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Inhibitory potential of ginger extracts against enzymes linked to type 2 diabetes, inflammation and induced oxidative stress

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Pages 106-110 | Published online: 28 Sep 2010

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Marjan Tajik Kord, Fatemeh Pourrajab & Seyedhossein Hekmatimoghaddam. (2020) Ginger Extract Increases GLUT-4 Expression Preferentially Through AMPK Than PI3K Signalling Pathways in C2C12 Muscle Cells. Diabetes, Metabolic Syndrome and Obesity 13, pages 3231-3238.
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Roya Rafie, Seyed Ahmad Hosseini, Eskandar Hajiani, Amal Saki Malehi & Seyed Ali Mard. (2020) Effect of Ginger Powder Supplementation in Patients with Non-Alcoholic Fatty Liver Disease: A Randomized Clinical Trial. Clinical and Experimental Gastroenterology 13, pages 35-45.
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K.R. Ajish, K.A. Antu, M.P. Riya, M.R. Preetharani, K.G. Raghu, B.P. Dhanya & K.V. Radhakrishnan. (2015) Studies on α-glucosidase, aldose reductase and glycation inhibitory properties of sesquiterpenes and flavonoids of Zingiber zerumbet Smith. Natural Product Research 29:10, pages 947-952.
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M. Tauseef Sultan, Masood Sadiq Buttxs, Mir M. Nasir Qayyum & Hafiz Ansar Rasul Suleria. (2014) Immunity: Plants as Effective Mediators. Critical Reviews in Food Science and Nutrition 54:10, pages 1298-1308.
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Shahid AkbarShahid Akbar. 2020. Handbook of 200 Medicinal Plants. Handbook of 200 Medicinal Plants 1957 1997 .
Andreia S.P. Pereira, Antonio J. Banegas-Luna, Jorge Peña-García, Horacio Pérez-Sánchez & Zeno Apostolides. (2019) Evaluation of the Anti-Diabetic Activity of Some Common Herbs and Spices: Providing New Insights with Inverse Virtual Screening. Molecules 24:22, pages 4030.
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Junhong Chen, Jing Sun, Richard A. Prinz, Yi Li & Xiulong Xu. (2018) Gingerenone A Sensitizes the Insulin Receptor and Increases Glucose Uptake by Inhibiting the Activity of p70 S6 Kinase. Molecular Nutrition & Food Research 62:23, pages 1800709.
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Abdollah Jafarzadeh & Maryam Nemati. (2018) Therapeutic potentials of ginger for treatment of Multiple sclerosis: A review with emphasis on its immunomodulatory, anti-inflammatory and anti-oxidative properties. Journal of Neuroimmunology 324, pages 54-75.
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Jie Zhu, Hao Chen, Zhixiu Song, Xudong Wang & Zhenshuang Sun. (2018) Effects of Ginger (Zingiber officinale Roscoe) on Type 2 Diabetes Mellitus and Components of the Metabolic Syndrome: A Systematic Review and Meta-Analysis of Randomized Controlled Trials . Evidence-Based Complementary and Alternative Medicine 2018, pages 1-11.
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Gehan F. Abdel Raoof & Khaled Y. Mohamed. 2018. 323 374 .
Sunil T. Pai. 2018. Integrative Medicine. Integrative Medicine 120 132.e8 .
Xinger Li, Haiyan Liu, Huiping Feng, Zhongren Xian, Yanhong Chen, Jianping Chen, Chunzhi Tang, Xinsheng Lai, Xiaoling Lan, Huanzhen Huang & Dongdong Yu. (2017) Acupuncture paired with herbal medicine for prediabetes: study protocol for a randomized controlled trial. Trials 18:1.
Crossref
Motahareh Makhdoomi Arzati, Niyaz Mohammadzadeh Honarvar, Ahmad Saedisomeolia, Siyamand Anvari, Mohammad Effatpanah, Raoofe Makhdoomi Arzati, Mir Saeed Yekaninejad, Rezvan Hashemi & Mahmoud Djalali. (2017) The Effects of Ginger on Fasting Blood Sugar, Hemoglobin A1c, and Lipid Profiles in Patients with Type 2 Diabetes. International Journal of Endocrinology and Metabolism In Press:In Press.
