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Inhalation Toxicology
International Forum for Respiratory Research
Volume 4, 1992 - Issue 2
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Research Article

2-Week and 13-Week Inhalation Studies of Aerosolized Glycerol in Rats

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Pages 95-111 | Published online: 27 Sep 2008

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Peter M. J. Bos, Lya G. Soeteman-Hernández & Reinskje Talhout. (2021) Risk assessment of components in tobacco smoke and e-cigarette aerosols: a pragmatic choice of dose metrics. Inhalation Toxicology 33:3, pages 81-95.
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Michael S. Werley, Ann M. Jerome & Michael J. Oldham. (2014) Toxicological evaluation of aerosols of a tobacco extract formulation and nicotine formulation in acute and short-term inhalation studies. Inhalation Toxicology 26:4, pages 207-221.
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Ryan J. Potts, Daniel R. Meckley, W. Keith Shreve, Deborah H. Pence, Paul H. Ayres, David Doolittle, James E. Swauger & John W. Sagartz. (2007) Comparative 13-Week Inhalation Study of Cigarette Smoke from Cigarettes Containing Cast Sheet Tobacco. Inhalation Toxicology 19:8, pages 701-724.
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Paul H. Ayres, Johnnie R. Hayes, Mark A. Higuchi, Arnold T. Mosberg, John W. Sagartz. (2001) SUBCHRONIC INHALATION BY RATS OF MAINSTREAM SMOKE FROM A CIGARETTE THAT PRIMARILY HEATS TOBACCO COMPARED TO A CIGARETTE THAT BURNS TOBACCO. Inhalation Toxicology 13:2, pages 149-186.
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Alexander N. LarcombeMaxine A. JankaBenjamin J. MullinsLuke J. BerryArne BredinPeter J. Franklin. (2017) The effects of electronic cigarette aerosol exposure on inflammation and lung function in mice. American Journal of Physiology-Lung Cellular and Molecular Physiology 313:1, pages L67-L79.
Crossref
A. Hartwig. 2002. The MAK‐Collection for Occupational Health and Safety. The MAK‐Collection for Occupational Health and Safety 337 356 .
A. Hartwig. 2002. The MAK‐Collection for Occupational Health and Safety. The MAK‐Collection for Occupational Health and Safety 369 374 .
K.E. Farsalinos. 2017. Analytical Assessment of E-Cigarettes. Analytical Assessment of E-Cigarettes 75 122 .
Peter M. J. Bos, Anne S. Kienhuis & Reinskje Talhout. (2016) Author's response to: "Harmful effects form one puff of shisha-pen vapor: methodological and interpretational problems in the risk assessment analysis". Tobacco Induced Diseases 14:1.
Crossref
A. Hartwig. 2002. The MAK‐Collection for Occupational Health and Safety. The MAK‐Collection for Occupational Health and Safety 2571 2586 .
Chitra Dinakar & George T. O’Connor. (2016) The Health Effects of Electronic Cigarettes. New England Journal of Medicine 375:14, pages 1372-1381.
Crossref
A. Hartwig. 2002. The MAK‐Collection for Occupational Health and Safety. The MAK‐Collection for Occupational Health and Safety 1743 1790 .
B. Laube, R. Bartsch, G. Schriever‐Schwemmer & A. Hartwig. 2002. The MAK‐Collection for Occupational Health and Safety. The MAK‐Collection for Occupational Health and Safety 219 223 .
Anne S Kienhuis, Lya G Soeteman-Hernandez, Peter MJ Bos, Hans WJM Cremers, Walther N Klerx & Reinskje Talhout. (2015) Potential harmful health effects of inhaling nicotine-free shisha-pen vapor: a chemical risk assessment of the main components propylene glycol and glycerol. Tobacco Induced Diseases 13:1.
Crossref
. 2002. The MAK-Collection for Occupational Health and Safety. The MAK-Collection for Occupational Health and Safety 1 58 .
. 2002. The MAK‐Collection for Occupational Health and Safety. The MAK‐Collection for Occupational Health and Safety 1 20 .
