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Review

Immune checkpoint inhibitors for small cell lung cancer: opportunities and challenges

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Pages 4605-4620 | Published online: 13 Jun 2019

Keep up to date with the latest research on this topic with citation updates for this article.

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Martin Wermke, Enriqueta Felip, Valentina Gambardella, Yasutoshi Kuboki, Daniel Morgensztern, Zohra Oum’ Hamed, Meiruo Liu, Matus Studeny & Taofeek K Owonikoko. (2022) Phase I trial of the DLL3/CD3 bispecific T-cell engager BI 764532 in DLL3-positive small-cell lung cancer and neuroendocrine carcinomas. Future Oncology 18:24, pages 2639-2649.
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Gerhard Hamilton & Adelina Plangger. (2021) The Impact of NK Cell-Based Therapeutics for the Treatment of Lung Cancer for Biologics: Targets and Therapy. Biologics: Targets and Therapy 15, pages 265-277.
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Articles from other publishers (17)

Sebastian Klein, Annalena Schulte, Christoph Arolt, Yuri Tolkach, Hans Christian Reinhardt, Reinhard Buettner & Alexander Quaas. (2023) Intratumoral Abundance of M2-Macrophages is Associated With Unfavorable Prognosis and Markers of T-Cell Exhaustion in Small Cell Lung Cancer Patients. Modern Pathology 36:10, pages 100272.
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Hasan Mutlu, Hakan Bozcuk, Mehmet Artaç & İrfan Eser. (2023) First-line immune-checkpoint inhibitor treatment in extensive-disease small-cell lung cancer: A classical and network meta-analysis. Journal of Cancer Research and Therapeutics 19:8, pages 6.
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Patrice Lazure, Aparna R. Parikh, Neal E. Ready, Marianne J. Davies, Sophie Péloquin, Jeffrey M. Caterino, Robert Lewandowski, Alexander J. Lazar & Suzanne Murray. (2022) Challenges associated with the integration of immuno-oncology agents in clinical practice. BMC Medical Education 22:1.
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Jia-Jun Wu, Jing-Wen Huang, Kuo-Hsuan Hsu, Yen-Hsiang Huang, Kun-Chieh Chen, Jeng-Sen Tseng, Tsung-Ying Yang & Gee-Chen Chang. (2022) Thoracic radiotherapy may improve the outcome of extensive stage small cell lung carcinoma patients treated with first-line immunotherapy plus chemotherapy. Anti-Cancer Drugs 33:10, pages e842-e849.
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Ji Hyun Lee, Ji Woong Kim, Ha Rim Yang, Seong-Won Song, Song-Jae Lee, Yeongha Jeon, Anna Ju, Narim Lee, Min-Gu Kim, Minjoo Kim, Kyusang Hwang, Jin Hwan Yoon, Hyunbo Shim & Sukmook Lee. (2022) A Fully-Human Antibody Specifically Targeting a Membrane-Bound Fragment of CADM1 Potentiates the T Cell-Mediated Death of Human Small-Cell Lung Cancer Cells. International Journal of Molecular Sciences 23:13, pages 6895.
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Yulian Xu, Mingxian Chen, Yanpeng Ding, Feng Guo, Min Chen & Tianzhen Lu. (2021) The efficacy and safety of immune checkpoint inhibitor in patients with relapsed small‐cell lung cancer: A systematic review and meta‐analysis. Journal of Clinical Pharmacy and Therapeutics 47:4, pages 421-429.
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Byoung Chul Cho, Kiyotaka Yoh, Ruth Perets, Adnan Nagrial, David R. Spigel, Martin Gutierrez, Dong-Wan Kim, Dusan Kotasek, Drew Rasco, Jiaxin Niu, Miyako Satouchi, Myung-Ju Ahn, Dae Ho Lee, Corinne Maurice-Dror, Shabana Siddiqi, Yixin Ren, Rachel A. Altura & Jair Bar. (2021) Anti–cytotoxic T-lymphocyte–associated antigen-4 monoclonal antibody quavonlimab in combination with pembrolizumab: Safety and efficacy from a phase I study in previously treated extensive-stage small cell lung cancer. Lung Cancer 159, pages 162-170.
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Justyna Błach, Kamila Wojas-Krawczyk, Marcin Nicoś & Paweł Krawczyk. (2021) Failure of Immunotherapy—The Molecular and Immunological Origin of Immunotherapy Resistance in Lung Cancer. International Journal of Molecular Sciences 22:16, pages 9030.
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Mingrui Zhu, Yi Huang, Matthew E. Bender, Luc Girard, Rahul Kollipara, Buse Eglenen-Polat, Yujiro Naito, Trisha K. Savage, Kenneth E. Huffman, Shohei Koyama, Atsushi Kumanogoh, John D. Minna, Jane E. Johnson & Esra A. Akbay. (2021) Evasion of Innate Immunity Contributes to Small Cell Lung Cancer Progression and Metastasis. Cancer Research 81:7, pages 1813-1826.
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Dan Guo, Qiu Xie, Shuai Jiang, Ting Xie, Yaru Li, Xin Huang, Fangyuan Li, Tingting Wang, Jian Sun, Anqi Wang, Zixin Zhang, Hao Li, Xiaochen Bo, Hebing Chen & Zhiyong Liang. (2021) Synergistic alterations in the multilevel chromatin structure anchor dysregulated genes in small cell lung cancer. Computational and Structural Biotechnology Journal 19, pages 5946-5959.
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Laura Boyero, Amparo Sánchez-Gastaldo, Miriam Alonso, José Francisco Noguera-Uclés, Sonia Molina-Pinelo & Reyes Bernabé-Caro. (2020) Primary and Acquired Resistance to Immunotherapy in Lung Cancer: Unveiling the Mechanisms Underlying of Immune Checkpoint Blockade Therapy. Cancers 12:12, pages 3729.
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Hui-liu Zhao, Jia-hua Yu, Ling-sha Huang, Pei-zhang Li, Ming Lao, Bo Zhu & Chao Ou. (2020) Relationship between vascular endothelial growth factor -2578C > a gene polymorphism and lung cancer risk: a meta-analysis. BMC Medical Genetics 21:1.
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Yuwen Wang, Songyun Zou, Zhuyun Zhao, Po Liu, Changneng Ke & Shi Xu. (2020) New insights into small‐cell lung cancer development and therapy. Cell Biology International 44:8, pages 1564-1576.
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Paola De Cicco, Giuseppe Ercolano & Angela Ianaro. (2020) The New Era of Cancer Immunotherapy: Targeting Myeloid-Derived Suppressor Cells to Overcome Immune Evasion. Frontiers in Immunology 11.
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Huarong Cai, Haimei Zhang & Yuequan Jiang. (2020) Prognostic and Clinicopathological Value of Programmed Cell Death Ligand1 Expression in Patients With Small Cell Lung Cancer: A Meta-Analysis. Frontiers in Oncology 10.
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Xin Chen, Norhan Amar, Yuankui Zhu, Chunguang Wang, Chunjiao Xia, Xiaoqing Yang, Dongde Wu & Mingqian Feng. (2020) Combined DLL3-targeted bispecific antibody with PD-1 inhibition is efficient to suppress small cell lung cancer growth. Journal for ImmunoTherapy of Cancer 8:1, pages e000785.
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Giuseppe Ercolano, Maryline Falquet, Giulia Vanoni, Sara Trabanelli & Camilla Jandus. (2019) ILC2s: New Actors in Tumor Immunity. Frontiers in Immunology 10.
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