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Clinical consequences of polypharmacy in elderly

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Xiaoxiao Lu, Bruno Emond, Laura Morrison, Frederic Kinkead, Patrick Lefebvre, Marie-Hélène Lafeuille, Wasiulla Khan, Linda H Wu, Zaina P Qureshi & Ryan Jacobs. (2023) Real-World Comparison of First-Line Treatment Adherence Between Single-Agent Ibrutinib and Acalabrutinib in Patients with Chronic Lymphocytic Leukemia. Patient Preference and Adherence 17, pages 2073-2084.
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Mette K. Thomsen, Katrine B. Løppenthin, Pernille E. Bidstrup, Elisabeth W. Andersen, Susanne Dalton, Lone N. Petersen, Helle Pappot, Christiane E. Mortensen, Mikkel B. Christensen, Anne Frølich, Ulrik Lassen & Christoffer Johansen. (2023) Impact of multimorbidity and polypharmacy on mortality after cancer: a nationwide registry-based cohort study in Denmark 2005–2017. Acta Oncologica 62:12, pages 1653-1660.
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Annemarie A. Schuller & Arie R. Hoeksema. (2023) Determinants and barriers for visiting a dental clinic among (frail) older individuals. Acta Odontologica Scandinavica 81:3, pages 227-234.
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Michael A Veronin. (2022) An Atypical Case of Extreme Polypharmacy. Drug, Healthcare and Patient Safety 14, pages 19-26.
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Cheng Cheng & Jie Bai. (2022) What Should Clinicians Do for Older Adults with Polypharmacy and Depression? [Response to Letter]. Clinical Interventions in Aging 17, pages 601-602.
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Linh Dang, Aparna Ananthasubramaniam & Briana Mezuk. (2022) Spotlight on the Challenges of Depression following Retirement and Opportunities for Interventions. Clinical Interventions in Aging 17, pages 1037-1056.
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Hesah Alshammari, Eman Al-Saeed, Zamzam Ahmed & Zoe Aslanpour. (2022) Prevalence and Predictors of Potentially Inappropriate Medications Among Patients Aged ≥65 Years on Hospital Admissions in Kuwait. Clinical Interventions in Aging 17, pages 1025-1036.
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Susan M. Britza, Ian F. Musgrave & Roger W. Byard. (2022) Implications for herbal polypharmacy: coumarin-induced hepatotoxicity increased through common herbal phytochemicals astragaloside IV and atractylenolide I. Toxicology Mechanisms and Methods 32:8, pages 606-615.
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Win Min Oo, Ali Mobasheri & David J Hunter. (2022) A narrative review of anti-obesity medications for obese patients with osteoarthritis. Expert Opinion on Pharmacotherapy 23:12, pages 1381-1395.
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Alemayehu Mekonnen, Bernice Redley, Kimberley Crawford, Stephanie Jones, Barbora de Courten & Elizabeth Manias. (2022) Associations between hyper-polypharmacy and potentially inappropriate prescribing with clinical and functional outcomes in older adults. Expert Opinion on Drug Safety 21:7, pages 985-994.
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Zeynep Sayın, Mesut Sancar, Yasin Özen & Betul Okuyan. (2022) Polypharmacy, potentially inappropriate prescribing and medication complexity in Turkish older patients in the community pharmacy setting. Acta Clinica Belgica 77:2, pages 273-279.
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Kathryn A. Martinez, Debra T. Linfield, Niyati M. Gupta, Mohana Vamsi Alapati, Daniel Moussa, Bo Hu, Luke Dogyun Kim, Simon Lam, Giavanna Russo-Alvarez & Michael B. Rothberg. (2022) Patient and physician factors contributing to polypharmacy among older patients. Current Medical Research and Opinion 38:1, pages 123-130.
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Sirasa Ruangritchankul, Prawat Chantharit, Sahaphume Srisuma & Leonard C Gray. (2021) Adverse Drug Reactions of Acetylcholinesterase Inhibitors in Older People Living with Dementia: A Comprehensive Literature Review. Therapeutics and Clinical Risk Management 17, pages 927-949.
