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Research Article

Apigenin inhibits allergen-induced airway inflammation and switches immune response in a murine model of asthma

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Pages 364-370 | Received 16 Aug 2009, Accepted 08 Oct 2009, Published online: 22 Jan 2010

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R Amini, R Yazdanparast & SH Ghaffari. (2014) Apigenin modulates the expression levels of pro-inflammatory mediators to reduce the human insulin amyloid-induced oxidant damages in SK-N-MC cells. Human & Experimental Toxicology 34:6, pages 642-653.
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Anna Rzepecka-Stojko, Agata Kabała-Dzik, Aleksandra Moździerz, Robert Kubina, Robert Wojtyczka, Rafał Stojko, Arkadiusz Dziedzic, Żaneta Jastrzębska-Stojko, Magdalena Jurzak, Ewa Buszman & Jerzy Stojko. (2015) Caffeic Acid Phenethyl Ester and Ethanol Extract of Propolis Induce the Complementary Cytotoxic Effect on Triple-Negative Breast Cancer Cell Lines. Molecules 20:5, pages 9242-9262.
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Xiaoxuan Zhang, Guangji Wang, Emily C. Gurley & Huiping Zhou. (2014) Flavonoid Apigenin Inhibits Lipopolysaccharide-Induced Inflammatory Response through Multiple Mechanisms in Macrophages. PLoS ONE 9:9, pages e107072.
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Md. Asaduzzaman SikderHyun Jae LeeJiho RyuSu Hyun ParkJu-Ock KimJang-Hee HongJeong Ho SeokChoong Jae Lee. (2014) Apigenin and Wogonin Regulate Epidermal Growth Factor Receptor Signaling Pathway Involved in MUC5AC Mucin Gene Expression and Production from Cultured Airway Epithelial Cells. Tuberculosis and Respiratory Diseases 76:3, pages 120.
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Jun Zhao, Zhan Zhang, Jinfeng Dai, Li wang, Chengxiang Zhang, Yuting Ye & Lei Li. (2014) Synergistic protective effect of chlorogenic acid, apigenin and caffeic acid against carbon tetrachloride-induced hepatotoxicity in male mice. RSC Adv. 4:81, pages 43057-43063.
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Barbara Romano, Ester Pagano, Vittorino Montanaro, Alfonso L. Fortunato, Natasa Milic & Francesca Borrelli. (2013) Novel Insights into the Pharmacology of Flavonoids. Phytotherapy Research 27:11, pages 1588-1596.
Crossref
Rahim Amini, Razieh Yazdanparast & Seifollah Bahramikia. (2013) Apigenin reduces human insulin fibrillation in vitro and protects SK-N-MC cells against insulin amyloids. International Journal of Biological Macromolecules 60, pages 334-340.
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Ilaria Lampronti, Monica Borgatti, Silvia Vertuani, Stefano Manfredini & Roberto Gambari. (2013) Modulation of the Expression of the Proinflammatory IL-8 Gene in Cystic Fibrosis Cells by Extracts Deriving from Olive Mill Waste Water. Evidence-Based Complementary and Alternative Medicine 2013, pages 1-11.
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Ju-Ock Kim, Md. Asaduzzaman Sikder, Hyun Jae Lee, Mustafizur Rahman, Jang-Hyun Kim, Gyu Tae Chang & Choong Jae Lee. (2012) Phorbol Ester or Epidermal Growth-factor-induced MUC5AC Mucin Gene Expression and Production from Airway Epithelial Cells are Inhibited by Apigenin and Wogonin. Phytotherapy Research 26:12, pages 1784-1788.
Crossref
Jia Wang, Yanyan Liao, Jianglin Fan, Ting Ye, Xia Sun & Sijun Dong. (2012) Apigenin Inhibits the Expression of IL-6, IL-8, and ICAM-1 in DEHP-Stimulated Human Umbilical Vein Endothelial Cells and In Vivo. Inflammation 35:4, pages 1466-1476.
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Waldiceu A. VerriJr.Jr., Fabiana T.M.C. Vicentini, Marcela M. Baracat, Sandra R. Georgetti, Renato D.R. Cardoso, Thiago M. Cunha, Sergio H. Ferreira, Fernando Q. Cunha, Maria J.V. Fonseca & Rubia Casagrande. 2012. Bioactive Natural Products. Bioactive Natural Products 297 330 .
Wilson Maldonado-Rojas & Jesus Olivero-Verbel. (2011) Potential interaction of natural dietary bioactive compounds with COX-2. Journal of Molecular Graphics and Modelling 30, pages 157-166.
Crossref
Hee Sun Park, So Ri Kim, Ju Ock Kim & Yong Chul Lee. (2010) The Roles of Phytochemicals in Bronchial Asthma. Molecules 15:10, pages 6810-6834.
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