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Expert Opinion on Therapeutic Targets Volume 14, 2010 - Issue 5
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New pathways of the renin–angiotensin system: the role of ACE2 in cardiovascular pathophysiology and therapy

Paulo Castro-Chaves University of Porto, Department of Physiology, Faculty of Medicine, Alameda Prof. Hernâni Monteiro, 4200-319 Porto, Portugal +351 22 551 36 44; +351 22 551 36 46; [email protected]
,
Rui Cerqueira University of Porto, Department of Physiology, Faculty of Medicine, Alameda Prof. Hernâni Monteiro, 4200-319 Porto, Portugal +351 22 551 36 44; +351 22 551 36 46; [email protected]
,
Mariana Pintalhao University of Porto, Department of Physiology, Faculty of Medicine, Alameda Prof. Hernâni Monteiro, 4200-319 Porto, Portugal +351 22 551 36 44; +351 22 551 36 46; [email protected]
&
Adelino F Leite-Moreira University of Porto, Department of Physiology, Faculty of Medicine, Alameda Prof. Hernâni Monteiro, 4200-319 Porto, Portugal +351 22 551 36 44; +351 22 551 36 46; [email protected]
Pages 485-496 | Published online: 14 Apr 2010

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Gabriele Fragasso, Francesco Maranta, Claudia Montanaro, Anna Salerno, Camilla Torlasco & Alberto Margonato. (2012) Pathophysiologic therapeutic targets in hypertension: a cardiological point of view. Expert Opinion on Therapeutic Targets 16:2, pages 179-193.
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Articles from other publishers (22)

