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Ye Wang, Yanfang Liu, Xinyang Du, Hong Ma & Jing Yao. (2020) The Anti-Cancer Mechanisms of Berberine: A Review. Cancer Management and Research 12, pages 695-702.
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Jin Wang, Lin Wang, Guan-Hua Lou, Hai-Rong Zeng, Ju Hu, Qin-Wan Huang, Wei Peng & Xiang-Bo Yang. (2019) Coptidis Rhizoma: a comprehensive review of its traditional uses, botany, phytochemistry, pharmacology and toxicology. Pharmaceutical Biology 57:1, pages 193-225.
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Fa Jin, Tao Xie, Xiaoguang Huang & Xinde Zhao. (2018) Berberine inhibits angiogenesis in glioblastoma xenografts by targeting the VEGFR2/ERK pathway. Pharmaceutical Biology 56:1, pages 665-671.
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Chi Zhang, Xi Yang, Qu Zhang, Baixia Yang, Liping Xu, Qin Qin, Hongcheng Zhu, Jia Liu, Jing Cai, Guangzhou Tao, Jianxin Ma, Xiaolin Ge, Sheng Zhang, Hongyan Cheng & Xinchen Sun. (2014) Berberine radiosensitizes human nasopharyngeal carcinoma by suppressing hypoxia-inducible factor-1α expression. Acta Oto-Laryngologica 134:2, pages 185-192.
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Xi Yang, Baixia Yang, Jing Cai, Chi Zhang, Qu Zhang, Liping Xu, Qin Qin, Hongcheng Zhu, Jianxin Ma, Guangzhou Tao, Hongyan Cheng & Xinchen Sun. (2013) Berberine enhances radiosensitivity of esophageal squamous cancer by targeting HIF-1α in vitro and in vivo. Cancer Biology & Therapy 14:11, pages 1068-1073.
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Blazej Zbytek, Danielle L. Peacock, Tiffany N. Seagroves & Andrzej Slominski. (2013) Putative role of HIF transcriptional activity in melanocytes and melanoma biology. Dermato-Endocrinology 5:2, pages 239-251.
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Articles from other publishers (64)
Preeti Tamane, Kakasaheb Mahadik & Varsha Pokharkar. (2023) Buccal spray of standardized Berberis aristata extract causes tumour regression, chemoprotection and downregulation of inflammatory mediators in oral cancer hamster model. Journal of Ethnopharmacology 317, pages 116732.
Crossref
Crossref
Doaa Ibrahim, Safaa I. Khater, Ahmed Abdelfattah-Hassan, Leena S. Alqahtani, Aya Sh. Metwally, Shefaa M. Bazeed, Aya Elgamal, Nagwa I. Sheraiba, Elham M. Hussein, Fatmah Ali Alasmary, Gamal A. Salem, Mohamed Ali & Hala Mahfouz. (2023) Prospects of new targeted nanotherapy combining liponiosomes with berberine to combat colorectal cancer development: An in vivo experimental model. International Journal of Pharmaceutics 647, pages 123511.
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Jia-hua Feng, Kang Chen, Si-yu Shen, Yun-feng Luo, Xi-hong Liu, Xin Chen, Wei Gao & Yu-ru Tong. (2023) The composition, pharmacological effects, related mechanisms and drug delivery of alkaloids from Corydalis yanhusuo. Biomedicine & Pharmacotherapy 167, pages 115511.
Crossref
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Jhansi Nathan, Rabiathul Shameera, Nalini Devarajan & Elumalai Perumal. (2023) Role of berberine on angiogenesis and blood flow hemodynamics using zebrafish model. Journal of Applied Toxicology.
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Crossref
Anjana Goel. (2023) Current understanding and future prospects on Berberine for anticancer therapy. Chemical Biology & Drug Design 102:1, pages 177-200.
Crossref
Crossref
Shareefa A. AlGhamdi, Fahad A. Al-Abbasi, Amira M. Alghamdi, Asma B. Omer, Obaid Afzal, Abdulmalik S. A. Altamimi, Abdulaziz Alamri, Sami I. Alzarea, Waleed Hassan Almalki & Imran Kazmi. (2023) Barbigerone prevents scopolamine-induced memory impairment in rats by inhibiting oxidative stress and acetylcholinesterase levels. Royal Society Open Science 10:4.
