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Journal of Enzyme Inhibition and Medicinal Chemistry Volume 23, 2008 - Issue 5
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Research Article

Synthesis of New Pyrrolo[1,2-a]quinoxaline Derivatives as Potential Inhibitors of Akt Kinase

Vanessa Desplat PPF Médicaments-Parasitologie, UFR des Sciences Pharmaceutiques, Université Bordeaux 2, 146 rue Léo Saignat, 33076 Bordeaux Cedex, France
,
Ambre Geneste
,
Marc-Antoine Begorre
,
Solene Belisle Fabre EA 4138 - Pharmacochimie, UFR des Sciences Pharmaceutiques, Université Bordeaux 2, 146 rue Léo Saignat, 33076 Bordeaux Cedex, France
,
Stephane Brajot PPF Médicaments-Parasitologie, UFR des Sciences Pharmaceutiques, Université Bordeaux 2, 146 rue Léo Saignat, 33076 Bordeaux Cedex, France
,
Stephane Massip EA 4138 - Pharmacochimie, UFR des Sciences Pharmaceutiques, Université Bordeaux 2, 146 rue Léo Saignat, 33076 Bordeaux Cedex, France
,
Denis Thiolat PPF Médicaments-Parasitologie, UFR des Sciences Pharmaceutiques, Université Bordeaux 2, 146 rue Léo Saignat, 33076 Bordeaux Cedex, France
,
Djavad Mossalayi PPF Médicaments-Parasitologie, UFR des Sciences Pharmaceutiques, Université Bordeaux 2, 146 rue Léo Saignat, 33076 Bordeaux Cedex, France
,
Christian Jarry EA 4138 - Pharmacochimie, UFR des Sciences Pharmaceutiques, Université Bordeaux 2, 146 rue Léo Saignat, 33076 Bordeaux Cedex, France
&
Jean Guillon EA 4138 - Pharmacochimie, UFR des Sciences Pharmaceutiques, Université Bordeaux 2, 146 rue Léo Saignat, 33076 Bordeaux Cedex, FranceCorrespondence[email protected]
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Pages 648-658 | Received 18 Dec 2007, Accepted 07 May 2008, Published online: 20 Oct 2008

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Simhachalam Gorle, V. N. Chandra Sekhar, L. Vaikunta Rao, K. Raghavendra Rao & Raghunadh Akula. (2023) Glucose as an eco-friendly reducing agent for a one-pot multicomponent synthesis of quinoxalines. Synthetic Communications 53:5, pages 414-425.
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Jean Guillon, Anita Cohen, Nassima Meriem Gueddouda, Rabindra Nath Das, Stéphane Moreau, Luisa Ronga, Solène Savrimoutou, Louise Basmaciyan, Alix Monnier, Myriam Monget, Sandra Rubio, Timothée Garnerin, Nadine Azas, Jean-Louis Mergny, Catherine Mullié & Pascal Sonnet. (2017) Design, synthesis and antimalarial activity of novel bis{N-[(pyrrolo[1,2-a]quinoxalin-4-yl)benzyl]-3-aminopropyl}amine derivatives. Journal of Enzyme Inhibition and Medicinal Chemistry 32:1, pages 547-563.
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Vanessa Desplat, Stéphane Moreau, Solene Belisle-Fabre, Denis Thiolat, Juliette Uranga, Romain Lucas, Laure de Moor, Stéphane Massip, Christian Jarry, Djavad M. Mossalayi, Pascal Sonnet, Gérard Déléris & Jean Guillon. (2011) Synthesis and evaluation of the antiproliferative activity of novel isoindolo[2,1-a]quinoxaline and indolo[1,2-a]quinoxaline derivatives. Journal of Enzyme Inhibition and Medicinal Chemistry 26:5, pages 657-667.
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Vanessa Desplat, Stephane Moreau, Aurore Gay, Solene Belisle Fabre, Denis Thiolat, Stephane Massip, Gregory Macky, Frederic Godde, Djavad Mossalayi, Christian Jarry & Jean Guillon. (2010) Synthesis and evaluation of the antiproliferative activity of novel pyrrolo[1,2-a]quinoxaline derivatives, potential inhibitors of Akt kinase. Part II. Journal of Enzyme Inhibition and Medicinal Chemistry 25:2, pages 204-215.
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Articles from other publishers (59)

Monu Agarwal, Kanchan Verma, Gargi Pathak, Sakshi Pathak, Jaya Mathur & Mahendra Kumar. (2023) Advances in Isocyanide‐Based Multicomponent Synthesis of Quinoxaline Scaffolds. ChemistrySelect 8:34.
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Gorle SimhachalamL. Vaikunta RaoDasi Samsonu & Akula Raghunadh. (2023) Iodine-Catalyzed One-Pot Multicomponent Synthesis of Pyrrolo/indolo[1,2-a]quinoxalines Substituted with ortho-Carbonyl Alkyl Benzoates/Benzoic Acids via Spirocyclic Ring Opening. Synlett 34:13, pages 1616-1620.
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Da Hye Lee, Ga Young Kim & Jinho Kim. (2023) Efficient synthesis of pyrrolo[1,2-α]quinoxalines mediated by ethyl 2-(4-nitrophenyl)azocarboxylate. New Journal of Chemistry 47:4, pages 2060-2067.
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Meiqi Geng, Minzhao Huang, Jinqiang Kuang, Weiwei Fang, MaoZhong Miao & Yongmin Ma. (2022) Application of N , N -Dimethylethanolamine as a One-Carbon Synthon for the Synthesis of Pyrrolo[1,2- a ]quinoxalines, Quinazolin-4-ones, and Benzo[4,5]imidazoquinazolines via [5 + 1] Annulation . The Journal of Organic Chemistry 87:21, pages 14753-14762.
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Muhammad Idham Darussalam Mardjan. 2022. Comprehensive Heterocyclic Chemistry IV. Comprehensive Heterocyclic Chemistry IV 622 658 .
Shichen Li, Jianing Ren, Chengcheng Ding, Yishou Wang & Chen Ma. (2021) N , N -Dimethylformamide as Carbon Synthons for the Synthesis of N -Heterocycles: Pyrrolo/Indolo[1,2- a ]quinoxalines and Quinazolin-4-ones . The Journal of Organic Chemistry 86:23, pages 16848-16857.
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Jiwon Ahn, Seok Beom Lee, Injae Song, Simin Chun, Dong-Chan Oh & Suckchang Hong. (2021) Synthesis of 4-Aryl Pyrrolo[1,2-α]quinoxalines via Iron-Catalyzed Oxidative Coupling from an Unactivated Methyl Arene . The Journal of Organic Chemistry 86:11, pages 7390-7402.
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