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Research Article

Long interspersed nuclear elements (LINE-1): Potential triggers of systemic autoimmune disease

Pages 7-16 | Published online: 07 Dec 2009

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (6)

Vassilis E. Papadopoulos, Charalampos Skarlis, Maria-Eleftheria Evangelopoulos & Clio P. Mavragani. (2021) Type I interferon detection in autoimmune diseases: challenges and clinical applications. Expert Review of Clinical Immunology 17:8, pages 883-903.
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Pier-Angelo Tovo, Ivana Rabbone, Davide Tinti, Ilaria Galliano, Michela Trada, Valentina Daprà, Franco Cerutti & Massimiliano Bergallo. (2020) Enhanced expression of human endogenous retroviruses in new-onset type 1 diabetes: Potential pathogenetic and therapeutic implications. Autoimmunity 53:5, pages 283-288.
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Rossella Talotta, Fabiola Atzeni & Magdalena Janina Laska. (2020) Retroviruses in the pathogenesis of systemic lupus erythematosus: Are they potential therapeutic targets?. Autoimmunity 53:4, pages 177-191.
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Christopher H. Mauney & Thomas Hollis. (2018) SAMHD1: Recurring roles in cell cycle, viral restriction, cancer, and innate immunity. Autoimmunity 51:3, pages 96-110.
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Elisa Orecchini, Loredana Frassinelli & Alessandro Michienzi. (2017) Restricting retrotransposons: ADAR1 is another guardian of the human genome. RNA Biology 14:11, pages 1485-1491.
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Andras Perl. (2010) Pathogenic mechanisms in systemic lupus erythematosus. Autoimmunity 43:1, pages 1-6.
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Anran Liu & Songcheng Ying. (2023) Aicardi–Goutières syndrome: A monogenic type I interferonopathy . Scandinavian Journal of Immunology.
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Wilson McKerrow, Larisa Kagermazova, Nicole Doudican, Nicholas Frazzette, Efiyenia Ismini Kaparos, Shane A Evans, Azucena Rocha, John M Sedivy, Nicola Neretti, John Carucci, Jef D Boeke & David Fenyö. (2023) LINE-1 retrotransposon expression in cancerous, epithelial and neuronal cells revealed by 5′ single-cell RNA-Seq. Nucleic Acids Research 51:5, pages 2033-2045.
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Ahmad Luqman-Fatah, Yuzo Watanabe, Kazuko Uno, Fuyuki Ishikawa, John V. Moran & Tomoichiro Miyoshi. (2023) The interferon stimulated gene-encoded protein HELZ2 inhibits human LINE-1 retrotransposition and LINE-1 RNA-mediated type I interferon induction. Nature Communications 14:1.
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Sezer Okay. (2022) Involvement of retroelements in the autoimmune response in humans. Exploration of Medicine, pages 280-288.
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Xu Zhao, Yifei Zhao, Juan Du, Pujun Gao & Ke Zhao. (2021) The Interplay Among HIV, LINE-1, and the Interferon Signaling System. Frontiers in Immunology 12.
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Ana Gázquez-Gutiérrez, Jeroen Witteveldt, Sara R. Heras & Sara Macias. (2021) Sensing of transposable elements by the antiviral innate immune system. RNA 27:7, pages 735-752.
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Kennedy C. Ukadike & Tomas Mustelin. (2021) Implications of Endogenous Retroelements in the Etiopathogenesis of Systemic Lupus Erythematosus. Journal of Clinical Medicine 10:4, pages 856.
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Jeremy Kiripolsky & Jill M. Kramer. 2021. Sjögren's Syndrome and Oral Health. Sjögren's Syndrome and Oral Health 71 93 .
Chiara Rizzo, Giulia Grasso, Giulia Maria Destro Castaniti, Francesco Ciccia & Giuliana Guggino. (2020) Primary Sjogren Syndrome: Focus on Innate Immune Cells and Inflammation. Vaccines 8:2, pages 272.
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Mary K. Crow. (2019) Reactivity of IgG With the p40 Protein Encoded by the Long Interspersed Nuclear Element 1 Retroelement: Comment on the Article by Carter et al. Arthritis & Rheumatology 72:2, pages 374-376.
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Cihangir Yandım & Gökhan Karakülah. (2019) Expression dynamics of repetitive DNA in early human embryonic development. BMC Genomics 20:1.
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Lindsay M. Payer & Kathleen H. Burns. (2019) Transposable elements in human genetic disease. Nature Reviews Genetics 20:12, pages 760-772.
