Chemistry 23:4, pages 562-573.
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Kamil Musilek, Ondrej Holas, Kamil Kuca, Daniel Jun, Vlastimil Dohnal, Veronika Opletalova & Martin Dolezal. (2008) Synthesis of monooxime-monocarbamoyl bispyridinium compounds bearing (E)-but-2-ene linker and evaluation of their reactivation activity against tabun- and paraoxon-inhibited acetylcholinesterase. Journal of Enzyme Inhibition and Medicinal Chemistry 23:1, pages 70-76.
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Kamil Kuca, Jiri Cabal, Daniel Jun & Martina Hrabinova. (2007) Potency of Five Structurally Different Acetylcholinesterase Reactivators to Reactivate Human Brain Cholinesterases Inhibited by Cyclosarin. Clinical Toxicology 45:5, pages 512-515.
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Kamil Musilek, Ondrej Holas, Kamil Kuca, Daniel Jun, Vlastimil Dohnal & Martin Dolezal. (2007) Synthesis of a novel series of non-symmetrical bispyridinium compounds bearing a xylene linker and evaluation of their reactivation activity against tabun and paraoxon-inhibited acetylcholinesterase. Journal of Enzyme Inhibition and Medicinal Chemistry 22:4, pages 425-432.
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Kamil Kuca, Jiri Cabal, Daniel Jun, Jiri Bajgar & Martina Hrabinova. (2006) Potency of new structurally different oximes to reactivate cyclosarin-inhibited human brain acetylcholinesterases. Journal of Enzyme Inhibition and Medicinal Chemistry 21:6, pages 663-666.
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Martina Hrabinova, Kamil Musilek, Daniel Jun & Kamil Kuca. (2006) New group of xylene linker-containing acetylcholinesterase reactivators as antidotes against the nerve agent cyclosarin. Journal of Enzyme Inhibition and Medicinal Chemistry 21:5, pages 515-519.
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Articles from other publishers (37)
Ashima Thakur, Jayant Patwa, Abha Sharma & Swaran Jeet Singh Flora. (2022) Synthesis, Molecular Docking, BSA, and In Vitro Reactivation Study of
Imidazopyridine Oximes Against Paraoxon Inhibited Acetylcholinesterase. Medicinal Chemistry 18:2, pages 273-287.
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Miloš P. Stojiljković, Milan Jokanović, Dragana Lončar-Stojiljković & Ranko Škrbić. 2020. Handbook of Toxicology of Chemical Warfare Agents. Handbook of Toxicology of Chemical Warfare Agents
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Shibaji Ghosh, Nellore Bhanu Chandar, Kalyanashis Jana & Bishwajit Ganguly. (2017) Revealing the importance of linkers in K-series oxime reactivators for tabun-inhibited AChE using quantum chemical, docking and SMD studies. Journal of Computer-Aided Molecular Design 31:8, pages 729-742.
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Lukas Gorecki, Jan Korabecny, Kamil Musilek, David Malinak, Eugenie Nepovimova, Rafael Dolezal, Daniel Jun, Ondrej Soukup & Kamil Kuca. (2016) SAR study to find optimal cholinesterase reactivator against organophosphorous nerve agents and pesticides. Archives of Toxicology 90:12, pages 2831-2859.
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Michael Winter, Timo Wille, Kamil Musilek, Kamil Kuca, Horst Thiermann & Franz Worek. (2016) Investigation of the reactivation kinetics of a large series of bispyridinium oximes with organophosphate-inhibited human acetylcholinesterase. Toxicology Letters 244, pages 136-142.
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J. Janockova, E. Zilecka, J. Kasparkova, V. Brabec, O. Soukup, K. Kuca & M. Kozurkova. (2016) Assessment of DNA-binding affinity of cholinesterase reactivators and electrophoretic determination of their effect on topoisomerase I and II activity. Molecular BioSystems 12:9, pages 2910-2920.
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Gabriele Horn, Timo Wille, Kamil Musilek, Kamil Kuca, Horst Thiermann & Franz Worek. (2014) Reactivation kinetics of 31 structurally different bispyridinium oximes with organophosphate-inhibited human butyrylcholinesterase. Archives of Toxicology 89:3, pages 405-414.
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Kamil Musilek, Jan Korabecny, Daniel Jun, Jiri Kassa & Kamil Kuca. 2015. Handbook of Toxicology of Chemical Warfare Agents. Handbook of Toxicology of Chemical Warfare Agents
1071
1087
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Christina M. Wilhelm, Thomas H. Snider, Michael C. Babin, David A. Jett, Gennady E. PlatoffJr.Jr. & David T. Yeung. (2014) A comprehensive evaluation of the efficacy of leading oxime therapies in guinea pigs exposed to organophosphorus chemical warfare agents or pesticides. Toxicology and Applied Pharmacology 281:3, pages 254-265.
