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Alpha-Tocopherol Succinate and Induction of G-CSF

Alpha-tocopherol succinate protects mice from gamma-radiation by induction of granulocyte-colony stimulating factor

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Pages 12-21 | Received 26 Mar 2009, Accepted 20 Jul 2009, Published online: 13 Jan 2010

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Vijay K. Singh, Meera Srivastava & Thomas M Seed. (2023) Protein biomarkers for radiation injury and testing of medical countermeasure efficacy: promises, pitfalls, and future directions. Expert Review of Proteomics 20:10, pages 221-246.
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Alexandra C. Miller, Rafael Rivas, Robert McMahon, Karvelisse Miller, Leonard Tesoro, Vilmar Villa, Daminik Yanushkevich & Paul Lison. (2017) Radiation protection and mitigation potential of phenylbutyrate: delivered via oral administration. International Journal of Radiation Biology 93:9, pages 907-919.
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Vijay K Singh, Victoria L Newman, Patricia LP Romaine, Martin Hauer-Jensen & Harvey B Pollard. (2016) Use of biomarkers for assessing radiation injury and efficacy of countermeasures. Expert Review of Molecular Diagnostics 16:1, pages 65-81.
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Thomas B. Elliott, David L. Bolduc, G. David Ledney, Juliann G. Kiang, Oluseyi O. Fatanmi, Stephen Y. Wise, Patricia L. P. Romaine, Victoria L. Newman & Vijay K. Singh. (2015) Combined immunomodulator and antimicrobial therapy eliminates polymicrobial sepsis and modulates cytokine production in combined injured mice. International Journal of Radiation Biology 91:9, pages 690-702.
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Vijay K. Singh, Stephen Y. Wise, Pankaj K. Singh, Ana Posarac, Oluseyi O. Fatanmi, Elizabeth J. Ducey, David L. Bolduc, Thomas B. Elliott & Thomas M. Seed. (2013) Alpha-tocopherol succinate-mobilized progenitors improve intestinal integrity after whole body irradiation. International Journal of Radiation Biology 89:5, pages 334-345.
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Vijay K. Singh, Elizabeth J. Ducey, Darren S. Brown & Mark H. Whitnall. (2012) A review of radiation countermeasure work ongoing at the Armed Forces Radiobiology Research Institute. International Journal of Radiation Biology 88:4, pages 296-310.
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Elliot Rosen, Oluseyi O. Fatanmi, Stephen Y. Wise, V. Ashutosh Rao & Vijay K. Singh. (2020) Tocol Prophylaxis for Total-body Irradiation: A Proteomic Analysis in Murine Model. Health Physics 119:1, pages 12-20.
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Elizabeth R. Stirling, Katherine L. Cook, David D. Roberts & David R. Soto-Pantoja. (2019) Metabolomic Analysis Reveals Unique Biochemical Signatures Associated with Protection from Radiation Induced Lung Injury by Lack of cd47 Receptor Gene Expression. Metabolites 9:10, pages 218.
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Lynnette Cary, Daniel Noutai, Rudolph Salber, Opeyemi Fadiyimu, Arthur Gross, Graca Almeida-Porada, Yared Kidane & Mark Whitnall. (2019) Bone Marrow Endothelial Cells Influence Function and Phenotype of Hematopoietic Stem and Progenitor Cells after Mixed Neutron/Gamma Radiation. International Journal of Molecular Sciences 20:7, pages 1795.
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Nataliya Uzlenkova. (2019) New pharmacological means of radiation protection (literature review). JOURNAL OF THE NATIONAL ACADEMY OF MEDICAL SCIENCES OF UKRAINE.
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M. A. Savitskaya & G. E. Onischcenko. (2018) Alpha-Tocopheryl Succinate Selectively Affects the Morphology and Motility of Normal and Tumor Epithelial Cells. Cell and Tissue Biology 12:2, pages 102-111.
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Zhong-Tang Li, Li-Mei Wang, Li-Rong Yi, Chao Jia, Fan Bai, Ren-Jun Peng, Zu-Yin Yu, Guo-Lin Xiong, Shuang Xing, Ya-Jun Shan, Ri-Fang Yang, Jun-Xing Dong & Yu-Wen Cong. (2017) Succinate ester derivative of δ-tocopherol enhances the protective effects against 60Co γ-ray-induced hematopoietic injury through granulocyte colony-stimulating factor induction in mice. Scientific Reports 7:1.
