537
Views
44
CrossRef citations to date
0
Altmetric
Research Article

Modulatory role of D-chiro-inositol (DCI) on LH and insulin secretion in obese PCOS patients

, , , , , , & show all
Pages 438-443 | Received 10 Dec 2014, Accepted 19 Feb 2014, Published online: 07 Mar 2014

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (10)

Alessandro D. Genazzani, Christian Battipaglia, Tabatha Petrillo, Nicola Piacquadio, Fedora Ambrosetti, Melania Arnesano, Elisa Semprini, Alessandra Sponzilli, Veronica Tomatis & Tommaso Simoncini. (2022) Familial diabetes predisposes PCOS patients to insulin resistance (IR), reproductive impairment and hepatic dysfunction: effects of d-chiro inositol (DCI) and alpha lipoic acid (ALA) administration on hepatic insulin extraction (HIE) index. Gynecological Endocrinology 38:8, pages 681-688.
Read now
Rosita A. Condorelli, Rossella Cannarella, Andrea Crafa, Federica Barbagallo, Carmelo Gusmano, Ottavia Avola, Laura M Mongioì, Livia Basile, Aldo E. Calogero & Sandro La Vignera. (2022) Advances in non-hormonal pharmacotherapy for the treatment of male infertility: the role of inositols. Expert Opinion on Pharmacotherapy 23:9, pages 1081-1090.
Read now
Alessandro Genazzani. (2020) Inositols: reflections on how to choose the appropriate one for PCOS. Gynecological Endocrinology 36:12, pages 1045-1046.
Read now
Paolo Giovanni Artini, Maria Elena Rosa Obino, Elisabetta Micelli, Elisa Malacarne, Chiara Vacca, Francesca Papini & Vito Cela. (2020) Effect of d-chiro-inositol and alpha-lipoic acid combination on COH outcomes in overweight/obese PCOS women. Gynecological Endocrinology 36:9, pages 755-759.
Read now
Alessandro D. Genazzani, Alessia Prati, Federico Marchini, Tabatha Petrillo, Antonella Napolitano & Tommaso Simoncini. (2019) Differential insulin response to oral glucose tolerance test (OGTT) in overweight/obese polycystic ovary syndrome patients undergoing to myo-inositol (MYO), alpha lipoic acid (ALA), or combination of both. Gynecological Endocrinology 35:12, pages 1088-1093.
Read now
Vittorio Unfer, Beatrice Orrù & Giovanni Monastra. (2016) Inositols: from physiology to rational therapy in gynecological clinical practice. Expert Opinion on Drug Metabolism & Toxicology 12:10, pages 1129-1131.
Read now
Ewa M. Milewska, Adam Czyzyk, Blazej Meczekalski & Alessandro D. Genazzani. (2016) Inositol and human reproduction. From cellular metabolism to clinical use. Gynecological Endocrinology 32:9, pages 690-695.
Read now
Cristiana Paul, Antonio Simone Laganà, Paolo Maniglio, Onofrio Triolo & David M. Brady. (2016) Inositol’s and other nutraceuticals’ synergistic actions counteract insulin resistance in polycystic ovarian syndrome and metabolic syndrome: state-of-the-art and future perspectives. Gynecological Endocrinology 32:6, pages 431-438.
Read now
Antonio Cianci, Marco Panella, Michele Fichera, Cristina Falduzzi, Manuela Bartolo & Salvatore Caruso. (2015) d-chiro-Inositol and alpha lipoic acid treatment of metabolic and menses disorders in women with PCOS. Gynecological Endocrinology 31:6, pages 483-486.
Read now
Antonio La Marca, Valentina Grisendi, Giulia Dondi, Giovanna Sighinolfi & Antonio Cianci. (2015) The menstrual cycle regularization following d-chiro-inositol treatment in PCOS women: a retrospective study. Gynecological Endocrinology 31:1, pages 52-56.
Read now

Articles from other publishers (34)