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Konstantis F. Konidaris, Georgios A. Dalkas, Eugenia Katsoulakou, George Pairas, Catherine P. Raptopoulou, Fotini N. Lamari, Georgios A. Spyroulias & Evy Manessi-Zoupa. (2014) ZnII/pyridyloxime complexes as potential reactivators of OP-inhibited acetylcholinesterase: In vitro and docking simulation studies. Journal of Inorganic Biochemistry 134, pages 12-19.
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Nadezhda Shchepina, Viktor Avrorin, Gennadii Badun, Galina Alexandrova, Irina Agafonova & Nina Popova. (2014) Quinolinium Structure as Labeled Biomarkers. Open Journal of Synthesis Theory and Applications 03:03, pages 21-26.
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Jana Janockova, Zuzana Gulasova, Kamil Musilek, Kamil Kuca & Maria Kozurkova. (2013) Novel cholinesterase modulators and their ability to interact with DNA. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy 115, pages 364-369.
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Kamil Musilek, Martin Dolezal, Frank Gunn‐Moore & Kamil Kuca. (2011) Design, evaluation and structure—Activity relationship studies of the AChE reactivators against organophosphorus pesticides. Medicinal Research Reviews 31:4, pages 548-575.
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Daniel Jun, Lucie Musilova, Kamil Musilek & Kamil Kuca. (2011) In Vitro Ability of Currently Available Oximes to Reactivate Organophosphate Pesticide-Inhibited Human Acetylcholinesterase and Butyrylcholinesterase. International Journal of Molecular Sciences 12:3, pages 2077-2087.
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Kamil Musilek, Marketa Komloova, Ondrej Holas, Anna Horova, Miroslav Pohanka, Frank Gunn-Moore, Vlastimil Dohnal, Martin Dolezal & Kamil Kuca. (2011) Mono-oxime bisquaternary acetylcholinesterase reactivators with prop-1,3-diyl linkage—Preparation, in vitro screening and molecular docking. Bioorganic & Medicinal Chemistry 19:2, pages 754-762.
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O. Soukup, Z. Kristofikova, J. Proska, G. Tobin, J. Patocka, J. Marek, D. Jun, J. Fusek, D. Ripova & K. Kuca. (2010) Novel acetylcholinesterase reactivator K112 and its cholinergic properties. Biomedicine & Pharmacotherapy 64:8, pages 541-545.
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Kamil Kuca, Jiri Cabal, Daniel Jun, Kamil Musilek, Ondrej Soukup, Miroslav Pohanka, Jaroslav Pejchal, Kyung-Ae Oh, Garp Yeol Yang & Young-Sik Jung. (2010) Reactivation of VX-inhibited AChE by novel oximes having two oxygen atoms in the linker. Environmental Toxicology and Pharmacology 30:1, pages 85-87.
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Agnieszka Skórska-Stania, Magdalena Śliwa, Kamil Musilek, Kamil Kuca, Josef Jampilek, Robert Musiol, Barbara J. Oleksyn & Jiri Dohnal. (2010) Selected AChE reactivators in different crystalline environment: salts and enzyme. Structural Chemistry 21:3, pages 495-501.
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Kamil Musilek, Marketa Komloova, Vlasta Zavadova, Ondrej Holas, Martina Hrabinova, Miroslav Pohanka, Vlastimil Dohnal, Florian Nachon, Martin Dolezal, Kamil Kuca & Young-Sik Jung. (2010) Preparation and in vitro screening of symmetrical bispyridinium cholinesterase inhibitors bearing different connecting linkage—initial study for Myasthenia gravis implications. Bioorganic & Medicinal Chemistry Letters 20:5, pages 1763-1766.
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Kamil Musilek, Ondrej Holas, Jan Misik, Miroslav Pohanka, Ladislav Novotny, Vlastimil Dohnal, Veronika Opletalova & Kamil Kuca. (2010) Monooxime-monocarbamoyl Bispyridinium Xylene-Linked Reactivators of Acetylcholinesterase-Synthesis, In vitro and Toxicity Evaluation, and Docking Studies. ChemMedChem 5:2, pages 247-254.
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Jiří Bajgar. (2010) Optimal Choice of Acetylcholinesterase Reactivators for Antidoral Treatment of Nerve Agent Intoxication. Acta Medica (Hradec Kralove, Czech Republic) 53:4, pages 207-211.
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Kamil Kuca, Jiri Cabal, Yung Sik Jung, Kamil Musilek, Ondrej Soukup, Daniel Jun, Miroslav Pohanka, Lucie Musilova, Jana Karasová, Ladislav Novotný & Martina Hrabinova. (2009) Reactivation of Human Brain Homogenate Cholinesterases Inhibited by Tabun using Newly Developed Oximes K117 and K127. Basic & Clinical Pharmacology & Toxicology 105:3, pages 207-210.
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Kamil Kuca, Kamil Musilek, Daniel Jun, Jiri Bajgar & Jiri Kassa. 2009. Handbook of Toxicology of Chemical Warfare Agents. Handbook of Toxicology of Chemical Warfare Agents
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Kamil Musilek, Jiri Kucera, Daniel Jun, Vlastimil Dohnal, Veronika Opletalova & Kamil Kuca. (2008) Monoquaternary pyridinium salts with modified side chain—synthesis and evaluation on model of tabun- and paraoxon-inhibited acetylcholinesterase. Bioorganic & Medicinal Chemistry 16:17, pages 8218-8223.