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Xin Liu, Yufeng Ye, Yi Chen, Xiaona Li, Baixiang Feng, Ganxiang Cao, Jianpeng Xiao, Weilin Zeng, Xing Li, Jiufeng Sun, Dan Ning, Yi Yang, Zhenjiang Yao, Yuming Guo, Qiong Wang, Yonghui Zhang, Wenjun Ma, Qingfeng Du, Bo Zhang & Tao Liu. (2019) Effects of prenatal exposure to air particulate matter on the risk of preterm birth and roles of maternal and cord blood LINE-1 methylation: A birth cohort study in Guangzhou, China. Environment International 133, pages 105177.
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Hannah E. Lapp & Richard G. Hunter. (2019) Early life exposures, neurodevelopmental disorders, and transposable elements. Neurobiology of Stress 11, pages 100174.
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Ilham A. Muslimov, Anna Iacoangeli, Taesun Eom, Anne Ruiz, Madisen Lee, Stacy Stephenson, Ellen M. Ginzler & Henri Tiedge. (2019) Neuronal BC RNA Transport Impairments Caused by Systemic Lupus Erythematosus Autoantibodies. The Journal of Neuroscience 39:39, pages 7759-7777.
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Eloy Almenar-Pérez, Tamara Ovejero, Teresa Sánchez-Fito, José A. Espejo, Lubov Nathanson & Elisa Oltra. (2019) Epigenetic Components of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Uncover Potential Transposable Element Activation. Clinical Therapeutics 41:4, pages 675-698.
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Mary K. CrowMikhail OlferievKyriakos A. Kirou. (2019) Type I Interferons in Autoimmune Disease. Annual Review of Pathology: Mechanisms of Disease 14:1, pages 369-393.
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René A. J. Crans, Jana Janssens, Sofie Daelemans, Elise Wouters, Robrecht Raedt, Debby Van Dam, Peter P. De Deyn, Kathleen Van Craenenbroeck & Christophe P. Stove. (2019) The validation of Short Interspersed Nuclear Elements (SINEs) as a RT-qPCR normalization strategy in a rodent model for temporal lobe epilepsy. PLOS ONE 14:1, pages e0210567.
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Charles-Henri Lecellier, Wyeth W Wasserman & Anthony Mathelier. (2018) Human Enhancers Harboring Specific Sequence Composition, Activity, and Genome Organization Are Linked to the Immune Response. Genetics 209:4, pages 1055-1071.
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Cristina M. Lanata, Joanne Nititham, Kimberly E. Taylor, Sharon A. Chung, Dara G. Torgerson, Michael F. Seldin, Bernardo A. Pons-Estel, Teresa Tusié-Luna, Betty P. Tsao, Eric F. Morand, Marta E. Alarcón-Riquelme & Lindsey A. Criswell. (2018) Genetic contributions to lupus nephritis in a multi-ethnic cohort of systemic lupus erythematous patients. PLOS ONE 13:6, pages e0199003.
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Ke Zhao, Juan Du, Yanfeng Peng, Peng Li, Shaohua Wang, Yu Wang, Jingwei Hou, Jian Kang, Wenwen Zheng, Shucheng Hua & Xiao-Fang Yu. (2018) LINE1 contributes to autoimmunity through both RIG-I- and MDA5-mediated RNA sensing pathways. Journal of Autoimmunity 90, pages 105-115.
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Marina Dunaeva, Merel Derksen & Ger J. M. Pruijn. (2017) LINE-1 Hypermethylation in Serum Cell-Free DNA of Relapsing Remitting Multiple Sclerosis Patients. Molecular Neurobiology 55:6, pages 4681-4688.
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Gaëtane Nocturne & Xavier Mariette. (2018) B cells in the pathogenesis of primary Sjögren syndrome. Nature Reviews Rheumatology 14:3, pages 133-145.
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Clio P. Mavragani, Adrianos Nezos, Irina Sagalovskiy, Surya Seshan, Kyriakos A. Kirou & Mary K. Crow. (2018) Defective regulation of L1 endogenous retroelements in primary Sjogren's syndrome and systemic lupus erythematosus: Role of methylating enzymes. Journal of Autoimmunity 88, pages 75-82.
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Saba Valadkhan & Puri Fortes. (2018) Regulation of the Interferon Response by lncRNAs in HCV Infection. Frontiers in Microbiology 9.
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Eleni-Marina Kalogirou, Evangelia P. Piperi, Konstantinos I. Tosios, Evangelos Tsiambas, Galinos Fanourakis & Alexandra Sklavounou. (2018) Ductal cells of minor salivary glands in Sjögren's syndrome express LINE-1 ORF2p and APOBEC3B. Journal of Oral Pathology & Medicine 47:2, pages 179-185.
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Jenna M. Antonucci, Corine St. Gelais & Li Wu. (2017) The Dynamic Interplay between HIV-1, SAMHD1, and the Innate Antiviral Response. Frontiers in Immunology 8.