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Kylie O'Brien & Avni SaliKylie O’Brien & Avni Sali. 2017. A Clinician's Guide to Integrative Oncology. A Clinician's Guide to Integrative Oncology 231 303 .
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Vijay K. Singh, Oluseyi O. Fatanmi, Amit Verma, Victoria L. Newman, Stephen Y. Wise, Patricia L.P. Romaine & Allison N. Berg. (2016) Progenitor Cell Mobilization by Gamma-tocotrienol. Health Physics 111:2, pages 85-92.
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Vijay Singh & Martin Hauer-Jensen. (2016) γ-Tocotrienol as a Promising Countermeasure for Acute Radiation Syndrome: Current Status. International Journal of Molecular Sciences 17:5, pages 663.
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Eliot M. Rosen, Regina Day & Vijay K. Singh. (2015) New Approaches to Radiation Protection. Frontiers in Oncology 4.
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Pankaj K. Singh & Sunil Krishnan. (2015) Vitamin E Analogs as Radiation Response Modifiers. Evidence-Based Complementary and Alternative Medicine 2015, pages 1-16.
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Vijay K. Singh, Victoria L. Newman & Thomas M. Seed. (2015) Colony-stimulating factors for the treatment of the hematopoietic component of the acute radiation syndrome (H-ARS): A review. Cytokine 71:1, pages 22-37.
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Mikhail V Vasin. (2014) Comments on the mechanisms of action of radiation protective agents: basis components and their polyvalence. SpringerPlus 3:1.
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Vijay K. Singh, Stephen Y. Wise, Oluseyi O. Fatanmi, Jessica Scott, Patricia L. P. Romaine, Victoria L. Newman, Amit Verma, Thomas B. Elliott & Thomas M. Seed. (2014) Progenitors Mobilized by Gamma-Tocotrienol as an Effective Radiation Countermeasure. PLoS ONE 9:11, pages e114078.
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V. K. Singh, P. L. P. Romaine, V. L. Newman & T. M. Seed. (2014) Tocols induce G-CSF and mobilise progenitors that mitigate radiation injury. Radiation Protection Dosimetry 162:1-2, pages 83-87.
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Vijay K Singh, Stephen Y Wise, Oluseyi O Fatanmi, Lindsay A Beattie & Thomas M Seed. (2014) Preclinical Development of a Bridging Therapy for Radiation Casualties. Health Physics 106:6, pages 689-698.
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Vijay K. Singh, Stephen Y. Wise, Jessica R. Scott, Patricia L.P. Romaine, Victoria L. Newman & Oluseyi O. Fatanmi. (2014) Radioprotective efficacy of delta-tocotrienol, a vitamin E isoform, is mediated through granulocyte colony-stimulating factor. Life Sciences 98:2, pages 113-122.
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Jae Ho KimKenneth A. JenrowStephen L. Brown. (2014) Mechanisms of radiation-induced normal tissue toxicity and implications for future clinical trials. Radiation Oncology Journal 32:3, pages 103.
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Vijay K. Singh, Stephen Y. Wise, Oluseyi O. Fatanmi, Lindsay A. Beattie, Elizabeth J. Ducey & Thomas M. Seed. (2014) Alpha-tocopherol succinate- and AMD3100-mobilized progenitors mitigate radiation combined injury in mice. Journal of Radiation Research 55:1, pages 41-53.
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Vijay K. Singh, Lindsay A. Beattie & Thomas M. Seed. (2013) Vitamin E: tocopherols and tocotrienols as potential radiation countermeasures. Journal of Radiation Research 54:6, pages 973-988.
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Shubhankar Suman, Kamal Datta, Kushal Chakraborty, Shilpa S. Kulkarni, Kathryn Doiron, Albert J. FornaceJr.Jr., K. Sree Kumar, Martin Hauer-Jensen & Sanchita P. Ghosh. (2013) Gamma tocotrienol, a potent radioprotector, preferentially upregulates expression of anti-apoptotic genes to promote intestinal cell survival. Food and Chemical Toxicology 60, pages 488-496.
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Zohreh Noaparast & Seyed Jalal Hosseinimehr. (2013) Radioprotective agents for the prevention of side effects induced by radioiodine-131 therapy. Future Oncology 9:8, pages 1145-1159.