Crossref
Jing Wang, Weixin Ke, Rui Bao, Xiaosong Hu & Fang Chen. (2017) Beneficial effects of ginger Zingiber officinale Roscoe on obesity and metabolic syndrome: a review . Annals of the New York Academy of Sciences 1398:1, pages 83-98.
Crossref
Maliheh Najari Beidokhti & Anna K. Jäger. (2017) Review of antidiabetic fruits, vegetables, beverages, oils and spices commonly consumed in the diet. Journal of Ethnopharmacology 201, pages 26-41.
Crossref
Md. Asiful Islam, Fahmida Alam, Md. Solayman, Md. Ibrahim Khalil, Mohammad Amjad Kamal & Siew Hua Gan. (2016) Dietary Phytochemicals: Natural Swords Combating Inflammation and Oxidation-Mediated Degenerative Diseases. Oxidative Medicine and Cellular Longevity 2016, pages 1-25.
Crossref
Soo Kyung Jo, In Sook Kim, Shaheed Ur Rehman, Sang Keun Ha, Ho-Young Park, Yong Kon Park & Hye Hyun Yoo. (2015) Characterization of metabolites produced from the biotransformation of 6-shogaol formed by Aspergillus niger. European Food Research and Technology 242:1, pages 137-142.
Crossref
Vahideh Ebrahimzadeh Attari, Sepideh Mahluji, Mohammad Asghari Jafarabadi & Alireza Ostadrahimi. (2015) Effects of Supplementation with Ginger (Zingiber officinale Roscoe) on Serum Glucose, Lipid Profile and Oxidative Stress in Obese Women: A Randomized, Placebo-Controlled Clinical Trial. Pharmaceutical Sciences 21:4, pages 184-191.
Crossref
Karunrat Sakulnarmrat, George Srzednicki & Izabela Konczak. (2015) Antioxidant, enzyme inhibitory and antiproliferative activity of polyphenolic-rich fraction of commercial dry ginger powder. International Journal of Food Science & Technology 50:10, pages 2229-2235.
Crossref
Neda Javadi, Faridah Abas, Ahmed Mediani, Azizah Abd Hamid, Alfi Khatib, Sanimah Simoh & Khozirah Shaari. (2015) Effect of storage time on metabolite profile and alpha-glucosidase inhibitory activity of Cosmos caudatus leaves – GCMS based metabolomics approach. Journal of Food and Drug Analysis 23:3, pages 433-441.
Crossref
D. N. Olennikov & N. I. Kashchenko. (2015) 1-Dehydro-[14]-Gingerdione, a New Constituent from Zingiber officinale. Chemistry of Natural Compounds 51:5, pages 877-881.
Crossref
Farzad Shidfar, Asadollah Rajab, Tayebeh Rahideh, Nafiseh Khandouzi, Sharieh Hosseini & Shahrzad Shidfar. (2015) The effect of ginger ( Zingiber officinale ) on glycemic markers in patients with type 2 diabetes . Journal of Complementary and Integrative Medicine 12:2, pages 165-170.
Crossref
Laleh Khodaie & Omid Sadeghpoor. (2015) Ginger From Ancient Times to the New Outlook. Jundishapur Journal of Natural Pharmaceutical Products 10:1.
Crossref
A. Jafarzadeh, M. Mohammadi-Kordkhayli, R. Ahangar-Parvin, V. Azizi, H. Khoramdel-Azad, A. Shamsizadeh, A. Ayoobi, M. Nemati, Z.M. Hassan, S.M. Moazeni & M. Khaksari. (2014) Ginger extracts influence the expression of IL-27 and IL-33 in the central nervous system in experimental autoimmune encephalomyelitis and ameliorates the clinical symptoms of disease. Journal of Neuroimmunology 276:1-2, pages 80-88.
Crossref
K.R. Ajish, B.P. Dhanya, Nayana Joseph, M. Priya Rani, K.G. Raghu, V.P. Vineetha & K.V. Radhakrishnan. (2014) Synthesis of novel zerumbone derivatives via regioselective palladium catalyzed decarboxylative coupling reaction: a new class of α-glucosidase inhibitors. Tetrahedron Letters 55:3, pages 665-670.
Crossref
M. Thomson, K.K. Al-Qattan, J.S. Divya & M. Ali. (2013) Ameliorative Actions of Garlic (Allium sativum) and Ginger (Zingiber officinale) on Biomarkers of Diabetes and Diabetic Nephropathy in Rats: Comparison to Aspirin. International Journal of Pharmacology 9:8, pages 501-512.