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Miaomiao Li, Dong Zhang, Mengying Zhu, Yuxian Shen, Wei Wei, Songcheng Ying, Heinrich Korner & Jun Li. (2017) Roles of SAMHD1 in antiviral defense, autoimmunity and cancer. Reviews in Medical Virology 27:4, pages e1931.
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Peng Li, Juan Du, John L. Goodier, Jingwei Hou, Jian Kang, Haig H. KazazianJrJr, Ke Zhao & Xiao-Fang Yu. (2017) Aicardi–Goutières syndrome protein TREX1 suppresses L1 and maintains genome integrity through exonuclease-independent ORF1p depletion. Nucleic Acids Research 45:8, pages 4619-4631.
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Neil Hunter. (2017) Oocyte Quality Control: Causes, Mechanisms, and Consequences. Cold Spring Harbor Symposia on Quantitative Biology 82, pages 235-247.
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Jeong-An Gim, Gyu-Hwi Nam, Woo-Jin Kim, Hee-Eun Lee, Anshuman Mishra, Yunjeong Choe, Chan-Il Park, Do-Hyung Kim, Yung Hyun Choi, Hee-Jae Cha, Dahye Yoon, Suhkmann Kim & Heui-Soo Kim. (2016) Detection of LINE RT elements in the olive flounder (Paralichthys olivaceus) genome and expression analysis after infection with S. parauberis. Genes & Genomics 38:11, pages 1105-1110.
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Clio P. Mavragani, Irina Sagalovskiy, Qiu Guo, Adrianos Nezos, Efstathia K. Kapsogeorgou, Pin Lu, Jun Liang Zhou, Kyriakos A. Kirou, Surya V. Seshan, Haralampos M. Moutsopoulos & Mary K. Crow. (2016) Expression of Long Interspersed Nuclear Element 1 Retroelements and Induction of Type I Interferon in Patients With Systemic Autoimmune Disease. Arthritis & Rheumatology 68:11, pages 2686-2696.
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Carolina Ferreira Nicoletti, Carla Barbosa Nonino, Bruno Affonso Parenti de Oliveira, Marcela Augusta de Souza Pinhel, Maria Luisa Mansego, Fermin Ignacio Milagro, Maria Angeles Zulet & José Alfredo Martinez. (2015) DNA Methylation and Hydroxymethylation Levels in Relation to Two Weight Loss Strategies: Energy-Restricted Diet or Bariatric Surgery. Obesity Surgery 26:3, pages 603-611.
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Saba Valadkhan & Lalith S. Gunawardane. (2016) lncRNA-mediated regulation of the interferon response. Virus Research 212, pages 127-136.
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Qiujing Yu, Christopher J. Carbone, Yuliya V. Katlinskaya, Hui Zheng, Ke Zheng, Mengcheng Luo, P. Jeremy Wang, Roger A. Greenberg & Serge Y. Fuchs. (2015) Type I Interferon Controls Propagation of Long Interspersed Element-1. Journal of Biological Chemistry 290:16, pages 10191-10199.
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Xiaolan Huang, Gaixiu Su, Zhen Wang, Shaofang Shangguan, Xiaodai Cui, Jia Zhu, Min Kang, Shengnan Li, Ting Zhang, Fengqi Wu & Li Wang. (2013) Hypomethylation of long interspersed nucleotide element‐1 in peripheral mononuclear cells of juvenile systemic lupus erythematosus patients in C hina . International Journal of Rheumatic Diseases 17:3, pages 280-290.
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Clio P. Mavragani, Adrianos Nezos & Haralampos M. Moutsopoulos. (2013) New advances in the classification, pathogenesis and treatment of Sjogren's syndrome. Current Opinion in Rheumatology 25:5, pages 623-629.
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Ke Zhao, Juan Du, Xue Han, John L. Goodier, Peng Li, Xiaohong Zhou, Wei Wei, Sean L. Evans, Linzhang Li, Wenyan Zhang, Ling E. Cheung, Guanjun Wang, Haig H. KazazianJr.Jr. & Xiao-Fang Yu. (2013) Modulation of LINE-1 and Alu/SVA Retrotransposition by Aicardi-Goutières Syndrome-Related SAMHD1. Cell Reports 4:6, pages 1108-1115.
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Jeerawat Nakkuntod, Pattadon Sukkapan, Yingyos Avihingsanon, Apiwat Mutirangura & Nattiya Hirankarn. (2013) DNA methylation of human endogenous retrovirus in systemic lupus erythematosus. Journal of Human Genetics 58:5, pages 241-249.
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Jeerawat Nakkuntod, Yingyos Avihingsanon, Apiwat Mutirangura & Nattiya Hirankarn. (2011) Hypomethylation of LINE-1 but not Alu in lymphocyte subsets of systemic lupus erythematosus patients. Clinica Chimica Acta 412:15-16, pages 1457-1461.
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