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Expert Review of Vaccines Volume 2, 2003 - Issue 2
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Review

Development of a leishmaniasis vaccine: the importance of MPL

Steven G Reed Corixa Corporation, 1124 Columbia Street, Suite 200, Seattle, WA, USA & Infectious Disease Research Institute, 1124 Columbia Street, Suite 600, Seattle, WA, USA
,
Rhea N Coler Infectious Disease Research Institute, 1124 Columbia Street, Suite 600, Seattle, WA, USA
&
Antonio Campos-Neto Infectious Disease Research Institute, 1124 Columbia Street, Suite 600, Seattle, WA, USA
Pages 239-252 | Published online: 09 Jan 2014

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Tara Emami, Seyed Mahdi Rezayat, Ali Khamesipour, Rasool Madani, Gholamreza Habibi, Mansure Hojatizade & Mahmoud Reza Jaafari. (2018) The role of MPL and imiquimod adjuvants in enhancement of immune response and protection in BALB/c mice immunized with soluble Leishmania antigen (SLA) encapsulated in nanoliposome. Artificial Cells, Nanomedicine, and Biotechnology 46:sup2, pages 324-333.
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Delaram Doroud & Sima Rafati. (2012) Leishmaniasis: focus on the design of nanoparticulate vaccine delivery systems. Expert Review of Vaccines 11:1, pages 69-86.
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Shumaila Naz, Aiman Aroosh, Ayse Caner, Esra Atalay Şahar, Seray Toz, Yusuf Ozbel & Sumra Wajid Abbasi. (2023) Immunoinformatics Approach to Design a Multi-Epitope Vaccine against Cutaneous Leishmaniasis. Vaccines 11:2, pages 339.
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Marianna de Carvalho Clímaco, Lucas Kraemer & Ricardo Toshio Fujiwara. 2023. Vaccines for Neglected Pathogens: Strategies, Achievements and Challenges. Vaccines for Neglected Pathogens: Strategies, Achievements and Challenges 307 326 .
Pejman Hashemzadeh, Vajihe Ghorbanzadeh, Hamed Esmaeil Lashgarian, Farnaz Kheirandish & Hassan Dariushnejad. (2019) Harnessing Bioinformatic Approaches to Design Novel Multi-epitope Subunit Vaccine Against Leishmania infantum. International Journal of Peptide Research and Therapeutics 26:3, pages 1417-1428.
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Rory Brito, Frederico Guimarães, João Velloso, Rodrigo Corrêa-Oliveira, Jeronimo Ruiz, Alexandre Reis & Daniela Resende. (2017) Immunoinformatics Features Linked to Leishmania Vaccine Development: Data Integration of Experimental and In Silico Studies. International Journal of Molecular Sciences 18:2, pages 371.
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Alice Halliday, Joseph D. Turner, Ana Guimarães, Paul A. Bates & Mark J. Taylor. (2016) The TLR2/6 ligand PAM2CSK4 is a Th2 polarizing adjuvant in Leishmania major and Brugia malayi murine vaccine models. Parasites & Vectors 9:1.
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Mariana Costa Duarte, Daniela Pagliara Lage, Vívian Tamietti Martins, Miguel Angel Chávez-Fumagalli, Bruno Mendes Roatt, Daniel Menezes-Souza, Luiz Ricardo Goulart, Manuel Soto, Carlos Alberto Pereira Tavares & Eduardo Antonio Ferraz Coelho. (2016) Recent updates and perspectives on approaches for the development of vaccines against visceral leishmaniasis. Revista da Sociedade Brasileira de Medicina Tropical 49:4, pages 398-407.
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Rosa M. Reguera, Miguel Morán, Yolanda Pérez-Pertejo, Carlos García-Estrada & Rafael Balaña-Fouce. (2016) Current status on prevention and treatment of canine leishmaniasis. Veterinary Parasitology 227, pages 98-114.
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Tahereh Taheri & Sima Rafati. (2013) Leishmaniasis: recombinant DNA vaccination and different approaches for vaccine development. Clinical Investigation 3:11, pages 1023-1044.
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Jorge Alvar, Simon L. Croft, Paul Kaye, Ali Khamesipour, Shyam Sundar & Steven G. Reed. (2013) Case study for a vaccine against leishmaniasis. Vaccine 31, pages B244-B249.
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Shyam Sundar & Jaya Chakravarty. 2013. Challenges in Infectious Diseases. Challenges in Infectious Diseases 247 264 .
A. Adhikari, S. Majumder, S. Banerjee, G. Gupta, P. Bhattacharya, S. B. Majumdar, B. Saha & S. Majumdar. (2012) Mycobacterium indicus pranii (Mw)-mediated protection against visceral leishmaniasis: involvement of TLR4 signalling. Journal of Antimicrobial Chemotherapy 67:12, pages 2892-2902.
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Yasuyuki Goto & Steven G. Reed. 2012. Immunity to Parasitic Infection. Immunity to Parasitic Infection 431 440 .