. 2002. The MAK‐Collection for Occupational Health and Safety. The MAK‐Collection for Occupational Health and Safety 1 44 .
Maurizio Manigrasso, Giorgio Buonanno, Luca Stabile, Lidia Morawska & Pasquale Avino. (2015) Particle doses in the pulmonary lobes of electronic and conventional cigarette users. Environmental Pollution 202, pages 24-31.
Crossref
. 2002. The MAK‐Collection for Occupational Health and Safety. The MAK‐Collection for Occupational Health and Safety 1 14 .
. 2002. The MAK‐Collection for Occupational Health and Safety. The MAK‐Collection for Occupational Health and Safety 1 18 .
Charlotta Pisinger. (2014) Why public health people are more worried than excited over e-cigarettes. BMC Medicine 12:1.
Crossref
Anushi E Rajapaksa, Jenny J Ho, Aisha Qi, Rob Bischof, Tri-Hung Nguyen, Michelle Tate, David Piedrafita, Michelle P McIntosh, Leslie Y Yeo, Els Meeusen, Ross L Coppel & James R Friend. (2014) Effective pulmonary delivery of an aerosolized plasmid DNA vaccine via surface acoustic wave nebulization. Respiratory Research 15:1.
Crossref
Charlotta Pisinger & Martin Døssing. (2014) A systematic review of health effects of electronic cigarettes. Preventive Medicine 69, pages 248-260.
Crossref
Joseph Brain, Wolfgang Kreyling & John Godleski. 2014. Hayes' Principles and Methods of Toxicology, Sixth Edition. Hayes' Principles and Methods of Toxicology, Sixth Edition 1385 1444 .
Konstantinos E. Farsalinos & Riccardo Polosa. (2014) Safety evaluation and risk assessment of electronic cigarettes as tobacco cigarette substitutes: a systematic review. Therapeutic Advances in Drug Safety 5:2, pages 67-86.
Crossref
. 2002. The MAK‐Collection for Occupational Health and Safety. The MAK‐Collection for Occupational Health and Safety 1 18 .
. 2002. The MAK-Collection for Occupational Health and Safety. The MAK-Collection for Occupational Health and Safety 1 318 .
Jens Schubert, Jürgen Hahn, Gerhard Dettbarn, Albrecht Seidel, Andreas Luch & Thomas G. Schulz. (2011) Mainstream smoke of the waterpipe: Does this environmental matrix reveal as significant source of toxic compounds?. Toxicology Letters 205:3, pages 279-284.
Crossref
K.G. McAdam, E.O. Gregg, C. Liu, D.J. Dittrich, M.G. Duke & C.J. Proctor. (2011) The use of a novel tobacco-substitute sheet and smoke dilution to reduce toxicant yields in cigarette smoke. Food and Chemical Toxicology 49:8, pages 1684-1696.
Crossref
E Roemer, S Wittke, E TrellesSticken, JJ Piade, T Bonk & MK Schorp. (2010) The Addition of Cocoa, Glycerol, and Saccharose to the Tobacco of Cigarettes: Implications for Smoke Chemistry, In Vitro Cytotoxicity, Mutagenicity and Further Endpoints. Beiträge zur Tabakforschung International/Contributions to Tobacco Research 24:3, pages 117-138.
Crossref
P. Carthew, C. Clapp & S. Gutsell. (2009) Exposure based waiving: The application of the toxicological threshold of concern (TTC) to inhalation exposure for aerosol ingredients in consumer products. Food and Chemical Toxicology 47:6, pages 1287-1295.
Crossref
E.L. Carmines & C.L. Gaworski. (2005) Toxicological evaluation of glycerin as a cigarette ingredient. Food and Chemical Toxicology 43:10, pages 1521-1539.
Crossref
Roger A. Renne & Rodney A. Miller. 1996. Respiratory System. Respiratory System 43 51 .
Roger McClellan & Rogene HendersonDonald Dungworth, Fletcher Hahn & Kristen Nikula. 1995. Concepts In Inhalation Toxicology. Concepts In Inhalation Toxicology 535 578 .
Roger A. Renne, John W. Sagartz & Gary T. Burger. (2016) Interspecies Variations in the Histology of Toxicologically Important Areas in the Larynges of CRL:CD Rats and Syrian Golden Hamsters*†. Toxicologic Pathology 21:6, pages 542-546.
Crossref

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