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Effect of a supplementation with myo-inositol plus melatonin on oocyte quality in women who failed to conceive in previous in vitro fertilization cycles for poor oocyte quality: a prospective, longitudinal, cohort study

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Pages 857-861 | Received 09 Sep 2010, Accepted 15 Feb 2011, Published online: 05 Apr 2011

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Tingting Li, Xiaoping Liu, Xing Yang, Ningning Wang, Yanfang Wang, Wei Li, Xiaoyan Liang & Rui Huang. (2023) Comparison of the efficacy of depot GnRH agonist protocol and the GnRH antagonist protocol in patients with repeated IVF failure: a retrospective cohort study. Human Fertility 0:0, pages 1-8.
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Alessandro Pacchiarotti, Gianfranco Carlomagno, Gabriele Antonini & Arianna Pacchiarotti. (2016) Effect of myo-inositol and melatonin versus myo-inositol, in a randomized controlled trial, for improving in vitro fertilization of patients with polycystic ovarian syndrome. Gynecological Endocrinology 32:1, pages 69-73.
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Arturo Bevilacqua, Gianfranco Carlomagno, Sandro Gerli, Mario Montanino Oliva, Paul Devroey, Antonio Lanzone, Christophe Soulange, Fabio Facchinetti, Gian Carlo Di Renzo, Mariano Bizzarri, Moshe Hod, Pietro Cavalli, Rosario D’Anna, Salvatore Benvenga, Tony T. Chiu & Zdravko A. Kamenov. (2015) Results from the International Consensus Conference on myo-inositol and D-chiro-inositol in Obstetrics and Gynecology – assisted reproduction technology. Gynecological Endocrinology 31:6, pages 441-446.
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R. D’Anna, V. Di Benedetto, P. Rizzo, E. Raffone, M. L. Interdonato, F. Corrado & A. Di Benedetto. (2012) Myo-inositol may prevent gestational diabetes in PCOS women. Gynecological Endocrinology 28:6, pages 440-442.
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Konstantinos Sfakianoudis, Mara Simopoulou, Evangelos Maziotis, Polina Giannelou, Petroula Tsioulou, Anna Rapani, Agni Pantou, Konstantina Petroutsou, Irene Angeli, Efthymios Deligeoroglou, Michael Koutsilieris & Konstantinos Pantos. (2019) Evaluation of the Second Follicular Wave Phenomenon in Natural Cycle Assisted Reproduction: A Key Option for Poor Responders through Luteal Phase Oocyte Retrieval. Medicina 55:3, pages 68.
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Shavi Fernando & Luk Rombauts. 2019. How to Prepare the Egg and Embryo to Maximize IVF Success. How to Prepare the Egg and Embryo to Maximize IVF Success 155 166 .
Shavi Fernando, Euan Morrison Wallace, Beverley Vollenhoven, Nicholas Lolatgis, Nicole Hope, Melissa Wong, Mark Lawrence, Anthony Lawrence, Chris Russell, Kenneth Leong, Philip Thomas & Luk Rombauts. (2018) Melatonin in Assisted Reproductive Technology: A Pilot Double-Blind Randomized Placebo-Controlled Clinical Trial. Frontiers in Endocrinology 9.
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Gianfranco Carlomagno, Mirko Minini, Marco Tilotta & Vittorio Unfer. (2018) From Implantation to Birth: Insight into Molecular Melatonin Functions. International Journal of Molecular Sciences 19:9, pages 2802.
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Natasha A M Jackson, Angelina M Flores, Elizabeth D Eldon & Lisa S Klig. (2018) Disruption of INOS , a Gene Encoding myo -Inositol Phosphate Synthase, Causes Male Sterility in Drosophila melanogaster . G3 Genes|Genomes|Genetics 8:9, pages 2913-2922.
Crossref
Pedro-Antonio Regidor, Adolf Eduard Schindler, Bernd Lesoine & Rene Druckman. (2018) Management of women with PCOS using myo-inositol and folic acid. New clinical data and review of the literature. Hormone Molecular Biology and Clinical Investigation 34:2.
