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Yoon Kook Kim, Xinyuan Ning, Kashif M. Munir & Stephen N. Davis. (2022) Emerging drugs for the treatment of diabetic nephropathy. Expert Opinion on Emerging Drugs 27:4, pages 417-430.
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Xuan Huang, Juan Wu, Xinhui Liu, Haishan Wu, Jinjin Fan & Xiao Yang. (2020) The protective role of Nrf2 against aristolochic acid-induced renal tubular epithelial cell injury. Toxicology Mechanisms and Methods 30:8, pages 580-589.
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Yinyin Chen, Liyu He, Yiya Yang, Ying Chen, Yanran Song, Xi Lu & Yumei Liang. (2019) The inhibition of Nrf2 accelerates renal lipid deposition through suppressing the ACSL1 expression in obesity-related nephropathy. Renal Failure 41:1, pages 821-831.
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Md. Mohabbulla Mohib, S.M. Fazla Rabby, Tasfiq Zaman Paran, Md. Mehedee Hasan, Iqbal Ahmed, Nahid Hasan, Md. Abu Taher Sagor & Sarif Mohiuddin. (2016) Protective role of green tea on diabetic nephropathy—A review. Cogent Biology 2:1.
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Maka S Hedrington & Stephen N Davis. (2014) Discontinued in 2013: diabetic drugs. Expert Opinion on Investigational Drugs 23:12, pages 1703-1711.
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Cheng Xu, Xing Liu, Xiuwen Zhai, Gang Wang, Weisong Qin, Zheng Cheng & Zhaohong Chen. (2023) CDDO-Me ameliorates podocyte injury through anti-oxidative stress and regulation of actin cytoskeleton in adriamycin nephropathy. Biomedicine & Pharmacotherapy 167, pages 115617.
Crossref
Crossref
CYRIL JANE SHAMMAH & ANNADURAI THENMOZHI. (2023) ANTI-ATHEROGENIC ACTIVITY OF ETHYL ACETATE AND ETHANOLIC EXTRACTS OF CAESALPINIA BONDUCELLA LINN.F. ON HIGH-FAT DIET-INDUCED ATHEROSCLEROSIS IN RATS. Asian Journal of Pharmaceutical and Clinical Research, pages 111-115.
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Ana Cristina Simões e Silva, Eduardo A. Oliveira, Wai W. Cheung & Robert H. Mak. (2023) Redox Signaling in Chronic Kidney Disease-Associated Cachexia. Antioxidants 12:4, pages 945.
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Crossref
Yeldar Baiken, Zhannur Markhametova, Assem Ashimova, Ainur Zhulamanova, Assem Nogaibayeva, Larissa Kozina, Bakhyt Matkarimov, Bauyrzhan Aituov, Abduzhappar Gaipov & Askhat Myngbay. (2023) Elevated Levels of Plasma Collagen Triple Helix Repeat Containing 1 (CTHRC1) Are Strongly Associated with eGFR and Albuminuria in Chronic Kidney Disease. Medicina 59:4, pages 651.
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Crossref
Da-Wei Lin, Yung-Chien Hsu, Cheng-Chih Chang, Ching-Chuan Hsieh & Chun-Liang Lin. (2023) Insights into the Molecular Mechanisms of NRF2 in Kidney Injury and Diseases. International Journal of Molecular Sciences 24:7, pages 6053.
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Junsei Taira, Ryuji Tsuda, Chika Miyagi-Shiohira, Hirofumi Noguchi & Takayuki Ogi. (2023) Cytoprotective Effect of Pteryxin on Insulinoma MIN6 Cells Due to Antioxidant Enzymes Expression via Nrf2/ARE Activation. Antioxidants 12:3, pages 693.
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Crossref
Tai-Hsin Tsai, Yu-Feng Su, Cheng-Yu Tsai, Chieh-Hsin Wu, Kuan-Ting Lee & Yi-Chiang Hsu. (2023) RTA dh404 Induces Cell Cycle Arrest, Apoptosis, and Autophagy in Glioblastoma Cells. International Journal of Molecular Sciences 24:4, pages 4006.
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Yuta Ishizaki, Ken-ichiro Sasaki, Takahiro Yoshikawa, Takaharu Nakayoshi, Motoki Sasaki, Masanori Ohtsuka, Sachiko Hatada-Katakabe, Yuki Takata & Yoshihiro Fukumoto. (2023) RTA-dh404 decreased oxidative stress in mice ischemic limbs and augmented efficacy of therapeutic angiogenesis by intramuscular injection of adipose-derived regenerative cells in the limbs. European Journal of Pharmacology 938, pages 175422.
