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Review

Histone deacetylase inhibitors: discovery and development as anticancer agents

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Pages 1497-1511 | Published online: 25 Nov 2005

Keep up to date with the latest research on this topic with citation updates for this article.

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Varun Dewaker, Pratik Narain Srivastava, Saroj Verma, Ajay K. Srivastava & Yenamandra S. Prabhakar. (2022) Non-bonding energy directed designing of HDAC2 inhibitors through molecular dynamics simulation. Journal of Biomolecular Structure and Dynamics 40:24, pages 13432-13455.
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Varun Dewaker, Ajay K. Srivastava, Ashish Arora & Yenamandra S. Prabhakar. (2021) Investigation of HDAC8-ligands’ intermolecular forces through molecular dynamics simulations: profiling of non-bonding energies to design potential compounds as new anti-cancer agents. Journal of Biomolecular Structure and Dynamics 39:13, pages 4726-4751.
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Sk. Abdul Amin, Nilanjan Adhikari & Tarun Jha. (2021) Development of decision trees to discriminate HDAC8 inhibitors and non-inhibitors using recursive partitioning. Journal of Biomolecular Structure and Dynamics 39:1, pages 1-8.
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Suvankar Banerjee, Sk. Abdul Amin, Nilanjan Adhikari & Tarun Jha. (2020) Essential elements regulating HDAC8 inhibition: a classification based structural analysis and enzyme-inhibitor interaction study of hydroxamate based HDAC8 inhibitors. Journal of Biomolecular Structure and Dynamics 38:18, pages 5513-5525.
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Yudibeth Sixto-López, Martiniano Bello, Rolando Alberto Rodríguez-Fonseca, Martha Cecilia Rosales-Hernández, Marlet Martínez-Archundia, José Antonio Gómez-Vidal & José Correa-Basurto. (2017) Searching the conformational complexity and binding properties of HDAC6 through docking and molecular dynamic simulations. Journal of Biomolecular Structure and Dynamics 35:13, pages 2794-2814.
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Nguyen-Hai Nam, Tran Lan Huong, Do Thi Mai Dung, Phan Thi Phuong Dung, Dao Thi Kim Oanh, Sang Ho Park, Kyungrok Kim, Byung Woo Han, Jieun Yun, Jong Soon Kang, Youngsoo Kim & Sang-Bae Han. (2014) Synthesis, bioevaluation and docking study of 5-substitutedphenyl-1,3,4-thiadiazole-based hydroxamic acids as histone deacetylase inhibitors and antitumor agents. Journal of Enzyme Inhibition and Medicinal Chemistry 29:5, pages 611-618.
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MarianaS. Gerova & OgnyanI. Petrov. (2014) A Convenient Synthesis of the New Histone Deacetylase Inhibitor Scriptaid. Organic Preparations and Procedures International 46:1, pages 76-79.
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Nadine Martinet & Philippe Bertrand. (2011) Interpreting clinical assays for histone deacetylase inhibitors. Cancer Management and Research 3, pages 117-141.
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L Rhoda Molife & Johann S de Bono. (2011) Belinostat: clinical applications in solid tumors and lymphoma. Expert Opinion on Investigational Drugs 20:12, pages 1723-1732.
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Nozomu Tanji, Akira Ozawa, Tadahiko Kikugawa, Noriyoshi Miura, Toyokazu Sasaki, Kouji Azuma & Masayoshi Yokoyama. (2011) Potential of histone deacetylase inhibitors for bladder cancer treatment. Expert Review of Anticancer Therapy 11:6, pages 959-965.
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Chunlei Zhang & Madeleine Duvic. (2010) Vorinostat for the treatment of cutaneous T-cell lymphoma. Expert Review of Dermatology 5:4, pages 393-401.
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Faith M. Strickland & Bruce C. Richardson. (2008) Epigenetics in human autoimmunity. Autoimmunity 41:4, pages 278-286.
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Madeleine Duvic & Jenny Vu. (2007) Update on the treatment of cutaneous T-cell lymphoma (CTCL): Focus on vorinostat. Biologics: Targets and Therapy 1:4, pages 377-392.
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Madeleine Duvic & Jenny Vu. (2007) Vorinostat: a new oral histone deacetylase inhibitor approved for cutaneous T-cell lymphoma. Expert Opinion on Investigational Drugs 16:7, pages 1111-1120.
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Steve Price & Hazel J Dyke. (2007) Histone deacetylase inhibitors. Expert Opinion on Therapeutic Patents 17:7, pages 745-765.
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Sabina A Antoniu. (2006) Histone deacetylase pathway: an evolving therapeutic target in chronic obstructive pulmonary disease. Expert Opinion on Therapeutic Targets 10:2, pages 329-332.
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