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The Journal of Maternal-Fetal & Neonatal Medicine Volume 31, 2018 - Issue 2
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Original Article

Comparison of rapid MMP-8 and interleukin-6 point-of-care tests to identify intra-amniotic inflammation/infection and impending preterm delivery in patients with preterm labor and intact membranes*

Piya ChaemsaithongPerinatology Research Branch, NICHD/NIH/DHHS, Bethesda, MD, and Detroit, MI, USA; ;Department of Obstetrics and Gynecology, Wayne State University School of Medicine, Detroit, MI, USA; ;Department of Obstetrics and Gynecology, Block E East Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin New Territories, Hong Kong; Correspondence[email protected]
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Roberto RomeroPerinatology Research Branch, NICHD/NIH/DHHS, Bethesda, MD, and Detroit, MI, USA; ;Department of Obstetrics and Gynecology, University of Michigan, Ann Arbor, MI, USA; ;Department of Epidemiology and Biostatistics, Michigan State University, East Lansing, MI, USA; ;Center for Molecular Medicine and Genetics, Wayne State University, Detroit, MI, USACorrespondence[email protected]
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Nikolina DochevaPerinatology Research Branch, NICHD/NIH/DHHS, Bethesda, MD, and Detroit, MI, USA; ;Department of Obstetrics and Gynecology, Wayne State University School of Medicine, Detroit, MI, USA; View further author information
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Noppadol ChaiyasitPerinatology Research Branch, NICHD/NIH/DHHS, Bethesda, MD, and Detroit, MI, USA; ;Department of Obstetrics and Gynecology, Wayne State University School of Medicine, Detroit, MI, USA; View further author information
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Gaurav BhattiPerinatology Research Branch, NICHD/NIH/DHHS, Bethesda, MD, and Detroit, MI, USA; ;Department of Obstetrics and Gynecology, Wayne State University School of Medicine, Detroit, MI, USA; View further author information
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Percy PacoraPerinatology Research Branch, NICHD/NIH/DHHS, Bethesda, MD, and Detroit, MI, USA; ;Department of Obstetrics and Gynecology, Wayne State University School of Medicine, Detroit, MI, USA; View further author information
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Sonia S. HassanPerinatology Research Branch, NICHD/NIH/DHHS, Bethesda, MD, and Detroit, MI, USA; ;Department of Obstetrics and Gynecology, Wayne State University School of Medicine, Detroit, MI, USA; View further author information
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Lami YeoPerinatology Research Branch, NICHD/NIH/DHHS, Bethesda, MD, and Detroit, MI, USA; ;Department of Obstetrics and Gynecology, Wayne State University School of Medicine, Detroit, MI, USA; View further author information
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Offer ErezPerinatology Research Branch, NICHD/NIH/DHHS, Bethesda, MD, and Detroit, MI, USA; ;Department of Obstetrics and Gynecology, Wayne State University School of Medicine, Detroit, MI, USA; View further author information
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Pages 228-244 | Received 07 Oct 2016, Accepted 10 Jan 2017, Published online: 01 Mar 2017

