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Immunopharmacology and Immunotoxicology Volume 12, 1990 - Issue 4
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Research Article

Enhancement of Human T Lymphocyte Function by Prothymosin α: Incremed Production of Interleukin-2 and Expression of Interleukin-2 Receptors in Normal Human Peripheral Blood t Lymphocytes

Constantin N. Baxevanis Department of Immunology, Hellenic Anticancer Institute, GR-115 22, Athens
,
Stathis Frillingos Laboratory of Biological Chemistry, University of Ioannina Medical School, GR—451 10, Ioannina, Greece
,
Konstantin Seferiadis Laboratory of Biological Chemistry, University of Ioannina Medical School, GR—451 10, Ioannina, Greece
,
George J. Reclos Department of Immunology, Hellenic Anticancer Institute, GR-115 22, Athens
,
Paula Arsenis Department of Immunology, Hellenic Anticancer Institute, GR-115 22, Athens
,
Anna Katsiyiannis Department of Immunology, Hellenic Anticancer Institute, GR-115 22, Athens
,
Emmanuel Anastasopoulos Department of Immunology, Hellenic Anticancer Institute, GR-115 22, Athens
,
Orestes Tsolas Laboratory of Biological Chemistry, University of Ioannina Medical School, GR—451 10, Ioannina, Greece
&
Michail Papamichail Department of Immunology, Hellenic Anticancer Institute, GR-115 22, Athens
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Pages 595-617 | Published online: 28 Sep 2008

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Sergey Lunin, Maxim Khrenov, Olga Glushkova, Svetlana Parfenyuk, Tatyana Novoselova & E Novoselova. (2020) Precursors of thymic peptides as stress sensors. Expert Opinion on Biological Therapy 20:12, pages 1461-1475.
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Francisco J. Salgado, Alicia Piñeiro, Ana Canda-Sánchez, Juan Lojo & Montserrat Nogueira. (2005) Prothymosin alpha-receptor associates with lipid rafts in PHA-stimulated lymphocytes. Molecular Membrane Biology 22:3, pages 163-176.
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Articles from other publishers (19)

