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Current Medical Research and Opinion Volume 25, 2009 - Issue 9
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Review Article

Opioid switching and rotation in primary care: implementation and clinical utility

Neal E. Slatkin California Cancer Specialists Medical Group, Pasadena, CA, USACorrespondence[email protected]
Pages 2133-2150 | Accepted 16 Jun 2009, Published online: 14 Jul 2009

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Erwan Treillet, Sophie Laurent & Yacine Hadjiat. (2018) Practical management of opioid rotation and equianalgesia. Journal of Pain Research 11, pages 2587-2601.
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Beatrice Setnik, Carl L Roland, Kenneth W Sommerville, Glenn C Pixton, Robert Berke, Anne Calkins & Veeraindar Goli. (2015) A multicenter, primary-care-based, open-label study to assess the success of converting opioid-experienced patients with chronic moderate-to-severe pain to morphine sulfate and naltrexone hydrochloride extended-release capsules using a standardized conversion guide. Journal of Pain Research 8, pages 347-360.
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Howard S Smith & John F Peppin. (2014) Toward a systematic approach to opioid rotation. Journal of Pain Research 7, pages 589-608.
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Tracy L Skaer. (2014) Dosing considerations with transdermal formulations of fentanyl and buprenorphine for the treatment of cancer pain. Journal of Pain Research 7, pages 495-503.
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Elisa Mura, Stefano Govoni, Marco Racchi, Valeria Carossa, Guglielmina Nadia Ranzani, Massimo Allegri & Ron HN van Schaik. (2013) Consequences of the 118A>G polymorphism in the OPRM1 gene: translation from bench to bedside?. Journal of Pain Research 6, pages 331-353.
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Martin E Hale, Srinivas R Nalamachu, Arif Khan & Michael Kutch. (2013) Effectiveness and gastrointestinal tolerability during conversion and titration with once-daily OROS® hydromorphone extended release in opioid-tolerant patients with chronic low back pain. Journal of Pain Research 6, pages 319-329.
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Charles E Argoff, Steven P Stanos & Matthew S Wieman. (2013) Validity testing of patient objections to acceptance of tamper-resistant opioid formulations. Journal of Pain Research 6, pages 367-373.
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Srinivas Nalamachu. (2012) Opioid rotation with extended-release opioids: where should we begin?. International Journal of General Medicine 5, pages 11-17.
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Surasak Saokaew & Gary M. Oderda. (2012) Quality Assessment of the Methods Used in Published Opioid Conversion Reviews. Journal of Pain & Palliative Care Pharmacotherapy 26:4, pages 341-347.
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John H. Peniston. (2012) A Review of Pharmacotherapy for Chronic Low Back Pain with Considerations for Sports Medicine. The Physician and Sportsmedicine 40:4, pages 21-32.
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Marco Pappagallo & Marta Sokolowska. (2012) The Implications of Tamper–Resistant Formulations for Opioid Rotation. Postgraduate Medicine 124:5, pages 101-109.
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John H. Peniston, Xiaojun Hu, Susan L. Potts, Matthew S. Wieman & Dennis C. Turk. (2012) Tolerability of Concomitant Use of Selective Serotonin Reuptake Inhibitors or Serotonin-Norepinephrine Reuptake Inhibitors and Oxymorphone Extended Release. Postgraduate Medicine 124:2, pages 114-122.
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Eugene R. Viscusi & Marco Pappagallo. (2012) A Review of Opioids for In-Hospital Pain Management. Hospital Practice 40:1, pages 149-159.
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Roy D. Altman & Howard S. Smith. (2010) Opioid Therapy for Osteoarthritis and Chronic Low Back Pain. Postgraduate Medicine 122:6, pages 87-97.
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Miho Takemura, Kazuyuki Niki, Yoshiaki Okamoto, Tomohiro Kawamura, Makie Kohno, Yoshinobu Matsuda & Kenji Ikeda. (2023) Comparison of the Effects of OPRM1 A118G Polymorphism Using Different Opioids: A Prospective Study. Journal of Pain and Symptom Management.
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Mahip Acharya, Corey J. Hayes, Chenghui Li, Jacob T. Painter, Lindsey Dayer & Bradley C. Martin. (2022) Comparative Study of Opioid Initiation with Tramadol, short-acting Hydrocodone or short-acting Oxycodone on opioid-related Adverse Outcomes Among Chronic non-cancer Pain Subjects. The Clinical Journal of Pain Publish Ahead of Print.
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Edward C. Covington, Charles E. Argoff, Jane C. Ballantyne, Penney Cowan, Halena M. Gazelka, W. Michael Hooten, Stefan G. Kertesz, Ajay Manhapra, Jennifer L. Murphy, Steven P. StanosJr.Jr. & Mark D. Sullivan. (2020) Ensuring Patient Protections When Tapering Opioids: Consensus Panel Recommendations. Mayo Clinic Proceedings 95:10, pages 2155-2171.
