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Free Radical Research Volume 44, 2010 - Issue 9
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Research Article

Cathepsin D is one of the major enzymes involved in intracellular degradation of AGE-modified proteins

Stefanie Grimm Institute of Biological Chemistry and Nutrition, University of Hohenheim, Garbenstraße 28, 70593 Stuttgart, Germany
,
Lisa Ernst Institute of Biological Chemistry and Nutrition, University of Hohenheim, Garbenstraße 28, 70593 Stuttgart, Germany
,
Nicole Grötzinger Institute of Biological Chemistry and Nutrition, University of Hohenheim, Garbenstraße 28, 70593 Stuttgart, Germany
,
Annika Höhn Institute of Biological Chemistry and Nutrition, University of Hohenheim, Garbenstraße 28, 70593 Stuttgart, Germany
,
Nicolle Breusing Institute of Biological Chemistry and Nutrition, University of Hohenheim, Garbenstraße 28, 70593 Stuttgart, Germany
,
Thomas Reinheckel Institute for Molecular Medicine and Cell Research, Albert-Ludwigs-University Freiburg, Stefan-Meier-Strasse 17, 79104 Freiburg, Germany
&
Tilman Grune Institute of Biological Chemistry and Nutrition, University of Hohenheim, Garbenstraße 28, 70593 Stuttgart, GermanyCorrespondence[email protected]
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Pages 1013-1026 | Received 20 Jan 2010, Published online: 21 Jun 2010

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Nikoletta Papaevgeniou, Annika Hoehn, Josep A. Tur, Lars-Oliver Klotz, Tilman Grune & Niki Chondrogianni. (2019) Sugar-derived AGEs accelerate pharyngeal pumping rate and increase the lifespan of Caenorhabditis elegans. Free Radical Research 53:sup1, pages 1056-1067.
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O. Nedić, S. I. S. Rattan, T. Grune & I. P. Trougakos. (2013) Molecular effects of advanced glycation end products on cell signalling pathways, ageing and pathophysiology. Free Radical Research 47:sup1, pages 28-38.
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Giancarlo Aldini, Giulio Vistoli, Milan Stefek, N. Chondrogianni, Tilman Grune, Jolanta Sereikaite, Izabela Sadowska-Bartosz & Grzegorz Bartosz. (2013) Molecular strategies to prevent, inhibit, and degrade advanced glycoxidation and advanced lipoxidation end products. Free Radical Research 47:sup1, pages 93-137.
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Articles from other publishers (40)

Ioanna A. Anastasiou, Konstantinos N. Tentolouris, Vaia Lambadiari, Ioanna Eleftheriadou, Maria TektonidouNikolaos Tentolouris. (2023) Effects of Advanced Glycation End Products via Oxidative Stress on Beta Cells: Insights from in vitro and in vivo Studies and Update on Emerging Therapies. Mini-Reviews in Medicinal Chemistry 23:21, pages 2041-2052.
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Ning Ye, Linlin Miao, Fengzhi Wang, Shaojun Wu, Boquan Wu, Ying Zhou, Chang Wang & Guozhe Sun. (2023) Cathepsin D Attenuates the Proliferation of Vascular Smooth Muscle Cells Induced by the AGE/RAGE Pathway by Suppressing the ERK Signal. Current Pharmaceutical Design 29:30, pages 2387-2395.
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Wojciech Trybus, Ewa Trybus & Teodora Król. (2023) Lysosomes as a Target of Anticancer Therapy. International Journal of Molecular Sciences 24:3, pages 2176.
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Christine P. Limonte, Erkka Valo, Viktor Drel, Loki Natarajan, Manjula Darshi, Carol Forsblom, Clark M. Henderson, Andrew N. Hoofnagle, Wenjun Ju, Matthias Kretzler, Daniel Montemayor, Viji Nair, Robert G. Nelson, John F. O’Toole, Robert D. Toto, Sylvia E. Rosas, John Ruzinski, Niina Sandholm, Insa M. Schmidt, Tomas Vaisar, Sushrut S. Waikar, Jing Zhang, Peter Rossing, Tarunveer S. Ahluwalia, Per-Henrik Groop, Subramaniam Pennathur, Janet K. Snell-Bergeon, Tina Costacou, Trevor J. Orchard, Kumar Sharma & Ian H. de Boer. (2022) Urinary Proteomics Identifies Cathepsin D as a Biomarker of Rapid eGFR Decline in Type 1 Diabetes. Diabetes Care 45:6, pages 1416-1427.
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Katja C.W. van Dongen, Leonie Kappetein, Ignacio Miro Estruch, Clara Belzer, Karsten Beekmann & Ivonne M.C.M. Rietjens. (2022) Differences in kinetics and dynamics of endogenous versus exogenous advanced glycation end products (AGEs) and their precursors. Food and Chemical Toxicology 164, pages 112987.