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Shota Kaseda, Yuya Sannomiya, Jun Horizono, Jun Kuwazuru, Mary Ann Suico, Sayaka Ogi, Ryoko Sasaki, Hidetoshi Sunamoto, Hirohiko Fukiya, Hayato Nishiyama, Misato Kamura, Saki Niinou, Yuimi Koyama, Futoshi Nara, Tsuyoshi Shuto, Kazuhiro Onuma & Hirofumi Kai. (2022) Novel Keap1-Nrf2 Protein-Protein Interaction Inhibitor UBE-1099 Ameliorates Progressive Phenotype in Alport Syndrome Mouse Model. Kidney360 3:4, pages 687-699.
Crossref
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Adolf Koudelka, Veronika Cechova, Mauricio Rojas, Nilay Mitash, Anna Bondonese, Claudette St. Croix, Mark A. Ross & Bruce A. Freeman. (2022) Fatty acid nitroalkene reversal of established lung fibrosis. Redox Biology 50, pages 102226.
Crossref
Crossref
Susanne B. Nicholas. (2021) Novel Anti-inflammatory and Anti-fibrotic Agents for Diabetic Kidney Disease—From Bench to Bedside. Advances in Chronic Kidney Disease 28:4, pages 378-390.
Crossref
Crossref
Peter Stenvinkel, Glenn M. Chertow, Prasad Devarajan, Adeera Levin, Sharon P. Andreoli, Sripal Bangalore & Bradley A. Warady. (2021) Chronic Inflammation in Chronic Kidney Disease Progression: Role of Nrf2. Kidney International Reports 6:7, pages 1775-1787.
Crossref
Crossref
Emine Kadıoğlu, Yasemin Tekşen, Cengiz Koçak & Fatma Emel Koçak. (2019) Beneficial effects of bardoxolone methyl, an Nrf2 activator, on crush-related acute kidney injury in rats. European Journal of Trauma and Emergency Surgery 47:1, pages 241-250.
Crossref
Crossref
Melania Guerrero-Hue, Sandra Rayego-Mateos, Cristina Vázquez-Carballo, Alejandra Palomino-Antolín, Cristina García-Caballero, Lucas Opazo-Rios, José Luis Morgado-Pascual, Carmen Herencia, Sebastián Mas, Alberto Ortiz, Alfonso Rubio-Navarro, Javier Egea, José Manuel Villalba, Jesús Egido & Juan Antonio Moreno. (2020) Protective Role of Nrf2 in Renal Disease. Antioxidants 10:1, pages 39.
Crossref
Crossref
Hironori Kanda & Kengo Yamawaki. (2020) Bardoxolone methyl: drug development for diabetic kidney disease. Clinical and Experimental Nephrology 24:10, pages 857-864.
Crossref
Crossref
Donna D. Zhang & Eli Chapman. (2020) The role of natural products in revealing NRF2 function. Natural Product Reports 37:6, pages 797-826.
Crossref
Crossref
Masaomi Nangaku, Hironori Kanda, Hirotaka Takama, Tomohiro Ichikawa, Hiroki Hase & Tadao Akizawa. (2020) Randomized Clinical Trial on the Effect of Bardoxolone Methyl on GFR in Diabetic Kidney Disease Patients (TSUBAKI Study). Kidney International Reports 5:6, pages 879-890.
Crossref
Crossref
Maria V. Irazabal & Vicente E. Torres. (2020) Reactive Oxygen Species and Redox Signaling in Chronic Kidney Disease. Cells 9:6, pages 1342.
Crossref
Crossref
Alberto Jarrin Lopez, Hien Lau, Shiri Li & Hirohito Ichii. (2020) Potential Benefits of Nrf2/Keap1 Targeting in Pancreatic Islet Cell Transplantation. Antioxidants 9:4, pages 321.
Crossref
Crossref
Temitope Isaac Adelusi, Lei Du, Meng Hao, Xueyan Zhou, Qian Xuan, Chowdhury Apu, Ying Sun, Qian Lu & Xiaoxing Yin. (2020) Keap1/Nrf2/ARE signaling unfolds therapeutic targets for redox imbalanced-mediated diseases and diabetic nephropathy. Biomedicine & Pharmacotherapy 123, pages 109732.
Crossref
Crossref
Cody J. Schmidlin, Matthew B. Dodson & Donna D. Zhang. (2019) Filtering through the role of NRF2 in kidney disease. Archives of Pharmacal Research 43:3, pages 361-369.