Crossref
T. Feng, L. F. Schutz, B. C. Morrell, M. C. Perego & L. J. Spicer. (2018) Effect of melatonin on bovine theca cells in vitro. Reproduction, Fertility and Development 30:4, pages 643.
Crossref
Sebastian R. Hobson, Rebecca Lim & Euan M. Wallace. 2018. Preeclampsia. Preeclampsia 335 345 .
Elavarasan Subramani, Arun Prabhu Rameshbabu, Manivannan Jothiramajayam, Bhuvaneshwaran Subramanian, Debangana Chakravorty, Gunja Bose, Mamata Joshi, Chaitali Datta Ray, Indrani Lodh, Ratna Chattopadhyay, Sudipto Saha, Anita Mukherjee, Santanu Dhara, Baidyanath Chakravarty & Koel Chaudhury. (2017) Mycobacterial heat shock protein 65 mediated metabolic shift in decidualization of human endometrial stromal cells. Scientific Reports 7:1.
Crossref
Yan Hao, Zhiguo Zhang, Dan Han, Yunxia Cao, Ping Zhou, Zhaolian Wei, Mingrong Lv & Dawei Chen. (2017) Gene expression profiling of human blastocysts from in vivo and ‘rescue IVM’ with or without melatonin treatment. Molecular Medicine Reports 16:2, pages 1278-1288.
Crossref
Juan Manuel Jiménez Tuñón, Paloma Piqueras Trilles, Miguel Gallardo Molina, María Hebles Duvison, Beatriz Migueles Pastor, Pascual Sánchez Martín, Fernando Sánchez Martín & Rafael Sánchez-Borrego. (2017) A Double-Blind, Randomized Prospective Study to Evaluate the Efficacy of Previous Therapy With Melatonin, Myo-inositol, Folic Acid, and Selenium in Improving the Results of an Assisted Reproductive Treatment. Clinical Medicine Insights: Therapeutics 9, pages 1179559X1774290.
Crossref
G. Simi, A. R. Genazzani, M. E. R. Obino, F. Papini, S. Pinelli, V. Cela & P. G. Artini. (2017) Inositol and In Vitro Fertilization with Embryo Transfer. International Journal of Endocrinology 2017, pages 1-5.
Crossref
T.A. Meister, E. Rexhaj, S.F. Rimoldi, U. Scherrer & C. Sartori. (2017) Fetal programming and vascular dysfunction. Artery Research 21:C, pages 69.
Crossref
Sajal Gupta, Stefan S. du Plessis, Saad AlQasem, Mohammad Nouh & Zeynep Cakar. 2017. Oxidative Stress in Human Reproduction. Oxidative Stress in Human Reproduction 129 150 .
Cathy A. Goldstein & Yolanda R. Smith. (2016) Sleep, Circadian Rhythms, and Fertility. Current Sleep Medicine Reports 2:4, pages 206-217.
Crossref
Julie Brown, Tineke J Crawford, Jane Alsweiler & Caroline A Crowther. (2016) Dietary supplementation with myo-inositol in women during pregnancy for treating gestational diabetes. Cochrane Database of Systematic Reviews 2016:9.
Crossref
E. Subramani, M. Jothiramajayam, M. Dutta, D. Chakravorty, M. Joshi, S. Srivastava, A. Mukherjee, C. Datta Ray, B.N. Chakravarty & K. Chaudhury. (2016) NMR-based metabonomics for understanding the influence of dormant female genital tuberculosis on metabolism of the human endometrium. Human Reproduction 31:4, pages 854-865.
Crossref
Sebastian R Hobson, Joanne C Mockler, Rebecca Lim, Nicole O Alers, Suzanne L Miller & Euan M Wallace. (2016) Melatonin for treating pre-eclampsia. Cochrane Database of Systematic Reviews.
Crossref
Tineke J Crawford, Caroline A Crowther, Jane Alsweiler & Julie Brown. 1996. Cochrane Database of Systematic Reviews. Cochrane Database of Systematic Reviews.
Salvatore Giovanni Vitale, Paola Rossetti, Francesco Corrado, Agnese Maria Chiara Rapisarda, Sandro La Vignera, Rosita Angela Condorelli, Gaetano Valenti, Fabrizio Sapia, Antonio Simone Laganà & Massimo Buscema. (2016) How to Achieve High-Quality Oocytes? The Key Role of Myo-Inositol and Melatonin. International Journal of Endocrinology 2016, pages 1-9.
