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Original Article

Combination Regimen of Cladribine (2-Chlorodeoxyadenosine), Cytarabine and G-CSF (CLAG) as Induction Therapy for Patients with Relapsed or Refractory Acute Myeloid Leukemia

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Pages 121-129 | Received 12 Jan 2000, Published online: 01 Jul 2009

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Muhammad Umair Mushtaq, Alexandra M. Harrington, Sibgha Gull Chaudhary, Laura C. Michaelis, Karen-Sue B. Carlson, Sameem Abedin, Lyndsey Runass, Natalie S. Callander, Michael J. Fallon, Mark Juckett, Aric C. Hall, Peiman Hematti, Ryan J. Mattison, Ehab L. Atallah & Guru Subramanian Guru Murthy. (2021) Comparison of salvage chemotherapy regimens and prognostic significance of minimal residual disease in relapsed/refractory acute myeloid leukemia. Leukemia & Lymphoma 62:1, pages 158-166.
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Anqi Zhou, Qi Han, Huihui Song, Jie Zi, Jinlong Ma & Zheng Ge. (2019) Efficacy and toxicity of cladribine for the treatment of refractory acute myeloid leukemia: a meta-analysis. Drug Design, Development and Therapy 13, pages 1867-1878.
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Chantal Fridle, Michael Medinger, Matthias C. Wilk, Katja Seipel, Jakob Passweg, Markus G. Manz & Thomas Pabst. (2017) Cladribine, cytarabine and idarubicin (CLA-Ida) salvage chemotherapy in relapsed acute myeloid leukemia (AML). Leukemia & Lymphoma 58:5, pages 1068-1075.
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Tadeusz Robak. (2003) Purine Nucleoside Analogues in the Treatment of Myleoid Leukemias. Leukemia & Lymphoma 44:3, pages 391-409.
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Han Yao, Cheng Zhang, Xu Tan, Jieping Li, Xiaolin Yin, Xiaojuan Deng, Ting Chen, Jun Rao, Lei Gao, Peiyan Kong & Xi Zhang. (2023) Efficacy and toxicity of CLAG combined with pegylated liposomal doxorubicin in the treatment of refractory or relapsed acute myeloid leukemia . Cancer Medicine 12:11, pages 12377-12387.
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Shai Shimony, Maximilian Stahl & Richard M. Stone. (2023) Acute myeloid leukemia: 2023 update on diagnosis, risk‐stratification, and management. American Journal of Hematology 98:3, pages 502-526.
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Na Zhang, Jing-Bo Shao, Hong Li, Jing-Wei Yang, Kai Chen, Jia-Shi Zhu & Hui Jiang. (2019) Re-induction with modified CLAG regimen in relapsed or refractory acute myeloid leukemia in children bridging to allogeneic hematopoietic stem cell transplantation. World Journal of Pediatrics 16:2, pages 152-158.
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Peipei Ye, Renzhi Pei, Jie Jin, Jie Sun, Kongfei Li, Junjie Cao, Dandan Zhou & Ying Lu. (2019) Modified cladribine, cytarabine, and G-CSF as a salvage regimen in patients with relapsed/refractory acute myeloid leukemia: a bridge to myeloablative allogeneic hematopoietic stem cell transplantation. Annals of Hematology 98:9, pages 2073-2080.
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Ayman Qasrawi, Waled Bahaj, Lien Qasrawi, Omar Abughanimeh, John Foxworth & Rakesh Gaur. (2018) Cladribine in the remission induction of adult acute myeloid leukemia: where do we stand?. Annals of Hematology 98:3, pages 561-579.
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J. Zhang, Y. Sun, X. Zhang, B. Long, Y. Lu & X. Li. (2018) Treatment of High-Risk Acute Myeloid Leukemia With Cladribine, Cytarabine, Mitoxantrone, and Granulocyte Colony-Stimulating Factor Then Subsequent Bridging to Myeloablative Allogeneic Hematopoietic Stem Cell Transplantation: A Case Series. Transplantation Proceedings 50:1, pages 246-249.
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Abu-Sayeef Mirza, Jeffrey E. Lancet, Kendra Sweet, Eric Padron, Javier Pinilla-Ibarz, Lisa Nardelli, Christopher Cubitt, Alan F. List & Rami S. Komrokji. (2017) A Phase II Study of CLAG Regimen Combined With Imatinib Mesylate for Relapsed or Refractory Acute Myeloid Leukemia. Clinical Lymphoma Myeloma and Leukemia 17:12, pages 902-907.
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Karen Seiter, Nasir Ahmed, Azfar Shaikh, Paul Baskind & Delong Liu. (2016) CLAG-based induction therapy in previously untreated high risk acute myeloid leukemia patients. Leukemia Research 46, pages 74-78.
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Katherine Linder, Deepthi Gandhiraj, Madhura Hanmantgad, Karen Seiter & Delong Liu. (2016) Complete remission after single agent blinatumomab in a patient with pre-B acute lymphoid leukemia relapsed and refractory to three prior regimens: hyperCVAD, high dose cytarabine mitoxantrone and CLAG. Experimental Hematology & Oncology 5:1.
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Jeffrey C. Bryan & Elias J. Jabbour. (2015) Management of Relapsed/Refractory Acute Myeloid Leukemia in the Elderly: Current Strategies and Developments. Drugs & Aging 32:8, pages 623-637.
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Kamal K.S. Abbi, Witold Rybka, W. Christopher Ehmann & David F. Claxton. (2015) Phase I/II Study of Clofarabine, Etoposide, and Mitoxantrone in Patients With Refractory or Relapsed Acute Leukemia. Clinical Lymphoma Myeloma and Leukemia 15:1, pages 41-46.
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Craig W. Freyer, Neha Gupta, Meir Wetzler & Eunice S. Wang. (2015) Revisiting the role of cladribine in acute myeloid leukemia: An improvement on past accomplishments or more old news?. American Journal of Hematology 90:1, pages 62-72.
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Jennifer Davila, Emily Slotkin & Thomas Renaud. (2013) Relapsed and Refractory Pediatric Acute Myeloid Leukemia: Current and Emerging Treatments. Pediatric Drugs 16:2, pages 151-168.
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Pawel Robak & Tadeusz Robak. (2013) Older and new purine nucleoside analogs for patients with acute leukemias. Cancer Treatment Reviews 39:8, pages 851-861.
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Andrew Wei & Tse-Chieh Teh. (2011) Salvaging AML with CLAG: Novel option, or more of the same?. Leukemia Research 35:3, pages 297-298.
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Mike G. Martin, John S. Welch, Kristan Augustin, Lindsay Hladnik, John F. DiPersio & Camille N. Abboud. (2009) Cladribine in the Treatment of Acute Myeloid Leukemia: A Single-Institution Experience. Clinical Lymphoma and Myeloma 9:4, pages 298-301.
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