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Rebecca Arden Harris, Henry R. Kranzler, Kyong-Mi Chang, Chyke A. Doubeni & Robert Gross. (2019) Long-term use of hydrocodone vs. oxycodone in primary care. Drug and Alcohol Dependence 205, pages 107524.
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Erin N. Bobeck, Shauna M. Schoo, Susan L. Ingram & Michael M. Morgan. (2019) Lack of Antinociceptive Cross-Tolerance With Co-Administration of Morphine and Fentanyl Into the Periaqueductal Gray of Male Sprague-Dawley Rats. The Journal of Pain 20:9, pages 1040-1047.
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Robert A. SwarmJudith A. PaiceDoralina L. AnghelescuMadhuri AreJustine Yang BruceSorin BugaMarcin ChwistekCharles CleelandDavid CraigEllin GaffordHeather GreenleeEric HansenArif H. KamalMihir M. KamdarSusan LeGrandSean MackeyM. Rachel McDowellNatalie MorylLisle M. NabellSuzanne Nesbit, Nina O’ConnorMichael W. RabowElizabeth RickersonRebecca ShatskyJill SindtSusan G. UrbaJeanie M. Youngwerth, Lydia J. Hammond & Lisa A. Gurski. (2019) Adult Cancer Pain, Version 3.2019, NCCN Clinical Practice Guidelines in Oncology. Journal of the National Comprehensive Cancer Network 17:8, pages 977-1007.
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Cl�udia Vieira, Rosa Fragoso, Deolinda Pereira & Rui Medeiros. (2018) Pain polymorphisms and opioids: An evidence based review. Molecular Medicine Reports.
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Charles J. Vierck & C. Richard Chapman. (2018) Prospective evaluation of chronic pain disorders and treatments. Journal of Neuroscience Methods 295, pages 104-110.
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Gillian C. BellKristine A. DonovanHoward L. McLeod. (2015) Clinical Implications of Opioid Pharmacogenomics in Patients with Cancer. Cancer Control 22:4, pages 426-432.
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Sarah McLean & Feargal Twomey. (2015) Methods of Rotation From Another Strong Opioid to Methadone for the Management of Cancer Pain: A Systematic Review of the Available Evidence. Journal of Pain and Symptom Management 50:2, pages 248-259.e1.
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Krzysztof Bańkowski, Olga M. Michalak, Anna Leśniak, Katarzyna E. Filip, Piotr Cmoch, Zbigniew Szewczuk, Piotr Stefanowicz & Jan Izdebski. (2015) N -terminal guanidinylation of the cyclic 1,4-ureido-deltorphin analogues: the synthesis, receptor binding studies, and resistance to proteolytic digestion . Journal of Peptide Science 21:6, pages 467-475.
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Julia Riley, Ruth Branford, Joanne Droney, Sophy Gretton, Hiroe Sato, Alison Kennett, Christina Oyebode, Michael Thick, Athol Wells, John Williams, Ken Welsh & Joy Ross. (2015) Morphine or Oxycodone for Cancer-Related Pain? A Randomized, Open-Label, Controlled Trial. Journal of Pain and Symptom Management 49:2, pages 161-172.
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Manuel J. Sánchez del Águila, Michael Schenk, Kai-Uwe Kern, Tanja Drost & Ilona Steigerwald. (2015) Practical Considerations for the Use of Tapentadol Prolonged Release for the Management of Severe Chronic Pain. Clinical Therapeutics 37:1, pages 94-113.
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Di Deng, Xin Wu, Ling Fu, Yunxiang Zhao, Gong Zhang, Chen Liang, Conghua Xie & Yunfeng Zhou. (2013) The Role of Analgesic Adjustment Strategies in Achieving Analgesic Efficacy in Opioid-Tolerant Hospice Patients in China. American Journal of Hospice and Palliative Medicine® 31:3, pages 315-321.
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Péter Heigl. (2014) Cancer pain management. Orvosi Hetilap 155:3, pages 93-99.
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Thomas B. Gregory. (2013) Hydromorphone: Evolving to Meet the Challenges of Today’s Health Care Environment. Clinical Therapeutics 35:12, pages 2007-2027.
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Joanne M. Droney, Sophy K. Gretton, Hiroe Sato, Joy R. Ross, Ruth Branford, Kenneth I. Welsh, William Cookson & Julia Riley. (2013) Analgesia and central side-effects: two separate dimensions of morphine response. British Journal of Clinical Pharmacology 75:5, pages 1340-1350.
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Amber M. BradleyJohn M. ValgusStephen Bernard. (2013) Converting to Transdermal Fentanyl: Avoidance of Underdosing. Journal of Palliative Medicine 16:4, pages 409-411.
