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Drug Evaluations

A review and update of the current status of the vasculature-disabling agent combretastatin-A4 phosphate (CA4P)

, PhD, , PhD & , MD PhD
Pages 189-197 | Published online: 21 Jan 2009

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Lalit Mohan Nainwal, Mohammad Mumtaz Alam, Mohammad Shaquiquzzaman, Akranth Marella & Ahmed Kamal. (2019) Combretastatin-based compounds with therapeutic characteristics: a patent review. Expert Opinion on Therapeutic Patents 29:9, pages 703-731.
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Ewan JD Robson & Prafull Ghatage. (2011) AMG 386: profile of a novel angiopoietin antagonist in patients with ovarian cancer. Expert Opinion on Investigational Drugs 20:2, pages 297-304.
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Andrew Eichholz, Shairoz Merchant & Andrew M Gaya. (2010) Anti-angiogenesis therapies: their potential in cancer management. OncoTargets and Therapy 3, pages 69-82.
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Si-Meng Chen, Ling-Hua Meng & Jian Ding. (2010) New microtubule-inhibiting anticancer agents. Expert Opinion on Investigational Drugs 19:3, pages 329-343.
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Bei Chen, Haifeng Jin & Kaichun Wu. (2009) Potential role of vascular targeted therapy to combat against tumor. Expert Opinion on Drug Delivery 6:7, pages 719-726.
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Eavan C. McLoughlin & Niamh M. O’Boyle. (2020) Colchicine-Binding Site Inhibitors from Chemistry to Clinic: A Review. Pharmaceuticals 13:1, pages 8.
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Juan L. Paris, Gonzalo Villaverde, Sergio Gómez-Graña & María Vallet-Regí. (2020) Nanoparticles for multimodal antivascular therapeutics: Dual drug release, photothermal and photodynamic therapy. Acta Biomaterialia 101, pages 459-468.
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Crossref
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Crossref
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Crossref
Natalia Piekuś-Słomka, Renata Mikstacka, Joanna Ronowicz & Stanisław Sobiak. (2019) Hybrid cis-stilbene Molecules: Novel Anticancer Agents. International Journal of Molecular Sciences 20:6, pages 1300.
Crossref
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Crossref
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Crossref
Olivia Goethe, Abigail Heuer, Xiaoshen Ma, Zhixun Wang & Seth B. Herzon. (2019) Antibacterial properties and clinical potential of pleuromutilins. Natural Product Reports 36:1, pages 220-247.
Crossref
Laura Conesa-Milián, Eva Falomir, Juan Murga, Miguel Carda & J. Alberto Marco. (2019) Synthesis and biological evaluation as antiangiogenic agents of ureas derived from 3′-aminocombretastatin A-4. European Journal of Medicinal Chemistry 162, pages 781-792.
Crossref
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Crossref
Casey J. Maguire, Zhi Chen, Vani P. Mocharla, Madhavi Sriram, Tracy E. Strecker, Ernest Hamel, Heling Zhou, Ramona Lopez, Yifan Wang, Ralph P. Mason, David J. ChaplinMary Lynn Trawick & Kevin G. Pinney. (2018) Synthesis of dihydronaphthalene analogues inspired by combretastatin A-4 and their biological evaluation as anticancer agents. MedChemComm 9:10, pages 1649-1662.
Crossref
Yewei Liu, Frederik De Keyzer, Yixin Wang, Fengna Wang, Yuanbo Feng, Feng Chen, Jie Yu, Jianjun Liu, Shaoli Song, Johan Swinnen, Guy Bormans, Raymond Oyen, Gang Huang & Yicheng Ni. (2018) The first study on therapeutic efficacies of a vascular disrupting agent CA4P among primary hepatocellular carcinomas with a full spectrum of differentiation and vascularity: Correlation of MRI‐microangiography‐histopathology in rats. International Journal of Cancer 143:7, pages 1817-1828.
Crossref
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Crossref
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Crossref
Ye-Wei Liu, Frederik De Keyzer, Yuan-Bo Feng, Feng Chen, Shao-Li Song, Johan Swinnen, Guy Bormans, Raymond Oyen, Gang Huang & Yi-Cheng Ni. (2018) Intra-individual comparison of therapeutic responses to vascular disrupting agent CA4P between rodent primary and secondary liver cancers. World Journal of Gastroenterology 24:25, pages 2710-2721.
Crossref
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Crossref
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Crossref
Alshimaa M.A. Aboeldahab, Eman A.M. Beshr, Mai E. Shoman, Safwat M. Rabea & Omar M. Aly. (2018) Spirohydantoins and 1,2,4-triazole-3-carboxamide derivatives as inhibitors of histone deacetylase: Design, synthesis, and biological evaluation. European Journal of Medicinal Chemistry 146, pages 79-92.
Crossref
Dongjian Zhang, Meng Gao, Nan Yao, Cuihua Jiang, Wei Liu, Tiannv Li, Shaoli Song, Dejian Huang, Zhiqi Yin, Yunliang Qiu & Qiaomei Jin. (2018) Preclinical Evaluation of Radioiodinated Hoechst 33258 for Early Prediction of Tumor Response to Treatment of Vascular-Disrupting Agents. Contrast Media & Molecular Imaging 2018, pages 1-9.
Crossref
Peace Mabeta & Lyndy J. McGaw. 2018. 53 67 .
Mengjie Li, Pritam Thapa, Pallavi Rajaputra, Moses Bio, Cody J. Peer, William D. Figg, Youngjae You & Sukyung Woo. (2017) Quantitative modeling of the dynamics and intracellular trafficking of far-red light-activatable prodrugs: implications in stimuli-responsive drug delivery system. Journal of Pharmacokinetics and Pharmacodynamics 44:6, pages 521-536.
Crossref
Yao Zong, Christie Shea, Katherine Maffucci & Iwao Ojima. (2017) Computational design and synthesis of novel fluoro-analogs of combretastatins A-4 and A-1. Journal of Fluorine Chemistry 203, pages 193-199.
Crossref
Yewei Liu, Ting Yin, Frederik De Keyzer, Yuanbo Feng, Feng Chen, Jianjun Liu, Shaoli Song, Jie Yu, Vincent Vandecaveye, Johan Swinnen, Guy Bormans, Uwe Himmelreich, Raymond Oyen, Jian Zhang, Gang Huang & Yicheng Ni. (2017) Micro-HCCs in rats with liver cirrhosis: paradoxical targeting effects with vascular disrupting agent CA4P. Oncotarget 8:33, pages 55204-55215.
Crossref
Yong-Fang Yao, Zhong-Chang Wang, Song-Yu Wu, Qing-fang Li, Chen Yu, Xin-Yi Liang, Peng-Cheng Lv, Yong-Tao Duan & Hai-Liang Zhu. (2017) Identification of novel 1-indolyl acetate-5-nitroimidazole derivatives of combretastatin A-4 as potential tubulin polymerization inhibitors. Biochemical Pharmacology 137, pages 10-28.
Crossref
Lingyu Wei, Jinjin Chen, Shuhua Zhao, Jianxun Ding & Xuesi Chen. (2017) Thermo-sensitive polypeptide hydrogel for locally sequential delivery of two-pronged antitumor drugs. Acta Biomaterialia 58, pages 44-53.
Crossref
Mu-Tian Cui, Li Jiang, Masuo Goto, Pei-Ling Hsu, Linna Li, Qi Zhang, Lei Wei, Shou-Jun Yuan, Ernest Hamel, Susan L. Morris-Natschke, Kuo-Hsiung Lee & Lan Xie. (2017) In Vivo and Mechanistic Studies on Antitumor Lead 7-Methoxy-4-(2-methylquinazolin-4-yl)-3,4-dihydroquinoxalin-2(1 H )-one and Its Modification as a Novel Class of Tubulin-Binding Tumor-Vascular Disrupting Agents . Journal of Medicinal Chemistry 60:13, pages 5586-5598.
