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Impact of Mucolytic Agents on COPD Exacerbations: A Pair-wise and Network Meta-analysis

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Pages 552-563 | Received 08 May 2017, Accepted 23 Jun 2017, Published online: 28 Jul 2017

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Luigino Calzetta, Beatrice Ludovica Ritondo, Maria Gabriella Matera, Alfredo Chetta & Paola Rogliani. (2022) Medium-dose ICS-containing FDCs reduce all-cause mortality in COPD patients: an in-depth analysis of dual and triple therapies. Expert Review of Respiratory Medicine 16:3, pages 357-365.
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Paola Rogliani, Beatrice Ludovica Ritondo, Bartolomeo Zerillo, Mario Cazzola, Maria Gabriella Matera & Luigino Calzetta. (2020) Adding a Second Bronchodilator in COPD: A Meta-Analysis on the Risk of Specific Cardiovascular Serious Adverse Events of Tiotropium/Olodaterol Fixed-Dose Combination. COPD: Journal of Chronic Obstructive Pulmonary Disease 17:2, pages 215-223.
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Timothy E. Albertson, James A. Chenoweth, Skyler J. Pearson & Susan Murin. (2020) The pharmacological management of asthma-chronic obstructive pulmonary disease overlap syndrome (ACOS). Expert Opinion on Pharmacotherapy 21:2, pages 213-231.
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Jean Bourbeau, Mohit Bhutani, Paul Hernandez, Shawn D. Aaron, Meyer Balter, Marie-France Beauchesne, Anthony D’Urzo, Roger Goldstein, Alan Kaplan, François Maltais, Don D. Sin & Darcy D. Marciniuk. (2019) Canadian Thoracic Society Clinical Practice Guideline on pharmacotherapy in patients with COPD – 2019 update of evidence. Canadian Journal of Respiratory, Critical Care, and Sleep Medicine 3:4, pages 210-232.
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Luigino Calzetta, Maria Gabriella Matera & Paola Rogliani. (2019) Monoclonal antibodies in severe asthma: is it worth it?. Expert Opinion on Drug Metabolism & Toxicology 15:6, pages 517-520.
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Peter MA Calverley, Clive Page, Roberto W Dal Negro, Giovanni Fontana, Mario Cazzola, Arrigo F Cicero, Edoardo Pozzi & Jadwiga A Wedzicha. (2019) Effect of Erdosteine on COPD Exacerbations in COPD Patients with Moderate Airflow Limitation. International Journal of Chronic Obstructive Pulmonary Disease 14, pages 2733-2744.
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Luigino Calzetta, Maria Gabriella Matera, Paola Rogliani & Mario Cazzola. (2018) Multifaceted activity of N-acetyl-l-cysteine in chronic obstructive pulmonary disease. Expert Review of Respiratory Medicine 12:8, pages 693-708.
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Zaurbek Aisanov, Sergey Avdeev, Vladimir Arkhipov, Andrey Belevskiy, Alexander Chuchalin, Igor Leshchenko, Svetlana Ovcharenko, Evgeny Shmelev & Marc Miravitlles. (2018) Russian guidelines for the management of COPD: algorithm of pharmacologic treatment. International Journal of Chronic Obstructive Pulmonary Disease 13, pages 183-187.
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Mario Cazzola, Paola Rogliani, Ermanno Puxeddu, Josuel Ora & Maria Gabriella Matera. (2018) An overview of the current management of chronic obstructive pulmonary disease: can we go beyond the GOLD recommendations?. Expert Review of Respiratory Medicine 12:1, pages 43-54.
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Begum Ergan, Simon Oczkowski, Bram Rochwerg, Annalisa Carlucci, Michelle Chatwin, Enrico Clini, Mark Elliott, Jesus Gonzalez-Bermejo, Nicholas Hart, Manel Lujan, Jacek Nasilowski, Stefano Nava, Jean Louis Pepin, Lara Pisani, Jan Hendrik Storre, Peter Wijkstra, Thomy Tonia, Jeanette Boyd, Raffaele Scala & Wolfram Windisch. (2019) European Respiratory Society guidelines on long-term home non-invasive ventilation for management of COPD. European Respiratory Journal 54:3, pages 1901003.