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José Joaquín Mira. (2021) How to reduce medication errors in patients over the age of 65?. Expert Opinion on Pharmacotherapy 22:18, pages 2417-2421.
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Minhee Sung, Kirsha Gordon, E. Jennifer Edelman, Kathleen M. Akgün, Krisann K. Oursler & Amy C. Justice. (2021) Polypharmacy and frailty among persons with HIV. AIDS Care 33:11, pages 1492-1499.
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Mark Benson, David Murphy, Lindsey Hall, Philip Vande Kamp & David J Cook. (2021) Medication management for complex patients in primary care: application of a remote, asynchronous clinical pharmacist model. Postgraduate Medicine 133:7, pages 784-790.
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Rui Barbosa, Luís Midão, Marta Almada & Elísio Costa. (2021) Cognitive performance in older adults across Europe based on the SHARE database. Aging, Neuropsychology, and Cognition 28:4, pages 584-599.
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Dorsa Maher, Nagham Ailabouni, Arduino A. Mangoni, Michael D. Wiese & Emily Reeve. (2021) Alterations in drug disposition in older adults: a focus on geriatric syndromes. Expert Opinion on Drug Metabolism & Toxicology 17:1, pages 41-52.
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Magnolia Cardona, Paulina Stehlik, Peter Fawzy, Oyungerel Byambasuren, Jarrah Anderson, Justin Clark, Shelley Sun & Ian Scott. (2021) Effectiveness and sustainability of deprescribing for hospitalized older patients near end of life: a systematic review. Expert Opinion on Drug Safety 20:1, pages 81-91.
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Caroline Krüger, Ingmar Schäfer, Hendrik van den Bussche, Michael Baehr, Horst Bickel, Angela Fuchs, Jochen Gensichen, Wolfgang Maier, Steffi G. Riedel-Heller, Hans-Helmut König, Anne Dahlhaus, Gerhard Schön, Siegfried Weyerer, Birgitt Wiese, Wolfgang von Renteln-Kruse, Claudia Langebrake & Martin Scherer. (2021) Non-random relations in drug use expressed as patterns comprising prescription and over-the-counter drugs in multimorbid elderly patients in primary care: Data of the exploratory analysis of the multicentre, observational cohort study MultiCare. European Journal of General Practice 27:1, pages 119-129.
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Jennifer Baumbusch & Isabel Sloan Yip. (2021) Exploring New Use of Cannabis among Older Adults. Clinical Gerontologist 44:1, pages 25-31.
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Sibel Eyigor, Yeşim Gökçe Kutsal, Fusun Toraman, Bekir Durmus, Kutay Ordu Gokkaya, Ali Aydeniz, Nurdan Paker & Pinar Borman. (2021) Polypharmacy, Physical and Nutritional Status, and Depression in the Elderly: Do Polypharmacy Deserve Some Credits in These Problems?. Experimental Aging Research 47:1, pages 79-91.
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Sayeeda Rahman, Keerti Singh, Sameer Dhingra, Jaykaran Charan, Paras Sharma, Salequl Islam, Dilshad Jahan, Katia Iskandar, Nandeeta Samad & Mainul Haque. (2020) The Double Burden of the COVID-19 Pandemic and Polypharmacy on Geriatric Population – Public Health Implications. Therapeutics and Clinical Risk Management 16, pages 1007-1022.
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Lauren Cadel, Amanda C. Everall, Sander L. Hitzig, Tanya L. Packer, Tejal Patel, Aisha Lofters & Sara J. T. Guilcher. (2020) Spinal cord injury and polypharmacy: a scoping review. Disability and Rehabilitation 42:26, pages 3858-3870.
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Thais Moreira, J Alvares-Teodoro, M. M Barbosa, R.C.R.M Do Nascimento, A. A Guerra Júnior & F. A Acurcio. (2020) Polypharmacy among adult and older adult users of primary care services delivered through the Unified Health System in Minas Gerais, Brazil. Expert Review of Clinical Pharmacology 13:12, pages 1401-1409.
