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The emerging role of P-glycoprotein inhibitors in drug delivery: a patent review

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Pages 561-576 | Published online: 26 Feb 2011

Keep up to date with the latest research on this topic with citation updates for this article.

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Haisheng Peng, Jiahe Wang, Jiayu Chen, Yanbo Peng, Xiaoxian Wang, Ying Chen, David L. Kaplan & Qun Wang. (2023) Challenges and opportunities in delivering oral peptides and proteins. Expert Opinion on Drug Delivery 20:10, pages 1349-1369.
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Veenu P. Mundada, Mitali H. Patel, Piyush K. Mundada & Krutika K. Sawant. (2020) Enhanced bioavailability and antihypertensive activity of nisoldipine loaded nanoemulsion: optimization, cytotoxicity and uptake across Caco-2 cell line, pharmacokinetic and pharmacodynamic studies. Drug Development and Industrial Pharmacy 46:3, pages 376-387.
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Marcello Leopoldo, Patrizia Nardulli, Marialessandra Contino, Francesco Leonetti, Gert Luurtsema & Nicola Antonio Colabufo. (2019) An updated patent review on P-glycoprotein inhibitors (2011-2018). Expert Opinion on Therapeutic Patents 29:6, pages 455-461.
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Mohamed Mokhtar, Patrick M. Gosselin, Lacasse François-Xavier & Patrice Hildgen. (2019) Tablet formulation of Famotidine-loaded P-gp inhibiting nanoparticles using PLA-g-PEG grafted polymer. Pharmaceutical Development and Technology 24:2, pages 211-221.
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Lalit Mohan Negi, Sushama Talegaonkar, Manu Jaggi & Anita K Verma. (2019) Hyaluronated imatinib liposomes with hybrid approach to target CD44 and P-gp overexpressing MDR cancer: an in-vitro, in-vivo and mechanistic investigation. Journal of Drug Targeting 27:2, pages 183-192.
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Jeong-Woong Seo, Kyu-Min Hwang, Sung-Hoon Lee, Dong-Wook Kim & Eun-Seok Park. (2018) Preparation and characterization of adefovir dipivoxil–stearic acid cocrystal with enhanced physicochemical properties. Pharmaceutical Development and Technology 23:9, pages 890-899.
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Niyaz Ahmad, Md Aftab Alam, Rizwan Ahmad, Sadiq Umar & Farhan Jalees Ahmad. (2018) RETRACTED ARTICLE: Improvement of oral efficacy of Irinotecan through biodegradable polymeric nanoparticles through in vitro and in vivo investigations. Journal of Microencapsulation 35:4, pages 327-343.
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Ronak Savla, Jeff Browne, Vincent Plassat, Kishor M. Wasan & Ellen K. Wasan. (2017) Review and analysis of FDA approved drugs using lipid-based formulations. Drug Development and Industrial Pharmacy 43:11, pages 1743-1758.
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Mohamed Mokhtar, Patrick Gosselin, François Lacasse & Patrice Hildgen. (2017) Design of PEG-grafted-PLA nanoparticles as oral permeability enhancer for P-gp substrate drug model Famotidine. Journal of Microencapsulation 34:1, pages 91-103.
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Sharmeen Fatma, Sushama Talegaonkar, Zeenat Iqbal, Amulya Kumar Panda, Lalit Mohan Negi, Dinesh Giri Goswami & Mohammad Tariq. (2016) Novel flavonoid-based biodegradable nanoparticles for effective oral delivery of etoposide by P-glycoprotein modulation: an in vitro, ex vivo and in vivo investigations. Drug Delivery 23:2, pages 500-511.
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Narayanan Kasinathan, Hitesh V. Jagani, Angel Treasa Alex, Subrahmanyam M. Volety & J. Venkata Rao. (2015) Strategies for drug delivery to the central nervous system by systemic route. Drug Delivery 22:3, pages 243-257.
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Ankit Saneja, Vaibhav Khare, Noor Alam, Ravindra Dhar Dubey & Prem N Gupta. (2014) Advances in P-glycoprotein-based approaches for delivering anticancer drugs: pharmacokinetic perspective and clinical relevance. Expert Opinion on Drug Delivery 11:1, pages 121-138.
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Abdul Ahad, Fahad I Al-Jenoobi, Abdullah M Al-Mohizea, Mohd Aqil & Kanchan Kohli. (2013) Transdermal delivery of calcium channel blockers for hypertension. Expert Opinion on Drug Delivery 10:8, pages 1137-1153.
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