Crossref
K.R. Ajish, Nayana Joseph, M. Priya Rani, K.G. Raghu, V.P. Vineetha & K.V. Radhakrishnan. (2013) Synthesis and biological evaluation of carbohydrate appended hydrazinocyclopentenes with potent glycation and α-glucosidase inhibition activities. Tetrahedron Letters 54:42, pages 5682-5685.
Crossref
Huadong Chen, Dominique Soroka, Yingdong Zhu & Shengmin Sang. (2013) Metabolism of ginger component [6]-shogaol in liver microsomes from mouse, rat, dog, monkey, and human. Molecular Nutrition & Food Research 57:5, pages 865-876.
Crossref
Rachel Mata, Sol Cristians, Sonia Escandón-Rivera, Krutzkaya Juárez-Reyes & Isabel Rivero-Cruz. (2013) Mexican Antidiabetic Herbs: Valuable Sources of Inhibitors of α-Glucosidases. Journal of Natural Products 76:3, pages 468-483.
Crossref
Chiara Di Lorenzo, Mario Dell'Agli, Elisa Colombo, Enrico Sangiovanni & Patrizia Restani. (2013) Metabolic Syndrome and Inflammation: A Critical Review of In Vitro and Clinical Approaches for Benefit Assessment of Plant Food Supplements . Evidence-Based Complementary and Alternative Medicine 2013, pages 1-10.
Crossref
Cicero L. T. Chang, Yenshou Lin, Arlene P. Bartolome, Yi-Ching Chen, Shao-Chih Chiu & Wen-Chin Yang. (2013) Herbal Therapies for Type 2 Diabetes Mellitus: Chemistry, Biology, and Potential Application of Selected Plants and Compounds. Evidence-Based Complementary and Alternative Medicine 2013, pages 1-33.
Crossref
A.R. Shivashankara, R. Haniadka, P. Sandhya, P.L. Palatty & M.S. Baliga. 2013. Bioactive Food as Dietary Interventions for Diabetes. Bioactive Food as Dietary Interventions for Diabetes 571 582 .
A.N. Prabhu, A.R. Shivashankara, R. Haniadka, P.L. Palatty, D. Prabhu & M.S. Baliga. 2013. Bioactive Food as Dietary Interventions for Cardiovascular Disease. Bioactive Food as Dietary Interventions for Cardiovascular Disease 693 704 .
George Q. Li, Antony Kam, Ka H. Wong, Xian Zhou, Eshaifol A. Omar, Ali Alqahtani, Kong M. Li, Valentina Razmovski-Naumovski & Kelvin Chan. 2013. Diabetes. Diabetes 396 413 .
Naila Abdul Sattar, Fatma Hussain, Tahira Iqbal & Munir Ahmad Sheikh. (2012) Determination of in vitro antidiabetic effects of Zingiber officinale Roscoe. Brazilian Journal of Pharmaceutical Sciences 48:4, pages 601-607.
Crossref
M Priya Rani, Mahesh S Krishna, Keezheveettil P Padmakumari, K Gopal Raghu & Andikannu Sundaresan. (2012) Zingiber officinale extract exhibits antidiabetic potential via modulating glucose uptake, protein glycation and inhibiting adipocyte differentiation: an in vitro study . Journal of the Science of Food and Agriculture 92:9, pages 1948-1955.
Crossref
Fang Peng, Qiaofeng Tao, Xiumei Wu, Hui Dou, Shawn Spencer, Chaoyong Mang, Lu Xu, Lianli Sun, Yu Zhao, Haibo Li, Su Zeng, Guangming Liu & Xiaojiang Hao. (2012) Cytotoxic, cytoprotective and antioxidant effects of isolated phenolic compounds from fresh ginger. Fitoterapia 83:3, pages 568-585.
Crossref
Yiming Li, Van H. Tran, Colin C. Duke & Basil D. Roufogalis. (2012) Preventive and Protective Properties of Zingiber officinale (Ginger) in Diabetes Mellitus, Diabetic Complications, and Associated Lipid and Other Metabolic Disorders: A Brief Review . Evidence-Based Complementary and Alternative Medicine 2012, pages 1-10.
Crossref
Sunil T. Pai. 2012. Integrative Medicine. Integrative Medicine 102 113.e5 .

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