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Review

Recent clinical experience with vaccines using MPL- and QS-21-containing Adjuvant Systems

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Pages 471-486 | Published online: 09 Jan 2014

Keep up to date with the latest research on this topic with citation updates for this article.

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Dylan A. Hendy, Alex Haven, Eric M. Bachelder & Kristy M. Ainslie. (2023) Preclinical developments in the delivery of protein antigens for vaccination. Expert Opinion on Drug Delivery 20:3, pages 367-384.
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Chengkai Zhou, Zhuojia Xu, Gen Li, Qi Gao, Qiang Sui & Tiehai Li. (2021) Efficient synthesis of monophosphoryl lipid A mimetic RC-529. Journal of Carbohydrate Chemistry 40:7-9, pages 501-517.
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G. G. Guerrero Manriquez & I. Tuero. (2021) Adjuvants: friends in vaccine formulations against infectious diseases. Human Vaccines & Immunotherapeutics 17:10, pages 3539-3550.
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Rui Yu, Yaping Mai, Yue Zhao, Yanhui Hou, Yanhua Liu & Jianhong Yang. (2019) Targeting strategies of liposomal subunit vaccine delivery systems to improve vaccine efficacy. Journal of Drug Targeting 27:7, pages 780-789.
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Nicolas Lecrenier, Pierre Beukelaers, Romulo Colindres, Desmond Curran, Carine De Kesel, Jean-Philippe De Saegher, Arnaud M Didierlaurent, Edouard Y Ledent, Johann F Mols, Tomas Mrkvan, Marie Normand-Bayle, Lidia Oostvogels, Fernanda Tavares Da Silva, Ventzislav Vassilev, Carlota Vinals & Alain Brecx. (2018) Development of adjuvanted recombinant zoster vaccine and its implications for shingles prevention. Expert Review of Vaccines 17:7, pages 619-634.
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Tino F. Schwarz, Stephanie Volpe, Gregory Catteau, Roman Chlibek, Marie Pierre David, Jan Hendrik Richardus, Himal Lal, Lidia Oostvogels, Karlis Pauksens, Stephanie Ravault, Lars Rombo, Gerard Sonder, Jan Smetana, Thomas Heineman & Adriana Bastidas. (2018) Persistence of immune response to an adjuvanted varicella-zoster virus subunit vaccine for up to year nine in older adults. Human Vaccines & Immunotherapeutics 14:6, pages 1370-1377.
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Philippe Moris, Erik Jongert & Robbert G. van der Most. (2018) Characterization of T-cell immune responses in clinical trials of the candidate RTS,S malaria vaccine. Human Vaccines & Immunotherapeutics 14:1, pages 17-27.
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Ruonan Bo, Yaqin Sun, Shuzhen Zhou, Ning Ou, Pengfei Gu, Zhenguang Liu, Yuanliang Hu, Jiaguo Liu & Deyun Wang. (2017) Simple nanoliposomes encapsulating Lycium barbarum polysaccharides as adjuvants improve humoral and cellular immunity in mice. International Journal of Nanomedicine 12, pages 6289-6301.
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Yahua Lin, Xin Wang, Xiaofen Huang, Jun Zhang, Ningshao Xia & Qinjian Zhao. (2017) Calcium phosphate nanoparticles as a new generation vaccine adjuvant. Expert Review of Vaccines 16:9, pages 895-906.
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Anthony L. Cunningham & Thomas Heineman. (2017) Vaccine profile of herpes zoster (HZ/su) subunit vaccine. Expert Review of Vaccines 16:7, pages 661-670.
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Olivier Godeaux, Martina Kovac, Daniel Shu, Katrijn Grupping, Laura Campora, Martine Douha, Thomas C. Heineman & Himal Lal. (2017) Immunogenicity and safety of an adjuvanted herpes zoster subunit candidate vaccine in adults ≥ 50 years of age with a prior history of herpes zoster: A phase III, non-randomized, open-label clinical trial. Human Vaccines & Immunotherapeutics 13:5, pages 1051-1058.
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Peter Vink, Masanari Shiramoto, Masayuki Ogawa, Masahiro Eda, Martine Douha, Thomas Heineman & Himal Lal. (2017) Safety and immunogenicity of a Herpes Zoster subunit vaccine in Japanese population aged ≥50 years when administered subcutaneously vs. intramuscularly. Human Vaccines & Immunotherapeutics 13:3, pages 574-578.
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Nathalie Garçon & Alberta Di Pasquale. (2017) From discovery to licensure, the Adjuvant System story. Human Vaccines & Immunotherapeutics 13:1, pages 19-33.
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Arnaud M. Didierlaurent, Béatrice Laupèze, Alberta Di Pasquale, Nadia Hergli, Catherine Collignon & Nathalie Garçon. (2017) Adjuvant system AS01: helping to overcome the challenges of modern vaccines. Expert Review of Vaccines 16:1, pages 55-63.
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Michel Fochesato, Najoua Dendouga & Mathieu Boxus. (2016) Comparative preclinical evaluation of AS01 versus other Adjuvant Systems in a candidate herpes zoster glycoprotein E subunit vaccine . Human Vaccines & Immunotherapeutics 12:8, pages 2092-2095.
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Carl R. Alving, Zoltan Beck, Gary R. Matyas & Mangala Rao. (2016) Liposomal adjuvants for human vaccines. Expert Opinion on Drug Delivery 13:6, pages 807-816.