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Isabella Damiani, Alberto Corsini & Stefano Bellosta. (2020) Potential statin drug interactions in elderly patients: a review. Expert Opinion on Drug Metabolism & Toxicology 16:12, pages 1133-1145.
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Debojit Bhattacharjee & Vivek Srivastava. (2020) Aspects of 3D printed drugs. Journal of Medical Engineering & Technology 44:8, pages 472-480.
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Géraldine Leguelinel-Blache, Christel Castelli, Jérémy Rolain, Sophie Bouvet, Sihame Chkair, Sarah Kabani, Bernadette Jalabert, Sabine Rouvière, Chloé Choukroun, Hélène Richard & Jean-Marie Kinowski. (2020) Impact of pharmacist-led multidisciplinary medication review on the safety and medication cost of the elderly people living in a nursing home: a before-after study. Expert Review of Pharmacoeconomics & Outcomes Research 20:5, pages 481-490.
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Raymond Milan & Helen-Maria Vasiliadis. (2020) The association between side effects and adherence to antidepressants among primary care community-dwelling older adults. Aging & Mental Health 24:8, pages 1229-1236.
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Tanveer Ahmed Khan, Shahzad Hussain, Aamer Ikram, Sidra Mahmood, Humayun Riaz, Ayesha Jamil, Amina Amin, Yaseen Ghulam Haider, Marva Sandhu, Atifa Mushtaq, Corrado Barbui, Chris F. Johnson & Brian Godman. (2020) Prevalence and treatment of neurological and psychiatric disorders among tertiary hospitals in Pakistan; findings and implications. Hospital Practice 48:3, pages 145-160.
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Sirasa Ruangritchankul, Nancye M Peel, Leila Shafiee Hanjani & Leonard C Gray. (2020) The Changes in Medication Prescribing Among the Older People with Cognitive Impairment in the Acute Care Setting. Clinical Interventions in Aging 15, pages 865-876.
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Cierra N. Sharp, Mark W. Linder & Roland Valdes$suffix/text()$suffix/text(). (2020) Polypharmacy: a healthcare conundrum with a pharmacogenetic solution. Critical Reviews in Clinical Laboratory Sciences 57:3, pages 161-180.
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Joshua M. Baruth, Melanie T. Gentry, Teresa A. Rummans, Donna M. Miller & M. Caroline Burton. (2020) Polypharmacy in older adults: the role of the multidisciplinary team. Hospital Practice 48:sup1, pages 56-62.
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Mouna Sawan, Emily Reeve, Justin Turner, Adam Todd, Michael A. Steinman, Mirko Petrovic & Danijela Gnjidic. (2020) A systems approach to identifying the challenges of implementing deprescribing in older adults across different health-care settings and countries: a narrative review. Expert Review of Clinical Pharmacology 13:3, pages 233-245.
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Anil Nanda, Alan P. Baptist, Rohit Divekar, Neil Parikh, Joram S. Seggev, Joseph S. Yusin & Sharmilee M. Nyenhuis. (2020) Asthma in the older adult. Journal of Asthma 57:3, pages 241-252.
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Matthew Dalstrom, Ryan Chung & Lynette Castronovo. (2020) Impacting Health through Cross-Border Pharmaceutical Purchases. Medical Anthropology 39:2, pages 182-195.
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Mollie L. Price, Claire A. Surr, Brendan Gough & Laura Ashley. (2020) Experiences and support needs of informal caregivers of people with multimorbidity: a scoping literature review. Psychology & Health 35:1, pages 36-69.
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Kristin M. Zimmerman, Courtney A. Bell, Krista L. Donohoe & Teresa M. Salgado. (2020) Medicine, pharmacy and nursing trainees’ perceptions of curriculum preparation to deprescribe and interprofessional roles in the deprescribing process. Gerontology & Geriatrics Education 41:1, pages 63-84.