Samradhi Singh, Namrata Pal, Swasti Shubham, Devojit Kumar Sarma, Vinod Verma, Francesco Marotta & Manoj Kumar. (2023) Polycystic Ovary Syndrome: Etiology, Current Management, and Future Therapeutics. Journal of Clinical Medicine 12:4, pages 1454.
Crossref
Alessandro D Genazzani & Andrea R Genazzani. (2023) Polycystic Ovary Syndrome as Metabolic Disease: New Insights on Insulin Resistance. European Endocrinology 19:1, pages 71.
Crossref
Lali Pkhaladze, Vittorio Unfer & Didier Dewailly. 2023. A Clinical Guide to Inositols. A Clinical Guide to Inositols 151 165 .
Tabatha Petrillo, Elisa Semprini, Veronica Tomatis, Melania Arnesano, Fedora Ambrosetti, Christian Battipaglia, Alessandra Sponzilli, Francesco Ricciardiello, Andrea R. Genazzani & Alessandro D. Genazzani. (2022) Putative Complementary Compounds to Counteract Insulin-Resistance in PCOS Patients. Biomedicines 10:8, pages 1924.
Crossref
Maurizio Nordio, Philip Kumanov, Alfonsina Chiefari & Giulia Puliani. (2021) d-Chiro-Inositol improves testosterone levels in older hypogonadal men with low-normal testosterone: a pilot study. Basic and Clinical Andrology 31:1.
Crossref
Tabatha Petrillo, Christian Battipaglia, Mohamed Ashraf Virmani, Andrea R. Genazzani & Alessandro D. Genazzani. (2021) Neuroendocrine Effects of Carnitines on Reproductive Impairments. International Journal of Molecular Sciences 22:19, pages 10781.
Crossref
Riccardo Gambioli, Mario Montanino Oliva, Maurizio Nordio, Alfonsina Chiefari, Giulia Puliani & Vittorio Unfer. (2021) New Insights into the Activities of D-Chiro-Inositol: A Narrative Review. Biomedicines 9:10, pages 1378.
Crossref
Selma FIRAT & Mehmet FİSUNOĞLU. (2021) Polikistik Over Sendromunda Güncel Terapötik Ajanlardan İnositol ve Alfa Lipoik Asit Takviyesi Üzerine Bir Derleme. Akdeniz Medical Journal 7:2, pages 184-196.
Crossref
Sadia Afrin, Abdelrahman AlAshqar, Malak El Sabeh, Mariko Miyashita-Ishiwata, Lauren Reschke, Joshua T. Brennan, Amanda Fader & Mostafa A. Borahay. (2021) Diet and Nutrition in Gynecological Disorders: A Focus on Clinical Studies. Nutrients 13:6, pages 1747.
Crossref
Maria Magdalena Montt-Guevara, Michele Finiguerra, Ilaria Marzi, Tiziana Fidecicchi, Amerigo Ferrari, Alessandro D. Genazzani & Tommaso Simoncini. (2021) D-Chiro-Inositol Regulates Insulin Signaling in Human Adipocytes. Frontiers in Endocrinology 12.
Crossref
Dusan Simic, Katarina Stefanovic, Dusan Djuric & Tamara Nikolic Turnic. (2021) Polycystic Ovary Syndrome: Pathophysiology, Presentation and Treatment a Mini-Review Article. Serbian Journal of Experimental and Clinical Research 0:0.
Crossref
Alessandro D. Genazzani, Ambrosetti Fedora, Despini Giulia, Manzo Alba, Caroli Martina, Arnesano Melania, Petrillo Tabatha, Tomatis Veronica & Andrea R. Genazzani. 2021. Impact of Polycystic Ovary, Metabolic Syndrome and Obesity on Women Health. Impact of Polycystic Ovary, Metabolic Syndrome and Obesity on Women Health 67 74 .
Alessia Prati, Andrea R. Genazzani & Alessandro D. Genazzani. 2021. Impact of Polycystic Ovary, Metabolic Syndrome and Obesity on Women Health. Impact of Polycystic Ovary, Metabolic Syndrome and Obesity on Women Health 43 66 .
A. Capozzi, G. Scambia & S Lello. (2020) Polycystic ovary syndrome (PCOS) and adolescence: How can we manage it?. European Journal of Obstetrics & Gynecology and Reproductive Biology 250, pages 235-240.
Crossref
M. Caputo, E. Bona, I. Leone, M.T. Samà, A. Nuzzo, A. Ferrero, G. Aimaretti, P. Marzullo & F. Prodam. (2020) Inositols and metabolic disorders: From farm to bedside. Journal of Traditional and Complementary Medicine 10:3, pages 252-259.
Crossref
Sergio Davinelli, Daria Nicolosi, Cinzia Di Cesare, Giovanni Scapagnini & Roberto Di Marco. (2020) Targeting Metabolic Consequences of Insulin Resistance in Polycystic Ovary Syndrome by D-chiro-inositol and Emerging Nutraceuticals: A Focused Review. Journal of Clinical Medicine 9:4, pages 987.
Crossref
