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Expert Opinion on Drug Discovery Volume 5, 2010 - Issue 1
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Technology Evaluation

GlycoFi's technology to control the glycosylation of recombinant therapeutic proteins

Alain Beck Centre d'Immunologie Pierre Fabre, 5 Avenue Napoléon III, F74160, Saint-Julien-en-Genevois, France + 33 4 50 35 35 55; + 33 4 50 35 35 90; [email protected] ( www.cipf.com)
,
Olivier Cochet Centre d'Immunologie Pierre Fabre, 5 Avenue Napoléon III, F74160, Saint-Julien-en-Genevois, France + 33 4 50 35 35 55; + 33 4 50 35 35 90; [email protected] ( www.cipf.com)
&
Thierry Wurch Centre d'Immunologie Pierre Fabre, 5 Avenue Napoléon III, F74160, Saint-Julien-en-Genevois, France + 33 4 50 35 35 55; + 33 4 50 35 35 90; [email protected] ( www.cipf.com)
Pages 95-111 | Published online: 01 Dec 2009

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Isabelle Legastelois, Sophie Buffin, Isabelle Peubez, Charlotte Mignon, Régis Sodoyer & Bettina Werle. (2017) Non-conventional expression systems for the production of vaccine proteins and immunotherapeutic molecules. Human Vaccines & Immunotherapeutics 13:4, pages 947-961.
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Rabah Gahoual, Michaël Biacchi, Johana Chicher, Lauriane Kuhn, Philippe Hammann, Alain Beck, Emmanuelle Leize-Wagner & Yannis N François. (2014) Monoclonal antibodies biosimilarity assessment using transient isotachophoresis capillary zone electrophoresis-tandem mass spectrometry. mAbs 6:6, pages 1464-1473.
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Janice M Reichert, Alain Beck, Alexey A Lugovskoy, Thierry Wurch, Steven Coats & Randall J Brezski. (2014) 9th Annual European Antibody Congress, November 11–13, 2013, Geneva, Switzerland. mAbs 6:2, pages 309-326.
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Rabah Gahoual, Alicia Burr, Jean-Marc Busnel, Lauriane Kuhn, Phillipe Hammann, Alain Beck, Yannis-Nicolas François & Emmanuelle Leize-Wagner. (2013) Rapid and multi-level characterization of trastuzumab using sheathless capillary electrophoresis-tandem mass spectrometry. mAbs 5:3, pages 479-490.
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Alain Beck & Janice M. Reichert. (2012) Marketing approval of mogamulizumab. mAbs 4:4, pages 419-425.
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Alain Beck & Thierry Wurch. (2011) 6th Annual European Antibody Congress 2010. mAbs 3:2, pages 111-132.
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Alain Beck. (2011) Biosimilar, biobetter and next generation therapeutic antibodies. mAbs 3:2, pages 107-110.
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Alain Beck, Janice M. Reichert & Thierry Wurch. (2010) 5th European Antibody Congress 2009. mAbs 2:2, pages 108-128.
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Articles from other publishers (48)

Frances Rocamora, Angelo G. Peralta, Seunghyeon Shin, James Sorrentino, Mina Ying Min Wu, Eric A. Toth, Thomas R. Fuerst & Nathan E. Lewis. (2023) Glycosylation shapes the efficacy and safety of diverse protein, gene and cell therapies. Biotechnology Advances 67, pages 108206.
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Sachin S. Shivatare, Vidya S. Shivatare & Chi-Huey Wong. (2022) Glycoconjugates: Synthesis, Functional Studies, and Therapeutic Developments. Chemical Reviews 122:20, pages 15603-15671.
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Kris Dammen-Brower, Paige Epler, Stanley Zhu, Zachary J. Bernstein, Paul R. Stabach, Demetrios T. Braddock, Jamie B. Spangler & Kevin J. Yarema. (2022) Strategies for Glycoengineering Therapeutic Proteins. Frontiers in Chemistry 10.
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Ting Wang, Li Liu & Josef Voglmeir. (2022) mAbs N-glycosylation: Implications for biotechnology and analytics. Carbohydrate Research 514, pages 108541.
