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Research Article

Chitosan: A Unique Polysaccharide for Drug Delivery

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Pages 979-993 | Published online: 20 Oct 2008

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Sakshi Nangia, Sudhir Warkar & Deeksha Katyal. (2018) A review on environmental applications of chitosan biopolymeric hydrogel based composites. Journal of Macromolecular Science, Part A 55:11-12, pages 747-763.
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Naresh Kumar, Raj Kumar Salar, Minakshi Prasad & Koushlesh Ranjan. (2018) Synthesis, characterization and anticancer activity of vincristine loaded folic acid-chitosan conjugated nanoparticles on NCI-H460 non-small cell lung cancer cell line. Egyptian Journal of Basic and Applied Sciences 5:1, pages 87-99.
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Xuelei Yin, Shuaishuai Feng, Yingying Chi, Jinhu Liu, Kaoxiang Sun, Chuanyou Guo & Zimei Wu. (2018) Estrogen-functionalized liposomes grafted with glutathione-responsive sheddable chotooligosaccharides for the therapy of osteosarcoma. Drug Delivery 25:1, pages 900-908.
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Nadiah Zafar, Geraldine Agusti, Hatem Fessi & Abdelhamid Elaissari. (2017) Elaboration of sponge-like biodegradable cationic particles via double-emulsion solvent evaporation. Journal of Dispersion Science and Technology 38:4, pages 577-583.
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Gulam Mustafa, Abdulmohsen H. Alrohaimi, Aseem Bhatnagar, Sanjula Baboota, Javed Ali & Alka Ahuja. (2016) Brain targeting by intranasal drug delivery (INDD): a combined effect of trans-neural and para-neuronal pathway. Drug Delivery 23:3, pages 923-929.
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Saravanakumar Arthanari, Ganesh Mani, Mei Mei Peng & Hyun Tae Jang. (2016) Chitosan–HPMC-blended microspheres as a vaccine carrier for the delivery of tetanus toxoid. Artificial Cells, Nanomedicine, and Biotechnology 44:2, pages 517-523.
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Michael J Mitchell & Michael R King. (2015) Leukocytes as carriers for targeted cancer drug delivery. Expert Opinion on Drug Delivery 12:3, pages 375-392.
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Guo Dong Zhao, Rui Sun, Shi Lei Ni & Qiang Xia. (2015) Development and characterisation of a novel chitosan-coated antioxidant liposome containing both coenzyme Q10 and alpha-lipoic acid. Journal of Microencapsulation 32:2, pages 157-165.
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Agustina García, Darío Leonardi, Gisela N. Piccirilli, María E. Mamprin, Alejandro C. Olivieri & María C. Lamas. (2015) Spray drying formulation of albendazole microspheres by experimental design. In vitro–in vivo studies. Drug Development and Industrial Pharmacy 41:2, pages 244-252.
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Seyed Mohamad Sadegh Modaresi, Shahram Ejtemaei Mehr, Mohammad Ali Faramarzi, Elina Esmaeilzadeh Gharehdaghi, Mahnaz Azarnia, Mohammad Hossein Modarressi, Hadi Baharifar, Seyed Javad Vaez & Amir Amani. (2014) Preparation and characterization of self-assembled chitosan nanoparticles for the sustained delivery of streptokinase: an in vivo study. Pharmaceutical Development and Technology 19:5, pages 593-597.
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Joe M. Viljoen, Jan H. Steenekamp, Andries F. Marais & Awie F. Kotzé. (2014) Effect of moisture content, temperature and exposure time on the physical stability of chitosan powder and tablets. Drug Development and Industrial Pharmacy 40:6, pages 730-742.
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Kıvılcım Öztürk, Ali Serol Ertürk, Can Sarısözen, Metin Tulu & Sema Çalış. (2014) Cytotoxicity and in vitro characterization studies of synthesized Jeffamine-cored PAMAM dendrimers. Journal of Microencapsulation 31:2, pages 127-136.