Ana Paula Fernandes, Eduardo Antonio Ferraz Coelho, George Luiz Lins Machado-Coelho, Gabriel GrimaldiJuniorJunior & Ricardo Tostes Gazzinelli. (2012) Making an anti-amastigote vaccine for visceral leishmaniasis: rational, update and perspectives. Current Opinion in Microbiology 15:4, pages 476-485.
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S. S. KASHINO, C. ABEIJON, L. QIN, K. A. KANUNFRE, F. S. KUBRUSLY, F. O. SILVA, D. L. COSTA, D. CAMPOSJRJR, C. H. N. COSTA, I. RAW & A. CAMPOS‐NETO. (2012) Identification of Leishmania infantum chagasi proteins in urine of patients with visceral leishmaniasis: a promising antigen discovery approach of vaccine candidates . Parasite Immunology 34:7, pages 360-371.
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Nada S. Daifalla, Abebe Genetu Bayih & Lashitew Gedamu. (2012) Leishmania donovani recombinant iron superoxide dismutase B1 protein in the presence of TLR-based adjuvants induces partial protection of BALB/c mice against Leishmania major infection. Experimental Parasitology 131:3, pages 317-324.
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Joshua M. Mutiso, John C. Macharia, Evans Taracha, Kellern Wafula, Hitler Rikoi & Michael M. Gicheru. (2012) Safety and skin delayed-type hypersensitivity response in vervet monkeys immunized with Leishmania donovani sonicate antigen delivered with adjuvants. Revista do Instituto de Medicina Tropical de São Paulo 54:1, pages 37-41.
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Joshua Muli Mutiso, John Chege Macharia, Evans Taracha & Michael Muita Gicheru. (2012) Leishmania donovani whole cell antigen delivered with adjuvants protects against visceral leishmaniasis in vervet monkeys (Chlorocebus aethiops). Journal of Biomedical Research 26:1, pages 8-16.
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Nada S. Daifalla, A. Genetu Bayih & Lashitew Gedamu. (2011) Immunogenicity of Leishmania donovani iron superoxide dismutase B1 and peroxidoxin 4 in BALB/c mice: The contribution of Toll-like receptor agonists as adjuvant. Experimental Parasitology 129:3, pages 292-298.
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Jaya Chakravarty, Subodh Kumar, Sonali Trivedi, Vijay K. Rai, Anup Singh, Jill A. Ashman, Elsa M. Laughlin, Rhea N. Coler, Stuart J. Kahn, Anna Marie Beckmann, Karen D. Cowgill, Steven G. Reed, Shyam Sundar & Franco M. Piazza. (2011) A clinical trial to evaluate the safety and immunogenicity of the LEISH-F1+MPL-SE vaccine for use in the prevention of visceral leishmaniasis. Vaccine 29:19, pages 3531-3537.
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Malcolm S. Duthie, Hillarie Plessner Windish, Christopher B. Fox & Steven G. Reed. (2011) Use of defined TLR ligands as adjuvants within human vaccines. Immunological Reviews 239:1, pages 178-196.
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Jeffrey M. Bethony, Rhea N. Cole, Xiaoti Guo, Shaden Kamhawi, Marshall W. Lightowlers, Alex Loukas, William Petri, Steven Reed, Jesus G. Valenzuela & Peter J. Hotez. (2011) Vaccines to combat the neglected tropical diseases. Immunological Reviews 239:1, pages 237-270.
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Vanitha S. Raman, Ajay Bhatia, Alex Picone, Jacqueline Whittle, Hilton R. Bailor, Joanne O’Donnell, Sowmya Pattabhi, Jeffrey A. Guderian, Raodoh Mohamath, Malcolm S. Duthie & Steven G. Reed. (2010) Applying TLR Synergy in Immunotherapy: Implications in Cutaneous Leishmaniasis. The Journal of Immunology 185:3, pages 1701-1710.
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Joelma Trigo, Melissa Abbehusen, Eduardo M. Netto, Maria Nakatani, Geraldo Pedral-Sampaio, Robson Silva de Jesus, Yasuyuki Goto, Jeffrey Guderian, Randall F. Howard & Steven G. Reed. (2010) Treatment of canine visceral leishmaniasis by the vaccine Leish-111f+MPL-SE. Vaccine 28:19, pages 3333-3340.
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Vanitha S. Raman, Joanne O'Donnell, H. Remy Bailor, Wakako Goto, Ramanuj Lahiri, Thomas P. Gillis, Steven G. Reed & Malcolm S. Duthie. (2009) Vaccination with the ML0276 Antigen Reduces Local Inflammation but Not Bacterial Burden during Experimental M ycobacterium leprae Infection . Infection and Immunity 77:12, pages 5623-5630.
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Iván D. Vélez, Katherine Gilchrist, Sofía Martínez, José R. Ramírez-Pineda, Jill A. Ashman, Fabiana P. Alves, Rhea N. Coler, Lisa Y. Bogatzki, Stuart J. Kahn, Anna Marie Beckmann, Karen D. Cowgill, Steven G. Reed & Franco M. Piazza. (2009) Safety and immunogenicity of a defined vaccine for the prevention of cutaneous leishmaniasis. Vaccine 28:2, pages 329-337.