Crossref
Bernd Lesoine & Pedro-Antonio Regidor. (2016) Prospective Randomized Study on the Influence of Myoinositol in PCOS Women Undergoing IVF in the Improvement of Oocyte Quality, Fertilization Rate, and Embryo Quality. International Journal of Endocrinology 2016, pages 1-5.
Crossref
Tineke J Crawford, Caroline A Crowther, Jane Alsweiler & Julie Brown. (2015) Antenatal dietary supplementation with myo-inositol in women during pregnancy for preventing gestational diabetes. Cochrane Database of Systematic Reviews 2015:12.
Crossref
Francesca Caprio, Maria Diletta D’Eufemia, Carlo Trotta, Maria Rosaria Campitiello, Raffaele Ianniello, Daniela Mele & Nicola Colacurci. (2015) Myo-inositol therapy for poor-responders during IVF: a prospective controlled observational trial. Journal of Ovarian Research 8:1.
Crossref
Emrush RexhajAgim PirevaAriane Paoloni-GiacobinoYves AllemannDavid CernyPierre Dessen, Claudio Sartori, Urs Scherrer & Stefano F. Rimoldi. (2015) Prevention of vascular dysfunction and arterial hypertension in mice generated by assisted reproductive technologies by addition of melatonin to culture media. American Journal of Physiology-Heart and Circulatory Physiology 309:7, pages H1151-H1156.
Crossref
Hideki Igarashi, Toshifumi Takahashi & Satoru Nagase. (2015) Oocyte aging underlies female reproductive aging: biological mechanisms and therapeutic strategies. Reproductive Medicine and Biology 14:4, pages 159-169.
Crossref
Sebastian R Hobson, Joanne C Mockler, Rebecca Lim, Nicole O Alers, Suzanne L Miller & Euan M Wallace. (2015) Melatonin for preventing pre-eclampsia. Cochrane Database of Systematic Reviews.
Crossref
Julie Brown, Tineke J Crawford, Jane Alsweiler & Caroline A Crowther. 1996. Cochrane Database of Systematic Reviews. Cochrane Database of Systematic Reviews.
Shavi Fernando & Luk Rombauts. (2014) Melatonin: shedding light on infertility? - a review of the recent literature. Journal of Ovarian Research 7:1.
Crossref
S. Fernando, T. Osianlis, B. Vollenhoven, E. Wallace & L. Rombauts. (2014) A pilot double-blind randomised placebo-controlled dose-response trial assessing the effects of melatonin on infertility treatment (MIART): study protocol. BMJ Open 4:8, pages e005986-e005986.
Crossref
Ashok Agarwal, Damayanthi Durairajanayagam, Gurpriya Virk & Stefan S. Du PlessisAshok Agarwal, Damayanthi Durairajanayagam, Gurpriya Virk & Stefan S. Du Plessis. 2014. Strategies to Ameliorate Oxidative Stress During Assisted Reproduction. Strategies to Ameliorate Oxidative Stress During Assisted Reproduction 23 38 .
Sandra Colazingari, Mariangela Treglia, Robert Najjar & Arturo Bevilacqua. (2013) The combined therapy myo-inositol plus d-chiro-inositol, rather than d-chiro-inositol, is able to improve IVF outcomes: results from a randomized controlled trial. Archives of Gynecology and Obstetrics 288:6, pages 1405-1411.
Crossref
Ronald G. Reichert. 2013. Textbook of Natural Medicine. Textbook of Natural Medicine 857 867 .
Jane Lyttleton. 2013. Treatment of Infertility with Chinese Medicine. Treatment of Infertility with Chinese Medicine 406 440 .
Ozlem Gun Eryilmaz, Aysun Devran, Esma Sarikaya, Fatma Nur Aksakal, Leyla Mollamahmutoğlu & Nedim Cicek. (2011) Melatonin improves the oocyte and the embryo in IVF patients with sleep disturbances, but does not improve the sleeping problems. Journal of Assisted Reproduction and Genetics 28:9, pages 815-820.
Crossref

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