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Research Article

Acute Toxicity of Stevioside, A Natural Sweetener, and its Metabolite, Steviol, in Several Animal Species

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Pages 31-44 | Published online: 27 Sep 2008

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (6)

Xiaomin Zou, QiWen Tan, Bey-Hing Goh, Learn-Han Lee, Kai-Leng Tan & Hooi-Leng Ser. (2020) ‘Sweeter’ than its name: anti-inflammatory activities of Stevia rebaudiana. All Life 13:1, pages 286-309.
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Jun-Ming Chen, Yong-Mei Xia, Yan-Dong Zhang, Tong-Tong Zhang, Qing-Rui Peng & Yun Fang. (2018) Influence of substrates on the in vitro kinetics of steviol glucuronidation and interaction between steviol glycosides metabolites and UGT2B7. International Journal of Food Sciences and Nutrition 69:4, pages 472-479.
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Irma Aranda-González, Maira Segura-Campos, Yolanda Moguel-Ordoñez & David Betancur-Ancona. (2014) Stevia rebaudiana Bertoni. Un potencial adyuvante en el tratamiento de la diabetes mellitus. CyTA - Journal of Food 12:3, pages 218-226.
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Kumiko Takahashi, Yongkun Sun, Ikumi Yanagiuchi, Toshiyuki Hosokawa, Takeshi Saito, Miyako Komori, Tatsufumi Okino & Masaaki Kurasaki. (2012) Stevioside enhances apoptosis induced by serum deprivation in PC12 cells. Toxicology Mechanisms and Methods 22:4, pages 243-249.
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Fernando Tateo, Monica Bononi, Mauro Giorgio Mariotti, Laura Cornara & Giorgina Serrato-Valenti. (2001) Trichomes on vegetative and reproductive organs of Stevia rebaudiana (Asteraceae). Structure and secretory products. Plant Biosystems - An International Journal Dealing with all Aspects of Plant Biology 135:1, pages 25-37.
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C. Wasuntarawat, P. Temcharoen, C. Toskulkao, P. Mungkornkarn, M. Suttajit & T. Glinsukon. (1998) Developmental Toxicity of Steviol, a Metabolite of Stevioside, in the Hamster. Drug and Chemical Toxicology 21:2, pages 207-222.
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Articles from other publishers (42)