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Rafael Gálvez, Michael Schäfer, Guy Hans, Dietmar Falke & Ilona Steigerwald. (2013) Tapentadol Prolonged Release Versus Strong Opioids for Severe, Chronic Low Back Pain: Results of an Open-Label, Phase 3b Study. Advances in Therapy 30:3, pages 229-259.
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Sebastiano Mercadante, Alessandro Valle, Giampiero Porzio, Flavio Fusco, Federica Aielli, Claudio Adile & Alessandra Casuccio. (2013) Opioid Switching in Patients With Advanced Cancer Followed at Home. A Retrospective Analysis. Journal of Pain and Symptom Management 45:2, pages 298-304.
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Asbjørn M. Drewes, Rasmus D. Jensen, Lecia M. Nielsen, Joanne Droney, Lona L. Christrup, Lars Arendt-Nielsen, Julia Riley & Albert Dahan. (2013) Differences between opioids: pharmacological, experimental, clinical and economical perspectives. British Journal of Clinical Pharmacology 75:1, pages 60-78.
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Srinivas R. Nalamachu, Michael Kutch & Martin E. Hale. (2012) Safety and Tolerability of Once-Daily OROS® Hydromorphone Extended-Release in Opioid-Tolerant Adults With Moderate-to-Severe Chronic Cancer and Noncancer Pain: Pooled Analysis of 11 Clinical Studies. Journal of Pain and Symptom Management 44:6, pages 852-865.
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Srinivas R. Nalamachu. (2012) Opioid Rotation in Clinical Practice. Advances in Therapy 29:10, pages 849-863.
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Annette L. van Ojik, Paul A. F. Jansen, Jacobus R. B. J. Brouwers & Eric N. van Roon. (2012) Treatment of Chronic Pain in Older People. Drugs & Aging 29:8, pages 615-625.
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Steven P. Stanos, Patricia Bruckenthal & Robert L. Barkin. (2012) Strategies to Reduce the Tampering and Subsequent Abuse of Long-acting Opioids: Potential Risks and Benefits of Formulations With Physical or Pharmacologic Deterrents to Tampering. Mayo Clinic Proceedings 87:7, pages 683-694.
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Lynn R. Webster & Perry G. Fine. (2012) Review and Critique of Opioid Rotation Practices and Associated Risks of Toxicity. Pain Medicine 13:4, pages 562-570.
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Sebastiano Mercadante. (2012) Switching Methadone: A 10-Year Experience of 345 Patients in an Acute Palliative Care Unit. Pain Medicine 13:3, pages 399-404.
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Sebastiano MercadanteEduardo Bruera. (2012) The Effect of Age on Opioid Switching to Methadone: A Systematic Review. Journal of Palliative Medicine 15:3, pages 347-351.
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Andrew I. Geller, Wilawan Nopkhun, Marly N. Dows-Martinez & Dale C. Strasser. (2012) Polypharmacy and the Role of Physical Medicine and Rehabilitation. PM&R 4:3, pages 198-219.
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Chihiro Kawano, Takeshi Hirayama, Toru Sasaki & Masakazu Kuroyama. (2012) Dose Conversion during Opioid Rotation from Continuous Intravenous Infusion of Morphine Hydrochloride to Oral Administration of Oxycodone Sustained-release Tablets. Iryo Yakugaku (Japanese Journal of Pharmaceutical Health Care and Sciences) 38:3, pages 170-176.
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Sebastiano Mercadante, Patrizia Ferrera, Patrizia Villari, Claudio Adile & Alessandra Casuccio. (2011) Switching from oxycodone to methadone in advanced cancer patients. Supportive Care in Cancer 20:1, pages 191-194.
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Howard S. Smith. (2011) Response to Bouloux: Use of Opioids in Long-Term Management of Temporomandibular Joint Dysfunction. Journal of Oral and Maxillofacial Surgery 69:11, pages 2689-2690.
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Elizabeth W. Loder & Paul Rizzoli. (2011) Tolerance and Loss of Beneficial Effect During Migraine Prophylaxis: Clinical Considerations. Headache: The Journal of Head and Face Pain 51:8, pages 1336-1345.
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Sebastiano Mercadante & Augusto Caraceni. (2011) Conversion ratios for opioid switching in the treatment of cancer pain: a systematic review. Palliative Medicine 25:5, pages 504-515.
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Shaifali Bhalla, Zhong Zhang, Nicole Patterson & Anil Gulati. (2010) Effect of endothelin-A receptor antagonist on mu, delta and kappa opioid receptor-mediated antinociception in mice. European Journal of Pharmacology 635:1-3, pages 62-71.
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Wendy M. Walwyn, Karen A. Miotto & Christopher J. Evans. (2010) Opioid pharmaceuticals and addiction: The issues, and research directions seeking solutions. Drug and Alcohol Dependence 108:3, pages 156-165.
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Natalie J. Carter & Gillian M. Keating. (2010) OROS® Hydromorphone Prolonged Release. CNS Drugs 24:4, pages 337-361.
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