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Original Research

The lysosome among targets of metformin: new anti-inflammatory uses for an old drug?

Pages 467-478 | Published online: 14 Apr 2010

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Zhihui Xu, Huijing Ye, Wei Xiao, Anqi Sun, Shenglan Yang, Te Zhang, Xiaotong Sha & Huasheng Yang. (2022) Metformin Attenuates Inflammation and Fibrosis in Thyroid-Associated Ophthalmopathy. International Journal of Molecular Sciences 23:24, pages 15508.
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Xiong Qin, Tongmeng Jiang, Sijia Liu, Jiachang Tan, Huayu Wu, Li Zheng & Jinmin Zhao. (2017) Effect of metformin on ossification and inflammation of fibroblasts in ankylosing spondylitis: An in vitro study. Journal of Cellular Biochemistry 119:1, pages 1074-1082.
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A.J. Scheen, N. Esser & N. Paquot. (2015) Antidiabetic agents: Potential anti-inflammatory activity beyond glucose control. Diabetes & Metabolism 41:3, pages 183-194.
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Dirk Woetzel, Rene Huber, Peter Kupfer, Dirk Pohlers, Michael Pfaff, Dominik Driesch, Thomas Häupl, Dirk Koczan, Peter Stiehl, Reinhard Guthke & Raimund W Kinne. (2014) Identification of rheumatoid arthritis and osteoarthritis patients by transcriptome-based rule set generation. Arthritis Research & Therapy 16:2, pages R84.
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Thomas D. Lockwood. (2013) Lysosomal metal, redox and proton cycles influencing the CysHis cathepsin reaction. Metallomics 5:2, pages 110.
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Alison M Connor, Nizar Mahomed, Rajiv Gandhi, Edward C Keystone & Stuart A Berger. (2012) TNFα modulates protein degradation pathways in rheumatoid arthritis synovial fibroblasts. Arthritis Research & Therapy 14:2, pages R62.
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Christoph Trautwein & Klaus Kümmerer. (2011) Incomplete aerobic degradation of the antidiabetic drug Metformin and identification of the bacterial dead-end transformation product Guanylurea. Chemosphere 85:5, pages 765-773.
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