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Shu Ning Ma, Hasniza Zaman Huri & Fariz Yahya. (2019) Drug-related problems in patients with rheumatoid arthritis. Therapeutics and Clinical Risk Management 15, pages 505-524.
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Filipa Pereira, Armin von Gunten, Joëlle Rosselet Amoussou, Isabella De Giorgi Salamun, Maria Manuela Martins & Henk Verloo. (2019) Polypharmacy Among Home-Dwelling Older Adults: The Urgent Need for an Evidence-Based Medication Management Model. Patient Preference and Adherence 13, pages 2137-2143.
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June M Tordoff, Charlotte Brenkley, Janet Krska & Alesha Smith. (2019) Exploring Medicines Burden Among Adults in New Zealand: A Cross-Sectional Survey. Patient Preference and Adherence 13, pages 2171-2184.
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Sara J. T. Guilcher, Amanda C. Everall, Tejal Patel, Tanya L. Packer, Sander L. Hitzig & Aisha K. Lofters. (2019) Medication adherence for persons with spinal cord injury and dysfunction from the perspectives of healthcare providers: A qualitative study. The Journal of Spinal Cord Medicine 42:sup1, pages 215-225.
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Nattawut Leelakanok & Ronilda R. D'Cunha. (2019) Association between polypharmacy and dementia – A systematic review and metaanalysis. Aging & Mental Health 23:8, pages 932-941.
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José Joaquín Mira. (2019) Medication errors in the older people population. Expert Review of Clinical Pharmacology 12:6, pages 491-494.
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A.B. Sanchez-Spitman, J.J. Swen, V.O. Dezentje, D.J.A.R. Moes, H. Gelderblom & H.J. Guchelaar. (2019) Clinical pharmacokinetics and pharmacogenetics of tamoxifen and endoxifen. Expert Review of Clinical Pharmacology 12:6, pages 523-536.
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L.E.J. Peeters, M.P. Kester, L. Feyz, P.M.L.A. Van Den Bemt, B.C.P. Koch, T. Van Gelder & J. Versmissen. (2019) Pharmacokinetic and pharmacodynamic considerations in the treatment of the elderly patient with hypertension. Expert Opinion on Drug Metabolism & Toxicology 15:4, pages 287-297.
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Zhuo Ma, Caixia Zhang, Xiangli Cui & Lihong Liu. (2019) Comparison of three criteria for potentially inappropriate medications in Chinese older adults. Clinical Interventions in Aging 14, pages 65-72.
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Stine B Bruun, Irene Petersen, Nickolaj R Kristensen, Deirdre Cronin-Fenton & Alma B Pedersen. (2019) Selective serotonin reuptake inhibitor use in hip fracture patients: a Danish nationwide prevalence study. Acta Orthopaedica 90:1, pages 33-39.
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Lena Thunander Sundbom & Kerstin Hedborg. (2019) Association between prescribed antidepressants and other prescribed drugs differ by gender: a nationwide register-based study in Sweden. Nordic Journal of Psychiatry 73:1, pages 73-79.
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Anna Giardini, Marina Maffoni, Przemyslaw Kardas & Elisio Costa. (2018) A cornerstone of healthy aging: do we need to rethink the concept of adherence in the elderly?. Patient Preference and Adherence 12, pages 1003-1005.
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Asam Latif, Baguiasri Mandane, Emma Anderson, Caroline Barraclough & Samantha Travis. (2018) Optimizing medicine use for people who are homebound: an evaluation of a pilot domiciliary Medicine Use Review (dMUR) service in England. Integrated Pharmacy Research and Practice 7, pages 33-40.
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Arthur G Roberts & Morgan E Gibbs. (2018) Mechanisms and the clinical relevance of complex drug–drug interactions. Clinical Pharmacology: Advances and Applications 10, pages 123-134.
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Jonas W. Wastesson, Lucas Morin, Edwin C.K. Tan & Kristina Johnell. (2018) An update on the clinical consequences of polypharmacy in older adults: a narrative review. Expert Opinion on Drug Safety 17:12, pages 1185-1196.