Crossref
Crossref
Popat Kumbhar, Kapil Kole, Arehalli Manjappa, Niraj Kumar Jha, John Disouza & Vandana Patravale. 2023. Drug Repurposing for Emerging Infectious Diseases and Cancer. Drug Repurposing for Emerging Infectious Diseases and Cancer
53
87
.
Saleh A. Almatroodi, Mohammed A. Alsahli & Arshad Husain Rahmani. (2022) Berberine: An Important Emphasis on Its Anticancer Effects through Modulation of Various Cell Signaling Pathways. Molecules 27:18, pages 5889.
Crossref
Crossref
Bahram Bibak, Farzaneh Shakeri, Zakieh Keshavarzi, Hamid Mollazadeh, Hossein Javid, Mohammad Jalili-Nik, Thozhukat Sathyapalan, Amir R. Afshari & Amirhossein Sahebkar. (2022) Anticancer Mechanisms of Berberine: A Good Choice for Glioblastoma
Multiforme Therapy. Current Medicinal Chemistry 29:26, pages 4507-4528.
Crossref
Crossref
Gopalsamy Rajiv Gandhi, Poovathumkal James Antony, Maria Júlia Miranda de Paula Lana, Brenda Fernandes Xavier da Silva, Roberta Vieira Oliveira, Gnanasekaran Jothi, Govindasamy Hariharan, Thiruchenduran Mohana, Ren-You Gan, Ricardo Queiroz Gurgel, Rosana Cipolotti & Lucindo José QuintansJúniorJúnior. (2022) Natural products modulating interleukins and other inflammatory mediators in tumor-bearing animals: A systematic review. Phytomedicine 100, pages 154038.
Crossref
Crossref
Ľudmila Balážová, Slavomír Kurhajec, Martin Kello, Zdenka Bedlovičová, Martina Zigová, Eva Petrovová, Katarína Beňová, Ján Mojžiš & Jarmila Eftimová. (2022) Antiproliferative Effect of Phellodendron amurense Rupr. Based on Angiogenesis. Life 12:5, pages 767.
Crossref
Crossref
Marwa A. Mahmoud, Mona A. El-Bana, Sfaa M. Morsy, Ehsan A. Badawy, Abd-Elrazik Farrag, Ahmed M. Badawy, Mosaad A. Abdel-Wahhab & Mohamed A. El-Dosoky. (2022) Synthesis and characterization of berberine-loaded chitosan nanoparticles for the protection of urethane-induced lung cancer. International Journal of Pharmaceutics 618, pages 121652.
Crossref
Crossref
Anna Och, Marek Och, Renata Nowak, Dominika Podgórska & Rafał Podgórski. (2022) Berberine, a Herbal Metabolite in the Metabolic Syndrome: The Risk Factors, Course, and Consequences of the Disease. Molecules 27:4, pages 1351.
Crossref
Crossref
Mark J. de Keijzer, Daniel J. de Klerk, Lianne R. de Haan, Robert T. van Kooten, Leonardo P. Franchi, Lionel M. Dias, Tony G. Kleijn, Diederick J. van Doorn & Michal Heger. 2022. Photodynamic Therapy. Photodynamic Therapy
285
403
.
Franklyn O. Ohiagu, Paul C. Chikezie, Chinwendu M. Chikezie & Christian E. Enyoh. (2021) Anticancer activity of Nigerian medicinal plants: a review. Future Journal of Pharmaceutical Sciences 7:1.
Crossref
Crossref
Paola Orlandi, Anna Solini, Marta Banchi, Maurizia Rossana Brunetto, Dania Cioni, Lorenzo Ghiadoni & Guido Bocci. (2021) Antiangiogenic Drugs in NASH: Evidence of a Possible New Therapeutic Approach. Pharmaceuticals 14:10, pages 995.
Crossref
Crossref
Dan-na Huang, Fang-fang Wu, Ai-hua Zhang, Hui Sun & Xi-jun Wang. (2021) Efficacy of berberine in treatment of rheumatoid arthritis: From multiple targets to therapeutic potential. Pharmacological Research 169, pages 105667.