Crossref
Michael Cahill, Kevin O’Shea, Larry Pierce, Hannah Winfield, Kevin Eccles, Simon Lawrence & Florence McCarthy. (2017) Synthesis and Antiproliferative Activity of Novel Heterocyclic Indole-Trimethoxyphenyl Conjugates. Pharmaceuticals 10:3, pages 62.
Crossref
Yanqing Pang, Jun Yan, Baijiao An, Ling Huang & Xingshu Li. (2017) The synthesis and evaluation of new butadiene derivatives as tubulin polymerization inhibitors. Bioorganic & Medicinal Chemistry 25:12, pages 3059-3067.
Crossref
Dana M. Chase, David J. Chaplin & Bradley J. Monk. (2017) The development and use of vascular targeted therapy in ovarian cancer. Gynecologic Oncology 145:2, pages 393-406.
Crossref
Romeo Romagnoli, Pier Giovanni Baraldi, Filippo Prencipe, Paola Oliva, Stefania Baraldi, Maria Kimatrai Salvador, Luisa Carlota Lopez-Cara, Andrea Brancale, Salvatore Ferla, Ernest Hamel, Roberto Ronca, Roberta Bortolozzi, Elena Mariotto, Elena Porcù, Giuseppe Basso & Giampietro Viola. (2017) Synthesis and Biological Evaluation of 2-Methyl-4,5-Disubstituted Oxazoles as a Novel Class of Highly Potent Antitubulin Agents. Scientific Reports 7:1.
Crossref
Yali Kong, Jacqueline Smith, Kongwen Li, Jake Cui, John Han, Shujie Hou & Milton L. Brown. (2017) Development of a novel near-infrared fluorescent theranostic combretastain A-4 analogue, YK-5-252, to target triple negative breast cancer. Bioorganic & Medicinal Chemistry 25:7, pages 2226-2233.
Crossref
Daniel Tarade, Dennis Ma, Christopher Pignanelli, Fadi Mansour, Daniel Simard, Sean van den Berg, James Gauld, James McNulty & Siyaram Pandey. (2017) Structurally simplified biphenyl combretastatin A4 derivatives retain in vitro anti-cancer activity dependent on mitotic arrest. PLOS ONE 12:3, pages e0171806.
Crossref
E. Abma, S. Daminet, P. Smets, Y. Ni & H. de Rooster. (2017) Combretastatin A4-phosphate and its potential in veterinary oncology: a review. Veterinary and Comparative Oncology 15:1, pages 184-193.
Crossref
A.V. Subba Rao, Konderu Swapna, Siddiq Pasha Shaik, V. Lakshma Nayak, T. Srinivasa Reddy, Satish Sunkari, Thokhir Basha Shaik, Chandrakant Bagul & Ahmed Kamal. (2017) Synthesis and biological evaluation of cis -restricted triazole/tetrazole mimics of combretastatin-benzothiazole hybrids as tubulin polymerization inhibitors and apoptosis inducers. Bioorganic & Medicinal Chemistry 25:3, pages 977-999.
Crossref
Richard P Hill. (2017) The changing paradigm of tumour response to irradiation. The British Journal of Radiology 90:1069, pages 20160474.
Crossref
Veerabhadrappa Bhavana, Setra Janardhana Shetty Sudharshan & Dyavaiah Madhu. 2017. Anticancer Plants: Clinical Trials and Nanotechnology. Anticancer Plants: Clinical Trials and Nanotechnology 51 104 .
Karol Jaroch, Maciej Karolak, Przemysław Górski, Alina Jaroch, Adrian Krajewski, Aleksandra Ilnicka, Anna Sloderbach, Tomasz Stefański & Stanisław Sobiak. (2016) Combretastatins: In vitro structure-activity relationship, mode of action and current clinical status. Pharmacological Reports 68:6, pages 1266-1275.
Crossref
Meng Gao, Dongjian Zhang, Qiaomei Jin, Cuihua Jiang, Cong Wang, Jindian Li, Fei Peng, Dejian Huang, Jian Zhang & Shaoli Song. (2016) Combretastatin-A4 phosphate improves the distribution and antitumor efficacy of albumin-bound paclitaxel in W256 breast carcinoma model. Oncotarget 7:36, pages 58133-58141.
Crossref
Md. Ashraf, Thokhir B. Shaik, M. Shaheer Malik, Riyaz Syed, Prema L. Mallipeddi, M.V.P.S. Vishnu Vardhan & Ahmed Kamal. (2016) Design and synthesis of cis-restricted benzimidazole and benzothiazole mimics of combretastatin A-4 as antimitotic agents with apoptosis inducing ability. Bioorganic & Medicinal Chemistry Letters 26:18, pages 4527-4535.
Crossref
Nosheen Hussain, David Connah, Hassan Ugail, Patricia A. Cooper, Robert A. Falconer, Laurence H. Patterson & Steven D. Shnyder. (2016) The use of thermographic imaging to evaluate therapeutic response in human tumour xenograft models. Scientific Reports 6:1.
Crossref
Mohsine Driowya, Julien Leclercq, Valerie Verones, Amélie Barczyk, Marie Lecoeur, Nicolas Renault, Nathalie Flouquet, Alina Ghinet, Pascal Berthelot & Nicolas Lebegue. (2016) Synthesis of triazoloquinazolinone based compounds as tubulin polymerization inhibitors and vascular disrupting agents. European Journal of Medicinal Chemistry 115, pages 393-405.
Crossref
Fuguo Han, Peng Wang, Wei Zhang, Jing Li, Qun Zhang, Xin Qi & Ming Liu. (2016) CA-1H, a novel oxazole bearing analogue of combretastatin A-4, disrupts the tumor vasculatures and inhibits the tumor growth via inhibiting tubulin polymerization. Biomedicine & Pharmacotherapy 80, pages 151-161.
Crossref
N. Bramhananda Reddy, Venkata Ramudu Burra, L. K. Ravindranath, Reddymasu Sreenivasulu & V. Naresh Kumar. (2016) Synthesis and biological evaluation of benzoxazole fused combretastatin derivatives as anticancer agents. Monatshefte für Chemie - Chemical Monthly 147:3, pages 593-598.
Crossref
Florence Colliez, Anne‐Catherine Fruytier, Julie Magat, Marie‐Aline Neveu, Patrice D. Cani, Bernard Gallez & Bénédicte F. Jordan. (2015) Monitoring Combretastatin A4–induced tumor hypoxia and hemodynamic changes using endogenous MR contrast and DCE‐MRI. Magnetic Resonance in Medicine 75:2, pages 866-872.
Crossref
Shun Zhang, Baijiao An, Jun Yan, Ling Huang & Xingshu Li. (2016) The synthesis and evaluation of new benzophenone derivatives as tubulin polymerization inhibitors. RSC Advances 6:91, pages 88453-88462.
Crossref
Lisa M. Greene, Mary J. Meegan & Daniela M. Zisterer. (2015) Combretastatins: More Than Just Vascular Targeting Agents?. Journal of Pharmacology and Experimental Therapeutics 355:2, pages 212-227.
Crossref
Qingen Ke, Mohammed A. Samad, Soochan Bae, David J. Chaplin & Peter M. Kang. (2015) Exaggerated hypertensive response to combretastatin A-4 phosphate in hypertensive rats: Effective pharmacological inhibition by diltiazem. Vascular Pharmacology 74, pages 73-79.