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Joshua Schrecker, Brandi Puet, Cheryl Hild & David M. Schwope. (2018) Characterization of drug-drug interactions in patients whose substance intake was objectively identified by detection in urine. Expert Opinion on Drug Metabolism & Toxicology 14:9, pages 973-978.
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Mateusz Cybulski, Lukasz Cybulski, Elzbieta Krajewska-Kulak, Magda Orzechowska & Urszula Cwalina. (2018) Preferences and attitudes of older adults of Bialystok, Poland toward the use of over-the-counter drugs. Clinical Interventions in Aging 13, pages 623-632.
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Maria Pina Dore, Giovanni Mario Pes, Stefano Bibbò, Patrizia Tedde & Gabrio Bassotti. (2018) Constipation in the elderly from Northern Sardinia is positively associated with depression, malnutrition and female gender. Scandinavian Journal of Gastroenterology 53:7, pages 797-802.
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Niki Katsiki, Genovefa Kolovou, Pablo Perez-Martinez & Dimitri P. Mikhailidis. (2018) Dyslipidaemia in the elderly: to treat or not to treat?. Expert Review of Clinical Pharmacology 11:3, pages 259-278.
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Sarika G. Paradkar & Shyamal R. Sinha. (2018) Drug utilization among hypertensive patients in the outpatient department of medicine in a tertiary care hospital: A cross-sectional study. Clinical and Experimental Hypertension 40:2, pages 150-154.
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Stefano Bellosta & Alberto Corsini. (2018) Statin drug interactions and related adverse reactions: an update. Expert Opinion on Drug Safety 17:1, pages 25-37.
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Raymond Milan, Helen-Maria Vasiliadis, Samantha Gontijo Guerra & Djamal Berbiche. (2017) Out-of-pocket costs and adherence to antihypertensive agents among older adults covered by the public drug insurance plan in Quebec. Patient Preference and Adherence 11, pages 1513-1522.
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Kieran Dalton & Stephen Byrne. (2017) Role of the pharmacist in reducing healthcare costs: current insights. Integrated Pharmacy Research and Practice 6, pages 37-46.
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Amura Francesca Fog, Gunnar Kvalvaag, Knut Engedal & Jørund Straand. (2017) Drug-related problems and changes in drug utilization after medication reviews in nursing homes in Oslo, Norway. Scandinavian Journal of Primary Health Care 35:4, pages 329-335.
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Melanie M. VanDyke & Ann M. Steffen. (2017) Medication Saving Behaviors of Older Adults: Scale Developed to Assess Family Caregiver Perspectives. Clinical Gerontologist 40:4, pages 258-267.
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Diana R. Mager & Rose Iannino-Renz. (2017) Use of Sedative-Hypnotic Drugs Among Older Adults. Journal of Community Health Nursing 34:2, pages 63-68.
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Chanel F. Whittaker, Sarah E. Tom, Angel Bivens & Wendy Klein-Schwartz. (2017) Evaluation of an Educational Intervention on Knowledge and Awareness of Medication Safety in Older Adults with Low Health Literacy. American Journal of Health Education 48:2, pages 100-107.
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Jorge Enrique Machado-Alba, Andrés Gaviria-Mendoza, Manuel Enrique Machado-Duque & Laura Chica. (2017) Deprescribing: a new goal focused on the patient. Expert Opinion on Drug Safety 16:2, pages 111-112.
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Nicola Allegri, Federica Rossi, Federica Del Signore, Paolo Bertazzoni, Roberto Bellazzi, Giorgio Sandrini, Tomaso Vecchi, Davide Liccione, Alessia Pascale & Stefano Govoni. (2017) Drug prescription appropriateness in the elderly: an Italian study. Clinical Interventions in Aging 12, pages 325-333.
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Joseph Finkelstein, Carol Friedman, George Hripcsak & Manuel Cabrera. (2016) Pharmacogenetic polymorphism as an independent risk factor for frequent hospitalizations in older adults with polypharmacy: a pilot study. Pharmacogenomics and Personalized Medicine 9, pages 107-116.
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