Mengyuan Xiao, Weikai ZengJunxian WangFeng YaoZijian PengGuangyan LiuLiqin YuWenyan WeiShengzhi ZhouKaize LiLuyao WuKunpeng ZhuYuejie GuanHuanyu ChenZhenjun LiuJianying Chen. (2021) Exosomes Protect Against Acute Myocardial Infarction in Rats by Regulating the Renin-Angiotensin System. Stem Cells and Development 30:12, pages 622-631.
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Sohair R. Fahmy, Ayman S. Mohamed, Mohamed Hosney, Hanan A. Issa, Sarah S. Hassanein & Amel M. Soliman. (2019) Hepatotoxicity effect of short-term Bradykinin potentiating factor in cholestatic rats. Toxicology Letters 301, pages 73-78.
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Maíra Casalechi, Cynthia Dela Cruz, Luiza C. Lima, Luciana P. Maciel, Virgínia M. Pereira & Fernando M. Reis. (2018) Angiotensin peptides in the non-gravid uterus: Paracrine actions beyond circulation. Peptides 101, pages 145-149.
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Corey S. MoranErik BirosSmriti M. KrishnaYutang WangChris TikellisSusan K. MortonJoseph V. MoxonMark E. CooperPaul E. NormanLouise M. BurrellMerlin C. ThomasJonathan Golledge. (2017) Resveratrol Inhibits Growth of Experimental Abdominal Aortic Aneurysm Associated With Upregulation of Angiotensin-Converting Enzyme 2. Arteriosclerosis, Thrombosis, and Vascular Biology 37:11, pages 2195-2203.
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Nageh Ahmed El-Mahdy, Magda El-Sayed El-Sayad & Aya Hassan El-Kadem. (2016) Combination of telmisartan with sildenafil ameliorate progression of diabetic nephropathy in streptozotocin-induced diabetic model. Biomedicine & Pharmacotherapy 81, pages 136-144.
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Francesco Maranta, Roberto Spoladore & Gabriele Fragasso. 2017. Hypertension: from basic research to clinical practice. Hypertension: from basic research to clinical practice 37 59 .
Kaustav Majumder, Guanxiang Liang, Yanhong Chen, LeLuo Guan, Sandra T. Davidge & Jianping Wu. (2015) Egg ovotransferrin‐derived ACE inhibitory peptide IRW increases ACE2 but decreases proinflammatory genes expression in mesenteric artery of spontaneously hypertensive rats. Molecular Nutrition & Food Research 59:9, pages 1735-1744.
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Huijing Xia, Thyago Moreira de Queiroz, Srinivas Sriramula, Yumei Feng, Tanya Johnson, Imran N. Mungrue & Eric Lazartigues. (2015) Brain ACE2 overexpression reduces DOCA-salt hypertension independently of endoplasmic reticulum stress. American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 308:5, pages R370-R378.
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Zhong-Xin Li. (2015) Hemodynamics and vasoactive substance levels during renal congestion that occurs in the anhepatic phase of liver transplantation. World Journal of Gastroenterology 21:18, pages 5482.
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Satrupa Das, Sitara Roy, Vandana Sharma, Subhash Kaul, Akka Jyothy & Anjana Munshi. (2014) Association of ACE gene I/D polymorphism and ACE levels with hemorrhagic stroke: comparison with ischemic stroke. Neurological Sciences 36:1, pages 137-142.
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Luís Mendonça, Pedro Mendes-Ferreira, Ana Bento-Leite, Rui Cerqueira, Mário Jorge Amorim, Paulo Pinho, Cármen Brás-Silva, Adelino F. Leite-Moreira & Paulo Castro-Chaves. (2014) Angiotensin-(1–7) Modulates Angiotensin II-Induced Vasoconstriction in Human Mammary Artery. Cardiovascular Drugs and Therapy 28:6, pages 513-522.
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Xiaoling Tao, Jinqi Fan, Guoying Kao, Xiaoge Zhang, Li Su, Yuehui Yin & Bernhard Zrenner. (2014) Angiotensin-(1-7) attenuates angiotensin II-induced signalling associated with activation of a tyrosine phosphatase in Sprague-Dawley rats cardiac fibroblasts. Biology of the Cell 106:6, pages 182-192.
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Robert W. Regenhardt, Fiona Desland, Adam P. Mecca, David J. Pioquinto, Aqeela Afzal, J. Mocco & Colin Sumners. (2013) Anti-inflammatory effects of angiotensin-(1-7) in ischemic stroke. Neuropharmacology 71, pages 154-163.
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Danielle G. Passos-Silva, Thiago Verano-Braga & Robson A. S. Santos. (2012) Angiotensin-(1–7): beyond the cardio-renal actions. Clinical Science 124:7, pages 443-456.
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Yutang Wang, Chris Tikellis, Merlin C. Thomas & Jonathan Golledge. (2013) Angiotensin converting enzyme 2 and atherosclerosis. Atherosclerosis 226:1, pages 3-8.
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En-tong Yi, Rui-xia Liu, Yan Wen & Cheng-hong Yin. (2012) Telmisartan attenuates hepatic fibrosis in bile duct-ligated rats. Acta Pharmacologica Sinica 33:12, pages 1518-1524.
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Preethi Samuel, Quaisar Ali, Rifat Sabuhi, Yonnie Wu & Tahir Hussain. (2012) High Na intake increases renal angiotensin II levels and reduces expression of the ACE2-AT 2 R-MasR axis in obese Zucker rats . American Journal of Physiology-Renal Physiology 303:3, pages F412-F419.
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Lukas Schwentner, Achim Wöckel, Daniel Herr & Christine Wulff. (2011) Is there a role of the local tissue RAS in the regulation of physiologic and pathophysiologic conditions in the reproductive tract?. Journal of the Renin-Angiotensin-Aldosterone System 12:4, pages 385-393.
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Adam P. Mecca, Robert W. Regenhardt, Timothy E. O’Connor, Jason P. Joseph, Mohan K. Raizada, Michael J. Katovich & Colin Sumners. (2011) Cerebroprotection by angiotensin-(1-7) in endothelin-1-induced ischaemic stroke. Experimental Physiology 96:10, pages 1084-1096.
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M Kamruzzman Munshi, Mohammad N Uddin & Shannon S Glaser. (2011) The role of the renin–angiotensin system in liver fibrosis. Experimental Biology and Medicine 236:5, pages 557-566.
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Qianni Cheng & Po Sing Leung. (2011) An update on the islet renin–angiotensin system. Peptides 32:5, pages 1087-1095.
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José Butori Lopes de Faria, Kamila Cristina Silva & Jacqueline Mendonça Lopes de Faria. (2011) The contribution of hypertension to diabetic nephropathy and retinopathy: the role of inflammation and oxidative stress. Hypertension Research 34:4, pages 413-422.
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