Crossref
Crossref
Jin Huang, Wei Feng, Shanshan Li, Huiling Tang, Siru Qin, Wei Li, Yinan Gong, Yuxin Fang, Yangyang Liu, Shenjun Wang, Yi Guo, Zhifang Xu & Qian Shen. (2021) Berberine Exerts Anti-cancer Activity by Modulating Adenosine Monophosphate- Activated Protein Kinase (AMPK) and the Phosphatidylinositol 3-Kinase/ Protein Kinase B (PI3K/AKT) Signaling Pathways. Current Pharmaceutical Design 27:4, pages 565-574.
Crossref
Crossref
Thomas Efferth & Franz Oesch. (2021) Repurposing of plant alkaloids for cancer therapy: Pharmacology and toxicology. Seminars in Cancer Biology 68, pages 143-163.
Crossref
Crossref
Anna Och, Rafał Podgórski & Renata Nowak. (2020) Biological Activity of Berberine—A Summary Update. Toxins 12:11, pages 713.
Crossref
Crossref
Sudip Kumar Mandal, Amal Kumar Maji, Siddhartha Kumar Mishra, Pir Mohammad Ishfaq, Hari Prasad Devkota, Ana Sanches Silva & Niranjan Das. (2020) Goldenseal (Hydrastis canadensis L.) and its active constituents: A critical review of their efficacy and toxicological issues. Pharmacological Research 160, pages 105085.
Crossref
Crossref
Zhe Zhang, Li Zhou, Na Xie, Edouard C. Nice, Tao Zhang, Yongping Cui & Canhua Huang. (2020) Overcoming cancer therapeutic bottleneck by drug repurposing. Signal Transduction and Targeted Therapy 5:1.
Crossref
Crossref
Yi Liu, Ke-xin Zhu, Lei Cao, Zhi-fu Xie, Min Gu, Wei Lü, Jing-ya Li & Fa-jun Nan. (2020) Berberine derivatives with a long alkyl chain branched by hydroxyl group and methoxycarbonyl group at 9-position show improved anti-proliferation activity and membrane permeability in A549 cells. Acta Pharmacologica Sinica 41:6, pages 813-824.
Crossref
Crossref
Nadire Özenver & Thomas Efferth. (2020) Small molecule inhibitors and stimulators of inducible nitric oxide synthase in cancer cells from natural origin (phytochemicals, marine compounds, antibiotics). Biochemical Pharmacology 176, pages 113792.
Crossref
Crossref
Solomon Habtemariam. (2020) Recent Advances in Berberine Inspired Anticancer Approaches: From Drug Combination to Novel Formulation Technology and Derivatization. Molecules 25:6, pages 1426.
Crossref
Crossref
Saeed Pirouzpanah, Sanaz Asemani, Ali Shayanfar, Behzad Baradaran & Vahid Montazeri. (2019) The effects of Berberis vulgaris consumption on plasma levels of IGF-1, IGFBPs, PPAR-γ and the expression of angiogenic genes in women with benign breast disease: a randomized controlled clinical trial. BMC Complementary and Alternative Medicine 19:1.
Crossref
Crossref
Fabrizio Fontana, Michela Raimondi, Alessandro Di Domizio, Roberta M. Moretti, Marina Montagnani Marelli & Patrizia Limonta. (2019) Unraveling the molecular mechanisms and the potential chemopreventive/therapeutic properties of natural compounds in melanoma. Seminars in Cancer Biology 59, pages 266-282.
Crossref
Crossref
Zi-Yu Chang, Chin-Chang Chen, Hsuan-Miao Liu, Yuan-Chieh Yeh, Tung-Yi Lin, Tzung-Yan Lee & Tse-Hung Huang. (2019) Positive Effects of Ger-Gen-Chyn-Lian-Tang on Cholestatic Liver Fibrosis in Bile Duct Ligation-Challenged Mice. International Journal of Molecular Sciences 20:17, pages 4181.
