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Journal of Enzyme Inhibition and Medicinal Chemistry Volume 38, 2023 - Issue 1
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Research Paper

Synthesis, DFT calculations, and anti-proliferative evaluation of pyrimidine and selenadiazolopyrimidine derivatives as dual Topoisomerase II and HSP90 inhibitors

Samar El-Kalyoubia Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Port Said University, Port Said, EgyptCorrespondence[email protected] [email protected]
ORCID Iconhttps://orcid.org/0000-0002-4648-5184View further author information
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Samiha A. El-Sebaeyb Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy (Girls), Al-Azhar University, Cairo, EgyptCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0002-9928-9080View further author information
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A. M. Rashadc Accelerator and Ion Sources Department, Nuclear Research Center, Atomic Energy Authority, Cairo, Egypt;d Central Lab for Elemental and Isotopic Analysis, NRC, Atomic Energy Authority, Cairo, EgyptView further author information
,
Hanan A. AL-Ghulikahe Department of Chemistry, College of Science, Princess Nourah Bint Abdulrahman University, Riyadh, Saudi ArabiaORCID Iconhttps://orcid.org/0000-0002-3253-9698View further author information
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Mostafa M. Ghorabf Department of Drug Radiation Research, National Centre for Radiation Research and Technology (NCRRT), Egyptian Atomic Energy Authority (EAEA), Cairo, EgyptCorrespondence[email protected]
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&
Sherin M. Elfekyg Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Mansoura University, Mansoura, EgyptORCID Iconhttps://orcid.org/0000-0002-5774-8007View further author information
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Article: 2198163 | Received 16 Feb 2023, Accepted 27 Mar 2023, Published online: 10 Apr 2023

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Samar El-Kalyoubi, Mohamed M. Khalifa, Mahmoud T. Abo-Elfadl, Ahmed A. El-Sayed, Ahmed Elkamhawy, Kyeong Lee & Ahmed A. Al-Karmalawy. (2023) Design and synthesis of new spirooxindole candidates and their selenium nanoparticles as potential dual Topo I/II inhibitors, DNA intercalators, and apoptotic inducers. Journal of Enzyme Inhibition and Medicinal Chemistry 38:1.
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Samar El-Kalyoubi, Samiha A. El-Sebaey, Ahmed A. El-Sayed, Moustafa S. Abdelhamid, Fatimah Agili & Sherin M. Elfeky. (2023) Novel pyrimidine Schiff bases and their selenium-containing nanoparticles as dual inhibitors of CDK1 and tubulin polymerase: design, synthesis, anti-proliferative evaluation, and molecular modelling. Journal of Enzyme Inhibition and Medicinal Chemistry 38:1.
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Articles from other publishers (3)

Meng Zhou, Tao Jin, Ying Liu, Shuo Wang, Jiankang Feng, Shihe Shao, Chichong Lu & Guofan Jin. (2024) Design, synthesis, cell imaging, and bioactivity assessment of novel Rhodamine-Pyrimidine nido-carborane derivatives as fluorescent anticancer agents. Journal of Molecular Structure 1299, pages 137211.
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Heba A. Elsebaie, Eman A. El-Bastawissy, Kamel M. Elberembally, Eman F. Khaleel, Rehab Mustafa Badi, Moataz A. Shaldam, Wagdy M. Eldehna, Haytham O. Tawfik & Tarek F. El-Moselhy. (2023) Novel 4-(2-arylidenehydrazineyl)thienopyrimidine derivatives as anticancer EGFR inhibitors: Design, synthesis, biological evaluation, kinome selectivity and in silico insights. Bioorganic Chemistry 140, pages 106799.
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Samar El-Kalyoubi, Samiha A. El-Sebaey, Sherin M. Elfeky, Hanan A. AL-Ghulikah & Mona S. El-Zoghbi. (2023) Novel Aminopyrimidine-2,4-diones, 2-Thiopyrimidine-4-ones, and 6-Arylpteridines as Dual-Target Inhibitors of BRD4/PLK1: Design, Synthesis, Cytotoxicity, and Computational Studies. Pharmaceuticals 16:9, pages 1303.
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