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Original Articles

Induction of hypoxia by vascular disrupting agents and the significance for their combination with radiation therapy

, &
Pages 1320-1326 | Received 26 Jun 2013, Accepted 08 Jul 2013, Published online: 29 Aug 2013

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Steffen Nielsen, Mateusz K. Sitarz, Priyanshu M. Sinha, Charlemagne A. Folefac, Morten Høyer, Brita S. Sørensen & Michael R. Horsman. (2023) Using immunotherapy to enhance the response of a C3H mammary carcinoma to proton radiation. Acta Oncologica 62:11, pages 1581-1586.
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Pernille B. Elming, Brita S. Sørensen, Harald Spejlborg, Jens Overgaard & Michael R. Horsman. (2021) Does the combination of hyperthermia with low LET (linear energy transfer) radiation induce anti-tumor effects equivalent to those seen with high LET radiation alone?. International Journal of Hyperthermia 38:1, pages 105-110.
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Ane B. Iversen, Morten Busk, Lotte B. Bertelsen, Christoffer Laustsen, Ole L. Munk, Thomas Nielsen, Thomas R. Wittenborn, Johan Bussink, Jasper Lok, Hans Stødkilde-Jørgensen & Michael R. Horsman. (2017) The potential of hyperpolarized 13C magnetic resonance spectroscopy to monitor the effect of combretastatin based vascular disrupting agents. Acta Oncologica 56:11, pages 1626-1633.
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Pei-Shin Jiang, Hsin-Yu Tsai, Philip Drake, Fu-Nien Wang & Chi-Shiun Chiang. (2017) Gadolinium-doped iron oxide nanoparticles induced magnetic field hyperthermia combined with radiotherapy increases tumour response by vascular disruption and improved oxygenation. International Journal of Hyperthermia 33:7, pages 770-778.
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Michael R. Horsman. (2016) Realistic biological approaches for improving thermoradiotherapy. International Journal of Hyperthermia 32:1, pages 14-22.
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Cai Grau, Jens Overgaard, Morten Høyer, Kari Tanderup, Jacob Christian Lindegaard & Ludvig Paul Muren. (2015) Biology-guided adaptive radiotherapy (BiGART) is progressing towards clinical reality. Acta Oncologica 54:9, pages 1245-1250.
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Thomas R. Wittenborn & Michael R. Horsman. (2015) Targeting tumour hypoxia to improve outcome of stereotactic radiotherapy. Acta Oncologica 54:9, pages 1385-1392.
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Michael R. Horsman. (2015) Therapeutic potential of using the vascular disrupting agent OXi4503 to enhance mild temperature thermoradiation. International Journal of Hyperthermia 31:5, pages 453-459.
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Daniel J Inglis, Tina C Lavranos, Donna M Beaumont, Annabell F Leske, Chloe K Brown, Allison J Hall & Gabriel Kremmidiotis. (2014) The vascular disrupting agent BNC105 potentiates the efficacy of VEGF and mTOR inhibitors in renal and breast cancer. Cancer Biology & Therapy 15:11, pages 1552-1560.
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Articles from other publishers (13)

M.R. Horsman, B.S. Sørensen, M. Busk & D.W. Siemann. (2021) Therapeutic Modification of Hypoxia. Clinical Oncology 33:11, pages e492-e509.
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Min-Young Kim, Jung-Young Shin, Jeong-Oh Kim, Kyoung-Hwa Son, Yeon Sil Kim, Chan Kwon Jung & Jin-Hyoung Kang. (2020) Anti-tumor efficacy of CKD-516 in combination with radiation in xenograft mouse model of lung squamous cell carcinoma. BMC Cancer 20:1.
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Michael R. Horsman, Thomas R. Wittenborn, Patricia S. Nielsen & Pernille B. Elming. (2020) Tumors Resistant to Checkpoint Inhibitors Can Become Sensitive after Treatment with Vascular Disrupting Agents. International Journal of Molecular Sciences 21:13, pages 4778.
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Haiyang Yu, Na Shen, Yanli Bao, Li Chen & Zhaohui Tang. (2020) Tumor regression and potentiation of polymeric vascular disrupting therapy through reprogramming of a hypoxia microenvironment with temsirolimus. Biomaterials Science 8:1, pages 325-332.
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Hanjiao Qin, Haiyang Yu, Jiyao Sheng, Dawei Zhang, Na Shen, Linlin Liu, Zhaohui Tang & Xuesi Chen. (2019) PI3Kgamma Inhibitor Attenuates Immunosuppressive Effect of Poly( l ‐Glutamic Acid)‐Combretastatin A4 Conjugate in Metastatic Breast Cancer . Advanced Science 6:12, pages 1900327.
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Simon Lønbro, Jennifer M. Wiggins, Thomas Wittenborn, Pernille Byrialsen Elming, Lori Rice, Christine Pampo, Jennifer A. Lee, Dietmar W. Siemann & Michael R. Horsman. (2019) Reliability of blood lactate as a measure of exercise intensity in different strains of mice during forced treadmill running. PLOS ONE 14:5, pages e0215584.
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Sven De Bruycker, Christel Vangestel, Steven Staelens, Tim Van den Wyngaert & Sigrid Stroobants. (2018) How to Modulate Tumor Hypoxia for Preclinical In Vivo Imaging Research. Contrast Media & Molecular Imaging 2018, pages 1-17.
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Amir Daei Farshchi Adli, Rana Jahanban-Esfahlan, Khaled Seidi, Sonia Samandari-Rad & Nosratollah Zarghami. (2018) An overview on Vadimezan (DMXAA): The vascular disrupting agent. Chemical Biology & Drug Design 91:5, pages 996-1006.
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Michael R. Horsman & Jens Overgaard. (2016) The impact of hypoxia and its modification of the outcome of radiotherapy. Journal of Radiation Research 57:S1, pages i90-i98.
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Wenjie Liang, Yicheng Ni & Feng Chen. (2016) Tumor resistance to vascular disrupting agents: mechanisms, imaging, and solutions. Oncotarget 7:13, pages 15444-15459.
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Florence Colliez, Anne‐Catherine Fruytier, Julie Magat, Marie‐Aline Neveu, Patrice D. Cani, Bernard Gallez & Bénédicte F. Jordan. (2015) Monitoring Combretastatin A4–induced tumor hypoxia and hemodynamic changes using endogenous MR contrast and DCE‐MRI. Magnetic Resonance in Medicine 75:2, pages 866-872.
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Dietmar W. Siemann & Michael R. Horsman. (2015) Modulation of the tumor vasculature and oxygenation to improve therapy. Pharmacology & Therapeutics 153, pages 107-124.
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Florence Colliez, Marie-Aline Neveu, Julie Magat, Thanh Trang Cao Pham, Bernard Gallez & Bénédicte F. Jordan. (2014) Qualification of a Noninvasive Magnetic Resonance Imaging Biomarker to Assess Tumor Oxygenation. Clinical Cancer Research 20:21, pages 5403-5411.
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