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Research Article

Pathological complete response and sphincter-sparing surgery after neoadjuvant radiochemotherapy with regional hyperthermia for locally advanced rectal cancer compared with radiochemotherapy alone

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Pages 707-714 | Received 15 Apr 2012, Accepted 15 Aug 2012, Published online: 24 Sep 2012

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Read on this site (7)

Akke Bakker, Remko Zweije, H. Petra Kok, Lukas J. A. Stalpers, G. Henrike Westerveld, Karel A. Hinnen, Geertjan van Tienhoven, M. Willemijn Kolff & Hans Crezee. (2022) Comparison of the clinical performance of a hybrid Alba 4D and the AMC-4 locoregional hyperthermia systems. International Journal of Hyperthermia 39:1, pages 1408-1414.
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Yuxia Wang, Siyi Lu, Yuxia Shao, Ran Peng, Xuemin Li, Junjie Wang & Hao Wang. (2022) Deep regional hyperthermia combined with modern concurrent chemoradiotherapy increases T-downstaging rate in locally advanced rectal cancer. International Journal of Hyperthermia 39:1, pages 431-436.
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Sunghyun Kim, Jun Hyeok Lee, Jihye Cha & Sei Hwan You. (2021) Beneficial effects of modulated electro-hyperthermia during neoadjuvant treatment for locally advanced rectal cancer. International Journal of Hyperthermia 38:1, pages 144-151.
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K. Zwirner, P. Bonomo, U. Lamprecht, D. Zips & C. Gani. (2018) External validation of a rectal cancer outcome prediction model with a cohort of patients treated with preoperative radiochemotherapy and deep regional hyperthermia. International Journal of Hyperthermia 34:4, pages 455-460.
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D. Schlesinger, M. Lee, G. ter Haar, B. Sela, M. Eames, J. Snell, N. Kassell, J. Sheehan, J. M. Larner & J. -F. Aubry. (2017) Equivalence of cell survival data for radiation dose and thermal dose in ablative treatments: analysis applied to essential tremor thalamotomy by focused ultrasound and gamma knife. International Journal of Hyperthermia 33:4, pages 401-410.
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Cihan Gani, Christopher Schroeder, Vanessa Heinrich, Patrick Spillner, Ulf Lamprecht, Bernhard Berger & Daniel Zips. (2016) Long-term local control and survival after preoperative radiochemotherapy in combination with deep regional hyperthermia in locally advanced rectal cancer. International Journal of Hyperthermia 32:2, pages 187-192.
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Abhishek A Solanki, Daniel T Chang & Stanley L Liauw. (2013) Future directions in combined modality therapy for rectal cancer: reevaluating the role of total mesorectal excision after chemoradiotherapy. OncoTargets and Therapy 6, pages 1097-1110.
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Articles from other publishers (31)

