Advanced search
Publication Cover
International Journal of Radiation Biology Volume 86, 2010 - Issue 2
Submit an article Journal homepage
262
Views
34
CrossRef citations to date
0
Altmetric
Radiation Effects on Rat Brain

Metalloporphyrin antioxidants ameliorate normal tissue radiation damage in rat brain

Robert D. PearlsteinCorrespondence[email protected]
,
Yoshinori Higuchi
,
Maria MoldovanDepartment of Radiation Medicine, Loma Linda University, Loma Linda, California, USA
,
Kwame JohnsonDepartments of Surgery/Neurosurgery, Anesthesiology, and School of Medicine, Duke University and Medical Center, Durham, North Carolina, USA
,
Shiro FukudaDepartments of Surgery/Neurosurgery, Anesthesiology, and School of Medicine, Duke University and Medical Center, Durham, North Carolina, USA
,
Daila S. GridleyDepartment of Radiation Medicine, Loma Linda University, Loma Linda, California, USA
,
James D. CrapoDepartment of Medicine, National Jewish Medical and Research Center, Denver Colorado, USA
,
David S. WarnerDepartments of Surgery/Neurosurgery, Anesthesiology, and School of Medicine, Duke University and Medical Center, Durham, North Carolina, USA
&
James M. SlaterDepartment of Radiation Medicine, Loma Linda University, Loma Linda, California, USA
 show all
Pages 145-163 | Received 22 Sep 2008, Accepted 31 Aug 2009, Published online: 11 Feb 2010

Citations (34)

Keep up to date with the latest research on this topic with citation updates for this article.

Subscribe to citation updates

Read on this site (5)

Vijay K. Singh, Melissa Garcia & Thomas M. Seed. (2017) A review of radiation countermeasures focusing on injury-specific medicinals and regulatory approval status: part II. Countermeasures for limited indications, internalized radionuclides, emesis, late effects, and agents demonstrating efficacy in large animals with or without FDA IND status. International Journal of Radiation Biology 93:9, pages 870-884.
Read now
Vijay K. Singh & Ayodele O. Olabisi. (2017) Nonhuman primates as models for the discovery and development of radiation countermeasures. Expert Opinion on Drug Discovery 12:7, pages 695-709.
Read now
Vijay K Singh, Victoria L Newman, Allison N Berg & Thomas J MacVittie. (2015) Animal models for acute radiation syndrome drug discovery. Expert Opinion on Drug Discovery 10:5, pages 497-517.
Read now
Lauren M Slosky & Todd W Vanderah. (2015) Therapeutic potential of peroxynitrite decomposition catalysts: a patent review. Expert Opinion on Therapeutic Patents 25:4, pages 443-466.
Read now
Vijay K Singh, Victoria L Newman, Patricia LP Romaine, Stephen Y Wise & Thomas M Seed. (2014) Radiation countermeasure agents: an update (2011 – 2014). Expert Opinion on Therapeutic Patents 24:11, pages 1229-1255.
Read now

Articles from other publishers (29)