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Shilpa Kulkarni, Pankaj K. Singh, Sanchita P. Ghosh, Ana Posarac & Vijay K. Singh. (2013) Granulocyte colony-stimulating factor antibody abrogates radioprotective efficacy of gamma-tocotrienol, a promising radiation countermeasure. Cytokine 62:2, pages 278-285.
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V. K. Singh, P. K. Singh, S. Y. Wise, A. Posarac & O. O. Fatanmi. (2012) Radioprotective properties of tocopherol succinate against ionizing radiation in mice. Journal of Radiation Research 54:2, pages 210-220.
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Xinyue Lu, Dilber Nurmemet, David L Bolduc, Thomas B Elliott & Juliann G Kiang. (2013) Radioprotective effects of oral 17-dimethylaminoethylamino-17-demethoxygeldanamycin in mice: bone marrow and small intestine. Cell & Bioscience 3:1, pages 36.
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Vadim I. Krivokrysenko, Alexander N. Shakhov, Vijay K. Singh, Frederick Bone, Yevgeniy Kononov, Inna Shyshynova, Alec Cheney, Ratan K. Maitra, Andrei Purmal, Mark H. Whitnall, Andrei V. Gudkov & Elena Feinstein. (2012) Identification of Granulocyte Colony-Stimulating Factor and Interleukin-6 as Candidate Biomarkers of CBLB502 Efficacy as a Medical Radiation Countermeasure. Journal of Pharmacology and Experimental Therapeutics 343:2, pages 497-508.
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Marcy B. Grace, Vijay K. Singh, Juong G. Rhee, William E. JacksonIIIIII, Tzu-Cheg Kao & Mark H. Whitnall. (2012) 5-AED enhances survival of irradiated mice in a G-CSF-dependent manner, stimulates innate immune cell function, reduces radiation-induced DNA damage and induces genes that modulate cell cycle progression and apoptosis. Journal of Radiation Research 53:6, pages 840-853.
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Vijay K. Singh, Stephen Y. Wise, Pankaj K. Singh, Elizabeth J. Ducey, Oluseyi O. Fatanmi & Thomas M. Seed. (2012) α-Tocopherol succinate– and AMD3100-mobilized progenitors mitigate radiation-induced gastrointestinal injury in mice. Experimental Hematology 40:5, pages 407-417.
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Pankaj K Singh, Stephen Y Wise, Elizabeth J Ducey, Oluseyi O Fatanmi, Thomas B Elliott & Vijay K Singh. (2012) α-Tocopherol Succinate Protects Mice against Radiation-Induced Gastrointestinal Injury. Radiation Research 177:2, pages 133-145.
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Denis O Rodgerson. (2012) Potential for a pluripotent adult stem cell treatment for acute radiation sickness. World Journal of Experimental Medicine 2:3, pages 37.
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Pankaj K. Singh, Stephen Y. Wise, Elizabeth J. Ducey, Darren S. Brown & Vijay K. Singh. (2011) Radioprotective efficacy of tocopherol succinate is mediated through granulocyte-colony stimulating factor. Cytokine 56:2, pages 411-421.
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Alexandra C. Miller, Stuart Cohen, Michael Stewart, Rafael Rivas & Paul Lison. (2011) Radioprotection by the histone deacetylase inhibitor phenylbutyrate. Radiation and Environmental Biophysics 50:4, pages 585-596.
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Amanda Nogueira-Pedro, Christiano M V Barbosa, Helena Regina Comodo Segreto, Lisandro Lungato, Vania D'Almeida, Andrea Aparecida F S Moraes, Antonio Miranda, Edgar Julian Paredes-Gamero & Alice Teixeira Ferreira. (2011) α-Tocopherol induces hematopoietic stem/progenitor cell expansion and ERK1/2-mediated differentiation. Journal of Leukocyte Biology 90:6, pages 1111-1117.
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M. Hofer, M. Pospíšil, L. Dušek, Z. Hoferová & L. Weiterová. (2011) A Single Dose of an Inhibitor of Cyclooxygenase 2, Meloxicam, Administered Shortly after Irradiation Increases Survival of Lethally Irradiated Mice. Radiation Research 176:2, pages 269-272.
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Vijay K. Singh, Vaishali I. Parekh, Darren S. Brown, Tzu-Cheg Kao & Steven R. Mog. (2011) Tocopherol Succinate: Modulation of Antioxidant Enzymes and Oncogene Expression, and Hematopoietic Recovery. International Journal of Radiation Oncology*Biology*Physics 79:2, pages 571-578.
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