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Gemma Aragonès, Sheldon Rowan, Sarah G Francisco, Wenxin Yang, Jasper Weinberg, Allen Taylor & Eloy Bejarano. (2020) Glyoxalase System as a Therapeutic Target against Diabetic Retinopathy. Antioxidants 9:11, pages 1062.
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Fiona Limanaqi, Francesca Biagioni, Federica Mastroiacovo, Maico Polzella, Gloria Lazzeri & Francesco Fornai. (2020) Merging the Multi-Target Effects of Phytochemicals in Neurodegeneration: From Oxidative Stress to Protein Aggregation and Inflammation. Antioxidants 9:10, pages 1022.
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Jana Raupbach, Christiane Ott, Jeannette Koenig & Tilman Grune. (2020) Proteasomal degradation of glycated proteins depends on substrate unfolding: Preferred degradation of moderately modified myoglobin. Free Radical Biology and Medicine 152, pages 516-524.
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Fiona Limanaqi, Francesca Biagioni, Stefano Gambardella, Pietro Familiari, Alessandro Frati & Francesco Fornai. (2020) Promiscuous Roles of Autophagy and Proteasome in Neurodegenerative Proteinopathies. International Journal of Molecular Sciences 21:8, pages 3028.
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Tilman Grune. (2020) Oxidized protein aggregates: Formation and biological effects. Free Radical Biology and Medicine 150, pages 120-124.
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Seu-Hwa Chen, Kuo-Ching Yuan, Yu-Chieh Lee, Chun-Kuang Shih, Sung-Hui Tseng, Alexey A. Tinkov, Anatoly V. Skalny & Jung-Su Chang. (2020) Iron and Advanced Glycation End Products: Emerging Role of Iron in Androgen Deficiency in Obesity. Antioxidants 9:3, pages 261.
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Francesc X. Guix. (2019) The interplay between aging‐associated loss of protein homeostasis and extracellular vesicles in neurodegeneration. Journal of Neuroscience Research 98:2, pages 262-283.
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C. G. Schalkwijk & C. D. A. Stehouwer. (2020) Methylglyoxal, a Highly Reactive Dicarbonyl Compound, in Diabetes, Its Vascular Complications, and Other Age-Related Diseases. Physiological Reviews 100:1, pages 407-461.
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Gerald H. Lushington & Anthony C. Barnes. (2019) Protein Glycation: An Old Villain is Shedding Secrets. Combinatorial Chemistry & High Throughput Screening 22:6, pages 362-369.
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Aurore Desmons, Anaïs Okwieka, Manon Doué, Laëtitia Gorisse, Vincent Vuiblet, Christine Pietrement, Philippe Gillery & Stéphane Jaisson. (2019) Proteasome-dependent degradation of intracellular carbamylated proteins. Aging 11:11, pages 3624-3638.
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Mariane Lutz, Eduardo Fuentes, Felipe Ávila, Marcelo Alarcón & Iván Palomo. (2019) Roles of Phenolic Compounds in the Reduction of Risk Factors of Cardiovascular Diseases. Molecules 24:2, pages 366.
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Sheldon Rowan, Eloy Bejarano & Allen Taylor. (2018) Mechanistic targeting of advanced glycation end-products in age-related diseases. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 1864:12, pages 3631-3643.
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Kerstin Nowotny, David Schröter, Monika Schreiner & Tilman Grune. (2018) Dietary advanced glycation end products and their relevance for human health. Ageing Research Reviews 47, pages 55-66.
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Xinya Xu, Yue Zheng, Yunfen Huang, Jian Chen, Zijian Gong, Yuying Li, Chun Lu, Wei Lai & Qingfang Xu. (2018) Cathepsin D contributes to the accumulation of advanced glycation end products during photoaging. Journal of Dermatological Science 90:3, pages 263-275.
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Yanfu Han, Tianjun Sun, Ran Tao, Yanqing Han & Jing Liu. (2017) Clinical application prospect of umbilical cord-derived mesenchymal stem cells on clearance of advanced glycation end products through autophagy on diabetic wound. European Journal of Medical Research 22:1.
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Kuo-Ching Chao, Seu-Hwa Chen, Chun-Chao Chang, Yu-Chieh Lee, Chi-Mei Wang & Jung-Su Chang. (2017) Effects of ferric citrate supplementation on advanced glycation end products in a rat model of streptozotocin/nicotinamide-induced diabetes. Molecular Nutrition & Food Research 61:5, pages 1600753.
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Fabio Di DomenicoEugenio BaroneMarzia PerluigiD. Allan Butterfield. (2017) The Triangle of Death in Alzheimer's Disease Brain: The Aberrant Cross-Talk Among Energy Metabolism, Mammalian Target of Rapamycin Signaling, and Protein Homeostasis Revealed by Redox Proteomics. Antioxidants & Redox Signaling 26:8, pages 364-387.