Crossref
Pamela Castilho Carvalho, Edson Anjos Santos, Beatriz Ursinos Catelán Schneider, Renata Matuo, João Renato Pesarini, Andréa Luiza Cunha-Laura, Antônio Carlos Duenhas Monreal, Dênis Pires Lima, Andréia Conceição Milan Brochado Antoniolli & Rodrigo Juliano Oliveira. (2015) Diaryl sulfide analogs of combretastatin A-4: Toxicogenetic, immunomodulatory and apoptotic evaluations and prospects for use as a new chemotherapeutic drug. Environmental Toxicology and Pharmacology 40:3, pages 715-721.
Crossref
Wantong Song, Zhaohui Tang, Dawei Zhang, Haiyang Yu & Xuesi Chen. (2015) Coadministration of Vascular Disrupting Agents and Nanomedicines to Eradicate Tumors from Peripheral and Central Regions. Small 11:31, pages 3755-3761.
Crossref
Jun-Hang Jiang, Can-Hui Zheng, Chong-Qing Wang, Juan Wang, Wei Tian, Chao Yang, Yun-Long Song, Yong Hu, Ju Zhu & You-Yun Zhou. (2015) Synthesis and biological evaluation of 5,6,7-trimethoxy-1-benzylidene-3,4-dihydro-naphthalen-2-one as tubulin-polymerization inhibitors. Chinese Chemical Letters 26:5, pages 607-609.
Crossref
Romeo Romagnoli, Pier Giovanni Baraldi, Maria Kimatrai Salvador, Filippo Prencipe, Carlota Lopez-Cara, Santiago Schiaffino Ortega, Andrea BrancaleErnest Hamel, Ignazio Castagliuolo, Stefania Mitola, Roberto Ronca, Roberta Bortolozzi, Elena Porcù, Giuseppe Basso & Giampietro Viola. (2015) Design, Synthesis, in Vitro, and in Vivo Anticancer and Antiangiogenic Activity of Novel 3-Arylaminobenzofuran Derivatives Targeting the Colchicine Site on Tubulin. Journal of Medicinal Chemistry 58:7, pages 3209-3222.
Crossref
Junhang Jiang, Canhui Zheng, Kongkai Zhu, Jia Liu, Nannan Sun, Chongqing Wang, Hualiang Jiang, Ju Zhu, Cheng Luo & Youjun Zhou. (2015) Quantum Chemistry Calculation-Aided Structural Optimization of Combretastatin A-4-like Tubulin Polymerization Inhibitors: Improved Stability and Biological Activity. Journal of Medicinal Chemistry 58:5, pages 2538-2546.
Crossref
Nan Yao, Meng Gao, Ke Ren, Xiao Jiang, Yue Li, Cuihua Jiang, Dejian Huang, Wei Liu, Xiaoning Wang, Zhijun Fang, Ziping Sun, Jian Zhang & Yicheng Ni. (2015) PD806. Anti-Cancer Drugs 26:2, pages 148-159.
Crossref
Daniele Fanale, Giuseppe Bronte, Francesco Passiglia, Valentina Calò, Marta Castiglia, Florinda Di Piazza, Nadia Barraco, Antonina Cangemi, Maria Teresa Catarella, Lavinia Insalaco, Angela Listì, Rossella Maragliano, Daniela Massihnia, Alessandro Perez, Francesca Toia, Giuseppe Cicero & Viviana Bazan. (2015) Stabilizing versus Destabilizing the Microtubules: A Double-Edge Sword for an Effective Cancer Treatment Option?. Analytical Cellular Pathology 2015, pages 1-19.
Crossref
Jun Yan, Yanqing Pang, Jie Chen, Jianfei Sheng, Jinhui Hu, Ling Huang & Xingshu Li. (2015) Synthesis, biological evaluation and mechanism study of a class of cyclic combretastatin A-4 analogues as novel antitumour agents. RSC Advances 5:119, pages 98527-98537.
Crossref
Jie Chen, Jun Yan, Jinhui Hu, Yanqing Pang, Ling Huang & Xingshu Li. (2015) Synthesis, biological evaluation and mechanism study of chalcone analogues as novel anti-cancer agents. RSC Advances 5:83, pages 68128-68135.
Crossref
Nikhil R. Madadi, Hongliang Zong, Amit Ketkar, Chen Zheng, Narsimha R. Penthala, Venumadhav Janganati, Shobanbabu Bommagani, Robert L. Eoff, Monica L. Guzman & Peter A. Crooks. (2015) Synthesis and evaluation of a series of resveratrol analogues as potent anti-cancer agents that target tubulin. MedChemComm 6:5, pages 788-794.
Crossref
Bret Tréguier, Marie Lawson, Guillaume Bernadat, Jérôme Bignon, Joëlle Dubois, Jean-Daniel Brion, Mouad Alami & Abdallah Hamze. (2014) Synthesis of a 3-(α-Styryl)benzo[ b ]-thiophene Library via Bromocyclization of Alkynes and Palladium-Catalyzed Tosylhydrazones Cross-Couplings: Evaluation as Antitubulin Agents . ACS Combinatorial Science 16:12, pages 702-710.
Crossref
Samir Mehndiratta, Yi-Fang Chiang, Mei-Jung Lai, Hsueh-Yun Lee, Mei-Chuan Chen, Ching-Chuan Kuo, Chi-Yen Chang, Jang-Yang Chang & Jing-Ping Liou. (2014) Concise syntheses of 7-anilino-indoline-N-benzenesulfonamides as antimitotic and vascular disrupting agents. Bioorganic & Medicinal Chemistry 22:17, pages 4917-4923.
Crossref
Romeo Romagnoli, Pier Giovanni Baraldi, Maria Kimatrai Salvador, Filippo Prencipe, Valerio Bertolasi, Michela CancellieriAndrea BrancaleErnest Hamel, Ignazio Castagliuolo, Francesca Consolaro, Elena Porcù, Giuseppe Basso & Giampietro Viola. (2014) Synthesis, Antimitotic and Antivascular Activity of 1-(3′,4′,5′-Trimethoxybenzoyl)-3-arylamino-5-amino-1,2,4-triazoles. Journal of Medicinal Chemistry 57:15, pages 6795-6808.
Crossref
John A. Beutler, Gordon M. Cragg, Maurice Iwu, David J. Newman & Christopher Okunji. 2014. Novel Plant Bioresources. Novel Plant Bioresources 131 149 .
Pierre P.J. Da Silva, Lyamin Z. Bendjeddou & Laurent Meijer. (2014) Recherche de substances naturelles à activité thérapeutique (2). médecine/sciences 30:3, pages 319-328.
Crossref
Verena K. Kretzschmann & Robert Fürst. (2013) Plant-derived vascular disrupting agents: compounds, actions, and clinical trials. Phytochemistry Reviews 13:1, pages 191-206.
Crossref
Eiman Mukhtar, Vaqar Mustafa Adhami & Hasan Mukhtar. (2014) Targeting Microtubules by Natural Agents for Cancer Therapy. Molecular Cancer Therapeutics 13:2, pages 275-284.
Crossref
Dmitry V. Tsyganov, Victor N. Khrustalev, Leonid D. Konyushkin, Mikhail M. Raihstat, Sergei I. Firgang, Roman V. Semenov, Alex S. Kiselyov, Marina N. Semenova & Victor V. Semenov. (2014) 3-(5-)-Amino-o-diarylisoxazoles: Regioselective synthesis and antitubulin activity. European Journal of Medicinal Chemistry 73, pages 112-125.
Crossref
Anant R. Kapdi & Dharmendra Prajapati. (2014) Regioselective palladium-catalysed cross-coupling reactions: a powerful synthetic tool. RSC Adv. 4:78, pages 41245-41259.
