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Original Research

LABA/LAMA combinations versus LAMA monotherapy or LABA/ICS in COPD: a systematic review and meta-analysis

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Pages 907-922 | Published online: 17 Mar 2017

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Ying Lan, Nan Yang, Yirong Wang, Yan Yang, Min Xu & Qin He. (2023) Cost-Effectiveness Analysis of Fixed-Dose Tiotropium/Olodaterol versus Tiotropium for COPD Patients in China. International Journal of Chronic Obstructive Pulmonary Disease 18, pages 2093-2103.
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Alexandrosz Czira, Gema Requena, Victoria Banks, Robert Wood, Theo Tritton, Catherine M Castillo, Jie Yeap, Rosie Wild, Chris Compton, Kieran J Rothnie, Felix Herth, Jennifer K Quint & Afisi S Ismaila. (2023) Comparative Effectiveness of Umeclidinium/Vilanterol versus Inhaled Corticosteroid/Long-Acting β2-Agonist in Patients with Chronic Obstructive Pulmonary Disease in a Primary Care Setting in England. International Journal of Chronic Obstructive Pulmonary Disease 18, pages 643-659.
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Ji Won Park, Yoonki Hong, Chin Kook Rhee, Hye Sook Choi, Kyungjoo Kim, Kwang Ha Yoo, Ki-Suck Jung & Joo Hun Park. (2023) The Impact of Inhaled Corticosteroids on the Prognosis of Chronic Obstructive Pulmonary Disease. International Journal of Chronic Obstructive Pulmonary Disease 18, pages 733-743.
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Qing Song, Ling Lin, Aiyuan Zhou, Wei Cheng, Cong Liu, Yating Peng, Zijing Zhou, Yuqin Zeng, Dingding Deng, Dan Liu, Zhiping Yu, Yan Chen, Shan Cai & Ping Chen. (2023) The effects of different inhalation therapies on less symptomatic chronic obstructive pulmonary disease patients in a Chinese population: a real-world study. Annals of Medicine 55:1, pages 1317-1324.
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Yanling Ding, Lina Sun, Ying Wang, Jing Zhang & Yahong Chen. (2022) Efficacy of ICS versus Non-ICS Combination Therapy in COPD: A Meta-Analysis of Randomised Controlled Trials. International Journal of Chronic Obstructive Pulmonary Disease 17, pages 1051-1067.
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Soham Shukla, Dhvani Shah, Alan Martin, Nancy A Risebrough, Robyn Kendall, Claus F Vogelmeier, Isabelle Boucot, Lee Tombs, Leif Bjermer, Paul W Jones, Edward Kerwin, Chris Compton, François Maltais, David A Lipson & Afisi S Ismaila. (2021) Economic Evaluation of Umeclidinium/Vilanterol versus Umeclidinium or Salmeterol in Symptomatic Non-Exacerbating Patients with COPD from a UK Perspective Using the GALAXY Model. International Journal of Chronic Obstructive Pulmonary Disease 16, pages 3105-3118.
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Arschang Valipour, Sergey Avdeev, Adam Barczyk, Valentina Bayer, Zvi Fridlender, Mariela Georgieva, Ondřej Kudela, Alexey Medvedchikov, Ramona Miron, Maria Sanzharovskaya, Virginija Šileikienė, Jurij Šorli, Marc Spielmanns & Zsuzsanna Szalai. (2021) Therapeutic Success of Tiotropium/Olodaterol, Measured Using the Clinical COPD Questionnaire (CCQ), in Routine Clinical Practice: A Multinational Non-Interventional Study. International Journal of Chronic Obstructive Pulmonary Disease 16, pages 615-628.
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Leif Bjermer, Isabelle H Boucot, François Maltais, Edward M Kerwin, Ian P Naya, Lee Tombs, Paul W Jones, Chris Compton, David A Lipson & Claus F Vogelmeier. (2021) Dual Bronchodilator Therapy as First-Line Treatment in Maintenance-Naïve Patients with Symptomatic COPD: A Pre-Specified Analysis of the EMAX Trial. International Journal of Chronic Obstructive Pulmonary Disease 16, pages 1939-1956.
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Anthony D. D’Urzo, Dave Singh, James F. Donohue, Kenneth R. Chapman & Robert A. Wise. (2021) Aclidinium bromide/formoterol fumarate as a treatment for COPD: an update. Expert Review of Respiratory Medicine 15:9, pages 1093-1106.
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Gerard Criner & Sean Duffy. (2021) Reducing and managing chronic obstructive pulmonary disease exacerbations with tiotropium + olodaterol. Current Medical Research and Opinion 37:2, pages 275-284.
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Carlos Cabrera López, Enrique Mascarós, Angel Azpeitia & Elena Villarrubia. (2020) A Simplified Algorithm for the Diagnosis, Treatment, and Management of COPD in Routine Primary Care Practice. International Journal of Chronic Obstructive Pulmonary Disease 15, pages 3347-3355.
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Chad Moretz, Beth Hahn, John White, Alyssa Goolsby Hunter, Breanna Essoi, Caitlin Elliott & Riju Ray. (2020) Symptom Burden and GOLD Classification in Medicare Advantage Patients with COPD Initiating Umeclidinium/Vilanterol or Fluticasone Propionate/Salmeterol Therapy. International Journal of Chronic Obstructive Pulmonary Disease 15, pages 2715-2725.
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Chad Moretz, Ashley L Cole, George Mu, Benjamin Wu, Amy Guisinger, Yunhao Liu, Beth Hahn & Lee Baylis. (2020) Evaluation of Medication Adherence and Rescue Medication Use in Non-Exacerbating Patients with COPD Receiving Umeclidinium/Vilanterol or Budesonide/Formoterol as Initial Maintenance Therapy. International Journal of Chronic Obstructive Pulmonary Disease 15, pages 2207-2215.