Sümeyye Gümüş Uzun, Berrin Zuhal Altunkaynak & Işınsu Alkan. (2023) The effects of myricitrin and chebulinic acid on the rat hippocampus exposed to gamma radiation: A stereological, histochemical and biochemical study. Journal of Chemical Neuroanatomy 132, pages 102305.
Crossref
Xiaowen Mao, Seta Stanbouly, Jacob Holley, Michael Pecaut & James Crapo. (2023) Evidence of Spaceflight-Induced Adverse Effects on Photoreceptors and Retinal Function in the Mouse Eye. International Journal of Molecular Sciences 24:8, pages 7362.
Crossref
Mutlay Sayan, Bilgehan Şahin, Teuta Zoto Mustafayev, Erva Şeyma Sare Kefelioğlu, Irina Vergalasova, Apar Gupta, Aykut Balmuk, Görkem Güngör, Nisha Ohri, Joseph Weiner, Ercan Karaarslan, Enis Özyar & Banu Atalar. (2021) Risk of symptomatic radiation necrosis in patients treated with stereotactic radiosurgery for brain metastases. Neurocirugía 32:6, pages 261-267.
Crossref
Mutlay Sayan, Bilgehan Şahin, Teuta Zoto Mustafayev, Erva Şeyma Sare Kefelioğlu, Irina Vergalasova, Apar Gupta, Aykut Balmuk, Görkem Güngör, Nisha Ohri, Joseph Weiner, Ercan Karaarslan, Enis Özyar & Banu Atalar. (2021) Risk of symptomatic radiation necrosis in patients treated with stereotactic radiosurgery for brain metastases. Neurocirugía (English Edition) 32:6, pages 261-267.
Crossref
Luca Possenti, Laura Mecchi, Andrea Rossoni, Veronica Sangalli, Simone Bersini, Alessandro Cicchetti, Maria Laura Costantino, Christian Candrian, Chiara Arrigoni, Tiziana Rancati & Matteo Moretti. (2021) Radiobiological Studies of Microvascular Damage through In Vitro Models: A Methodological Perspective. Cancers 13:5, pages 1182.
Crossref
Virginia Wotring. 2019. Principles of Clinical Medicine for Space Flight. Principles of Clinical Medicine for Space Flight 815 840 .
Emilie Mathieu, Anne-Sophie Bernard, Nicolas Delsuc, Elodie Quévrain, Géraldine Gazzah, Barry Lai, Florian Chain, Philippe Langella, Maria Bachelet, Joelle Masliah, Philippe Seksik & Clotilde Policar. (2017) A Cell-Penetrant Manganese Superoxide Dismutase (MnSOD) Mimic Is Able To Complement MnSOD and Exerts an Antiinflammatory Effect on Cellular and Animal Models of Inflammatory Bowel Diseases. Inorganic Chemistry 56:5, pages 2545-2555.
Crossref
Lianhong Yang, Jianhua Yang, Guoqian Li, Yi Li, Rong Wu, Jinping Cheng & Yamei Tang. (2016) Pathophysiological Responses in Rat and Mouse Models of Radiation-Induced Brain Injury. Molecular Neurobiology 54:2, pages 1022-1032.
Crossref
Elizabeth A. Kosmacek, Arpita Chatterjee, Qiang Tong, Chi Lin & Rebecca E. Oberley-Deegan. (2016) MnTnBuOE-2-PyP protects normal colorectal fibroblasts from radiation damage and simultaneously enhances radio/chemotherapeutic killing of colorectal cancer cells. Oncotarget 7:23, pages 34532-34545.
Crossref
Hongqing Zhuang, Yi Zheng, Junjie Wang, Joe Y. Chang, Xiaoguang Wang, Zhiyong Yuan & Ping Wang. (2015) Analysis of risk and predictors of brain radiation necrosis after radiosurgery. Oncotarget 7:7, pages 7773-7779.
Crossref
Rebecca E. Oberley-Deegan & James D. Crapo. 2016. Redox-Active Therapeutics. Redox-Active Therapeutics 405 431 .
Daniel M. Trifiletti, Cheng-Chia Lee, David Schlesinger, James M. Larner, Zhiyuan Xu & Jason P. Sheehan. (2015) Leukoencephalopathy After Stereotactic Radiosurgery for Brain Metastases. International Journal of Radiation Oncology*Biology*Physics 93:4, pages 870-878.
Crossref
Jan SlezakBranislav KuraTáňa RavingerováNarcisa TribulovaLudmila OkruhlicovaMiroslav Barancik. (2015) Mechanisms of cardiac radiation injury and potential preventive approaches. Canadian Journal of Physiology and Pharmacology 93:9, pages 737-753.
Crossref