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Adebayo J. Molehin, Juan U. Rojo, Sabrina Z. Siddiqui, Sean A. Gray, Darrick Carter & Afzal A. Siddiqui. (2016) Development of a schistosomiasis vaccine. Expert Review of Vaccines 15:5, pages 619-627.
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Masaud Shah, Muhammad Ayaz Anwar, Jae-Ho Kim & Sangdun Choi. (2016) Advances in Antiviral Therapies Targeting Toll-like Receptors. Expert Opinion on Investigational Drugs 25:4, pages 437-453.
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Anthony L. Cunningham. (2016) The herpes zoster subunit vaccine. Expert Opinion on Biological Therapy 16:2, pages 265-271.
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Jing Hu, Liying Qiu, Xiaoli Wang, Xiaopeng Zou, Mengji Lu & Jian Yin. (2015) Carbohydrate-based vaccine adjuvants – discovery and development. Expert Opinion on Drug Discovery 10:10, pages 1133-1144.
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Melissa Santone, Susanna Aprea, Tom Y H Wu, Michael P Cooke, M Lamine Mbow, Nicholas M Valiante, James S Rush, Stephanie Dougan, Ana Avalos, Hidde Ploegh, Ennio De Gregorio, Cecilia Buonsanti & Ugo D'Oro. (2015) A new TLR2 agonist promotes cross-presentation by mouse and human antigen presenting cells. Human Vaccines & Immunotherapeutics 11:8, pages 2038-2050.
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Afshin Zariri & Peter van der Ley. (2015) Biosynthetically engineered lipopolysaccharide as vaccine adjuvant. Expert Review of Vaccines 14:6, pages 861-876.
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Abid H. Banday, Salika Jeelani & Victor J. Hruby. (2015) Cancer vaccine adjuvants – recent clinical progress and future perspectives. Immunopharmacology and Immunotoxicology 37:1, pages 1-11.
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Tessa Moses, Kalliope K. Papadopoulou & Anne Osbourn. (2014) Metabolic and functional diversity of saponins, biosynthetic intermediates and semi-synthetic derivatives. Critical Reviews in Biochemistry and Molecular Biology 49:6, pages 439-462.
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Geert Leroux-Roels, Isabel Leroux-Roels, Frédéric Clement, Opokua Ofori-Anyinam, Marc Lievens, Erik Jongert, Philippe Moris, W Ripley Ballou & Joe Cohen. (2014) Evaluation of the immune response to RTS,S/AS01 and RTS,S/AS02 adjuvanted vaccines. Human Vaccines & Immunotherapeutics 10:8, pages 2211-2219.
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Elham Mohit, Atieh Hashemi & Mojgan Allahyari. (2014) Breast cancer immunotherapy: monoclonal antibodies and peptide-based vaccines. Expert Review of Clinical Immunology 10:7, pages 927-961.
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Himal Lal, Toufik Zahaf & Thomas Heineman. (2013) Safety and immunogenicity of an AS01-adjuvanted varicella zoster virus subunit candidate vaccine (HZ/su). Human Vaccines & Immunotherapeutics 9:7, pages 1425-1429.
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Christopher B Fox & Jean Haensler. (2013) An update on safety and immunogenicity of vaccines containing emulsion-based adjuvants. Expert Review of Vaccines 12:7, pages 747-758.
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Jessica C. Dong & Gary P. Kobinger. (2013) Hypothesis driven development of new adjuvants. Human Vaccines & Immunotherapeutics 9:4, pages 808-811.
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Swapan K Ghosh & Roshni Roy Chowdhury. (2013) Synthetic adjuvants for vaccine formulations: phytol derivatives. Expert Opinion on Drug Delivery 10:4, pages 437-450.
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Aiala Salvador, Rosa M Hernández, José Luis Pedraz & Manoli Igartua. (2012) Plasmodium falciparum malaria vaccines: current status, pitfalls and future directions. Expert Review of Vaccines 11:9, pages 1071-1086.
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Carl R Alving, Mangala Rao, Nicholas J Steers, Gary R Matyas & Alexander V Mayorov. (2012) Liposomes containing lipid A: an effective, safe, generic adjuvant system for synthetic vaccines. Expert Review of Vaccines 11:6, pages 733-744.
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Joseph U Igietseme, Francis O Eko & Carolyn M Black. (2011) Chlamydia vaccines: recent developments and the role of adjuvants in future formulations. Expert Review of Vaccines 10:11, pages 1585-1596.
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Arnaud M. Didierlaurent, Catherine Collignon, Patricia Bourguignon, Sandrine Wouters, Kaat Fierens, Michel Fochesato, Najoua Dendouga, Christelle Langlet, Bernard Malissen, Bart N. Lambrecht, Nathalie Garçon, Marcelle Van Mechelen & Sandra Morel. (2014) Enhancement of Adaptive Immunity by the Human Vaccine Adjuvant AS01 Depends on Activated Dendritic Cells. The Journal of Immunology 193:4, pages 1920-1930.
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Jean-Louis Excler, Julie Ake, Merlin L. Robb, Jerome H. Kim & Stanley A. Plotkin. (2014) Nonneutralizing Functional Antibodies: a New “Old” Paradigm for HIV Vaccines. Clinical and Vaccine Immunology 21:8, pages 1023-1036.
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