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D. E. Lorke, M. Y. Hasan, K. Arafat, K. Kuča, K. Musilek, A. Schmitt & G. A. Petroianu. (2008)
In vitro
oxime protection of human red blood cell acetylcholinesterase inhibited by diisopropyl‐fluorophosphate
. Journal of Applied Toxicology 28:4, pages 422-429.
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Kamil Musilek, Daniel Jun, Jiri Cabal, Jiri Kassa, Frank Gunn-Moore & Kamil Kuca. (2007)
Design of a Potent Reactivator of Tabun-Inhibited AcetylcholinesteraseSynthesis and Evaluation of (
E
)-1-(4-Carbamoylpyridinium)-4-(4-hydroxyiminomethylpyridinium)-but-2-ene Dibromide (K203)
. Journal of Medicinal Chemistry 50:22, pages 5514-5518.
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Kamil Musilek, Ondrej Holas, Daniel Jun, Vlastimil Dohnal, Frank Gunn-Moore, Veronika Opletalova, Martin Dolezal & Kamil Kuca. (2007) Monooxime reactivators of acetylcholinesterase with (E)-but-2-ene linker—Preparation and reactivation of tabun- and paraoxon-inhibited acetylcholinesterase. Bioorganic & Medicinal Chemistry 15:21, pages 6733-6741.
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Kamil Kuca, Kamil Musilek, Martin Paar, Daniel Jun, Petr Stodulka, Martina Hrabinova & Jan Marek. (2007) Targeted Synthesis of 1-(4-Hydroxyiminomethylpyridinium)-3-pyridiniumpropane Dibromide – A New Nerve Agent Reactivator. Molecules 12:8, pages 1964-1972.
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Kamil Musilek, Ondrej Holas, Kamil Kuca, Daniel Jun, Vlastimil Dohnal, Veronika Opletalova & Martin Dolezal. (2007) Novel series of bispyridinium compounds bearing a (Z)-but-2-ene linker—Synthesis and evaluation of their reactivation activity against tabun and paraoxon-inhibited acetylcholinesterase. Bioorganic & Medicinal Chemistry Letters 17:11, pages 3172-3176.
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Kamil Kuca, Jiri Cabal, Daniel Jun & Kamil Musilek. (2007) In vitro reactivation potency of acetylcholinesterase reactivators — K074 and K075 — to reactivate tabun-inhibited human brain cholinesterases. Neurotoxicity Research 11:2, pages 101-106.
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Kamil Musílek, Kamil Kuča, Daniel Jun & Martin Doležal. (2007) In vitro reactivation potency of bispyridinium (E)-but-2-ene linked acetylcholinesterase reactivators against tabun-inhibited acetylcholinesterase. Journal of Applied Biomedicine 5:1, pages 25-30.
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K. Kuča, V. Račáková & D. Jun. (2007) Structure—activity relationships for in vitro oxime reactivation of chlorpyrifos-inhibited acetylcholinesterase. Chemical Papers 61:4.
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Kamil Musílek, Kamil Kuča & Daniel Jun. (2007) Evaluation of Potency of Known Oximes (Pralidoxime, Trimedoxime, HI-6, Methoxime, Obidoxime) to in vitro Reactivate Acetylcholinesterase Inhibited by Pesticides (Chlorpyrifos and Methylchlorpyrifos and Nerve Agent (Russian VX). Acta Medica (Hradec Kralove, Czech Republic) 50:3, pages 203-206.
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Kamil Musilek, Ondrej Holas, Kamil Kuca, Daniel Jun, Vlastimil Dohnal & Martin Dolezal. (2006) Synthesis of asymmetrical bispyridinium compounds bearing cyano-moiety and evaluation of their reactivation activity against tabun and paraoxon-inhibited acetylcholinesterase. Bioorganic & Medicinal Chemistry Letters 16:21, pages 5673-5676.
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. (2006) Potency of Several Structurally Different Acetylcholinesterase Reactivators to Reactivate House Fly and Bovine Acetylcholinesterases Inhibited by Paraoxon and DFP. Bulletin of the Korean Chemical Society 27:9, pages 1401-1404.
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Kyung-Ae Oh, Garp Yeol Yang, Daniel Jun, Kamil Kuca & Young-Sik Jung. (2006) Bis-pyridiumaldoxime reactivators connected with CH2O(CH2) OCH2 linkers between pyridinium rings and their reactivity against VX. Bioorganic & Medicinal Chemistry Letters 16:18, pages 4852-4855.
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Veronika Račáková, Daniel Jun, Veronika Opletalová & Kamil Kuča. (2006) Reactivation of acetycholinesterase inhibited by the pesticide chlorpyrifos. Journal of Applied Biomedicine 4:3, pages 147-151.
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