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Dahiana M. Gallo, Wendy Fitzgerald, Roberto Romero, Nardhy Gomez-Lopez, Dereje W. Gudicha, Nándor Gábor Than, Mariachiara Bosco, Tinnakorn Chaiworapongsa, Eunjung Jung, Arun Meyyazhagan, Manaphat Suksai, Francesca Gotsch, Offer Erez, Adi L. Tarca & Leonid Margolis. (2023) Proteomic profile of extracellular vesicles in maternal plasma of women with fetal death. The Journal of Maternal-Fetal & Neonatal Medicine 36:1.
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Kyung Joon Oh, Roberto Romero, Hyeon Ji Kim, JoonHo Lee, Joon-Seok Hong & Bo Hyun Yoon. (2022) Preterm labor with intact membranes: a simple noninvasive method to identify patients at risk for intra-amniotic infection and/or inflammation. The Journal of Maternal-Fetal & Neonatal Medicine 35:26, pages 10514-10529.
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Hana Burckova, Jaroslav Stranik, Ivana Musilova, Jana Matulova, Bo Jacobsson & Marian Kacerovsky. (2022) Intra-amniotic inflammatory complications in preterm prelabor rupture of membranes and long-term neurodevelopmental outcomes of infants: a systematic review. The Journal of Maternal-Fetal & Neonatal Medicine 35:25, pages 5993-5998.
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José Morales-Roselló, Gabriela Loscalzo, Gemma Perez, Alicia Soriano Payá, Vaidilė Jakaitė & Alfredo Perales-Marín. (2022) Association of first trimester fetal heart rate and nuchal translucency with preterm birth. The Journal of Maternal-Fetal & Neonatal Medicine 35:25, pages 5572-5579.
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Eun Jung Jung, Roberto Romero, Nardhy Gomez-Lopez, Carmen Paredes, Ramiro Diaz-Primera, Edgar Hernandez-Andrade, Chaur-Dong Hsu & Lami Yeo. (2022) Cervical insufficiency, amniotic fluid sludge, intra-amniotic infection, and maternal bacteremia: the need for a point-of-care test to assess inflammation and bacteria in amniotic fluid. The Journal of Maternal-Fetal & Neonatal Medicine 35:24, pages 4775-4781.
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George Schwenkel, Roberto Romero, Rebecca Slutsky, Kenichiro Motomura, Chaur-Dong Hsu & Nardhy Gomez-Lopez. (2021) HSP70: an alarmin that does not induce high rates of preterm birth but does cause adverse neonatal outcomes. The Journal of Maternal-Fetal & Neonatal Medicine 34:24, pages 4110-4118.
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Hassendrini N. Peiris, Roberto Romero, Kanchan Vaswani, Sarah Reed, Nardhy Gomez-Lopez, Adi L. Tarca, Dereje W. Gudicha, Offer Erez, Eli Maymon & Murray D. Mitchell. (2021) Preterm labor is characterized by a high abundance of amniotic fluid prostaglandins in patients with intra-amniotic infection or sterile intra-amniotic inflammation. The Journal of Maternal-Fetal & Neonatal Medicine 34:24, pages 4009-4024.
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Ji-Hee Sung, Suk-Joo Choi, Soo-young Oh & Cheong-Rae Roh. (2021) Should the diagnostic criteria for suspected clinical chorioamnionitis be changed?. The Journal of Maternal-Fetal & Neonatal Medicine 34:5, pages 824-833.
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Ivana Musilova, Martina Kolackova, Ctirad Andrys, Marcela Drahosova, Ivana Baranová, Marcela Chmelarova, Jaroslav Stranik, Bo Jacobsson & Marian Kacerovsky. (2021) Nicotinamide phosphoribosyltransferase and intra-amniotic inflammation in preterm prelabor rupture of membranes. The Journal of Maternal-Fetal & Neonatal Medicine 34:5, pages 736-746.
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Nardhy Gomez-Lopez, Roberto Romero, Bogdan Panaitescu, Derek Miller, Chengrui Zou, Dereje W. Gudicha, Adi L. Tarca, Robert Para, Percy Pacora, Sonia S. Hassan & Chaur-Dong Hsu. (2021) Gasdermin D: in vivo evidence of pyroptosis in spontaneous labor at term. The Journal of Maternal-Fetal & Neonatal Medicine 34:4, pages 569-579.
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Robert Para, Roberto Romero, Derek Miller, Bogdan Panaitescu, Aneesha Varrey, Tinnakorn Chaiworapongsa, Sonia S. Hassan, Chaur-Dong Hsu & Nardhy Gomez-Lopez. (2020) Human β-defensin-3 participates in intra-amniotic host defense in women with labor at term, spontaneous preterm labor and intact membranes, and preterm prelabor rupture of membranes. The Journal of Maternal-Fetal & Neonatal Medicine 33:24, pages 4117-4132.
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Percy Pacora, Roberto Romero, Offer Erez, Eli Maymon, Bogdan Panaitescu, Juan Pedro Kusanovic, Adi L. Tarca, Chaur-Dong Hsu & Sonia S. Hassan. (2019) The diagnostic performance of the beta-glucan assay in the detection of intra-amniotic infection with Candida species. The Journal of Maternal-Fetal & Neonatal Medicine 32:10, pages 1703-1720.
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N. Mutlu Karakaş, Ayse N. Ecevit, Yaprak Yalçın, Beril Özdemir, Hasibe Verdi, M. Ağah Tekindal, Namık Y. Özbek, Aylin Tarcan, Fatma B. Ataç & Ali Haberal. (2018) Effect of maternal and neonatal interleukin-6 − 174 G/C polymorphism on preterm birth and neonatal morbidity. The Journal of Maternal-Fetal & Neonatal Medicine 31:8, pages 1009-1015.
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