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Yuan Li, Ye Chang, Ning Ye, Dongxue Dai, Yintao Chen, Naijin Zhang, Guozhe Sun & Yingxian Sun. (2017) Advanced Glycation End Products Inhibit the Proliferation of Human Umbilical Vein Endothelial Cells by Inhibiting Cathepsin D. International Journal of Molecular Sciences 18:2, pages 436.
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Teresa Carbonell, Norma Alva, Sergio Sanchez-Nuño, Shannamar Dewey & Aldrin V. Gomes. (2016) Subnormothermic Perfusion in the Isolated Rat Liver Preserves the Antioxidant Glutathione and Enhances the Function of the Ubiquitin Proteasome System. Oxidative Medicine and Cellular Longevity 2016, pages 1-12.
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Kerstin Nowotny, Tobias Jung, Annika Höhn, Daniela Weber & Tilman Grune. (2015) Advanced Glycation End Products and Oxidative Stress in Type 2 Diabetes Mellitus. Biomolecules 5:1, pages 194-222.
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Fabio Di Domenico, Elizabeth Head, D. Allan Butterfield & Marzia Perluigi. (2014) Oxidative Stress and Proteostasis Network: Culprit and Casualty of Alzheimer’s-Like Neurodegeneration. Advances in Geriatrics 2014, pages 1-14.
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Annika Höhn, Tobias Jung & Tilman Grune. (2014) Pathophysiological importance of aggregated damaged proteins. Free Radical Biology and Medicine 71, pages 70-89.
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Zhang Shu-shan, Dai Jian-jun, Wu Cai-feng, Zhang Ting-yu & Zhang De-fu. (2014) Comparative proteomic analysis of hearts of adult SCNT Bama miniature pigs (Sus scrofa). Theriogenology 81:7, pages 901-905.
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Christiane Ott, Kathleen Jacobs, Elisa Haucke, Anne Navarrete Santos, Tilman Grune & Andreas Simm. (2014) Role of advanced glycation end products in cellular signaling. Redox Biology 2, pages 411-429.
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Kerstin Nowotny & Tilman Grune. (2014) Degradation of oxidized and glycoxidized collagen: Role of collagen cross-linking. Archives of Biochemistry and Biophysics 542, pages 56-64.
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Eleni N. Tsakiri, Kalliopi K. Iliaki, Annika Höhn, Stefanie Grimm, Issidora S. Papassideri, Tilman Grune & Ioannis P. Trougakos. (2013) Diet-derived advanced glycation end products or lipofuscin disrupts proteostasis and reduces life span in Drosophila melanogaster. Free Radical Biology and Medicine 65, pages 1155-1163.
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Fabio Di Domenico, Raffaella Coccia, Annalisa Cocciolo, M. Paul Murphy, Giovanna Cenini, Elizabeth Head, D. Allan Butterfield, Alessandra Giorgi, Maria Eugenia Schinina, Cesare Mancuso, Chiara Cini & Marzia Perluigi. (2013) Impairment of proteostasis network in Down syndrome prior to the development of Alzheimer's disease neuropathology: Redox proteomics analysis of human brain. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 1832:8, pages 1249-1259.
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Alexa Klettner, Anu Kauppinen, Janusz Blasiak, Johan Roider, Antero Salminen & Kai Kaarniranta. (2013) Cellular and molecular mechanisms of age-related macular degeneration: From impaired autophagy to neovascularization. The International Journal of Biochemistry & Cell Biology 45:7, pages 1457-1467.
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Annika H?hn & Tilman Grune. (2013) Lipofuscin: formation, effects and role of macroautophagy. Redox Biology 1:1, pages 140-144.
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Tilman Grune, Betul Catalgol & Tobias Jung. 2012. Protein Oxidation and Aging. Protein Oxidation and Aging 417 478 .
Tilman Grune, Betul Catalgol & Tobias Jung. 2012. Protein Oxidation and Aging. Protein Oxidation and Aging 1 214 .
Stefanie Grimm, Christiane Ott, Melanie Hörlacher, Daniela Weber, Annika Höhn & Tilman Grune. (2012) Advanced-glycation-end-product-induced formation of immunoproteasomes: involvement of RAGE and Jak2/STAT1. Biochemical Journal 448:1, pages 127-139.
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Stefanie Grimm, Melanie Horlacher, Betül Catalgol, Annika Hoehn, Thomas Reinheckel & Tilman Grune. (2012) Cathepsins D and L reduce the toxicity of advanced glycation end products. Free Radical Biology and Medicine 52:6, pages 1011-1023.
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Alvaro RuibalMichel HerranzJosé Ignacio Arias. (2017) Clinical and Biological Significance of Cathepsin D Levels in Breast Cancer Cytosol in Women over 70 years. Biomarkers in Cancer 4, pages BIC.S9096.
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Sarah D. Lamore, Shuxi Qiao, David Horn & Georg T. Wondrak. (2010) Proteomic Identification of Cathepsin B and Nucleophosmin as Novel UVA-Targets in Human Skin Fibroblasts. Photochemistry and Photobiology 86:6, pages 1307-1317.
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