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Adelina Ivanova & Francesco Falcioni. (2022) Challenges and Opportunities for the Large-Scale Chemoenzymatic Glycoengineering of Therapeutic N-Glycosylated Monoclonal Antibodies. Frontiers in Catalysis 1.
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Ratih Ratih, Mufarreh Asmari, Ahmed M. Abdel-Megied, Fawzy Elbarbry & Sami El Deeb. (2021) Biosimilars: Review of regulatory, manufacturing, analytical aspects and beyond. Microchemical Journal 165, pages 106143.
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Asif Shajahan, Stephanie Archer-Hartmann, Nitin T Supekar, Anne S Gleinich, Christian Heiss & Parastoo Azadi. (2021) Comprehensive characterization of N- and O- glycosylation of SARS-CoV-2 human receptor angiotensin converting enzyme 2. Glycobiology 31:4, pages 410-424.
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Arnaud Delobel. 2021. Mass Spectrometry of Glycoproteins. Mass Spectrometry of Glycoproteins 1 21 .
Shengjun Wang, Yongheng Rong, Yaoguang Wang, Decai Kong, Peng George Wang, Min Chen & Yun Kong. (2020) Homogeneous production and characterization of recombinant N-GlcNAc-protein in Pichia pastoris. Microbial Cell Factories 19:1.
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Hanxiao Jiang, Andrew A. Horwitz, Chapman Wright, Anna Tai, Elizabeth A. Znameroski, Yoseph Tsegaye, Hailley Warbington, Benjamin S. Bower, Christina Alves, Carl Co, Kanvasri Jonnalagadda, Darren Platt, Jessica M. Walter, Venkatesh Natarajan, Jeffrey A. Ubersax, Joel R. Cherry & J. Christopher Love. (2019) Challenging the workhorse: Comparative analysis of eukaryotic micro‐organisms for expressing monoclonal antibodies. Biotechnology and Bioengineering 116:6, pages 1449-1462.
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Amjad Hayat Khan & Rahmah Noordin. (2018) Strategies for humanizing glycosylation pathways and producing recombinant glycoproteins in microbial expression systems. Biotechnology Progress 35:2, pages e2752.
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Kerry R Love, Neil C Dalvie & J Christopher Love. (2018) The yeast stands alone: the future of protein biologic production. Current Opinion in Biotechnology 53, pages 50-58.
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Tariq Nadeem, Mohsin Ahmad Khan, Bushra Ijaz, Nadeem Ahmed, Zia ur Rahman, Muhammad Shahzad Latif, Qurban Ali & Muhammad Adeel Rana. (2018) Glycosylation of Recombinant Anticancer Therapeutics in Different Expression Systems with Emerging Technologies. Cancer Research 78:11, pages 2787-2798.
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László Hajba, Ákos Szekrényes, Beáta Borza & András Guttman. (2018) On the glycosylation aspects of biosimilarity. Drug Discovery Today 23:3, pages 616-625.
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Chiu-Ping LiuTsung-I. Tsai, Ting ChengVidya S. ShivatareChung-Yi WuChung-Yi WuChi-Huey Wong. (2018) Glycoengineering of antibody (Herceptin) through yeast expression and in vitro enzymatic glycosylation. Proceedings of the National Academy of Sciences 115:4, pages 720-725.
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Weilai Guo, Feng Tang, Ken Qin, Mang Zhou, Zhiping Le & Wei Huang. (2017) Glycoengineering and glycosite-specific labeling of serum IgGs from various species. Carbohydrate Research 446-447, pages 32-39.
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Hiroaki AsaiHirofumi OchiaiSofia Elouali. (2017) Biopharmaceutical Discovery by Organic Synthesis. Trends in Glycoscience and Glycotechnology 29:168, pages J41-J46.
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Hiroaki AsaiHirofumi OchiaiSofia Elouali. (2017) Biopharmaceutical Discovery by Organic Synthesis. Trends in Glycoscience and Glycotechnology 29:168, pages E63-E68.
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Cheng Liu & Su Yan. 2016. Biosimilars of Monoclonal Antibodies. Biosimilars of Monoclonal Antibodies 549 563 .