Anastasios I. Birmpilis, Antonios Paschalis, Apostolis Mourkakis, Panayiota Christodoulou, Ioannis V. Kostopoulos, Elina Antimissari, Georgia Terzoudi, Alexandros G. Georgakilas, Christina Armpilia, Panagiotis Papageorgis, Efstathios Kastritis, Evangelos Terpos, Meletios A. Dimopoulos, Hubert Kalbacher, Evangelia Livaniou, Maria-Ioanna Christodoulou & Ourania E. Tsitsilonis. (2022) Immunogenic Cell Death, DAMPs and Prothymosin α as a Putative Anticancer Immune Response Biomarker. Cells 11:9, pages 1415.
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Nicola T. Case, Kwamaa Duah, Brett Larsen, Cassandra J. Wong, Anne-Claude Gingras, Teresa R. O’Meara, Nicole Robbins, Amanda O. Veri, Luke Whitesell & Leah E. Cowen. (2021) The macrophage-derived protein PTMA induces filamentation of the human fungal pathogen Candida albicans. Cell Reports 36:8, pages 109584.
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Anastasios I. Birmpilis, Chrysoula-Evangelia Karachaliou, Pinelopi Samara, Kyriaki Ioannou, Platon Selemenakis, Ioannis V. Kostopoulos, Nadia Kavrochorianou, Hubert Kalbacher, Evangelia Livaniou, Sylva Haralambous, Athanasios Kotsinas, Farzin Farzaneh, Ioannis P. Trougakos, Wolfgang Voelter, Meletios-Athanasios Dimopoulos, Aristotelis Bamias & Ourania Tsitsilonis. (2019) Antitumor Reactive T-Cell Responses Are Enhanced In Vivo by DAMP Prothymosin Alpha and Its C-Terminal Decapeptide. Cancers 11:11, pages 1764.
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Nikos E. Papaioannou, Ioannis F. Voutsas, Pinelopi Samara & Ourania E. Tsitsilonis. (2016) A flow cytometric approach for studying alterations in the cytoplasmic concentration of calcium ions in immune cells following stimulation with thymic peptides. Cellular Immunology 302, pages 32-40.
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P. Samara, K. Ioannou & O.E. Tsitsilonis. 2016. Thymosins. Thymosins 179 207 .
Osigbemhe Iyalomhe, Yuanxiu Chen, Joanne Allard, Oyonumo Ntekim, Sheree Johnson, Vernon Bond, David Goerlitz, James Li & Thomas O. Obisesan. (2015) A standardized randomized 6-month aerobic exercise-training down-regulated pro-inflammatory genes, but up-regulated anti-inflammatory, neuron survival and axon growth-related genes. Experimental Gerontology 69, pages 159-169.
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Gokhlesh Kumar, Ahmed Abd-Elfattah & Mansour El-Matbouli. (2015) Identification of differentially expressed genes of brown trout (Salmo trutta) and rainbow trout (Oncorhynchus mykiss) in response to Tetracapsuloides bryosalmonae (Myxozoa). Parasitology Research 114:3, pages 929-939.
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Kyriaki Ioannou, Pinelopi Samara, Evangelia Livaniou, Evelyna Derhovanessian & Ourania E. Tsitsilonis. (2012) Prothymosin alpha: a ubiquitous polypeptide with potential use in cancer diagnosis and therapy. Cancer Immunology, Immunotherapy 61:5, pages 599-614.
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Arno Sungarian, Deus Cielo, Prakash Sampath, Nathaniel Bowling, Peter Moskal, Jack R. Wands & Suzanne M. de la Monte. (2009) Potential Role of Thymosin- 1 Adjuvant Therapy for Glioblastoma . Journal of Oncology 2009, pages 1-11.
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Margarita Skopeliti, Ulrich Kratzer, Florian Altenberend, George Panayotou, Hubert Kalbacher, Stefan Stevanovic, Wolfgang Voelter & Ourania E. Tsitsilonis. (2007) Proteomic exploitation on prothymosin α‐induced mononuclear cell activation. PROTEOMICS 7:11, pages 1814-1824.
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Margarita Skopeliti, Ioannis F. Voutsas, Persefoni Klimentzou, Marinos L. Tsiatas, Alexander Beck, Aristotelis Bamias, Maria Moraki, Evangelia Livaniou, Monica Neagu, Wolfgang Voelter & Ourania E. Tsitsilonis. (2006) The immunologically active site of prothymosin α is located at the carboxy-terminus of the polypeptide. Evaluation of its in vitro effects in cancer patients. Cancer Immunology, Immunotherapy 55:10, pages 1247-1257.
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Alexandra G Evstafieva, George A Belov, Yuri P Rubtsov, Markus Kalkum, Bertrand Joseph, Nina V Chichkova, Elena A Sukhacheva, Alexey A Bogdanov, Ralf F Pettersson, Vadim I Agol & Andrey B Vartapetian. (2003) Apoptosis-related fragmentation, translocation, and properties of human prothymosin alpha. Experimental Cell Research 284:2, pages 209-221.
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A. Piñeiro, M. Begoña Bugía, M. Pilar Arias, O.J. Cordero & M. Nogueira. (2001) Identification of Receptors for Prothymosin α on Human Lymphocytes. Biological Chemistry 382:10.
Crossref
St. Theodoropoulou, G. Spanakos, C.N. Baxevanis, M. Economou, A.D. Gritzapis, M.P. Papamichail & C.N. Stefanis. (2001) Cytokine serum levels, autologous mixed lymphocyte reaction and surface marker analysis in never medicated and chronically medicated schizophrenic patients. Schizophrenia Research 47:1, pages 13-25.
Crossref
Alicia Piñeiro, Oscar J Cordero & Montserrat Nogueira. (2000) Fifteen years of prothymosin alpha: contradictory past and new horizons. Peptides 21:9, pages 1433-1446.
Crossref
F. Maggiolo, A. Taras, F. Suter, Maria Grazia Pravettoni, Manuela Leone & Antonella Ingrosso. (1997) Zidovudine and thymus humoral factor gamma-2 in the treatment of HIV infection: Preliminary clinical experience. Infection 25:1, pages 35-38.
Crossref
Alexandra G. Evstafieva, Nina V. Chichkova, Tatyana N. Makarova, Andrey B. Vartapetian, Anna V. Vasilenko, Vjacheslav M. Abramov & Alexey A. Bogdanov. (2005) Overproduction in Escherichia Coli , Purification and Properties of Human Prothymosin α . European Journal of Biochemistry 231:3, pages 639-643.
Crossref
Constantin N. Baxevanis & Michael Papamichail. (1994) Characterization of the anti-tumor immune response in human cancers and strategies for immunotherapy. Critical Reviews in Oncology/Hematology 16:3, pages 157-179.
Crossref
Allan L. Goldstein. 1993. Combination Therapies 2. Combination Therapies 2 39 48 .

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