Crossref
Crossref
Pengfei Guo, Chuipu Cai, Xiaoqin Wu, Xiude Fan, Wei Huang, Jingwei Zhou, Qihui Wu, Yujie Huang, Wei Zhao, Fengxue Zhang, Qi Wang, Yongbin Zhang & Jiansong Fang. (2019) An Insight Into the Molecular Mechanism of Berberine Towards Multiple Cancer Types Through Systems Pharmacology. Frontiers in Pharmacology 10.
Crossref
Crossref
Anna Belanova, Darya Beseda, Victor Chmykhalo, Alisa Stepanova, Mariya Belousova, Vera Khrenkova, Nikolaos Gavalas & Peter Zolotukhin. (2019) Berberine Effects on NFκB, HIF1A and NFE2L2/AP-1 Pathways in HeLa Cells. Anti-Cancer Agents in Medicinal Chemistry 19:4, pages 487-501.
Crossref
Crossref
Masoud Alasvand, Vahideh Assadollahi, Roberto Ambra, Ehsan Hedayati, Wesam Kooti & Ilaria Peluso. (2019) Antiangiogenic Effect of Alkaloids. Oxidative Medicine and Cellular Longevity 2019, pages 1-16.
Crossref
Crossref
Maria Fareed, MH Qazi, Sarfaraz Ahmed, Sana Awan & Aamer Qazi. (2019) Cytotoxic Assessment of Quinoline Based Derivatives on Liver Cancer Cell Line. Pakistan BioMedical Journal 1:2.
Crossref
Crossref
Mona A. Abdelmoneem, Mazen Mahmoud, Amira Zaky, Maged W. Helmy, Marwa Sallam, Jia-You Fang, Kadria A. Elkhodairy & Ahmed O. Elzoghby. (2018) Dual-targeted casein micelles as green nanomedicine for synergistic phytotherapy of hepatocellular carcinoma. Journal of Controlled Release 287, pages 78-93.
Crossref
Crossref
Joaquín Araos, Jonathan P. Sleeman & Boyan K. Garvalov. (2018) The role of hypoxic signalling in metastasis: towards translating knowledge of basic biology into novel anti-tumour strategies. Clinical & Experimental Metastasis 35:7, pages 563-599.
Crossref
Crossref
Dalia M. Kabary, Maged W. Helmy, Elsayeda-Zeinab A. Abdelfattah, Jia-You Fang, Kadria A. Elkhodairy & Ahmed O. Elzoghby. (2018) Inhalable multi-compartmental phospholipid enveloped lipid core nanocomposites for localized mTOR inhibitor/herbal combined therapy of lung carcinoma. European Journal of Pharmaceutics and Biopharmaceutics 130, pages 152-164.
Crossref
Crossref
Dalia M. Kabary, Maged W. Helmy, Kadria A. Elkhodairy, Jia-You Fang & Ahmed O. Elzoghby. (2018) Hyaluronate/lactoferrin layer-by-layer-coated lipid nanocarriers for targeted co-delivery of rapamycin and berberine to lung carcinoma. Colloids and Surfaces B: Biointerfaces 169, pages 183-194.
Crossref
Crossref
Jie Ying, Miaomiao Zhang, Xiaoyan Qiu & Yu Lu. (2018) The potential of herb medicines in the treatment of esophageal cancer. Biomedicine & Pharmacotherapy 103, pages 381-390.
Crossref
Crossref
Gabriele D'Uva, Denisa Baci, Adriana Albini & Douglas M. Noonan. (2018) Cancer chemoprevention revisited: Cytochrome P450 family 1B1 as a target in the tumor and the microenvironment. Cancer Treatment Reviews 63, pages 1-18.
Crossref
Crossref
Gorla V. Reddy, Nagendra S. Yarla, Shobha Ediga, Dinesh K. Tiwari, Naresh Kumar, Sandhya Singh, Vasundhra Bhandari, Priyanka Voori Giri, Anupam Bishayee, Chintalapally V. Rao & Pallu Reddanna. 2017. Natural Products Targeting Clinically Relevant Enzymes. Natural Products Targeting Clinically Relevant Enzymes
163
208
.