Vijay K. Singh, Patricia L.P. Romaine & Thomas M. Seed. (2015) Medical Countermeasures for Radiation Exposure and Related Injuries. Health Physics 108:6, pages 607-630.
Crossref
Douglas H. Weitzel, Artak Tovmasyan, Kathleen A. Ashcraft, Zrinka Rajic, Tin Weitner, Chunlei Liu, Wei Li, Anne F. Buckley, Mark R. Prasad, Kenneth H. Young, Ramona M. Rodriguiz, William C. Wetsel, Katherine B. Peters, Ivan Spasojevic, James E. HerndonIIII, Ines Batinic-Haberle & Mark W. Dewhirst. (2015) Radioprotection of the Brain White Matter by Mn(III) N -Butoxyethylpyridylporphyrin–Based Superoxide Dismutase Mimic MnTnBuOE-2-PyP5+ . Molecular Cancer Therapeutics 14:1, pages 70-79.
Crossref
Meghan M. Delmastro-GreenwoodHubert M. TseJon D. Piganelli. (2014) Effects of Metalloporphyrins on Reducing Inflammation and Autoimmunity. Antioxidants & Redox Signaling 20:15, pages 2465-2477.
Crossref
Ines Batinic-HaberleArtak TovmasyanEmily R. H. RobertsZeljko VujaskovicKam W. LeongIvan Spasojevic. (2014) SOD Therapeutics: Latest Insights into Their Structure-Activity Relationships and Impact on the Cellular Redox-Based Signaling Pathways. Antioxidants & Redox Signaling 20:15, pages 2372-2415.
Crossref
Shayne C. Gad, Dexter W. SullivanJrJr, James D. Crapo & Charles B. Spainhour. (2013) A Nonclinical Safety Assessment of MnTE-2-PyP, a Manganese Porphyrin. International Journal of Toxicology 32:4, pages 274-287.
Crossref
Shin Bi Oh, Hee Ra Park, Young Jung Jang, Seon Young Choi, Tae Gen Son & Jaewon Lee. (2013) Baicalein attenuates impaired hippocampal neurogenesis and the neurocognitive deficits induced by γ-ray radiation. British Journal of Pharmacology 168:2, pages 421-431.
Crossref
John O. Archambeau, Artak Tovmasyan, Robert D. Pearlstein, James D. Crapo & Ines Batinic-Haberle. (2013) Superoxide dismutase mimic, MnTE-2-PyP5+ ameliorates acute and chronic proctitis following focal proton irradiation of the rat rectum. Redox Biology 1:1, pages 599-607.
Crossref
S. MehrotraM. J. PecautT. L. FreemanJ. D. CrapoA. RizviX. Luo-OwenJ. M. SlaterD. S. Gridley. (2012) Analysis of a Metalloporphyrin Antioxidant Mimetic (MnTE-2-PyP) as a Radiomitigator: Prostate Tumor and Immune Status. Technology in Cancer Research & Treatment 11:5, pages 447-457.
Crossref
Xiao Wen Mao, James D. Crapo & Daila S. Gridley. (2012) Mitochondrial Oxidative Stress-Induced Apoptosis and Radioprotection in Proton-Irradiated Rat Retina. Radiation Research 178:3, pages 118-125.
Crossref
Anne-Sophie Bernard, Claire Giroud, H. Y. Vincent Ching, Anne Meunier, Vinita Ambike, Christian Amatore, Manon Guille Collignon, Frédéric Lemaître & Clotilde Policar. (2012) Evaluation of the anti-oxidant properties of a SOD-mimic Mn-complex in activated macrophages. Dalton Transactions 41:21, pages 6399.
Crossref
Michael J. Daly. (2012) Death by protein damage in irradiated cells. DNA Repair 11:1, pages 12-21.
Crossref
Michael J. Aminoff,Yuen T. So. 2012. Neurology in Clinical Practice. Neurology in Clinical Practice 1353 1376 .
Jerry D. Slater. 2012. Ion Beam Therapy. Ion Beam Therapy 581 595 .
Ines Batinic-Haberle, Zrinka Rajic, Artak Tovmasyan, Julio S. Reboucas, Xiaodong Ye, Kam W. Leong, Mark W. Dewhirst, Zeljko Vujaskovic, Ludmil Benov & Ivan Spasojevic. (2011) Diverse functions of cationic Mn(III) N-substituted pyridylporphyrins, recognized as SOD mimics. Free Radical Biology and Medicine 51:5, pages 1035-1053.
Crossref
. (2011) Current World Literature. Current Opinion in Pediatrics 23:2, pages 253-261.
Crossref
Tomoyuki KOGA, Masahiro SHIN & Nobuhito SAITO. (2010) Role of Gamma Knife Radiosurgery in Neurosurgery: Past and Future Perspectives. Neurologia medico-chirurgica 50:9, pages 737-748.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.