Maria Kristina Parr, Othman Montacir & Houda Montacir. (2016) Physicochemical characterization of biopharmaceuticals. Journal of Pharmaceutical and Biomedical Analysis 130, pages 366-389.
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Fabian Higel, Andreas Seidl, Fritz Sörgel & Wolfgang Friess. (2016) N-glycosylation heterogeneity and the influence on structure, function and pharmacokinetics of monoclonal antibodies and Fc fusion proteins. European Journal of Pharmaceutics and Biopharmaceutics 100, pages 94-100.
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Feng Tang, Yang Yang, Yubo Tang, Shuai Tang, Liyun Yang, Bingyang Sun, Bofeng Jiang, Jinhua Dong, Hong Liu, Min Huang, Mei-Yu Geng & Wei Huang. (2016) One-pot N-glycosylation remodeling of IgG with non-natural sialylglycopeptides enables glycosite-specific and dual-payload antibody–drug conjugates. Organic & Biomolecular Chemistry 14:40, pages 9501-9518.
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Liming Liu. (2015) Antibody Glycosylation and Its Impact on the Pharmacokinetics and Pharmacodynamics of Monoclonal Antibodies and Fc-Fusion Proteins. Journal of Pharmaceutical Sciences 104:6, pages 1866-1884.
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Alain Beck, François Debaene, Hélène Diemer, Elsa Wagner-Rousset, Olivier Colas, Alain Van Dorsselaer & Sarah Cianférani. (2015) Cutting-edge mass spectrometry characterization of originator, biosimilar and biobetter antibodies. Journal of Mass Spectrometry 50:2, pages 285-297.
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Bo Jiang, Rebecca Argyros, John Bukowski, Stephanie Nelson, Nathan Sharkey, Sehoon Kim, Victoria Copeland, Robert C. Davidson, Ronghua Chen, Jun Zhuang, Natarajan Sethuraman & Terrance A. Stadheim. (2015) Inactivation of a GAL4 -Like Transcription Factor Improves Cell Fitness and Product Yield in Glycoengineered Pichia pastoris Strains . Applied and Environmental Microbiology 81:1, pages 260-271.
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Balakrishnan S. Moorthy, Bo Xie, Ehab M. Moussa, Lavanya K. Iyer, Saradha Chandrasekhar, Jainik P. Panchal & Elizabeth M. Topp. 2015. Biobetters. Biobetters 105 135 .
Michael A Meehl & Terrance A Stadheim. (2014) Biopharmaceutical discovery and production in yeast. Current Opinion in Biotechnology 30, pages 120-127.
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Andriy Sibirny, Catherine Madzak & Patrick Fickers. 2014. Microbial Biotechnology. Microbial Biotechnology 63 112 .
Tadashi Ueda. (2014) Next-generation optimized biotherapeutics — A review and preclinical study. Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics 1844:11, pages 2053-2057.
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Marjorie A. Shapiro, Patrick G. Swann & M. Stacey Ricci. 2014. Handbook of Therapeutic Antibodies. Handbook of Therapeutic Antibodies 1231 1262 .
Alexander Jacobi, Barbara Enenkel, Patrick Garidel, Christian Eckermann, Mathias Knappenberger, Ingo Presser & Hitto Kaufmann. 2014. Handbook of Therapeutic Antibodies. Handbook of Therapeutic Antibodies 601 664 .
Sita Awasthi, John W. Balliet, Jessica A. Flynn, John M. Lubinski, Carolyn E. Shaw, Daniel J. DiStefano, Michael Cai, Martha Brown, Judith F. Smith, Rose Kowalski, Ryan Swoyer, Jennifer Galli, Victoria Copeland, Sandra Rios, Robert C. Davidson, Maya Salnikova, Susan Kingsley, Janine Bryan, Danilo R. Casimiro & Harvey M. Friedman. (2014) Protection Provided by a Herpes Simplex Virus 2 (HSV-2) Glycoprotein C and D Subunit Antigen Vaccine against Genital HSV-2 Infection in HSV-1-Seropositive Guinea Pigs. Journal of Virology 88:4, pages 2000-2010.