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Steven G. Reed, Sylvie Bertholet, Rhea N. Coler & Martin Friede. (2009) New horizons in adjuvants for vaccine development. Trends in Immunology 30:1, pages 23-32.
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Suvercha Bhardwaj, R.K. Vasishta & Sunil K. Arora. (2009) Vaccination with a novel recombinant Leishmania antigen plus MPL provides partial protection against L. donovani challenge in experimental model of visceral leishmaniasis. Experimental Parasitology 121:1, pages 29-37.
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Parul Tripathi, Vinod Singh & Sita Naik. (2007) Immune response to leishmania: paradox rather than paradigm. FEMS Immunology & Medical Microbiology 51:2, pages 229-242.
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François Chappuis, Shyam Sundar, Asrat Hailu, Hashim Ghalib, Suman Rijal, Rosanna W. Peeling, Jorge Alvar & Marleen Boelaert. (2007) Visceral leishmaniasis: what are the needs for diagnosis, treatment and control?. Nature Reviews Microbiology 5:S11, pages S7-S16.
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François Chappuis, Shyam Sundar, Asrat Hailu, Hashim Ghalib, Suman Rijal, Rosanna W. Peeling, Jorge Alvar & Marleen Boelaert. (2007) Visceral leishmaniasis: what are the needs for diagnosis, treatment and control?. Nature Reviews Microbiology 5:11, pages 873-882.
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G. Salay, M. L. Dorta, N. M. Santos, R. A. Mortara, C. Brodskyn, C. I. Oliveira, C. L. Barbiéri & M. M. Rodrigues. (2007) Testing of Four Leishmania Vaccine Candidates in a Mouse Model of Infection with Leishmania ( Viannia ) braziliensis , the Main Causative Agent of Cutaneous Leishmaniasis in the New World . Clinical and Vaccine Immunology 14:9, pages 1173-1181.
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Jeroen Geurtsen, H. Alexander Banus, Eric R. Gremmer, Henke Ferguson, Liset J. J. de la Fonteyne-Blankestijn, Jolanda P. Vermeulen, Jan A. M. A. Dormans, Jan Tommassen, Peter van der Ley, Frits R. Mooi & Rob J. Vandebriel. (2007) Lipopolysaccharide Analogs Improve Efficacy of Acellular Pertussis Vaccine and Reduce Type I Hypersensitivity in Mice. Clinical and Vaccine Immunology 14:7, pages 821-829.
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L. KEDZIERSKI, Y. ZHU & E. HANDMAN. (2007) Leishmania vaccines: progress and problems . Parasitology 133:S2, pages S87-S112.
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Reginaldo B. Gonçalves, Onir Leshem, Karen Bernards, John R. Webb, Philip P. Stashenko & Antonio Campos-Neto. (2006) T-Cell Expression Cloning of Porphyromonas gingivalis Genes Coding for T Helper-Biased Immune Responses during Infection . Infection and Immunity 74:7, pages 3958-3966.
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Sandeep Mukherjee, Suely S. Kashino, Yanni Zhang, Nada Daifalla, Virmondes RodriguesJrJr, Steven G. Reed & Antonio Campos-Neto. (2005) Cloning of the Gene Encoding a Protective Mycobacterium tuberculosis Secreted Protein Detected In Vivo during the Initial Phases of the Infectious Process . The Journal of Immunology 175:8, pages 5298-5305.
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A. Campos-Neto. (2005) What about Th1/Th2 in cutaneous leishmaniasis vaccine discovery?. Brazilian Journal of Medical and Biological Research 38:7, pages 979-984.
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Jianmin Xue, Chiung-Yu Hung, Jieh-Juen Yu & Garry T. Cole. (2005) Immune response of vaccinated and non-vaccinated mice to Coccidioides posadasii infection. Vaccine 23:27, pages 3535-3544.
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M. Fraize, M. E. Sarciron, S. Azzouz, N. Issaadi, G. Bosquet & A. F. Petavy. (2005) Immunogenicity of two Echinococcus granulosus antigens EgA31 and EgTrp in mice. Parasitology Research 96:2, pages 113-120.
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N. Robert Bergquist, Lydia R. Leonardo & Graham F. Mitchell. (2005) Vaccine-linked chemotherapy: can schistosomiasis control benefit from an integrated approach?. Trends in Parasitology 21:3, pages 112-117.
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Sergio de Almeida Basano & Luís Marcelo Aranha Camargo. (2004) Leishmaniose tegumentar americana: histórico, epidemiologia e perspectivas de controle. Revista Brasileira de Epidemiologia 7:3, pages 328-337.
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Uta G. Lange, Pietro Mastroeni, Jenefer M. Blackwell & Carmel B. Stober. (2004) DNA- Salmonella enterica Serovar Typhimurium Primer-Booster Vaccination Biases towards T Helper 1 Responses and Enhances Protection against Leishmania major Infection in Mice . Infection and Immunity 72:8, pages 4924-4928.
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Hubert Denise, Graham H. Coombs & Jeremy C. Mottram. (2004) Generation of Leishmania mutants lacking antibiotic resistance genes using a versatile hit-and-run targeting strategy . FEMS Microbiology Letters 235:1, pages 89-94.
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