Crossref
Crossref
Marie Ito, Tetsuhiro Tanaka & Masaomi Nangaku. (2020) Nuclear factor erythroid 2-related factor 2 as a treatment target of kidney diseases. Current Opinion in Nephrology and Hypertension 29:1, pages 128-135.
Crossref
Crossref
Hajime Nagasu, Yuji Sogawa, Kengo Kidokoro, Seiji Itano, Toshiya Yamamoto, Minoru Satoh, Tamaki Sasaki, Takafumi Suzuki, Masayuki Yamamoto, W. Christian Wigley, Joel W. Proksch, Colin J. Meyer & Naoki Kashihara. (2019) Bardoxolone methyl analog attenuates proteinuria‐induced tubular damage by modulating mitochondrial function. The FASEB Journal 33:11, pages 12253-12263.
Crossref
Crossref
Peter Rossing, Geoffrey A. Block, Melanie P. Chin, Angie Goldsberry, Hiddo J.L. Heerspink, Peter A. McCullough, Colin J. Meyer, David Packham, Pablo E. Pergola, Bruce Spinowitz, Stuart M. Sprague, David G. Warnock & Glenn M. Chertow. (2019) Effect of bardoxolone methyl on the urine albumin-to-creatinine ratio in patients with type 2 diabetes and stage 4 chronic kidney disease. Kidney International 96:4, pages 1030-1036.
Crossref
Crossref
Feng-zhen Lian, Pan Cheng, Cheng-shao Ruan, Xin-xin Ling, Xiao-yun Wang, Ming Pan, Mei-ling Chen, Ai-zong Shen & Shan Gao. (2019) Xin-Ji-Er-Kang ameliorates kidney injury following myocardial infarction by inhibiting oxidative stress via Nrf2/HO-1 pathway in rats. Biomedicine & Pharmacotherapy 117, pages 109124.
Crossref
Crossref
Tamami Fujiki, Fumiaki Ando, Kana Murakami, Kiyoshi Isobe, Takayasu Mori, Koichiro Susa, Naohiro Nomura, Eisei Sohara, Tatemitsu Rai & Shinichi Uchida. (2019) Tolvaptan activates the Nrf2/HO-1 antioxidant pathway through PERK phosphorylation. Scientific Reports 9:1.
Crossref
Crossref
Hong-feng Zhang, Jia-hong Wang, Yan-li Wang, Cheng Gao, Yan-ting Gu, Jian Huang, Jin-hui Wang & Zhou Zhang. (2019)
Salvianolic Acid A Protects the Kidney against Oxidative Stress by Activating the Akt/GSK-3
β
/Nrf2 Signaling Pathway and Inhibiting the NF-
κ
B Signaling Pathway in 5/6 Nephrectomized Rats
. Oxidative Medicine and Cellular Longevity 2019, pages 1-16.
Crossref
Crossref
Melanie P. Chin, Shannon Rich, Angie Goldsberry, Megan O'Grady & Colin J. Meyer. (2019) Effects of Bardoxolone Methyl on QT Interval in Healthy Volunteers. Cardiorenal Medicine 9:5, pages 326-333.
Crossref
Crossref
Dana V. Rizk, Arnold L. Silva, Pablo E. Pergola, Robert Toto, David G. Warnock, Melanie P. Chin, Angie Goldsberry, Megan O’Grady, Colin J. Meyer & Peter A. McCullough. (2019) Effects of Bardoxolone Methyl on Magnesium in Patients with Type 2 Diabetes Mellitus and Chronic Kidney Disease. Cardiorenal Medicine 9:5, pages 316-325.
Crossref
Crossref
Hong-feng Zhang, Yan-li Wang, Cheng Gao, Yan-ting Gu, Jian Huang, Jin-hui Wang, Jia-hong Wang & Zhou Zhang. (2018) Salvianolic acid A attenuates kidney injury and inflammation by inhibiting NF-κB and p38 MAPK signaling pathways in 5/6 nephrectomized rats. Acta Pharmacologica Sinica 39:12, pages 1855-1864.
Crossref
Crossref
Robert D. Toto. (2018) Bardoxolone—the Phoenix?. Journal of the American Society of Nephrology 29:2, pages 360-361.
Crossref
Crossref
Melanie P. Chin, George L. Bakris, Geoffrey A. Block, Glenn M. Chertow, Angie Goldsberry, Lesley A. Inker, Hiddo J.L. Heerspink, Megan O’Grady, Pablo E. Pergola, Christoph Wanner, David G. Warnock & Colin J. Meyer. (2018) Bardoxolone Methyl Improves Kidney Function in Patients with Chronic Kidney Disease Stage 4 and Type 2 Diabetes: Post-Hoc Analyses from Bardoxolone Methyl Evaluation in Patients with Chronic Kidney Disease and Type 2 Diabetes Study. American Journal of Nephrology 47:1, pages 40-47.