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Elina Esmaeilzadeh-Gharehdaghi, Mohammad Ali Faramarzi, Mohammad Ali Amini, Esmaeil Moazeni & Amir Amani. (2014) Processing/formulation parameters determining dispersity of chitosan particles: an ANNs study. Journal of Microencapsulation 31:1, pages 77-85.
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Chino D Cambridge, Shree R Singh, Alain B Waffo, Stacie J Fairley & Vida A Dennis. (2013) Formulation, characterization, and expression of a recombinant MOMP Chlamydia trachomatis DNA vaccine encapsulated in chitosan nanoparticles. International Journal of Nanomedicine 8, pages 1759-1771.
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M. Geetha Devi, Susmita Dutta, Ashraf Talib Al Hinai & S. Feroz. (2013) Encapsulation and Release of Moxifloxacin Hydrochloride in Chitosan–Dextran Sulphate Microcapsules. Indian Chemical Engineer 55:4, pages 258-270.
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Kunal Pal, Beauty Behera, Saroj Roy, Sirsendu Sekhar Ray & Goutam Thakur. (2013) Chitosan Based Delivery Systems on a Length Scale: Nano to Macro. Soft Materials 11:2, pages 125-142.
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M.M. Naim & H.E.M. Abdel Razek. (2013) Chelation and permeation of heavy metals using affinity membranes from cellulose acetate–chitosan blends. Desalination and Water Treatment 51:1-3, pages 644-657.
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Elina Esmaeilzadeh-Gharedaghi, Mohammad Ali Faramarzi, Mohammad Ali Amini, Abdolhossein Rouholamini Najafabadi, Seyed Mahdi Rezayat & Amir Amani. (2012) Effects of processing parameters on particle size of ultrasound prepared chitosan nanoparticles: An Artificial Neural Networks Study. Pharmaceutical Development and Technology 17:5, pages 638-647.
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Tania Ahmed, Helder Marçal, Scott Johnson, Bryan N. Brown & L. John R. Foster. (2012) Coalescence of Extracellular Matrix (ECM) from Porcine Urinary Bladder (UBM) with a Laser-Activated Chitosan-Based Surgical Adhesive. Journal of Biomaterials Science, Polymer Edition 23:12, pages 1521-1538.
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M. Kamburov & I. Lalov. (2012) Preparation of Chitosan Beads for Trypsin Immobilization. Biotechnology & Biotechnological Equipment 26:sup1, pages 156-163.
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Parisa Yousefpour, Fatemeh Atyabi, Ebrahim Vasheghani-Farahani, Ali-Akbar Mousavi Movahedi & Rassoul Dinarvand. (2011) Targeted delivery of doxorubicin-utilizing chitosan nanoparticles surface-functionalized with anti-Her2 trastuzumab. International Journal of Nanomedicine 6, pages 1977-1990.
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Yu Zheng, Xiangrong Song, Gu He, Zheng Cai, Yan Zhou, Bo Yu, Jiapeng Xu, Yuquan Wei & Shixiang Hou. (2011) Receptor-mediated gene delivery by folate-poly(ethylene glycol)-grafted-trimethyl chitosan in vitro. Journal of Drug Targeting 19:8, pages 647-656.
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Saravanakumar Arthanari, Nachipalayam Muthusamy Ramaswamy & Kavaratti Raju Mani. (2011) Development, Characterization, and In Vitro Evaluation of Chitosan and Alginate Microspheres Loaded Tetanus Toxoid Vaccine: A Comparative Study. International Journal of Green Nanotechnology 3:2, pages 83-91.
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Valentina Iannuccelli, Monica Montanari, Davide Bertelli, Federica Pellati & Gilberto Coppi. (2011) Microparticulate polyelectrolyte complexes for gentamicin transport across intestinal epithelia. Drug Delivery 18:1, pages 26-37.