Florence Lefranc, Nurhayat Tabanca & Robert Kiss. (2017) Assessing the anticancer effects associated with food products and/or nutraceuticals using in vitro and in vivo preclinical development-related pharmacological tests. Seminars in Cancer Biology 46, pages 14-32.
Crossref
Crossref
Danciu Corina, Soica Codruta, Antal Diana, Alexandra Popescu, Roxana Ghiulai, Ioana Zinuca Pavel, Stefana Avram, Minda Daliana & Cristina Dehelean. 2017. Natural Products and Cancer Drug Discovery. Natural Products and Cancer Drug Discovery.
Siliang Wang, Peiliang Shen, Jinrong Zhou & Yin Lu. (2017) Diet phytochemicals and cutaneous carcinoma chemoprevention: A review. Pharmacological Research 119, pages 327-346.
Crossref
Crossref
Lenka Varinska, Peter Kubatka, Jan Mojzis, Anthony Zulli, Katarina Gazdikova, Pavol Zubor, Dietrich Büsselberg, Martin Caprnda, Radka Opatrilova, Iveta Gasparova, Martin Klabusay, Martin Pec, Eitan Fibach, Mariusz Adamek & Peter Kruzliak. (2017) Angiomodulators in cancer therapy: New perspectives. Biomedicine & Pharmacotherapy 89, pages 578-590.
Crossref
Crossref
Seong-Gon Kim, HaeYong Kweon & Suk-Keun Lee. (2016) Uncommon presentation of potential medication-related osteonecrosis of the jaw. SpringerPlus 5:1.
Crossref
Crossref
Jiasi Wu, Yingfan Hu, Li Xiang, Sheng Li, Yi Yuan, Xiaomei Chen, Yan Zhang, Wenge Huang, Xianli Meng & Ping Wang. (2016) San-Huang-Xie-Xin-Tang Constituents Exert Drug-Drug Interaction of Mutual Reinforcement at Both Pharmacodynamics and Pharmacokinetic Level: A Review. Frontiers in Pharmacology 7.
Crossref
Crossref
Zhixiang Wang, Yuan Liu, Yong Xue, Haiyan Hu, Jieyu Ye, Xiaodong Li, Zhigang Lu, Fanyi Meng & Shuang Liang. (2016) Berberine acts as a putative epigenetic modulator by affecting the histone code. Toxicology in Vitro 36, pages 10-17.
Crossref
Crossref
Nagendra Sastry Yarla, Anupam Bishayee, Gautam Sethi, Pallu Reddanna, Arunasree M. Kalle, Bhadrapura Lakkappa Dhananjaya, Kaladhar S.V.G.K. Dowluru, Ramakrishna Chintala & Govinda Rao Duddukuri. (2016) Targeting arachidonic acid pathway by natural products for cancer prevention and therapy. Seminars in Cancer Biology 40-41, pages 48-81.
Crossref
Crossref
Maria Karmella Apaya, Meng-Ting Chang & Lie-Fen Shyur. (2016) Phytomedicine polypharmacology: Cancer therapy through modulating the tumor microenvironment and oxylipin dynamics. Pharmacology & Therapeutics 162, pages 58-68.
Crossref
Crossref
Mario Alberto Leyva-Peralta, Ramón Enrique Robles-Zepeda, Adriana Garibay-Escobar, Eduardo Ruiz-Bustos, Laura Patricia Alvarez-Berber & Juan Carlos Gálvez-Ruiz. (2015) In vitro anti-proliferative activity of Argemone gracilenta and identification of some active components. BMC Complementary and Alternative Medicine 15:1.
Crossref
Crossref
Ning Wang, Hor-Yue Tan, Lei Li, Man-Fung Yuen & Yibin Feng. (2015) Berberine and Coptidis Rhizoma as potential anticancer agents: Recent updates and future perspectives. Journal of Ethnopharmacology 176, pages 35-48.
Crossref
Crossref
Elisa Pierpaoli, Elisa Damiani, Fiorenza Orlando, Guendalina Lucarini, Beatrice Bartozzi, Paolo Lombardi, Carmela Salvatore, Cristina Geroni, Abele Donati & Mauro Provinciali. (2015) Antiangiogenic and antitumor activities of berberine derivative NAX014 compound in a transgenic murine model of HER2/neu-positive mammary carcinoma. Carcinogenesis 36:10, pages 1169-1179.