Yang Wang, Xiang Luo, Li Chen, Abdullateef Taiye Mustapha, Xiaojie Yu, Cunshan Zhou & Clinton Emeka Okonkwo. (2022) Natural and low‐caloric rebaudioside A as a substitute for dietary sugars: A comprehensive review. Comprehensive Reviews in Food Science and Food Safety 22:1, pages 615-642.
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Tania Gómez-Sierra, Estefani Yaquelin Hernández-Cruz, Ariadna Jazmín Ortega-Lozano, Alexis Paulina Jiménez-Uribe, Jose Pedraza Chaverri & Estefany Ingrid Medina-Reyes. 2023. Natural Additives in Foods. Natural Additives in Foods 303 323 .
Pengyu Lei, Haojie Chen, Jiahui Ma, Yimen Fang, Linkai Qu, Qinsi Yang, Bo Peng, Xingxing Zhang, Libo Jin & Da Sun. (2022) Research progress on extraction technology and biomedical function of natural sugar substitutes. Frontiers in Nutrition 9.
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Afiq A. Azrul-Murad, Christina S.Y. Yong, Yoeng L. Tan & Nurul I. Ab Ghani. (2022) Identification and characterization of genic simple sequence repeats from the leaf and stem transcriptomes of Stevia rebaudiana Bertoni. Scientia Horticulturae 300, pages 111067.
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Henrique Jorge Novaes Morgan, Aislan Quintiliano Delgado, Luiz Leonardo Saldanha, Nathalia Aparecida De Paula Camaforte, Anne Lígia Dokkedal & José Roberto Bosqueiro. (2021) Vochysia tucanorum Mart. butanol fraction presents antitumoral activity in vivo and prevents the installation of cachexia in solid Ehrlich tumor model. BMC Complementary Medicine and Therapies 21:1.
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Alexandra D. Voloshina, Anastasiia S. Sapunova, Natalia V. Kulik, Mayya G. Belenok, Irina Yu Strobykina, Anna P. Lyubina, Syumbelya K. Gumerova & Vladimir E. Kataev. (2021) Antimicrobial and cytotoxic effects of ammonium derivatives of diterpenoids steviol and isosteviol. Bioorganic & Medicinal Chemistry 32, pages 115974.
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Elsa Díaz-Montes, Octavio García-Depraect & Roberto Castro-Muñoz. 2021. Steviol Glycosides. Steviol Glycosides 159 199 .
Limin Wang & Wenbiao Wu. (2019) Angiotensin-converting enzyme inhibiting ability of ethanol extracts, steviol glycosides and protein hydrolysates from stevia leaves. Food & Function 10:12, pages 7967-7972.
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Sateesh Alavala, Rajendra Sangaraju, Nasiruddin Nalban, Bidya Dhar Sahu, Mahesh Kumar Jerald, Eswar Kumar Kilari & Ramakrishna Sistla. (2019) Stevioside, a diterpenoid glycoside, shows anti-inflammatory property against Dextran Sulphate Sodium-induced ulcerative colitis in mice. European Journal of Pharmacology 855, pages 192-201.
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Ria R. deGuzman, David J. Midmore & Kerry B. Walsh. (2019) Do Steviol Glycosides Provide Ecological Fitness to Stevia rebaudiana through Impact on Dietary Preference of Plant Pests and Herbivores? . Journal of Natural Products 82:5, pages 1200-1206.
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Junming Chen, Yongmei Xia, Xiaochen Sui, Qingrui Peng, Tongtong Zhang, Jian Li & Jue Zhang. (2018) Steviol, a natural product inhibits proliferation of the gastrointestinal cancer cells intensively. Oncotarget 9:41, pages 26299-26308.
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Solomon Oladapo Rotimi, Oluwakemi Anuoluwapo Rotimi, Isaacson Bababode Adelani, Chinonye Onuzulu, Patience Obi & Rotimi Okungbaye. (2018) Stevioside modulates oxidative damage in the liver and kidney of high fat/low streptozocin diabetic rats. Heliyon 4:5, pages e00640.
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Naresh Kumar, Nidhi Goel, Tara Chand Yadav & Vikas Pruthi. (2017) Quantum chemical, ADMET and molecular docking studies of ferulic acid amide derivatives with a novel anticancer drug target. Medicinal Chemistry Research 26:8, pages 1822-1834.
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Rouhollah Gazor, Ardalan Pasdaran Lashgari, Shabnam Almasi & Saeed Ghasemi. (2016) Effect of Brown Algae Cystoseira trinodis Methanolic Extract on Renal Tissue. Pharmaceutical Sciences 22:1, pages 49-53.
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Hana Kim, Yeong Ok Song & Jeehyun Lee. (2015) Descriptive Sensory Evaluation and Consumer Acceptability of Sujeonggwa in a Tea Bag. Korean journal of food and cookery science 31:3, pages 280-287.
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Mohammed Abdalbasit A. Gasmalla, Ruijin Yang & Xiao Hua. (2014) Stevia rebaudiana Bertoni: An alternative Sugar Replacer and Its Application in Food Industry. Food Engineering Reviews 6:4, pages 150-162.
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Soon-Nam Choi, Hyun-Jung Kim, Mi-Kyoung Joo & Nam-Yong Chung. (2013) Quality Characteristics of Castella Prepared by Substituting Sugar with Stevia Leaf Powder. Korean journal of food and cookery science 29:2, pages 153-160.
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Akula Ramakrishna & Gokare Aswathanarayana Ravishankar. 2013. Natural Products. Natural Products 3193 3203 .
Hye-Young Lee, Jong-Koo Kang, In-Seok Bang & Cheol-Beom Park. (2012) Increase of Liver Organ Weight in B6C3F1 Mice Fed with High dose Stevioside for 14 Days. Journal of Food Hygiene and Safety 27:3, pages 306-311.
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Michael G. Lindley. 2012. Sweeteners and Sugar Alternatives in Food Technology. Sweeteners and Sugar Alternatives in Food Technology 185 212 .
Rodrigo R. Catharino & Leonardo S. Santos. (2012) On-line monitoring of stevioside sweetener hydrolysis to steviol in acidic aqueous solutions. Food Chemistry 133:4, pages 1632-1635.