Crossref
Mark S. Butler, Avril A. B. Robertson & Matthew A. Cooper. (2014) Natural product and natural product derived drugs in clinical trials. Nat. Prod. Rep. 31:11, pages 1612-1661.
Crossref
Dmitry V. Demchuk, Alexander V. Samet, Natalia B. Chernysheva, Vladimir I. Ushkarov, Galina A. Stashina, Leonid D. Konyushkin, Mikhail M. Raihstat, Sergei I. Firgang, Alex A. Philchenkov, Michael P. Zavelevich, Ludmila M. Kuiava, Vasyl F. Chekhun, Dmitry Yu. Blokhin, Alex S. Kiselyov, Marina N. Semenova & Victor V. Semenov. (2014) Synthesis and antiproliferative activity of conformationally restricted 1,2,3-triazole analogues of combretastatins in the sea urchin embryo model and against human cancer cell lines. Bioorganic & Medicinal Chemistry 22:2, pages 738-755.
Crossref
Einat Sadot. 2014. Applied Plant Cell Biology. Applied Plant Cell Biology 301 323 .
Lasse Evensen, Kristin Odlo, David R. Micklem, Amanda Littlewood-Evans, Jeanette Wood, Christian Kuzniewski, Karl-Heinz Altmann, Trond Vidar Hansen & James B. Lorens. (2013) Contextual Compound Screening for Improved Therapeutic Discovery. ChemBioChem 14:18, pages 2512-2518.
Crossref
Mohamed A Ibrahim, Diana V Do, Yasir J Sepah, Syed M Shah, Elizabeth Van Anden, Gulnar Hafiz, J Kevin Donahue, Richard Rivers, Jai Balkissoon, James T Handa, Peter A Campochiaro & Quan Dong Nguyen. (2013) Vascular disrupting agent for neovascular age related macular degeneration: a pilot study of the safety and efficacy of intravenous combretastatin a-4 phosphate. BMC Pharmacology and Toxicology 14:1.
Crossref
Romeo Romagnoli, Pier Giovanni Baraldi, Carlota Lopez-Cara, Delia Preti, Mojgan Aghazadeh Tabrizi, Jan Balzarini, Marcella BassettoAndrea BrancaleXian-Hua Fu, Yang Gao, Jun Li, Su-Zhan Zhang, Ernest Hamel, Roberta Bortolozzi, Giuseppe Basso & Giampietro Viola. (2013) Concise Synthesis and Biological Evaluation of 2-Aroyl-5-Amino Benzo[ b ]thiophene Derivatives As a Novel Class of Potent Antimitotic Agents . Journal of Medicinal Chemistry 56:22, pages 9296-9309.
Crossref
Dilu Feng, Michael D. Menger & Matthias W. Laschke. (2013) Vascular disrupting effects of combretastatin A4 phosphate on murine endometriotic lesions. Fertility and Sterility 100:5, pages 1459-1467.e1.
Crossref
Hsueh-Yun Lee, Shiow-Lin Pan, Min-Chieh Su, Yi-Min Liu, Ching-Chuan Kuo, Yi-Ting Chang, Jian-Sung Wu, Chih-Ying Nien, Samir Mehndiratta, Chi-Yen Chang, Su-Ying Wu, Mei-Jung Lai, Jang-Yang Chang & Jing-Ping Liou. (2013) Furanylazaindoles: Potent Anticancer Agents in Vitro and in Vivo. Journal of Medicinal Chemistry 56:20, pages 8008-8018.
Crossref
Jie Zhou, Jing Jin, Yi Zhang, Yuwen Yin, Xiaoguang Chen & Bailing Xu. (2013) Synthesis and antiproliferative evaluation of novel benzoimidazole-contained oxazole-bridged analogs of combretastatin A-4. European Journal of Medicinal Chemistry 68, pages 222-232.
Crossref
Dmitry V. Tsyganov, Leonid D. Konyushkin, Irina B. Karmanova, Sergei I. Firgang, Yuri A. Strelenko, Marina N. Semenova, Alex S. Kiselyov & Victor V. Semenov. (2013) cis -Restricted 3-Aminopyrazole Analogues of Combretastatins: Synthesis from Plant Polyalkoxybenzenes and Biological Evaluation in the Cytotoxicity and Phenotypic Sea Urchin Embryo Assays . Journal of Natural Products 76:8, pages 1485-1491.
Crossref
Ganesh S. Jedhe, Debasish Paul, Rajesh G. Gonnade, Manas K. Santra, Ernest Hamel, Tam Luong Nguyen & Gangadhar J. Sanjayan. (2013) Correlation of hydrogen-bonding propensity and anticancer profile of tetrazole-tethered combretastatin analogues. Bioorganic & Medicinal Chemistry Letters 23:16, pages 4680-4684.
Crossref
Francisco Torrens & Gloria Castellano. (2013) Molecular Classification of 5-Amino-2-Aroylquinolines and 4-Aroyl-6,7,8-Trimethoxyquinolines as Highly Potent Tubulin Polymerization Inhibitors. International Journal of Chemoinformatics and Chemical Engineering 3:2, pages 1-26.
Crossref
N S Sitnikov & A Yu Fedorov. (2013) Synthesis of allocolchicinoids: a 50 year journey. Russian Chemical Reviews 82:5, pages 393-411.
Crossref
Romeo Romagnoli, Pier Giovanni Baraldi, Maria Kimatrai Salvador, Delia Preti, Mojgan Aghazadeh Tabrizi, Marcella Bassetto, Andrea Brancale, Ernest Hamel, Ignazio Castagliuolo, Roberta Bortolozzi, Giuseppe Basso & Giampietro Viola. (2013) Synthesis and Biological Evaluation of 2-(Alkoxycarbonyl)-3-Anilinobenzo[ b ]thiophenes and Thieno[2,3- b ]pyridines as New Potent Anticancer Agents . Journal of Medicinal Chemistry 56:6, pages 2606-2618.
Crossref
Gulzeb Aziz, Kristin Odlo, Trond V. Hansen, Ragnhild E. Paulsen & Gro H. Mathisen. (2013) Combretastatin A-4 and structurally related triazole analogues induce caspase-3 and reactive oxygen species-dependent cell death in PC12 cells. European Journal of Pharmacology 703:1-3, pages 25-32.
Crossref
Ying-Qian Liu, Xiao-Jing Li, Chun-Yan Zhao, Xiang Nan, Jing Tian, Susan L. Morris-Natschke, Zhi-Jun Zhang, Xiao-Ming Yang, Liu Yang, Lin-Hai Li, Xing-Wen Zhou & Kuo-Hsiung Lee. (2013) Synthesis and mechanistic studies of novel spin-labeled combretastatin derivatives as potential antineoplastic agents. Bioorganic & Medicinal Chemistry 21:5, pages 1248-1256.
Crossref
Nancy Ty, Renée Pontikis, Guy G. Chabot, Emmanuelle Devillers, Lionel Quentin, Stéphane Bourg & Jean-Claude Florent. (2013) Synthesis and biological evaluation of enantiomerically pure cyclopropyl analogues of combretastatin A4. Bioorganic & Medicinal Chemistry 21:5, pages 1357-1366.
Crossref
Caroline J. Breitbach, Rozanne Arulanandam, Naomi De Silva, Steve H. Thorne, Richard Patt, Manijeh Daneshmand, Anne Moon, Carolina Ilkow, James Burke, Tae-Ho Hwang, Jeong Heo, Mong Cho, Hannah Chen, Fernando A. Angarita, Christina Addison, J. Andrea McCart, John C. Bell & David H. Kirn. (2013) Oncolytic Vaccinia Virus Disrupts Tumor-Associated Vasculature in Humans. Cancer Research 73:4, pages 1265-1275.