Xuejun Jiang, Feng Zhou, Fangjun Yuan, Xinyi Lei, Cui Liu & Zujin Ji. (2023) A novel treatment approach for a patient with advanced low rectal cancer: A case report and literature review. Medicine 102:14, pages e33497.
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Pierluigi Bonomo, Jairo Socarras Fernandez, Daniela Thorwarth, Marta Casati, Lorenzo Livi, Daniel Zips & Cihan Gani. (2022) Simulation CT-based radiomics for prediction of response after neoadjuvant chemo-radiotherapy in patients with locally advanced rectal cancer. Radiation Oncology 17:1.
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Alexander Pattyn, Karl Kratkiewicz, Naser Alijabbari, Paul L. Carson, Peter Littrup, J. Brian Fowlkes, Nebojsa Duric & Mohammad Mehrmohammadi. (2022) Feasibility of ultrasound tomography–guided localized mild hyperthermia using a ring transducer: Ex vivo and in silico studies. Medical Physics 49:9, pages 6120-6136.
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Yohan Lee, Sunghyun Kim, Hyejung Cha, Jae Hun Han, Hyun Joon Choi, Eun Go & Sei Hwan You. (2022) Long-Term Feasibility of 13.56 MHz Modulated Electro-Hyperthermia-Based Preoperative Thermoradiochemotherapy in Locally Advanced Rectal Cancer. Cancers 14:5, pages 1271.
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Liping Bai, Tobias Pfeifer, Wolfgang Gross, Carolina De La Torre, Shuyang Zhao, Li Liu, Michael Schaefer & Ingrid Herr. (2021) Establishment of Tumor Treating Fields Combined With Mild Hyperthermia as Novel Supporting Therapy for Pancreatic Cancer. Frontiers in Oncology 11.
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Cihan Gani, Ulf Lamprecht, Alexander Ziegler, Matthias Moll, Johanna Gellermann, Vanessa Heinrich, Svetlana Wenz, Falko Fend, Alfred Königsrainer, Michael Bitzer & Daniel Zips. (2021) Deep regional hyperthermia with preoperative radiochemotherapy in locally advanced rectal cancer, a prospective phase II trial. Radiotherapy and Oncology 159, pages 155-160.
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Oliver J. Ott, Cihan Gani, Lars H. Lindner, Manfred Schmidt, Ulf Lamprecht, Sultan Abdel-Rahman, Axel Hinke, Thomas Weissmann, Arndt Hartmann, Rolf D. Issels, Daniel Zips, Claus Belka, Robert Grützmann & Rainer Fietkau. (2021) Neoadjuvant Chemoradiation Combined with Regional Hyperthermia in Locally Advanced or Recurrent Rectal Cancer. Cancers 13:6, pages 1279.
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S. Yu. Ignatenkov, I. Yu. Kudryavtsev, K. A. Kuzminykh, O. A. Skugareva & E. A. Dobrosotskaya. (2020) Regional Hyperthermia in Neo-Adjuvant Chemoradiotherapy of Rectal Cancer. Journal of oncology: diagnostic radiology and radiotherapy 3:2, pages 43-50.
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Michaela Unsoeld, Ulf Lamprecht, Frank Traub, Barbara Hermes, Marcus Scharpf, Vlatko Potkrajcic, Daniel Zips, Frank Paulsen & Franziska Eckert. (2020) MR Thermometry Data Correlate with Pathological Response for Soft Tissue Sarcoma of the Lower Extremity in a Single Center Analysis of Prospectively Registered Patients. Cancers 12:4, pages 959.
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Giammaria Fiorentini, Donatella Sarti, Cosmo Damiano Gadaleta, Marco Ballerini, Caterina Fiorentini, Tommaso Garfagno, Girolamo Ranieri & Stefano Guadagni. (2020) A Narrative Review of Regional Hyperthermia: Updates From 2010 to 2019. Integrative Cancer Therapies 19, pages 153473542093264.
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M.M. Paulides, H. Dobsicek Trefna, S. Curto & D.B. Rodrigues. (2020) Recent technological advancements in radiofrequency- andmicrowave-mediated hyperthermia for enhancing drug delivery. Advanced Drug Delivery Reviews 163-164, pages 3-18.
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Cihan Gani, Nina Gani, Sebastian Zschaeck, Fabian Eberle, Norbert Schaeffeler, Thomas Hehr, Bernhard Berger, Stefan Georg Fischer, Johannes Claßen, Stephan Zipfel, Claus Rödel, Martin Teufel & Daniel Zips. (2019) Organ Preservation in Rectal Cancer: The Patients' Perspective. Frontiers in Oncology 9.
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Yi Cheng, Shanshan Weng, Linzhen Yu, Ning Zhu, Mengyuan Yang & Ying Yuan. (2019) The Role of Hyperthermia in the Multidisciplinary Treatment of Malignant Tumors. Integrative Cancer Therapies 18, pages 153473541987634.
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Cihan Gani, Andreas Kirschniak & Daniel Zips. (2019) Watchful Waiting after Radiochemotherapy in Rectal Cancer: When Is It Feasible?. Visceral Medicine 35:2, pages 119-123.