Crossref
Crossref
Irene Pierantonelli, Chiara Rychlicki, Laura Agostinelli, Debora Maria Giordano, Melania Gaggini, Cristina Fraumene, Chiara Saponaro, Valeria Manghina, Loris Sartini, Eleonora Mingarelli, Claudio Pinto, Emma Buzzigoli, Luciano Trozzi, Antonio Giordano, Marco Marzioni, Samuele De Minicis, Sergio Uzzau, Saverio Cinti, Amalia Gastaldelli & Gianluca Svegliati-Baroni. (2017) Lack of NLRP3-inflammasome leads to gut-liver axis derangement, gut dysbiosis and a worsened phenotype in a mouse model of NAFLD. Scientific Reports 7:1.
Crossref
Crossref
Masahiro Nezu, Norio Suzuki & Masayuki Yamamoto. (2017) Targeting the KEAP1-NRF2 System to Prevent Kidney Disease Progression. American Journal of Nephrology 45:6, pages 473-483.
Crossref
Crossref
C. L. Chen, C. Y. Chen, Y. P. Chen, Y. B. Huang, M. W. Lin, D. C. Wu, H. T. Huang, M. Y. Liu, H. W. Chang, Y. C. Kao & P. H. Yang. (2016) Betulinic acid enhances TGF-β signaling by altering TGF-β receptors partitioning between lipid-raft/caveolae and non-caveolae membrane microdomains in mink lung epithelial cells. Journal of Biomedical Science 23:1.
Crossref
Crossref
Zhi-Hao Zhang, Hua Chen, Nosratola D. Vaziri, Jia-Rong Mao, Li Zhang, Xu Bai & Ying-Yong Zhao. (2016) Metabolomic Signatures of Chronic Kidney Disease of Diverse Etiologies in the Rats and Humans. Journal of Proteome Research 15:10, pages 3802-3812.
Crossref
Crossref
Lourdes Robles, Nosratola D. Vaziri, Shiri Li, Yuichi Masuda, Chie Takasu, Mizuki Takasu, Kelly Vo, Seyed H. Farzaneh, Michael J. Stamos & Hirohito Ichii. (2016) Synthetic Triterpenoid RTA dh404 (CDDO-dhTFEA) Ameliorates Acute Pancreatitis. Pancreas 45:5, pages 720-729.
Crossref
Crossref
Chi H. L. DinhYinghua YuAlexander SzaboQingsheng ZhangPeng ZhangXu-Feng Huang. (2016) Bardoxolone Methyl Prevents High-Fat Diet-Induced Colon Inflammation in Mice. Journal of Histochemistry & Cytochemistry 64:4, pages 237-255.
Crossref
Crossref
Zhi-Hao Zhang, Nosratola D. Vaziri, Feng Wei, Xian-Long Cheng, Xu Bai & Ying-Yong Zhao. (2016) An integrated lipidomics and metabolomics reveal nephroprotective effect and biochemical mechanism of Rheum officinale in chronic renal failure. Scientific Reports 6:1.
Crossref
Crossref
R. M. Montero, A. Covic, L. Gnudi & D. Goldsmith. (2015) Diabetic nephropathy: What does the future hold?. International Urology and Nephrology 48:1, pages 99-113.
Crossref
Crossref
Bryan J. Mathis & Taixing Cui. 2016. Drug Discovery from Mother Nature. Drug Discovery from Mother Nature
291
314
.
Sadaf S. Khan & Susan E. Quaggin. (2015) Therapies on the Horizon for Diabetic Kidney Disease. Current Diabetes Reports 15:12.
Crossref
Crossref
Shiri Li, Nosratola D. Vaziri, Yuichi Masuda, Mohammad Hajighasemi-Ossareh, Lourdes Robles, Aimee Le, Kelly Vo, Jefferson Y. Chan, Clarence E. Foster, Michael J. Stamos & Hirohito Ichii. (2015) Pharmacological Activation of Nrf2 Pathway Improves Pancreatic Islet Isolation and Transplantation. Cell Transplantation 24:11, pages 2273-2283.
Crossref
Crossref
Yanqiu Wang, Bowen Wang, Feng Du, Xuesong Su, Guangping Sun, Guangyu Zhou, Xiaohui Bian & Na Liu. (2015) Epigallocatechin-3-Gallate Attenuates Oxidative Stress and Inflammation in Obstructive Nephropathy via NF-κB and Nrf2/HO-1 Signalling Pathway Regulation. Basic & Clinical Pharmacology & Toxicology 117:3, pages 164-172.