Crossref
Aleem Gangjee, Nilesh Zaware, Ravi Kumar Vyas Devambatla, Sudhir Raghavan, Cara D. Westbrook, Nicholas F. Dybdal-Hargreaves, Ernest Hamel & Susan L. Mooberry. (2013) Synthesis of N4-(substituted phenyl)-N4-alkyl/desalkyl-9H-pyrimido[4,5-b]indole-2,4-diamines and identification of new microtubule disrupting compounds that are effective against multidrug resistant cells. Bioorganic & Medicinal Chemistry 21:4, pages 891-902.
Crossref
Vivien Stocker, Alina Ghinet, Marie Leman, Benoît Rigo, Régis Millet, Amaury Farce, Déborah Desravines, Joëlle Dubois, Christophe Waterlot & Philippe Gautret. (2013) On the synthesis and biological properties of isocombretastatins: a case of ketone homologation during Wittig reaction attempts. RSC Advances 3:11, pages 3683.
Crossref
Thomas Nielsen, Lise Bentzen, Michael Pedersen, Trine Tramm, Paul F.J.W. Rijken, Johan Bussink, Michael R. Horsman & Leif Østergaard. (2012) Combretastatin A-4 Phosphate Affects Tumor Vessel Volume and Size Distribution as Assessed Using MRI-Based Vessel Size Imaging. Clinical Cancer Research 18:23, pages 6469-6477.
Crossref
De-Jun Ding, Xiao-Yan Cao, Fang Dai, Xiu-Zhuang Li, Guo-Yun Liu, Dong Lin, Xing Fu, Xiao-Ling Jin & Bo Zhou. (2012) Synthesis and antioxidant activity of hydroxylated phenanthrenes as cis-restricted resveratrol analogues. Food Chemistry 135:3, pages 1011-1019.
Crossref
Thi Thanh Binh Nguyen, Thierry Lomberget, Ngoc Chau Tran, Evelyne Colomb, Lore Nachtergaele, Sylviane Thoret, Joëlle Dubois, Joren Guillaume, Rawad Abdayem, Marek Haftek & Roland Barret. (2012) Synthesis and biological evaluation of novel heterocyclic derivatives of combretastatin A-4. Bioorganic & Medicinal Chemistry Letters 22:23, pages 7227-7231.
Crossref
Romeo Romagnoli, Pier Giovanni Baraldi, Maria Kimatrai Salvador, M. Encarnacion Camacho, Delia Preti, Mojgan Aghazadeh Tabrizi, Marcella Bassetto, Andrea Brancale, Ernest Hamel, Roberta Bortolozzi, Giuseppe Basso & Giampietro Viola. (2012) Synthesis and biological evaluation of 2-substituted-4-(3′,4′,5′-trimethoxyphenyl)-5-aryl thiazoles as anticancer agents. Bioorganic & Medicinal Chemistry 20:24, pages 7083-7094.
Crossref
Céline Clémenson, Cyrus Chargari, Laurent Désiré, Anne-Sophie Casagrande, Jean Bourhis & Eric Deutsch. (2012) Assessment of the novel tubulin-binding agent EHT 6706 in combination with ionizing radiation or chemotherapy. Investigational New Drugs 30:6, pages 2173-2186.
Crossref
Foxiao Qiao, Daiying Zuo, Xueqi Shen, Huan Qi, Haifeng Wang, Weige Zhang & Yingliang Wu. (2012) DAT-230, a novel microtubule inhibitor, exhibits potent anti-tumor activity by inducing G2/M phase arrest, apoptosis in vitro and perfusion decrease in vivo to HT-1080. Cancer Chemotherapy and Pharmacology 70:2, pages 259-270.
Crossref
Swati Parihar, Atul Gupta, Amit K. Chaturvedi, Jyoti Agarwal, Suaib Luqman, Bendangla Changkija, Murli Manohar, Debabrata Chanda, C.S. Chanotiya, Karuna Shanker, Anila Dwivedi, Rituraj Konwar & Arvind S. Negi. (2012) Gallic acid based steroidal phenstatin analogues for selective targeting of breast cancer cells through inhibiting tubulin polymerization. Steroids 77:8-9, pages 878-886.
Crossref
Nicholas S. Wilson, Annie Yang, Becky Yang, Suzana Couto, Howard Stern, Alvin Gogineni, Robert Pitti, Scot Marsters, Robby M. Weimer, Mallika Singh & Avi Ashkenazi. (2012) Proapoptotic Activation of Death Receptor 5 on Tumor Endothelial Cells Disrupts the Vasculature and Reduces Tumor Growth. Cancer Cell 22:1, pages 80-90.
Crossref
Mohamed Abdel-Aziz, Omar M. Aly, Sabine S. Khan, Kamalika Mukherjee & Susan Bane. (2012) Synthesis, Cytotoxic Properties and Tubulin Polymerization Inhibitory Activity of Novel 2-Pyrazoline Derivatives. Archiv der Pharmazie 345:7, pages 535-548.
Crossref
Jia Liu, Can-Hui Zheng, Xiao-Hui Ren, Feng Zhou, Wei Li, Ju Zhu, Jia-Guo Lv & You-Jun Zhou. (2012) Synthesis and Biological Evaluation of 1-Benzylidene-3,4-dihydronaphthalen-2-one as a New Class of Microtubule-Targeting Agents. Journal of Medicinal Chemistry 55:12, pages 5720-5733.
Crossref
Evelia Rasolofonjatovo, Olivier Provot, Abdallah Hamze, Jordi Rodrigo, Jérome Bignon, Joanna Wdzieczak-Bakala, Déborah Desravines, Joëlle Dubois, Jean-Daniel Brion & Mouad Alami. (2012) Conformationnally restricted naphthalene derivatives type isocombretastatin A-4 and isoerianin analogues: Synthesis, cytotoxicity and antitubulin activity. European Journal of Medicinal Chemistry 52, pages 22-32.
Crossref
Douglas E. Friesen, Khaled H. Barakat, Valentyna Semenchenko, Rolando Perez-Pineiro, Bruce W. Fenske, Jonathan Mane, David S. Wishart & Jack A. Tuszynski. (2012) Discovery of Small Molecule Inhibitors that Interact with γ-Tubulin. Chemical Biology & Drug Design 79:5, pages 639-652.
Crossref
ARIF HUSSAIN, MANUEL STEIMLE, HANS HOPPELER, OLIVER BAUM & STUART EGGINTON. (2012) The Vascular‐Disrupting Agent Combretastatin Impairs Splitting and Sprouting Forms of Physiological Angiogenesis. Microcirculation 19:4, pages 296-305.
Crossref
George R. Pettit, Heidi J. Rosenberg, Rachel Dixon, John C. Knight, Ernest Hamel, Jean-Charles Chapuis, Robin K. Pettit, Fiona Hogan, Brandy Sumner, Kenneth B. Ain & Brindi Trickey-Platt. (2012) Antineoplastic Agents. 548. Synthesis of Iodo- and Diiodocombstatin Phosphate Prodrugs. Journal of Natural Products 75:3, pages 385-393.
Crossref
Ahmed Kamal, Farheen Sultana, M. Janaki Ramaiah, Y. V. V. Srikanth, A. Viswanath, Chandan Kishor, Pranjal Sharma, S. N. C. V. L. Pushpavalli, Anthony Addlagatta & Manika Pal-Bhadra. (2012) 3-Substituted 2-Phenylimidazo[2,1-b]benzothiazoles: Synthesis, Anticancer Activity, and Inhibition of Tubulin Polymerization. ChemMedChem 7:2, pages 292-300.