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Pradeep K. Dhal, Steven C. Polomoscanik, Diego A. Gianolio, Patrick G. Starremans, Michelle Busch, Kim Alving, Bo Chen & Robert J. Miller. (2013) Well-Defined Aminooxy Terminated N -(2-Hydroxypropyl) Methacrylamide Macromers for Site Specific Bioconjugation of Glycoproteins . Bioconjugate Chemistry 24:6, pages 865-877.
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Alain Beck, Elsa Wagner-Rousset, Daniel Ayoub, Alain Van Dorsselaer & Sarah Sanglier-Cianférani. (2012) Characterization of Therapeutic Antibodies and Related Products. Analytical Chemistry 85:2, pages 715-736.
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Marie-Claire Janin-Bussat, Laure Tonini, Céline Huillet, Olivier Colas, Christine Klinguer-Hamour, Nathalie Corvaïa & Alain Beck. 2013. Glycosylation Engineering of Biopharmaceuticals. Glycosylation Engineering of Biopharmaceuticals 93 113 .
. 2012. Pharmaceutical Formulation Development of Peptides and Proteins. Pharmaceutical Formulation Development of Peptides and Proteins 30 47 .
Lars Hovgaard, Sven Frokjaer & Marco van de WeertNanni Din. 2012. Pharmaceutical Formulation Development of Peptides and Proteins, Second Edition. Pharmaceutical Formulation Development of Peptides and Proteins, Second Edition 17 34 .
Thomas A. Bowden, Kavitha Baruah, Charlotte H. Coles, David J. Harvey, Xiaojie Yu, Byeong-Doo Song, David I. Stuart, A. Radu Aricescu, Christopher N. Scanlan, E. Yvonne Jones & Max Crispin. (2012) Chemical and Structural Analysis of an Antibody Folding Intermediate Trapped during Glycan Biosynthesis. Journal of the American Chemical Society 134:42, pages 17554-17563.
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M. Jack Borrok, Sang Taek Jung, Tae Hyun Kang, Arthur F. Monzingo & George Georgiou. (2012) Revisiting the Role of Glycosylation in the Structure of Human IgG Fc. ACS Chemical Biology 7:9, pages 1596-1602.
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Thomayant Prueksaritanont & Cuyue Tang. (2012) ADME of Biologics—What Have We Learned from Small Molecules?. The AAPS Journal 14:3, pages 410-419.
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Alain Beck, Sarah Sanglier-Cianférani & Alain Van Dorsselaer. (2012) Biosimilar, Biobetter, and Next Generation Antibody Characterization by Mass Spectrometry. Analytical Chemistry 84:11, pages 4637-4646.
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Nigel F. Reuel, Bin Mu, Jingqing Zhang, Allison Hinckley & Michael S. Strano. (2012) Nanoengineered glycan sensors enabling native glycoprofiling for medicinal applications: towards profiling glycoproteins without labeling or liberation steps. Chemical Society Reviews 41:17, pages 5744.
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Francisco Valero. 2012. Lipases and Phospholipases. Lipases and Phospholipases 161 178 .
M. Crispin, C.N. Scanlan & T.A. Bowden. 2011. Comprehensive Biotechnology. Comprehensive Biotechnology 51 68 .
M. Crispin, C.N. Scanlan & T.A. Bowden. 2011. Comprehensive Biotechnology. Comprehensive Biotechnology 73 90 .
Dongxing Zha, Thomas Linden & Thomas Potgieter. 2011. Antibody Expression and Production. Antibody Expression and Production 77 98 .
Alain Beck, Thierry Wurch, Christian Bailly & Nathalie Corvaia. (2010) Strategies and challenges for the next generation of therapeutic antibodies. Nature Reviews Immunology 10:5, pages 345-352.
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Alain Beck, Elsa Wagner-Rousset, Thierry Wurch & Nathalie Corvaia. (2009) Anticorps thérapeutiques et dérivés : une palette de structures pour une pléthore d’indications. médecine/sciences 25:12, pages 1024-1032.
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