Crossref
Crossref
Nosratola D. Vaziri, Shuman Liu, Seyed H. Farzaneh, Sohrab Nazertehrani, Mahyar Khazaeli & Ying-Yong Zhao. (2015) Dose-dependent deleterious and salutary actions of the Nrf2 inducer dh404 in chronic kidney disease. Free Radical Biology and Medicine 86, pages 374-381.
Crossref
Crossref
Shanshan Zhou, Jingpeng Jin, Tao Bai, Leroy R. SachlebenJrJr, Lu Cai & Yang Zheng. (2015) Potential drugs which activate nuclear factor E2-related factor 2 signaling to prevent diabetic cardiovascular complications: A focus on fumaric acid esters. Life Sciences 134, pages 56-62.
Crossref
Crossref
Liliana M. Pedruzzi, Ludmila F. M. F. Cardozo, Julio B. Daleprane, Milena B. Stockler-Pinto, Elisa B. Monteiro, Maurilo LeiteJrJr, Nosratola D. Vaziri & Denise Mafra. (2015) Systemic inflammation and oxidative stress in hemodialysis patients are associated with down-regulation of Nrf2. Journal of Nephrology 28:4, pages 495-501.
Crossref
Crossref
Yuichi Masuda, Nosratola D. Vaziri, Shiri Li, Aimee Le, Mohammad Hajighasemi-Ossareh, Lourdes Robles, Clarence E. Foster, Michael J. Stamos, Ismail Al-Abodullah, Camillo Ricordi & Hirohito Ichii. (2015) The Effect of Nrf2 Pathway Activation on Human Pancreatic Islet Cells. PLOS ONE 10:6, pages e0131012.
Crossref
Crossref
Santiago CuevasYu YangPrasad KonkalmattLaureano D. AsicoJun FeranilJohn JonesVan Anthony VillarInes ArmandoPedro A. Jose. (2015) Role of Nuclear Factor Erythroid 2–Related Factor 2 in the Oxidative Stress–Dependent Hypertension Associated With the Depletion of DJ-1. Hypertension 65:6, pages 1251-1257.
Crossref
Crossref
Wei Ling Lau, Shu-Man Liu, Sogol Pahlevan, Jun Yuan, Mahyar Khazaeli, Zhenmin Ni, Jefferson Y. Chan & Nosratola D. Vaziri. (2014) Role of Nrf2 Dysfunction in Uremia-Associated Intestinal Inflammation and Epithelial Barrier Disruption. Digestive Diseases and Sciences 60:5, pages 1215-1222.
Crossref
Crossref
Yang Yang, Shuai Jiang, Juanjuan Yan, Yue Li, Zhenlong Xin, Yan Lin & Yan Qu. (2015) An overview of the molecular mechanisms and novel roles of Nrf2 in neurodegenerative disorders. Cytokine & Growth Factor Reviews 26:1, pages 47-57.
Crossref
Crossref
Guoyong Liu, Yan Shi, Xiaofei Peng, Hong Liu, Youming Peng & Liyu He. (2015) Astaxanthin Attenuates Adriamycin-Induced Focal Segmental Glomerulosclerosis. Pharmacology 95:3-4, pages 193-200.
Crossref
Crossref
Ying-Yong Zhao, Hua Chen, Ting Tian, Dan-Qian Chen, Xu Bai & Feng Wei. (2014) A Pharmaco-Metabonomic Study on Chronic Kidney Disease and Therapeutic Effect of Ergone by UPLC-QTOF/HDMS. PLoS ONE 9:12, pages e115467.
Crossref
Crossref
Melanie P. Chin, Danielle Wrolstad, George L. Bakris, Glenn M. Chertow, Dick de Zeeuw, Angie Goldsberry, Peter G. Linde, Peter A. McCullough, John J. McMurray, Janet Wittes & Colin J. Meyer. (2014) Risk Factors for Heart Failure in Patients With Type 2 Diabetes Mellitus and Stage 4 Chronic Kidney Disease Treated With Bardoxolone Methyl. Journal of Cardiac Failure 20:12, pages 953-958.
Crossref
Crossref
Bo-hyun Choi, Kyung-Shin Kang & Mi-Kyoung Kwak. (2014) Effect of Redox Modulating NRF2 Activators on Chronic Kidney Disease. Molecules 19:8, pages 12727-12759.
Crossref
Crossref