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Cihan Gani, Ulrich Grosse, Stephan Clasen, Andreas Kirschniak, Martin Goetz, Claus Rödel & Daniel Zips. (2018) Cost analysis of a wait-and-see strategy after radiochemotherapy in distal rectal cancerKostenanalyse der Wait-and-see-Strategie nach Radiochemotherapie beim distalen Rektumkarzinom. Strahlentherapie und Onkologie 194:11, pages 985-990.
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Hisanori Shoji, Masahiko Motegi, Kiyotaka Osawa, Takayuki Asao, Hiroyuki Kuwano, Takeo Takahashi & Kyoji Ogoshi. (2018) The first thermic treatment predicts following chemoradiation response with concurrent thermal therapy for the treatment of rectal cancer. Oncology Letters.
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Sang-Won Kim, Ji Woon Yea, Jae Hwang Kim, Mi Jin Gu & Min Kyu Kang. (2017) Selecting patients for hyperthermia combined with preoperative chemoradiotherapy for locally advanced rectal cancer. International Journal of Clinical Oncology 23:2, pages 287-297.
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Ming‐Chen Ba, Hui Long, Shuai Wang, Yin‐Bing Wu, Bo‐Huo Zhang, Zhao‐Fei Yan, Fei‐Hong Yu & Shu‐Zhong Cui. (2018) Hyperthermia enhances radiosensitivity of colorectal cancer cells through ROS inducing autophagic cell death. Journal of Cellular Biochemistry 119:4, pages 3763-3774.
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Jan C. Peeken, Peter Vaupel & Stephanie E. Combs. (2017) Integrating Hyperthermia into Modern Radiation Oncology: What Evidence Is Necessary?. Frontiers in Oncology 7.
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C. Gani, P. Bonomo, K. Zwirner, C. Schroeder, A. Menegakis, C. Rödel & D. Zips. (2017) Organ preservation in rectal cancer – Challenges and future strategies. Clinical and Translational Radiation Oncology 3, pages 9-15.
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Cihan Gani & Daniel Zips. (2017) Einfluss des Zeitintervalls auf die pCR-Rate. InFo Onkologie 20:2, pages 24-25.
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Hisanori Shoji, Masahiko Motegi, Kiyotaka Osawa, Hiroto Murata, Takayuki Asao, Hiroyuki Kuwano, Takeo Takahashi & kyoji Ogoshi. (2017) Gross tumor volume is a good predictor of rectal cancer tumor response before chemoradiation with concurrent thermal therapy. Annals of Cancer Research and Therapy 25:1, pages 22-29.
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Hisanori Shoji, Masahiko Motegi, Yosuke Takakusagi, Takayuki Asao, Hiroyuki Kuwano, Takeo Takahashi & Kyoji Ogoshi. (2017) Chemoradiotherapy and concurrent radiofrequency thermal therapy to treat primary rectal cancer and prediction of treatment responses. Oncology Reports 37:2, pages 695-704.
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HISANORI SHOJI, KAZUKI JINBO, KOUJI SUGAWARA, SATOSHI SUDA, MASAHIKO MOTEGI, HIROTO MURATA, KYOJI OGOSHI, TAKEO TAKAHASHI, TAKAYUKI ASAO & HIROYUKI KUWANO. (2017) Thermal Therapy as Multidisciplinary Therapy Applied to Rectal Cancer:直腸癌に対する集学的治療としての温熱療法:. Thermal Medicine 33:3, pages 75-89.
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Cihan Gani & Daniel Zips. (2016) Zeitintervall zwischen neoadjuvanter Radiochemotherapie und Operation beim RektumkarzinomTime interval between neoadjuvant radiochemotherapy and surgery in rectal cancer. Strahlentherapie und Onkologie 193:1, pages 91-92.
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Theodora Mantso, George Goussetis, Rodrigo Franco, Sotiris Botaitis, Aglaia Pappa & Mihalis Panayiotidis. (2016) Effects of hyperthermia as a mitigation strategy in DNA damage-based cancer therapies. Seminars in Cancer Biology 37-38, pages 96-105.
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Matthew Mallory, Emile Gogineni, Guy C. Jones, Lester Greer & Charles B. SimoneIIII. (2016) Therapeutic hyperthermia: The old, the new, and the upcoming. Critical Reviews in Oncology/Hematology 97, pages 56-64.
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Mark Dewhirst, Paul R. Stauffer, Shiva Das, Oana I. Craciunescu & Zeljko Vujaskovic. 2016. Clinical Radiation Oncology. Clinical Radiation Oncology 381 398.e6 .
Takayuki Asao, Hiroyuki Kuwano, Takeo Takahashi & Takashi Nakano. 2016. Hyperthermic Oncology from Bench to Bedside. Hyperthermic Oncology from Bench to Bedside 295 308 .
Oliver J. Ott & Manfred Schmidt. 2017. Re-Irradiation: New Frontiers. Re-Irradiation: New Frontiers 35 45 .
Arndt-Christian Müller, Daniel Zips, Vanessa Heinrich, Ulf Lamprecht, Otilia Voigt, Susen Burock, Volker Budach, Peter Wust & Pirus Ghadjar. (2015) Regional hyperthermia and moderately dose-escalated salvage radiotherapy for recurrent prostate cancer. Protocol of a phase II trial. Radiation Oncology 10:1.
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