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XingYi Li, XiangYe Kong, Shuai Shi, XiuHong Wang, YingChun Gu, Gang Guo, YongQiu Mao, Feng Luo, Xia Zhao, YuQuan Wei & ZhiYong Qian. (2010) Preparation, Characterization, and Self-assembly Behavior of a Novel MPEG/PCL-g-Chitosan Copolymer. Soft Materials 8:4, pages 320-337.
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Lissinda H. du Plessis, Awie F. Kotzé & Hans E. Junginger. (2010) Nasal and rectal delivery of insulin with chitosan and N-trimethyl chitosan chloride. Drug Delivery 17:6, pages 399-407.
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Himanshu Gupta, T. Velpandian & Sanyog Jain. (2010) Ion- and pH-activated novel in-situ gel system for sustained ocular drug delivery. Journal of Drug Targeting 18:7, pages 499-505.
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Neeraj Mishra, Amit K Goyal, Shailja Tiwari, Rishi Paliwal, Shivani R Paliwal, Bhuvaneshwar Vaidya, Sharad Mangal, Madhu Gupta, Devyani Dube, Abhinav Mehta & Suresh P Vyas. (2010) Recent advances in mucosal delivery of vaccines: role of mucoadhesive/biodegradable polymeric carriers. Expert Opinion on Therapeutic Patents 20:5, pages 661-679.
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Sushmitha Sundar, Joydip Kundu & Subhas C Kundu. (2010) Biopolymeric nanoparticles. Science and Technology of Advanced Materials 11:1.
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Xiao-Jie Ju, Rui Xie, Lihua Yang & Liang-Yin Chu. (2009) Biodegradable ‘intelligent’ materials in response to physical stimuli for biomedical applications. Expert Opinion on Therapeutic Patents 19:4, pages 493-507.
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R. Pignatello, L. Basile & G. Puglisi. (2009) Chitosan glutamate hydrogels with local anesthetic activity for buccal application. Drug Delivery 16:3, pages 176-181.
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NicholasA. Peppas, J. Brock Thomas & James McGinty. (2009) Molecular Aspects of Mucoadhesive Carrier Development for Drug Delivery and Improved Absorption. Journal of Biomaterials Science, Polymer Edition 20:1, pages 1-20.
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Dakshinamurthy Devanga Chinta, Richard A. Graves, Sarala Pamujula, Natalie Praetorius, Levon A. Bostanian & Tarun K. Mandal. (2009) Spray-Dried Chitosan as a Direct Compression Tableting Excipient. Drug Development and Industrial Pharmacy 35:1, pages 43-48.
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Atul Pathak, Suresh P Vyas & Kailash C Gupta. (2008) Nano-vectors for efficient liver specific gene transfer. International Journal of Nanomedicine 3:1, pages 31-49.
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Daniela Enescu & Camelia Elena Olteanu. (2008) FUNCTIONALIZED CHITOSAN AND ITS USE IN PHARMACEUTICAL, BIOMEDICAL, AND BIOTECHNOLOGICAL RESEARCH. Chemical Engineering Communications 195:10, pages 1269-1291.
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Giovanna Corti, Francesca Maestrelli, Marzia Cirri, Paola Mura & Naima Zerrouk. (2008) Dissolution and Permeation Properties of Naproxen From Solid-State Systems With Chitosan. Drug Delivery 15:5, pages 303-312.
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İ. Tuncer Değim, Fatmanur Tuğcu-Demiröz, Sibel Tamer-İlbasmış & Füsun Acartürk. (2008) Development of Controlled Release Sildenafil Formulations for Vaginal Administration. Drug Delivery 15:4, pages 259-265.
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Bhavik Manocha & Argyrios Margaritis. (2008) Production and Characterization of γ-Polyglutamic Acid Nanoparticles for Controlled Anticancer Drug Release. Critical Reviews in Biotechnology 28:2, pages 83-99.
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M. Rinaudo. (2007) Properties and degradation of selected polysaccharides: hyaluronan and chitosan. Corrosion Engineering, Science and Technology 42:4, pages 324-334.