Anna Wojciechowska, Adam Osowski, Marcin Jóźwik, Ryszard Górecki, Andrzej Rynkiewicz & Joanna Wojtkiewicz. (2019) Inositols’ Importance in the Improvement of the Endocrine–Metabolic Profile in PCOS. International Journal of Molecular Sciences 20:22, pages 5787.
Crossref
Dongyun He, Li Liu, Sheng Miao, Xiaoli Tong & Minjia Sheng. (2019) Probabilistic guided polycystic ovary syndrome recognition using learned quality kernel. Journal of Visual Communication and Image Representation 63, pages 102587.
Crossref
Marian G Showell, Rebecca Mackenzie-Proctor, Vanessa Jordan, Ruth Hodgson & Cindy Farquhar. (2018) Inositol for subfertile women with polycystic ovary syndrome. Cochrane Database of Systematic Reviews 2018:12.
Crossref
Agnieszka Owczarczyk-Saczonek, Lesław Lahuta, Magdalena Ligor, Waldemar Placek, Ryszard Górecki & Bogusław Buszewski. (2018) The Healing-Promoting Properties of Selected Cyclitols—A Review. Nutrients 10:12, pages 1891.
Crossref
Antonio Simone Laganà, Simone Garzon, Jvan Casarin, Massimo Franchi & Fabio Ghezzi. (2018) Inositol in Polycystic Ovary Syndrome: Restoring Fertility through a Pathophysiology-Based Approach. Trends in Endocrinology & Metabolism 29:11, pages 768-780.
Crossref
A. D. Genazzani, K. Shefer, D. Della Casa, A. Prati, A. Napolitano, A. Manzo, G. Despini & T. Simoncini. (2017) Modulatory effects of alpha-lipoic acid (ALA) administration on insulin sensitivity in obese PCOS patients. Journal of Endocrinological Investigation 41:5, pages 583-590.
Crossref
Giulia Mariani & José Bellver. (2018) Management Options for Infertile Women with Polycystic Ovary Syndrome. US Endocrinology 14:2, pages 67.
Crossref
John E. Nestler & Antonio Simone Laganà. 2018. Infertility in Women with Polycystic Ovary Syndrome. Infertility in Women with Polycystic Ovary Syndrome 213 226 .
Kendall C. Case, Michael Salsaa, Wenxi Yu & Miriam L. Greenberg. 2020. Lipid Signaling in Human Diseases. Lipid Signaling in Human Diseases 221 260 .
Maria A. Sortino, Salvatore Salomone, Michele O. Carruba & Filippo Drago. (2017) Polycystic Ovary Syndrome: Insights into the Therapeutic Approach with Inositols. Frontiers in Pharmacology 8.
Crossref
Alessandro D. Genazzani. (2016) Inositol as putative integrative treatment for PCOS. Reproductive BioMedicine Online 33:6, pages 770-780.
Crossref
Marian G Showell, Rebecca Mackenzie-Proctor, Vanessa Jordan, Ruth Hodgson, Julie Brown & Cindy Farquhar. (2016) Inositol for subfertile women with polycystic ovary syndrome. Cochrane Database of Systematic Reviews.
Crossref
Mark P. Thomas, Stephen J. Mills & Barry V. L. Potter. (2016) The “Other” Inositols and Their Phosphates: Synthesis, Biology, and Medicine (with Recent Advances in myo -Inositol Chemistry) . Angewandte Chemie International Edition 55:5, pages 1614-1650.
Crossref
Mark P. Thomas, Stephen J. Mills & Barry V. L. Potter. (2016) Die “anderen” Inositole und ihre Phosphate: Synthese, Biologie und Medizin (sowie jüngste Fortschritte in der myo -Inositolchemie) . Angewandte Chemie 128:5, pages 1644-1683.
Crossref
Mario Mancini, Alice Andreassi, Michela Salvioni, Fiore Pelliccione, Gianna Mantellassi & Giuseppe Banderali. (2016) Myoinositol and D-Chiro Inositol in Improving Insulin Resistance in Obese Male Children: Preliminary Data. International Journal of Endocrinology 2016, pages 1-5.
Crossref
Reshma M. Ansari. (2016) Potential use of durian fruit (Durio zibenthinus Linn) as an adjunct to treat infertility in polycystic ovarian syndrome. Journal of Integrative Medicine 14:1, pages 22-28.
Crossref
Antonio Simone Laganà & Alfonsa Pizzo. (2015) Authors’ reply to: “Empiric” inositol supplementation in normal-weight non-insulin resistant women with polycystic ovarian disease: from the absence of benefit to the potential adverse effects. Archives of Gynecology and Obstetrics 291:5, pages 959-960.
Crossref
Antonio Simone Laganà, Luisa Barbaro & Alfonsa Pizzo. (2014) Evaluation of ovarian function and metabolic factors in women affected by polycystic ovary syndrome after treatment with d-Chiro-Inositol. Archives of Gynecology and Obstetrics 291:5, pages 1181-1186.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.