Crossref
Romeo Romagnoli, Pier Giovanni Baraldi, Maria Kimatrai Salvador, Delia Preti, Mojgan Aghazadeh Tabrizi, Andrea BrancaleXian-Hua Fu, Jun Li, Su-Zhan Zhang, Ernest Hamel, Roberta BortolozziGiuseppe Basso & Giampietro Viola. (2011) Synthesis and Evaluation of 1,5-Disubstituted Tetrazoles as Rigid Analogues of Combretastatin A-4 with Potent Antiproliferative and Antitumor Activity. Journal of Medicinal Chemistry 55:1, pages 475-488.
Crossref
Huaijun Wang, Marlein Miranda Cona, Feng Chen, Jie Yu, Yuanbo Feng, Junjie Li, Frederik De Keyzer, Guy Marchal & Yicheng Ni. (2012) Comparison of two vascular-disrupting agents at a clinically relevant dose in rodent liver tumors with multiparametric magnetic resonance imaging biomarkers. Anti-Cancer Drugs 23:1, pages 12-21.
Crossref
Yanchun Wei, Qun Chen, Baoyan Wu, Aiguo Zhou & Da Xing. (2012) High-sensitivity in vivo imaging for tumors using a spectral up-conversion nanoparticle NaYF4: Yb3+, Er3+ in cooperation with a microtubulin inhibitor. Nanoscale 4:13, pages 3901.
Crossref
Rajendra P. Tanpure, Clinton S. George, Madhavi Sriram, Tracy E. Strecker, Justin K. Tidmore, Ernest Hamel, Amanda K. Charlton-Sevcik, David J. Chaplin, Mary Lynn Trawick & Kevin G. Pinney. (2012) An amino-benzosuberene analogue that inhibits tubulin assembly and demonstrates remarkable cytotoxicity. MedChemComm 3:6, pages 720.
Crossref
Zecheng Chen, Christopher J. O’Donnell & Andreas Maderna. (2012) Synthesis of 3-methoxy-9-(3,4,5-trimethoxyphenyl)-6,7-dihydro-5H-benzo[7]annulen-4-ol, a potent antineoplastic benzosuberene derivative for anti-cancer chemotherapy. Tetrahedron Letters 53:1, pages 64-66.
Crossref
Øyvind W. Akselsen, Kristin Odlo, Jing-Jy Cheng, Giorgio Maccari, Maurizio Botta & Trond Vidar Hansen. (2012) Synthesis, biological evaluation and molecular modeling of 1,2,3-triazole analogs of combretastatin A-1. Bioorganic & Medicinal Chemistry 20:1, pages 234-242.
Crossref
John A. Beutler, Gordon M. Cragg & David J. Newman. 2012. Drug Discovery in Africa. Drug Discovery in Africa 29 52 .
Hsueh-Yun Lee, Jang-Yang Chang, Chih-Ying Nien, Ching-Chuan Kuo, Kuang-Hsing Shih, Chun-Hsein Wu, Chi-Yen Chang, Wen-Yang Lai & Jing-Ping Liou. (2011) 5-Amino-2-aroylquinolines as Highly Potent Tubulin Polymerization Inhibitors. Part 2. The Impact of Bridging Groups at Position C-2. Journal of Medicinal Chemistry 54:24, pages 8517-8525.
Crossref
Abdallah Hamze, Evelia Rasolofonjatovo, Olivier Provot, Céline Mousset, Damien Veau, Jordi Rodrigo, Jérôme Bignon, Jian-Miao Liu, Joanna Wdzieczak-Bakala, Sylviane Thoret, Joëlle Dubois, Jean-Daniel Brion & Mouad Alami. (2011) B-Ring-Modified isoCombretastatin A-4 Analogues Endowed with Interesting Anticancer Activities. ChemMedChem 6:12, pages 2179-2191.
Crossref
Xian-hua Fu, Jun Li, Yong Zou, Yu-rong Hong, Zhi-xuan Fu, Jian-jin Huang, Su-zhan Zhang & Shu Zheng. (2011) Endostar enhances the antineoplastic effects of combretastatin A4 phosphate in an osteosarcoma xenograft. Cancer Letters 312:1, pages 109-116.
Crossref
Zhi-Ting Deng, Teng Feng, Peng Wang, Xin Qi, Xue-Hong Chen, Ying-Xia Li, Chun-Li Song, Mei-Yu Geng & Jing Li. (2011) Effects of the novel vascular targeting agent MDS-11P on tumor vascularity and its antitumor activity. Biochemical Pharmacology 82:12, pages 1832-1842.
Crossref
Alexander L. Ruchelman, Hon-Wah Man, Roger Chen, Wei Liu, Ling Lu, Dorota Cedzik, Ling Zhang, Jim Leisten, Alice Collette, Rama Krishna Narla, Heather K. Raymon & George W. Muller. (2011) 1,1-Diarylalkenes as anticancer agents: Dual inhibitors of tubulin polymerization and phosphodiesterase 4. Bioorganic & Medicinal Chemistry 19:21, pages 6356-6374.
Crossref
Sarah Jane Lunt, Simon Akerman, Sally A. Hill, Matthew Fisher, Victoria J. Wright, Constantino C. Reyes‐Aldasoro, Gillian M. Tozer & Chryso Kanthou. (2011) Vascular effects dominate solid tumor response to treatment with combretastatin A‐4‐phosphate. International Journal of Cancer 129:8, pages 1979-1989.
Crossref
David Cragg, Gordon Kingston & David NewmanKevin Pinney, George Pettit, Mary Trawick, Christopher Jelinek & David Chaplin. 2011. Anticancer Agents from Natural Products, Second Edition. Anticancer Agents from Natural Products, Second Edition 27 64 .
Romeo Romagnoli, Pier Giovanni Baraldi, Carlota Lopez-Cara, Olga Cruz-Lopez, Maria Dora Carrion, Maria Kimatrai Salvador, Jaime Bermejo, Sara Estévez, Francisco Estévez, Jan Balzarini, Andrea Brancale, Antonio Ricci, Longchuan Chen, Jae Gwan Kim & Ernest Hamel. (2011) Synthesis and Antitumor Molecular Mechanism of Agents Based on Amino 2-(3′,4′,5′-Trimethoxybenzoyl)benzo[b]furan: Inhibition of Tubulin and Induction of Apoptosis. ChemMedChem 6:10, pages 1841-1853.
Crossref
Mohamed Ali Soussi, Silvio Aprile, Samir Messaoudi, Olivier Provot, Erika Del Grosso, Jérôme Bignon, Joëlle Dubois, Jean-Daniel Brion, Giorgio Grosa & Mouad Alami. (2011) The Metabolic Fate of isoCombretastatin A-4 in Human Liver Microsomes: Identification, Synthesis and Biological Evaluation of Metabolites. ChemMedChem 6:10, pages 1781-1788.
Crossref
Alejandro D. Ricart, Edward A. Ashton, Matthew M. Cooney, John Sarantopoulos, Joanna M. Brell, Maria A. Feldman, Kale E. Ruby, Kazuko Matsuda, Mark S. Munsey, Gerardo Medina, Angela Zambito, Anthony W. Tolcher & Scot C. Remick. (2011) A phase I study of MN-029 (denibulin), a novel vascular-disrupting agent, in patients with advanced solid tumors. Cancer Chemotherapy and Pharmacology 68:4, pages 959-970.
Crossref
Bernard L. Flynn, Gurmit S. Gill, Damian W. Grobelny, Jason H. Chaplin, Dharam Paul, Annabell F. Leske, Tina C. Lavranos, David K. Chalmers, Susan A. Charman, Edmund Kostewicz, David M. Shackleford, Julia Morizzi, Ernest Hamel, M. Katherine Jung & Gabriel Kremmidiotis. (2011) Discovery of 7-Hydroxy-6-methoxy-2-methyl-3-(3,4,5-trimethoxybenzoyl)benzo[ b ]furan (BNC105), a Tubulin Polymerization Inhibitor with Potent Antiproliferative and Tumor Vascular Disrupting Properties . Journal of Medicinal Chemistry 54:17, pages 6014-6027.