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Peng Wang, Xiaolu Jiang, Yanhua Jiang, Xiaoke Hu, Haijin Mou, Man Li & Huashi Guan. (2007) antioxidative activities of three marine oligosaccharides. Natural Product Research 21:7, pages 646-654.
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Liandong Deng, Haiying Qi, Chunmei Yao, Menghuang Feng & Anjie Dong. (2007) Investigation on the properties of methoxy poly(ethylene glycol)/chitosan graft co-polymers. Journal of Biomaterials Science, Polymer Edition 18:12, pages 1575-1589.
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Praneet Opanasopit, Polawan Aumklad, Jarija Kowapradit, Tanasait Ngawhiranpat, Auayporn Apirakaramwong, Theerasak Rojanarata & Satit Puttipipatkhachorn. (2007) Effect of Salt Forms and Molecular Weight of Chitosans on In Vitro Permeability Enhancement in Intestinal Epithelial Cells (Caco-2). Pharmaceutical Development and Technology 12:5, pages 447-455.
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Himanshu Gupta, Sanyog Jain, Rashi Mathur, Pushpa Mishra, Anil K. Mishra & T. Velpandian. (2007) Sustained Ocular Drug Delivery from a Temperature and pH Triggered Novel In Situ Gel System. Drug Delivery 14:8, pages 507-515.
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Thawatchai Phaechamud & Garnpimol C. Ritthidej. (2007) Sustained-release from Layered Matrix System Comprising Chitosan and Xanthan Gum. Drug Development and Industrial Pharmacy 33:6, pages 595-605.
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Claudia Colonna, Bice Conti, Paola Perugini, Franca Pavanetto, Tiziana Modena, Rossella Dorati & Ida Genta. (2007) Chitosan glutamate nanoparticles for protein delivery: Development and effect on prolidase stability. Journal of Microencapsulation 24:6, pages 553-564.
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Qinghe Zhao, Zhengwei Mao, Changyou Gao & Jiacong Shen. (2006) Assembly of multilayer microcapsules on CaCO3 particles from biocompatible polysaccharides. Journal of Biomaterials Science, Polymer Edition 17:9, pages 997-1014.
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Zhilei Lu, Jan H. Steenekamp & Josias H. Hamman. (2005) Cross-Linked Cationic Polymer Microparticles: Effect of N-Trimethyl Chitosan Chloride on the Release and Permeation of Ibuprofen. Drug Development and Industrial Pharmacy 31:3, pages 311-317.
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M. Elhassan Imam & Andreas Bernkop-Schnürch. (2005) Controlled Drug Delivery Systems Based on Thiolated Chitosan Microspheres. Drug Development and Industrial Pharmacy 31:6, pages 557-565.
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K. Vidyalakshmi, K. N. Rashmi, T. M. Pramod Kumar & Siddaramaiah. (2004) Studies on Formulation and In Vitro Evaluation of PVA/Chitosan Blend Films for Drug Delivery. Journal of Macromolecular Science, Part A 41:10, pages 1115-1122.
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S. A. Agnihotri & T. M. Aminabhavi. (2004) Formulation and evaluation of novel tableted chitosan microparticles for the controlled release of clozapine. Journal of Microencapsulation 21:7, pages 709-718.
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Nagwa H. Foda, Hanan M. El‐laithy & Mina I. Tadros. (2004) Optimization of Biodegradable Sponges as Controlled Release Drug Matrices. I. Effect of Moisture Level on Chitosan Sponge Mechanical Properties. Drug Development and Industrial Pharmacy 30:4, pages 369-379.
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Nela Angelova & David Hunkeler. (2001) Effect of preparation conditions on properties and permeability of chitosan–sodium hexametaphosphate capsules . Journal of Biomaterials Science, Polymer Edition 12:12, pages 1317-1337.
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KAILASH C. GUPTA & MAJETI N. V. RAVI KUMAR. (2000) An Overview on Chitin and Chitosan Applications with an Emphasis on Controlled Drug Release Formulations. Journal of Macromolecular Science, Part C 40:4, pages 273-308.
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