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Goutam Brahmachari, Lalan C. Mandal, Rajiv Roy, Sadhan Mondal & Arun K. Brahmachari. (2010) Stevioside and Related Compounds – Molecules of Pharmaceutical Promise: A Critical Overview. Archiv der Pharmazie 344:1, pages 5-19.
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. (2010) Scientific Opinion on the safety of steviol glycosides for the proposed uses as a food additive. EFSA Journal 8:4.
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Claudio Gardana, Martina Scaglianti & Paolo Simonetti. (2010) Evaluation of steviol and its glycosides in Stevia rebaudiana leaves and commercial sweetener by ultra-high-performance liquid chromatography-mass spectrometry. Journal of Chromatography A 1217:9, pages 1463-1470.
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Varanuj Chatsudthipong & Chatchai Muanprasat. (2009) Stevioside and related compounds: Therapeutic benefits beyond sweetness. Pharmacology & Therapeutics 121:1, pages 41-54.
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M.C. Carakostas, L.L. Curry, A.C. Boileau & D.J. Brusick. (2008) Overview: The history, technical function and safety of rebaudioside A, a naturally occurring steviol glycoside, for use in food and beverages. Food and Chemical Toxicology 46:7, pages S1-S10.
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Leslie L. Curry & Ashley Roberts. (2008) Subchronic toxicity of rebaudioside A. Food and Chemical Toxicology 46:7, pages S11-S20.
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Chaiwat Boonkaewwan, Mei Ao, Chaivat Toskulkao & Mrinalini C. Rao. (2008) Specific Immunomodulatory and Secretory Activities of Stevioside and Steviol in Intestinal Cells. Journal of Agricultural and Food Chemistry 56:10, pages 3777-3784.
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A.P.M. Nunes, S.C. Ferreira-Machado, R.M. Nunes, F.J.S. Dantas, J.C.P. De Mattos & A. Caldeira-de-Araújo. (2007) Analysis of genotoxic potentiality of stevioside by comet assay. Food and Chemical Toxicology 45:4, pages 662-666.
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Pablo Garcia, Alaide De Oliveira & Ronan Batista. (2007) Occurrence, Biological Activities and Synthesis of Kaurane Diterpenes and their Glycosides. Molecules 12:3, pages 455-483.
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A. P. M Nunes, J. C. P. De Mattos, S. C. Ferreira-Machado, R. M. Nunes, N. R. Asad, F. J. S. Dantas, R. J. A. C. Bezerra & A. Caldeira-de-Araujo. (2006) Biological effects of stevioside on the survival of Escherichia colistrains and plasmid DNA. Molecular and Cellular Biochemistry 293:1-2, pages 187-192.
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Mike Lindley. 2006. Sweeteners and Sugar Alternatives in Food Technology. Sweeteners and Sugar Alternatives in Food Technology 329 364 .
Chutima Srimaroeng, Promsuk Jutabha, John B. Pritchard, Hitoshi Endou & Varanuj Chatsudthipong. (2005) Interactions of Stevioside and Steviol with Renal Organic Anion Transporters in S2 Cells and Mouse Renal Cortical Slices. Pharmaceutical Research 22:6, pages 858-866.
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Chutima Srimaroeng, Varanuj Chatsudthipong, Amy G. Aslamkhan & John B. Pritchard. (2005) Transport of the Natural Sweetener Stevioside and Its Aglycone Steviol by Human Organic Anion Transporter (hOAT1; SLC22A6) and hOAT3 (SLC22A8). Journal of Pharmacology and Experimental Therapeutics 313:2, pages 621-628.
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L. Z. Wang, B. C. Goh, L. Fan & H. S. Lee. (2003) Sensitive high‐performance liquid chromatography/mass spectrometry method for determination of steviol in rat plasma. Rapid Communications in Mass Spectrometry 18:1, pages 83-86.
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Narissara Lailerd, Vitoon Saengsirisuwan, Julie A Sloniger, Chaivat Toskulkao & Erik J Henriksen. (2004) Effects of stevioside on glucose transport activity in insulin-sensitive and insulin-resistant rat skeletal muscle. Metabolism 53:1, pages 101-107.
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Jan M.C. Geuns, Patrick Augustijns, Raf Mols, Johan G. Buyse & Bert Driessen. (2003) Metabolism of stevioside in pigs and intestinal absorption characteristics of stevioside, rebaudioside A and steviol. Food and Chemical Toxicology 41:11, pages 1599-1607.
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Jan M.C Geuns. (2003) Stevioside. Phytochemistry 64:5, pages 913-921.
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Eriko Koyama, Norifumi Sakai, Yuji Ohori, Ken Kitazawa, Osamu Izawa, Kunio Kakegawa, Akiharu Fujino & Michio Ui. (2003) Absorption and metabolism of glycosidic sweeteners of stevia mixture and their aglycone, steviol, in rats and humans. Food and Chemical Toxicology 41:6, pages 875-883.
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E Koyama, K Kitazawa, Y Ohori, O Izawa, K Kakegawa, A Fujino & M Ui. (2003) In vitro metabolism of the glycosidic sweeteners, stevia mixture and enzymatically modified stevia in human intestinal microflora. Food and Chemical Toxicology 41:3, pages 359-374.
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Jan M.C. Geuns. 2002. Bioactive Natural Products (Part H). Bioactive Natural Products (Part H) 299 319 .
GIUSEPPINA PAOLA PARPINELLO, ANDREA VERSARI, MASSIMO CASTELLARI & SERGIO GALASSI. (2007) STEVIOSIDE AS A REPLACEMENT OF SUCROSE IN PEACH JUICE: SENSORY EVALUATION. Journal of Sensory Studies 16:5, pages 471-484.
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