Crossref
Martin Arthuis, Renée Pontikis, Guy G. Chabot, Johanne Seguin, Lionel Quentin, Stéphane Bourg, Luc Morin-Allory & Jean-Claude Florent. (2011) Synthesis and Structure-Activity Relationships of Constrained Heterocyclic Analogues of Combretastatin A4. ChemMedChem 6:9, pages 1693-1705.
Crossref
Huaijun Wang, Marlein Miranda Cona, Feng Chen, Junjie Li, Jie Yu, Yuanbo Feng, Ronald Peeters, Frederik De Keyzer, Guy Marchal & Yicheng Ni. (2011) Comparison Between Nonspecific and Necrosis-avid Gadolinium Contrast Agents in Vascular Disrupting Agent-Induced Necrosis of Rodent Tumors at 3.0T. Investigative Radiology 46:9, pages 531-538.
Crossref
Mei-Jung Lai, Jang-Yang Chang, Hsueh-Yun Lee, Ching-Chuan Kuo, Mei-Hsiang Lin, Hsing-Pang Hsieh, Chi-Yen Chang, Jian-Sung Wu, Su-Ying Wu, Kuang-Shing Shey & Jing-Ping Liou. (2011) Synthesis and biological evaluation of 1-(4′-Indolyl and 6′-Quinolinyl) indoles as a new class of potent anticancer agents. European Journal of Medicinal Chemistry 46:9, pages 3623-3629.
Crossref
Bret Tréguier, Evelia Rasolofonjatovo, Abdallah Hamze, Olivier Provot, Joanna Wdzieczak‐Bakala, Joëlle Dubois, Jean‐Daniel Brion & Mouad Alami. (2011) Synthesis of 2‐(1‐Phenylvinyl)benzofurans and 2‐(1‐Phenylvinyl)indoles as Antimitotic Agents by a Tandem Palladium‐Assisted Coupling‐Cyclization Reaction between 1‐Phenylvinyl Iodides and ortho ‐Substituted Arylalkynes . European Journal of Organic Chemistry 2011:25, pages 4868-4876.
Crossref
Sewan Theeramunkong, Antonio Caldarelli, Alberto Massarotti, Silvio Aprile, Diego Caprioglio, Roberta Zaninetti, Alessia Teruggi, Tracey Pirali, Giorgio Grosa, Gian Cesare Tron & Armando A. Genazzani. (2011) Regioselective Suzuki Coupling of Dihaloheteroaromatic Compounds as a Rapid Strategy To Synthesize Potent Rigid Combretastatin Analogues. Journal of Medicinal Chemistry 54:14, pages 4977-4986.
Crossref
Rajendra P. Tanpure, Benson L. Nguyen, Tracy E. Strecker, Savannah Aguirre, Suman Sharma, David J. Chaplin, Bronwyn G. Siim, Ernest Hamel, John W. LippertIIIIII, George R. Pettit, Mary Lynn Trawick & Kevin G. Pinney. (2011) Regioselective Synthesis of Water-Soluble Monophosphate Derivatives of Combretastatin A-1. Journal of Natural Products 74:7, pages 1568-1574.
Crossref
Xuexin He, Su Li, He Huang, Zhiming Li, Likun Chen, Sheng Ye, Jiajia Huang, Jing Zhan & Tongyu Lin. (2011) A pharmacokinetic and safety study of single dose intravenous combretastatin A4 phosphate in Chinese patients with refractory solid tumours. British Journal of Clinical Pharmacology 71:6, pages 860-870.
Crossref
Raquel Álvarez, Vilmarí López, Carmen Mateo, Manuel Medarde & Rafael Peláez. (2011) New para – para Stilbenophanes: Synthesis by McMurry Coupling, Conformational Analysis and Inhibition of Tubulin Polymerisation . Chemistry – A European Journal 17:12, pages 3406-3419.
Crossref
Hsun‐Yueh Chuang, Jang‐Yang Chang, Mei‐Jung Lai, Ching‐Chuan Kuo, Hsueh‐Yun Lee, Hsing‐Pang Hsieh, Ying‐Jen Chen, Li‐Tzong Chen, Wen‐Yu Pan & Jing‐Ping Liou. (2011) 2‐Amino‐3,4,5‐Trimethoxybenzophenones as Potent Tubulin Polymerization Inhibitors. ChemMedChem 6:3, pages 450-456.
Crossref
Samir Messaoudi, Abdallah Hamze, Olivier Provot, Bret Tréguier, Jordi Rodrigo De Losada, Jérôme Bignon, Jian‐Miao Liu, Joanna Wdzieczak‐Bakala, Sylviane Thoret, Joëlle Dubois, Jean‐Daniel Brion & Mouad Alami. (2011) Discovery of Isoerianin Analogues as Promising Anticancer Agents. ChemMedChem 6:3, pages 488-497.
Crossref
A Palumbo, F Hauler, P Dziunycz, K Schwager, A Soltermann, F Pretto, C Alonso, G F Hofbauer, R W Boyle & D Neri. (2011) A chemically modified antibody mediates complete eradication of tumours by selective disruption of tumour blood vessels. British Journal of Cancer 104:7, pages 1106-1115.
Crossref
M. Lindborg, E. Cortez, I. Höidén-Guthenberg, E. Gunneriusson, E. von Hage, F. Syud, M. Morrison, L. Abrahmsén, N. Herne, K. Pietras & F.Y. Frejd. (2011) Engineered High-Affinity Affibody Molecules Targeting Platelet-Derived Growth Factor Receptor β In Vivo. Journal of Molecular Biology 407:2, pages 298-315.
Crossref
Ilia Y. Titov, Irina K. Sagamanova, Roman T. Gritsenko, Irina B. Karmanova, Olga P. Atamanenko, Marina N. Semenova & Victor V. Semenov. (2011) Application of plant allylpolyalkoxybenzenes in synthesis of antimitotic phenstatin analogues. Bioorganic & Medicinal Chemistry Letters 21:6, pages 1578-1581.
Crossref
Dietmar W. Siemann. (2011) The unique characteristics of tumor vasculature and preclinical evidence for its selective disruption by Tumor-Vascular Disrupting Agents. Cancer Treatment Reviews 37:1, pages 63-74.
Crossref
Alexander Ciupa, Natalie J. Griffiths, Stephanie K. Light, Pauline J. Wood & Lorenzo Caggiano. (2011) Design, synthesis and antiproliferative activity of urocanic-chalcone hybrid derivatives. MedChemComm 2:10, pages 1011.
Crossref
Hsueh-Yun Lee, Jang-Yang Chang, Ling-Yin Chang, Wen-Yang Lai, Mei-Jung Lai, Kuang-Hsing Shih, Ching-Chuan Kuo, Chi-Yen Chang & Jing-Ping Liou. (2011) Concise syntheses of N-aryl-5,6,7-trimethoxyindoles as antimitotic and vascular disrupting agents: application of the copper-mediated Ullmann-type arylation. Organic & Biomolecular Chemistry 9:9, pages 3154.
Crossref
Ralph P. Mason, Dawen Zhao, Li Liu, Mary Lynn Trawick & Kevin G. Pinney. (2011) A perspective on vascular disrupting agents that interact with tubulin: preclinical tumor imaging and biological assessment. Integrative Biology 3:4, pages 375.