Crossref
Crossref
Zhen-zhong Yang, Wei Liu, Feng Zhang, Zheng Li & Yi-yu Cheng. (2015) Deciphering the therapeutic mechanisms of Xiao-Ke-An in treatment of type 2 diabetes in mice by a Fangjiomics approach. Acta Pharmacologica Sinica 36:6, pages 699-707.
Crossref
Crossref
YOUNG CHAN SONG, YONGHEE LEE, HYEONG MI KIM, MOO YEOL HYUN, YUN YOUNG LIM, KYE YONG SONG & BEOM JOON KIM. (2015) Berberine regulates melanin synthesis by activating PI3K/AKT, ERK and GSK3β in B16F10 melanoma cells. International Journal of Molecular Medicine 35:4, pages 1011-1016.
Crossref
Crossref
Elisa Damiani, Elisa Pierpaoli, Fiorenza Orlando, Abele Donati & Mauro Provinciali. (2015)
Sidestream dark field videomicroscopy for
in vivo
evaluation of vascularization and perfusion of mammary tumours in HER2/neu transgenic mice
. Clinical and Experimental Pharmacology and Physiology 42:2, pages 225-229.
Crossref
Crossref
Oh Sung Kwon, Myoung Seok Jeong, Bonglee Kim & Sung-Hoon Kim. (2015)
Antiangiogenic Effect of Ethanol Extract of
Vigna angularis
via Inhibition of Phosphorylation of VEGFR2, Erk, and Akt
. Evidence-Based Complementary and Alternative Medicine 2015, pages 1-9.
Crossref
Crossref
A. AlQathama & J. M. Prieto. (2015) Natural products with therapeutic potential in melanoma metastasis. Natural Product Reports 32:8, pages 1170-1182.
Crossref
Crossref
Nan Yang, Julie Wang, Changda Liu, Ying Song, Shuwei Zhang, Jiachen Zi, Jixun Zhan, Madhan Masilamani, Amanda Cox, Anna Nowak-Wegrzyn, Hugh Sampson & Xiu-Min Li. (2014) Berberine and limonin suppress IgE production by human B cells and peripheral blood mononuclear cells from food-allergic patients. Annals of Allergy, Asthma & Immunology 113:5, pages 556-564.e4.
Crossref
Crossref
Min Cao, Pei Wang, Chunhong Sun, Wen He & Fengjun Wang. (2013) Amelioration of IFN-γ and TNF-α-Induced Intestinal Epithelial Barrier Dysfunction by Berberine via Suppression of MLCK-MLC Phosphorylation Signaling Pathway. PLoS ONE 8:5, pages e61944.
Crossref
Crossref
Murielle Mimeault & Surinder K. Batra. (2013) Hypoxia‐inducing factors as master regulators of stemness properties and altered metabolism of cancer‐ and metastasis‐initiating cells. Journal of Cellular and Molecular Medicine 17:1, pages 30-54.
Crossref
Crossref
Dan G. Duda. 2013. Angiogenesis Modulations in Health and Disease. Angiogenesis Modulations in Health and Disease
181
198
.
Dan G. Duda. (2012) Molecular Biomarkers of Response to Antiangiogenic Therapy for Cancer. ISRN Cell Biology 2012, pages 1-11.
Crossref
Crossref
Leonardo C. Welling, Eberval G. Figueiredo & Manoel J. Teixeira. (2012) Plants versus Tumors: The Search for New Targets in Neuro-Oncology. World Neurosurgery 78:1-2, pages 7-8.
Crossref
Crossref
Gregg L. Semenza. (2012) Hypoxia-inducible factors: mediators of cancer progression and targets for cancer therapy. Trends in Pharmacological Sciences 33:4, pages 207-214.
Crossref
Crossref
Jin-Jian Lu, Jiao-Lin Bao, Xiu-Ping Chen, Min Huang & Yi-Tao Wang. (2012) Alkaloids Isolated from Natural Herbs as the Anticancer Agents. Evidence-Based Complementary and Alternative Medicine 2012, pages 1-12.
Crossref
Crossref