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S Moitra. (2019) N-acetylcysteine (NAC) in COPD: benefits often lost in trials. QJM: An International Journal of Medicine 112:5, pages 387-388.
Crossref
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Juan Carlos Vázquez-García, Rafael de Jesús Hernández-Zenteno, José Rogelio  Pérez-Padilla, María del Carmen Cano-Salas, Margarita Fernández-Vega, Jorge Salas-Hernández, Marco Antonio  Figueroa-Morales, Rosaura Esperanza  Benítez-Pérez, Luis Adrián  Rendón-Pérez, Jesús Vázquez-Cortés, Mayra Edith  Mejía-Ávila, José Luis  Mayorga-Butrón, Moisés Acuña-Kaldman,  Rocío  Barriga-Acevedo, Alma Rosa  Bizarrón-Muro, Robert  Camargo-Ángeles, Catalina  Casillas-Suárez, Celia Oralia  Castañeda-Hernández, Rafael Patricio  Castañón-Rodríguez, Juan Francisco  Castillo-Sánchez, Arturo Cortés-Télles,  Jesús Javier  Díaz-Castañón, Abelardo  Elizondo Ríos, María Guadalupe  Espitia-Hernández, Martha Angélica García-Avilés,  Rogelio  García-Torrentera, Julio Edgardo González Aguirre, Fernando Carlos  Guillén-Ortega, José Carlos  Herrera-García, Marco Antonio  Loustaunau-Andrade, Gerardo Ezequiel Magdaleno Maldonado, Luz Audina Mendoza Topete, José Padua-García,  Andrés Palomar-Lever,  Rafael Francisco  Páramo-Arroyo, Saraí del Carmen  Toral-Freyre, José Felipe  Villegas-Elizondo & Edgar Gerardo  Zozoaga-Velázquez. (2019) Guía de Práctica Clínica Mexicana para el diagnóstico y tratamiento de la Enfermedad Pulmonar Obstructiva Crónica <br>GUÍA MEXICANA DE EPOC, 2020. NCT Neumología y Cirugía de Tórax 78:S1, pages 4-76.
Crossref
Hana Kotolová & Tomáš Hammer. (2018) Chronic obstructive pulmonary disease. Praktické lékárenství 14:4, pages 156-160.
Crossref
Vincent Su, Diahn-Warng Perng, Ting-Chun Chou, Yueh-Ching Chou, Yuh-Lih Chang, Chia-Chen Hsu, Chia-Lin Chou, Hsin-Chen Lee, Tzeng-Ji Chen & Po-Wei Hu. (2018) Mucolytic Agents and Statins Use is Associated with a Lower Risk of Acute Exacerbations in Patients with Bronchiectasis-Chronic Obstructive Pulmonary Disease Overlap. Journal of Clinical Medicine 7:12, pages 517.
Crossref
Mario Cazzola, Paola Rogliani, Luigino Calzetta & Maria Gabriella Matera. (2018) Triple therapy versus single and dual long-acting bronchodilator therapy in COPD: a systematic review and meta-analysis . European Respiratory Journal 52:6, pages 1801586.
Crossref
Umit M. Sahiner, Esra Birben, Serpil Erzurum, Cansin Sackesen & Ömer Kalayci. (2018) Oxidative stress in asthma: Part of the puzzle. Pediatric Allergy and Immunology 29:8, pages 789-800.
Crossref
Roberto Dal Negro, Edoardo Pozzi & Silvano G. Cella. (2018) Erdosteine: Drug exhibiting polypharmacy for the treatment of respiratory diseases. Pulmonary Pharmacology & Therapeutics 53, pages 80-85.
Crossref
Cong Liu, Yana Ma, Zhenlei Su, Runzhen Zhao, Xiaoli Zhao, Hong-Guang Nie, Ping Xu, Lili Zhu, Mo Zhang, Xiumin Li, Xiaoju Zhang, Michael A. Matthay & Hong-Long Ji. (2018) Meta-Analysis of Preclinical Studies of Fibrinolytic Therapy for Acute Lung Injury. Frontiers in Immunology 9.
Crossref
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Crossref
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Crossref
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Crossref
Janis K Shute, Ermanno Puxeddu & Luigino Calzetta. (2018) Therapeutic use of heparin and derivatives beyond anticoagulation in patients with bronchial asthma or COPD. Current Opinion in Pharmacology 40, pages 39-45.
Crossref
Neil C Thomson. (2018) Targeting oxidant-dependent mechanisms for the treatment of respiratory diseases and their comorbidities. Current Opinion in Pharmacology 40, pages 1-8.
Crossref
Mario Cazzola, Luigino Calzetta, Clive Page, Paola Rogliani & Maria Gabriella Matera. (2018) Impact of erdosteine on chronic bronchitis and COPD: A meta-analysis. Pulmonary Pharmacology & Therapeutics 48, pages 185-194.
Crossref
. 2018. Arzneimitteltherapie in der Palliativmedizin. Arzneimitteltherapie in der Palliativmedizin 203 252 .

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