Crossref
Morten Busk, Anja Bille Bohn, Marianne Skals, Tobias Wang & Michael R. Horsman. (2011) Combretastatin-induced hypertension and the consequences for its combination with other therapies. Vascular Pharmacology 54:1-2, pages 13-17.
Crossref
Lori Rice, Christine Pampo, Sharon Lepler, Amyn M. Rojiani & Dietmar W. Siemann. (2011) Support of a free radical mechanism for enhanced antitumor efficacy of the microtubule disruptor OXi4503. Microvascular Research 81:1, pages 44-51.
Crossref
Martin Arthuis, Renée Pontikis, Guy G. Chabot, Lionel Quentin, Daniel Scherman & Jean-Claude Florent. (2011) Domino approach to 2-aroyltrimethoxyindoles as novel heterocyclic combretastatin A4 analogues. European Journal of Medicinal Chemistry 46:1, pages 95-100.
Crossref
Victor V. Semenov, Alex S. Kiselyov, Ilia Y. Titov, Irina K. Sagamanova, Natalie N. Ikizalp, Natalia B. Chernysheva, Dmitry V. Tsyganov, Leonid D. Konyushkin, Sergei I. Firgang, Roman V. Semenov, Irina B. Karmanova, Mikhail M. Raihstat & Marina N. Semenova. (2010) Synthesis of Antimitotic Polyalkoxyphenyl Derivatives of Combretastatin Using Plant Allylpolyalkoxybenzenes. Journal of Natural Products 73:11, pages 1796-1802.
Crossref
Gerard J. Madlambayan, Amy M. Meacham, Koji Hosaka, Saad MirMarda Jorgensen, Edward W. Scott, Dietmar W. Siemann & Christopher R. Cogle. (2010) Leukemia regression by vascular disruption and antiangiogenic therapy. Blood 116:9, pages 1539-1547.
Crossref
Cenzo Congiu, Valentina Onnis, Loredana Vesci, Massimo Castorina & Claudio Pisano. (2010) Synthesis and in vitro antitumor activity of new 4,5-dihydropyrazole derivatives. Bioorganic & Medicinal Chemistry 18:17, pages 6238-6248.
Crossref
Kristin Odlo, Jérémie Fournier-Dit-Chabert, Sylvie Ducki, Osman A.B.S.M. Gani, Ingebrigt Sylte & Trond Vidar Hansen. (2010) 1,2,3-Triazole analogs of combretastatin A-4 as potential microtubule-binding agents. Bioorganic & Medicinal Chemistry 18:18, pages 6874-6885.
Crossref
Balasubramaniam Sivaraman & Indrapal Singh Aidhen. (2010) Weinreb Amide Based Building Blocks for Convenient Access to Analogues of Phenstatin. European Journal of Organic Chemistry 2010:26, pages 4991-5003.
Crossref
Rajendra P. TanpureTracy E. StreckerDavid J. ChaplinBronwyn G. SiimMary Lynn TrawickKevin G. Pinney. (2010) Regio- and Stereospecific Synthesis of Mono-β- d -Glucuronic Acid Derivatives of Combretastatin A-1 . Journal of Natural Products 73:6, pages 1093-1101.
Crossref
Bojan Burja, Tamara Čimbora-Zovko, Sanja Tomić, Tihana Jelušić, Marijan Kočevar, Slovenko Polanc & Maja Osmak. (2010) Pyrazolone-fused combretastatins and their precursors: synthesis, cytotoxicity, antitubulin activity and molecular modeling studies. Bioorganic & Medicinal Chemistry 18:7, pages 2375-2387.
Crossref
Chih-Ying Nien, Yun-Ching Chen, Ching-Chuan Kuo, Hsing-Pang Hsieh, Chi-Yen Chang, Jian-Sung Wu, Su-Ying Wu, Jing-Ping Liou & Jang-Yang Chang. (2010) 5-Amino-2-Aroylquinolines as Highly Potent Tubulin Polymerization Inhibitors. Journal of Medicinal Chemistry 53:5, pages 2309-2313.
Crossref
Jay Chauhan, Alexandre R. Monteil & Steven E. Patterson. (2010) Synthesis of novel benzo[b]furans and benzo[b]thiophenes: analogs of combretastatin and resveratrol. Heterocyclic Communications 16:4-6.
Crossref
Claudio Campa, Ciro Costagliola, Carlo Incorvaia, Carl Sheridan, Francesco Semeraro, Katia De Nadai, Adolfo Sebastiani & Francesco Parmeggiani. (2010) Inflammatory Mediators and Angiogenic Factors in Choroidal Neovascularization: Pathogenetic Interactions and Therapeutic Implications. Mediators of Inflammation 2010, pages 1-14.
Crossref
Jang-Yang Chang, Mei-Jung Lai, Yi-Ting Chang, Hsueh-Yun Lee, Yun-Ching Cheng, Ching-Chuan Kuo, Min-Chieh Su, Chi-Yen Chang & Jing-Ping Liou. (2010) Synthesis and biological evaluation of 7-arylindoline-1-benzenesulfonamides as a novel class of potent anticancer agents. MedChemComm 1:2, pages 152.
Crossref
Fatma M. Abdel Bar, Mohammad A. Khanfar, Ahmed Y. Elnagar, Farid A. Badria, Ahmed M. Zaghloul, Kadria F. Ahmad, Paul W. Sylvester & Khalid A. El Sayed. (2010) Design and pharmacophore modeling of biaryl methyl eugenol analogs as breast cancer invasion inhibitors. Bioorganic & Medicinal Chemistry 18:2, pages 496-507.
Crossref
R. Barbara Pedley & Gillian M. Tozer. 2010. Vascular Disruptive Agents for the Treatment of Cancer. Vascular Disruptive Agents for the Treatment of Cancer 49 75 .
Graeme J. Dougherty & David J. Chaplin. 2010. Vascular Disruptive Agents for the Treatment of Cancer. Vascular Disruptive Agents for the Treatment of Cancer 1 27 .
Rodney T. Brown, Victor L. Murrell, Austin McMordie, Madhavi Sriram, Kevin G. Pinney, Suman Sharma & David J. Chaplin. (2009) Carbon‐14 radiosynthesis of combretastatin A‐1 (CA1) and its corresponding phosphate prodrug (CA1P). Journal of Labelled Compounds and Radiopharmaceuticals 52:14, pages 567-570.
Crossref
Abdallah Hamze, Anne Giraud, Samir Messaoudi, Olivier Provot, Jean-François Peyrat, Jérôme Bignon, Jian-Miao Liu, Joanna Wdzieczak-Bakala, Sylviane Thoret, Joëlle Dubois, Jean-Daniel Brion & Mouad Alami. (2009) Synthesis, Biological Evaluation of 1,1-Diarylethylenes as a Novel Class of Antimitotic Agents. ChemMedChem 4:11, pages 1912-1924.
Crossref
Sylvie Ducki, Grant Mackenzie, Ben Greedy, Simon Armitage, Jérémie Fournier Dit Chabert, Elizabeth Bennett, Jim Nettles, James P. Snyder & Nicholas J. Lawrence. (2009) Combretastatin-like chalcones as inhibitors of microtubule polymerisation. Part 2: Structure-based discovery of alpha-aryl chalcones. Bioorganic & Medicinal Chemistry 17:22, pages 7711-7722.
Crossref
Sylvie Ducki, David Rennison, Meiko Woo, Alexander Kendall, Jérémie Fournier Dit Chabert, Alan T. McGown & Nicholas J. Lawrence. (2009) Combretastatin-like chalcones as inhibitors of microtubule polymerization. Part 1: Synthesis and biological evaluation of antivascular activity. Bioorganic & Medicinal Chemistry 17:22, pages 7698-7710.
Crossref

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