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Jesús Recio Iglesias, Jesús Díez-Manglano, Francisco López García, José Antonio Díaz Peromingo, Pere Almagro & José Manuel Varela Aguilar. (2020) Management of the COPD Patient with Comorbidities: An Experts Recommendation Document. International Journal of Chronic Obstructive Pulmonary Disease 15, pages 1015-1037.
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G. Hillas, A. Papaporfyriou, K. Dimakou & A. I. Papaioannou. (2020) Pharmacological treatment of stable COPD: need for a simplified approach. Postgraduate Medicine 132:2, pages 126-131.
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Neil S. Skolnik, Trang Susan Nguyen, Aarisha Shrestha, Riju Ray, Thomas C. Corbridge & Stephen A. Brunton. (2020) Current evidence for COPD management with dual long-acting muscarinic antagonist/long-acting β2-agonist bronchodilators. Postgraduate Medicine 132:2, pages 198-205.
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Timothy E Albertson, Willis S Bowman, Richart W Harper, Regina M Godbout & Susan Murin. (2019) Evidence-based review of data on the combination inhaler umeclidinium/vilanterol in patients with COPD. International Journal of Chronic Obstructive Pulmonary Disease 14, pages 1251-1265.
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Konstantin Tachkov, Maria Dimitrova, Konstantin Mitov, Alexandra Savova, Maria Kamusheva, Jordan Dimitrov, Manoela Manova, Daniela Grekova & Valentina Petkova. (2019) Micro and macro analysis on the burden of COPD hospitalizations on the Bulgarian healthcare system. Biotechnology & Biotechnological Equipment 33:1, pages 1-11.
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Edward Kerwin & Gary T. Ferguson. (2018) An overview of glycopyrrolate/eFlow® CS in COPD. Expert Review of Respiratory Medicine 12:6, pages 447-459.
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Paola Rogliani, Josuel Ora, Maria Gabriella Matera, Mario Cazzola & Luigino Calzetta. (2018) The safety of dual bronchodilation on cardiovascular serious adverse events in COPD. Expert Opinion on Drug Safety 17:6, pages 589-596.
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Maria Gabriella Matera, Luigino Calzetta, Ermanno Puxeddu, Paola Rogliani & Mario Cazzola. (2018) A safety comparison of LABA+LAMA vs LABA+ICS combination therapy for COPD. Expert Opinion on Drug Safety 17:5, pages 509-517.
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Keiji Oishi, Tsunahiko Hirano, Kazuki Hamada, Sho Uehara, Ryo Suetake, Yoshikazu Yamaji, Kosuke Ito, Maki Asami-Noyama, Nobutaka Edakuni & Kazuto Matsunaga. (2018) Characteristics of 2017 GOLD COPD group A: a multicenter cross-sectional CAP study in Japan. International Journal of Chronic Obstructive Pulmonary Disease 13, pages 3901-3907.
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Donald P Tashkin & Charlie Strange. (2018) Inhaled corticosteroids for chronic obstructive pulmonary disease: what is their role in therapy?. International Journal of Chronic Obstructive Pulmonary Disease 13, pages 2587-2601.
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Paola Rogliani, Luigino Calzetta, Fulvio Braido, Mario Cazzola, Enrico Clini, Girolamo Pelaia, Andrea Rossi, Nicola Scichilone & Fabiano Di Marco. (2018) LABA/LAMA fixed-dose combinations in patients with COPD: a systematic review. International Journal of Chronic Obstructive Pulmonary Disease 13, pages 3115-3130.
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Claus F Vogelmeier, Kenneth R Chapman, Marc Miravitlles, Nicolas Roche, Jørgen Vestbo, Chau Thach, Donald Banerji, Robert Fogel, Francesco Patalano, Petter Olsson, Konstantinos Kostikas & Jadwiga A Wedzicha. (2018) Exacerbation heterogeneity in COPD: subgroup analyses from the FLAME study. International Journal of Chronic Obstructive Pulmonary Disease 13, pages 1125-1134.
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Paola Rogliani, Maria Gabriella Matera, Josuel Ora, Mario Cazzola & Luigino Calzetta. (2017) The impact of dual bronchodilation on cardiovascular serious adverse events and mortality in COPD: a quantitative synthesis. International Journal of Chronic Obstructive Pulmonary Disease 12, pages 3469-3485.
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Josefin Sundh, Joakim Åberg, Mikael Hasselgren, Scott Montgomery, Björn Ställberg, Karin Lisspers & Christer Janson. (2017) Factors influencing pharmacological treatment in COPD: a comparison of 2005 and 2014. European Clinical Respiratory Journal 4:1.
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Paola Rogliani, Luigino Calzetta & Mario Cazzola. (2018) Is ICS–LAMA an alternative option to treat patients with COPD?. The Lancet Respiratory Medicine 6:5, pages 316-317.
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Yi-Han Hsiao, Ching-Min Tseng, Kang-Cheng Su, Wen-Chian Chen, Mo-Tzu Wu, Yu-Chung Wu, Shi-Chuan Chang, Yu-Chin Lee, Yu Ru Kou & Diahn-Warng Perng. (2018) Glycopyrronium bromide inhibits lung inflammation and small airway remodeling induced by subchronic cigarette smoke exposure in mice. Respiratory Physiology & Neurobiology 249, pages 16-22.
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