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Original Article

Pharmacodynamic effects on alertness of single doses of armodafinil in healthy subjects during a nocturnal period of acute sleep loss

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Pages 159-167 | Accepted 11 Nov 2005, Published online: 02 Dec 2005

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John R. Harsh, Roza Hayduk, Russell Rosenberg, Keith A. Wesnes, James K. Walsh, Sanjay Arora, Gwendolyn E. Niebler & Thomas Roth. (2006) The efficacy and safety of armodafinil as treatment for adults with excessive sleepiness associated with narcolepsy. Current Medical Research and Opinion 22:4, pages 761-774.
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Mona Darwish, Mary Kirby, Denise M. D’Andrea, Ronghua Yang, Edward T. Hellriegel & Philmore RobertsonJr.Jr.. (2010) Pharmacokinetics of armodafinil and modafinil after single and multiple doses in patients with excessive sleepiness associated with treated obstructive sleep apnea: A randomized, open-label, crossover study. Clinical Therapeutics 32:12, pages 2074-2087.
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Dimitris Repantis, Peter Schlattmann, Oona Laisney & Isabella Heuser. (2010) Modafinil and methylphenidate for neuroenhancement in healthy individuals: A systematic review. Pharmacological Research 62:3, pages 187-206.
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Marian Tsanov, Declan G. Lyons, Sally Barlow, Rodrigo E. González Reyes & Shane M. O’Mara. (2010) The psychostimulant modafinil facilitates water maze performance and augments synaptic potentiation in dentate gyrus. Neuropharmacology 59:1-2, pages 9-19.
Crossref
Imran Ahmed & Michael Thorpy. (2010) Clinical Features, Diagnosis and Treatment of Narcolepsy. Clinics in Chest Medicine 31:2, pages 371-381.
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FIONA C. BAKER & IAN M. COLRAIN. (2010) Daytime sleepiness, psychomotor performance, waking EEG spectra and evoked potentials in women with severe premenstrual syndrome. Journal of Sleep Research 19:1p2, pages 214-227.
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Meredith Broderick & Christian Guilleminault. 2010. Narcolepsy. Narcolepsy 301 311 .
Michael Thorpy. 2010. Narcolepsy. Narcolepsy 287 294 .
Charles A. Czeisler, James K. Walsh, Keith A. Wesnes, Thomas Roth & Sanjay Arora. (2009) Armodafinil for Treatment of Excessive Sleepiness Associated With Shift Work Disorder: A Randomized Controlled Study. Mayo Clinic Proceedings 84:11, pages 958-972.
Crossref
Mona Darwish, Mary Kirby & Edward T. Hellriegel. (2009) Comparison of Steady-State Plasma Concentrations of Armodafinil and Modafinil Late in the Day Following Morning Administration. Clinical Drug Investigation 29:9, pages 601-612.
Crossref
Mona Darwish, Mary Kirby, Edward T. Hellriegel & Philmore RobertsonJrJr. (2009) Armodafinil and Modafinil Have Substantially Different Pharmacokinetic Profiles Despite Having the Same Terminal Half-Lives. Clinical Drug Investigation 29:9, pages 613-623.
Crossref
Karly P. Garnock-Jones, Sohita Dhillon & Lesley J. Scott. (2009) Armodafinil. CNS Drugs 23:9, pages 793-803.
Crossref
Elaine M. Fiocchi, Yin-Guo Lin, Lisa Aimone, John A. Gruner & Dorothy G. Flood. (2009) Armodafinil promotes wakefulness and activates Fos in rat brain. Pharmacology Biochemistry and Behavior 92:3, pages 549-557.
Crossref
Michael Russo. (2009) Pharmacotherapy of Excessive Sleepiness: Focus on Armodafinil. Clinical Medicine. Therapeutics 1, pages CMT.S1994.
Crossref
Mona Darwish, Mary Kirby, Edward T Hellriegel, Ronghua Yang & Philmore RobertsonJrJr. (2009) Pharmacokinetic Profile of Armodafinil in Healthy Subjects. Clinical Drug Investigation 29:2, pages 87-100.
Crossref
C. Ballas & D.F. Dinges. 2009. Encyclopedia of Neuroscience. Encyclopedia of Neuroscience 419 424 .
C Ballas & D F Dinges. 2009. The Neuroscience of Sleep. The Neuroscience of Sleep 191 196 .
Qanta A. Ahmed. (2008) Effects of Common Medications Used for Sleep Disorders. Critical Care Clinics 24:3, pages 493-515.
Crossref
Michael J Minzenberg & Cameron S Carter. (2007) Modafinil: A Review of Neurochemical Actions and Effects on Cognition. Neuropsychopharmacology 33:7, pages 1477-1502.
Crossref
Julian Lim & David F. Dinges. (2008) Sleep Deprivation and Vigilant Attention . Annals of the New York Academy of Sciences 1129:1, pages 305-322.
Crossref
Ramisetti Nageswara Rao, Dhananjay D. Shinde & Murali V. N. Kumar Talluri. (2008) Enantioselective HPLC resolution of synthetic intermediates of armodafinil and related substances. Journal of Separation Science 31:6-7, pages 981-989.
Crossref
Kristin L. Bigos, Marci L. Chew & Robert R. Bies. (2008) Pharmacokinetics in geriatric psychiatry. Current Psychiatry Reports 10:1, pages 30-36.
Crossref
Thomas Roth, Gregory A. Rippon & Sanjay Arora. (2007) Armodafinil improves wakefulness and long-term episodic memory in nCPAP-adherent patients with excessive sleepiness associated with obstructive sleep apnea. Sleep and Breathing 12:1, pages 53-62.
Crossref
Raminder Kumar. (2008) Approved and Investigational Uses of Modafinil. Drugs 68:13, pages 1803-1839.
Crossref
Diane B. Boivin, Geneviève M. Tremblay & Francine O. James. (2007) Working on atypical schedules. Sleep Medicine 8:6, pages 578-589.
Crossref
Michael Thorpy. (2007) Therapeutic advances in narcolepsy. Sleep Medicine 8:4, pages 427-440.
Crossref
M. Hirshkowitz, J.E. Black, K. Wesnes, G. Niebler, S. Arora & T. Roth. (2007) Adjunct armodafinil improves wakefulness and memory in obstructive sleep apnea/hypopnea syndrome. Respiratory Medicine 101:3, pages 616-627.
Crossref
Andrew J. Hutt. (2007) CHIRALITY AND PHARMACOKINETICS: AN AREA OF NEGLECTED DIMENSIONALITY?. Drug Metabolism and Drug Interactions 22:2-3.
Crossref
Jonathan RL Schwartz. (2006) Emerging treatment options for excessive sleepiness associated with narcolepsy. Therapy 3:3, pages 375-382.
Crossref
Thomas Roth, David White, Wolfgang Schmidt-Nowara, Keith A. Wesnes, Gwendolyn Niebler, Sanjay Arora & Jed Black. (2006) Effects of Armodafinil in the Treatment of Residual Excessive Sleepiness Associated with Obstructive Sleep Apnea/Hypopnea Syndrome: A 12-Week, Multicenter, Double-Blind, Randomized, Placebo-Controlled Study in nCPAP-Adherent Adults. Clinical Therapeutics 28:5, pages 689-706.
Crossref
Jonathan R L Schwartz & Thomas Roth. (2006) Shift Work Sleep Disorder. Drugs 66:18, pages 2357-2370.
Crossref

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